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CPD (carboxypeptidase D)

Identity

Alias (NCBI)GP180
HGNC (Hugo) CPD
HGNC Alias symbGP180
HGNC Alias namemetallocarboxypeptidase D
LocusID (NCBI) 1362
Atlas_Id 46417
Location 17q11.2  [Link to chromosome band 17q11]
Location_base_pair Starts at 30378927 and ends at 30469989 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CPD (17q11.2) / AATF (17q12)CPD (17q11.2) / CPD (17q11.2)CPD (17q11.2) / ERBB2 (17q12)
CPD (17q11.2) / GSTO1 (10q25.1)CPD (17q11.2) / ORMDL3 (17q12)CPD (17q11.2) / PIGW (17q12)
CPD (17q11.2) / SKAP1 (17q21.32)CPD (17q11.2) / TBX2 (17q23.2)CPD (17q11.2) / UQCRQ (5q31.1)
GOSR1 (17q11.2) / CPD (17q11.2)NUFIP2 (17q11.2) / CPD (17q11.2)RGMB (5q15) / CPD (17q11.2)
SYAP1 (Xp22.2) / CPD (17q11.2)CPD 17q11.2 / AATF 17q12CPD 17q11.2 / ORMDL3 17q12
CPD 17q11.2 / PIGW 17q12CPD 17q11.2 / SKAP1 17q21.32CPD 17q11.2 / TBX2 17q23.2
NUFIP2 17q11.2 / CPD 17q11.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 7 ]
  NUFIP2/CPD (17q11)
t(17;17)(q11;q12) CPD/AATF
t(17;17)(q11;q12) CPD/ERBB2
t(17;17)(q11;q12) CPD/ORMDL3
t(17;17)(q11;q12) CPD/PIGW
t(17;17)(q11;q21) CPD/SKAP1
t(17;17)(q11;q23) CPD/TBX2

