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CPB2 (carboxypeptidase B2)

Identity

Alias_namescarboxypeptidase B2 (plasma, carboxypeptidase U)
carboxypeptidase B2 (plasma)
Alias_symbol (synonym)CPU
PCPB
TAFI
Other alias
HGNC (Hugo) CPB2
LocusID (NCBI) 1361
Atlas_Id 46024
Location 13q14.13  [Link to chromosome band 13q14]
Location_base_pair Starts at 46627322 and ends at 46679211 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
CPB2 (13q14.13) / NUP214 (9q34.13)WWP1 (8q21.3) / CPB2 (13q14.13)WWP1 8q21.3 / CPB2 13q14.13

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)CPB2   2300
Cards
Entrez_Gene (NCBI)CPB2  1361  carboxypeptidase B2
AliasesCPU; PCPB; TAFI
GeneCards (Weizmann)CPB2
Ensembl hg19 (Hinxton)ENSG00000080618 [Gene_View]  chr13:46627322-46679211 [Contig_View]  CPB2 [Vega]
Ensembl hg38 (Hinxton)ENSG00000080618 [Gene_View]  chr13:46627322-46679211 [Contig_View]  CPB2 [Vega]
ICGC DataPortalENSG00000080618
TCGA cBioPortalCPB2
AceView (NCBI)CPB2
Genatlas (Paris)CPB2
WikiGenes1361
SOURCE (Princeton)CPB2
Genetics Home Reference (NIH)CPB2
Genomic and cartography
GoldenPath hg19 (UCSC)CPB2  -     chr13:46627322-46679211 -  13q14.13   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)CPB2  -     13q14.13   [Description]    (hg38-Dec_2013)
EnsemblCPB2 - 13q14.13 [CytoView hg19]  CPB2 - 13q14.13 [CytoView hg38]
Mapping of homologs : NCBICPB2 [Mapview hg19]  CPB2 [Mapview hg38]
OMIM603101   
Gene and transcription
Genbank (Entrez)AA700377 AB011969 AK290829 AU100156 AV719308
RefSeq transcript (Entrez)NM_001278541 NM_001872 NM_016413
RefSeq genomic (Entrez)NC_000013 NC_018924 NG_032893 NT_024524 NW_004929388
Consensus coding sequences : CCDS (NCBI)CPB2
Cluster EST : UnigeneHs.512937 [ NCBI ]
CGAP (NCI)Hs.512937
Alternative Splicing GalleryENSG00000080618
Gene ExpressionCPB2 [ NCBI-GEO ]   CPB2 [ EBI - ARRAY_EXPRESS ]   CPB2 [ SEEK ]   CPB2 [ MEM ]
Gene Expression Viewer (FireBrowse)CPB2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)1361
GTEX Portal (Tissue expression)CPB2
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ96IY4   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ96IY4  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ96IY4
Splice isoforms : SwissVarQ96IY4
PhosPhoSitePlusQ96IY4
Domains : Interpro (EBI)Peptidase_M14    Prot_inh_M14A    Prot_inh_propept   
Domain families : Pfam (Sanger)Peptidase_M14 (PF00246)    Propep_M14 (PF02244)   
Domain families : Pfam (NCBI)pfam00246    pfam02244   
Domain families : Smart (EMBL)Zn_pept (SM00631)  
Conserved Domain (NCBI)CPB2
DMDM Disease mutations1361
Blocks (Seattle)CPB2
PDB (SRS)3D66    3D67    3D68    3LMS    4P10   
PDB (PDBSum)3D66    3D67    3D68    3LMS    4P10   
PDB (IMB)3D66    3D67    3D68    3LMS    4P10   
PDB (RSDB)3D66    3D67    3D68    3LMS    4P10   
Structural Biology KnowledgeBase3D66    3D67    3D68    3LMS    4P10   
SCOP (Structural Classification of Proteins)3D66    3D67    3D68    3LMS    4P10   
CATH (Classification of proteins structures)3D66    3D67    3D68    3LMS    4P10   
SuperfamilyQ96IY4
Human Protein AtlasENSG00000080618
Peptide AtlasQ96IY4
HPRD04374
IPIIPI00329775   IPI00293057   
Protein Interaction databases
DIP (DOE-UCLA)Q96IY4
IntAct (EBI)Q96IY4
FunCoupENSG00000080618
BioGRIDCPB2
STRING (EMBL)CPB2
ZODIACCPB2
Ontologies - Pathways
QuickGOQ96IY4
Ontology : AmiGOpositive regulation of extracellular matrix constituent secretion  metallocarboxypeptidase activity  extracellular space  cell  proteolysis  blood coagulation  zinc ion binding  response to heat  negative regulation of plasminogen activation  response to drug  fibrinolysis  negative regulation of fibrinolysis  extracellular exosome  cellular response to glucose stimulus  liver regeneration  negative regulation of hepatocyte proliferation  
Ontology : EGO-EBIpositive regulation of extracellular matrix constituent secretion  metallocarboxypeptidase activity  extracellular space  cell  proteolysis  blood coagulation  zinc ion binding  response to heat  negative regulation of plasminogen activation  response to drug  fibrinolysis  negative regulation of fibrinolysis  extracellular exosome  cellular response to glucose stimulus  liver regeneration  negative regulation of hepatocyte proliferation  
Pathways : BIOCARTAFibrinolysis Pathway [Genes]   
Pathways : KEGGComplement and coagulation cascades    Pancreatic secretion    Protein digestion and absorption   
NDEx NetworkCPB2
Atlas of Cancer Signalling NetworkCPB2
Wikipedia pathwaysCPB2
Orthology - Evolution
OrthoDB1361
GeneTree (enSembl)ENSG00000080618
Phylogenetic Trees/Animal Genes : TreeFamCPB2
HOVERGENQ96IY4
HOGENOMQ96IY4
Homologs : HomoloGeneCPB2
Homology/Alignments : Family Browser (UCSC)CPB2
Gene fusions - Rearrangements
Fusion : MitelmanWWP1/CPB2 [8q21.3/13q14.13]  [t(8;13)(q21;q14)]  
Fusion: TCGAWWP1 8q21.3 CPB2 13q14.13 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCPB2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CPB2
dbVarCPB2
ClinVarCPB2
1000_GenomesCPB2 
Exome Variant ServerCPB2
ExAC (Exome Aggregation Consortium)CPB2 (select the gene name)
Genetic variants : HAPMAP1361
Genomic Variants (DGV)CPB2 [DGVbeta]
DECIPHER (Syndromes)13:46627322-46679211  ENSG00000080618
CONAN: Copy Number AnalysisCPB2 
Mutations
ICGC Data PortalCPB2 
TCGA Data PortalCPB2 
Broad Tumor PortalCPB2
OASIS PortalCPB2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCPB2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDCPB2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch CPB2
DgiDB (Drug Gene Interaction Database)CPB2
DoCM (Curated mutations)CPB2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CPB2 (select a term)
intoGenCPB2
Cancer3DCPB2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM603101   
Orphanet
MedgenCPB2
Genetic Testing Registry CPB2
NextProtQ96IY4 [Medical]
TSGene1361
GENETestsCPB2
Huge Navigator CPB2 [HugePedia]
snp3D : Map Gene to Disease1361
BioCentury BCIQCPB2
ClinGenCPB2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD1361
Chemical/Pharm GKB GenePA26822
Clinical trialCPB2
Miscellaneous
canSAR (ICR)CPB2 (select the gene name)
Probes
Litterature
PubMed191 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineCPB2
EVEXCPB2
GoPubMedCPB2
iHOPCPB2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Mar 14 13:01:30 CET 2017

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