External links

Nomenclature
HGNC (Hugo)CPD   2301
Cards
Entrez_Gene (NCBI)CPD    carboxypeptidase D
AliasesGP180
GeneCards (Weizmann)CPD
Ensembl hg19 (Hinxton)ENSG00000108582 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000108582 [Gene_View]  ENSG00000108582 [Sequence]  chr17:30378927-30469989 [Contig_View]  CPD [Vega]
ICGC DataPortalENSG00000108582
TCGA cBioPortalCPD
AceView (NCBI)CPD
Genatlas (Paris)CPD
SOURCE (Princeton)CPD
Genetics Home Reference (NIH)CPD
Genomic and cartography
GoldenPath hg38 (UCSC)CPD  -     chr17:30378927-30469989 +  17q11.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)CPD  -     17q11.2   [Description]    (hg19-Feb_2009)
GoldenPathCPD - 17q11.2 [CytoView hg19]  CPD - 17q11.2 [CytoView hg38]
ImmunoBaseENSG00000108582
genome Data Viewer NCBICPD [Mapview hg19]  
OMIM603102   
Gene and transcription
Genbank (Entrez)AK302497 AK302878 AK316409 AL049339 BC020457
RefSeq transcript (Entrez)NM_001199775 NM_001304
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)CPD
Alternative Splicing GalleryENSG00000108582
Gene ExpressionCPD [ NCBI-GEO ]   CPD [ EBI - ARRAY_EXPRESS ]   CPD [ SEEK ]   CPD [ MEM ]
Gene Expression Viewer (FireBrowse)CPD [ Firebrowse - Broad ]
GenevisibleExpression of CPD in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)1362
GTEX Portal (Tissue expression)CPD
Human Protein AtlasENSG00000108582-CPD [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO75976   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO75976  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO75976
Splice isoforms : SwissVarO75976
Catalytic activity : Enzyme3.4.17.22 [ Enzyme-Expasy ]   3.4.17.223.4.17.22 [ IntEnz-EBI ]   3.4.17.22 [ BRENDA ]   3.4.17.22 [ KEGG ]   [ MEROPS ]
PhosPhoSitePlusO75976
Domaine pattern : Prosite (Expaxy)CARBOXYPEPT_ZN_1 (PS00132)    CARBOXYPEPT_ZN_2 (PS00133)   
Domains : Interpro (EBI)CarboxyPept-like_regulatory    M14_CPD_II    Pept_M14B_carboxypept_D2    Peptidase_M14   
Domain families : Pfam (Sanger)Peptidase_M14 (PF00246)   
Domain families : Pfam (NCBI)pfam00246   
Domain families : Smart (EMBL)Zn_pept (SM00631)  
Conserved Domain (NCBI)CPD
Blocks (Seattle)CPD
PDB (RSDB)5AQ0   
PDB Europe5AQ0   
PDB (PDBSum)5AQ0   
PDB (IMB)5AQ0   
Structural Biology KnowledgeBase5AQ0   
SCOP (Structural Classification of Proteins)5AQ0   
CATH (Classification of proteins structures)5AQ0   
SuperfamilyO75976
Human Protein Atlas [tissue]ENSG00000108582-CPD [tissue]
Peptide AtlasO75976
HPRD04375
IPIIPI00027078   IPI00921861   IPI00979354   
Protein Interaction databases
DIP (DOE-UCLA)O75976
IntAct (EBI)O75976
BioGRIDCPD
STRING (EMBL)CPD
ZODIACCPD
Ontologies - Pathways
QuickGOO75976
Ontology : AmiGOmetallocarboxypeptidase activity  serine-type carboxypeptidase activity  extracellular space  plasma membrane  peptide metabolic process  zinc ion binding  membrane  integral component of membrane  protein processing  extracellular exosome  
Ontology : EGO-EBImetallocarboxypeptidase activity  serine-type carboxypeptidase activity  extracellular space  plasma membrane  peptide metabolic process  zinc ion binding  membrane  integral component of membrane  protein processing  extracellular exosome  
NDEx NetworkCPD
Atlas of Cancer Signalling NetworkCPD
Wikipedia pathwaysCPD
Orthology - Evolution
OrthoDB1362
GeneTree (enSembl)ENSG00000108582
Phylogenetic Trees/Animal Genes : TreeFamCPD
HOGENOMO75976
Homologs : HomoloGeneCPD
Homology/Alignments : Family Browser (UCSC)CPD
Gene fusions - Rearrangements
Fusion : MitelmanCPD/AATF [17q11.2/17q12]  
Fusion : MitelmanCPD/ORMDL3 [17q11.2/17q12]  
Fusion : MitelmanCPD/PIGW [17q11.2/17q12]  
Fusion : MitelmanCPD/SKAP1 [17q11.2/17q21.32]  
Fusion : MitelmanCPD/TBX2 [17q11.2/17q23.2]  
Fusion : MitelmanNUFIP2/CPD [17q11.2/17q11.2]  
Fusion PortalCPD 17q11.2 AATF 17q12 BRCA
Fusion PortalCPD 17q11.2 ORMDL3 17q12 LUAD
Fusion PortalCPD 17q11.2 PIGW 17q12 PRAD
Fusion PortalCPD 17q11.2 SKAP1 17q21.32 BRCA
Fusion PortalCPD 17q11.2 TBX2 17q23.2 BRCA
Fusion PortalNUFIP2 17q11.2 CPD 17q11.2 PRAD
Fusion : QuiverCPD
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCPD [hg38]
dbVarCPD
ClinVarCPD
MonarchCPD
1000_GenomesCPD 
Exome Variant ServerCPD
GNOMAD BrowserENSG00000108582
Varsome BrowserCPD
Genomic Variants (DGV)CPD [DGVbeta]
DECIPHERCPD [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisCPD 
Mutations
ICGC Data PortalCPD 
TCGA Data PortalCPD 
Broad Tumor PortalCPD
OASIS PortalCPD [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCPD  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DCPD
Mutations and Diseases : HGMDCPD
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch CPD
DgiDB (Drug Gene Interaction Database)CPD
DoCM (Curated mutations)CPD (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CPD (select a term)
intoGenCPD
Cancer3DCPD(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM603102   
Orphanet
DisGeNETCPD
MedgenCPD
Genetic Testing Registry CPD
NextProtO75976 [Medical]
GENETestsCPD
Target ValidationCPD
Huge Navigator CPD [HugePedia]
ClinGenCPD
Clinical trials, drugs, therapy
MyCancerGenomeCPD
Protein Interactions : CTD
Pharm GKB GenePA26823
PharosO75976
Clinical trialCPD
Miscellaneous
canSAR (ICR)CPD (select the gene name)
HarmonizomeCPD
DataMed IndexCPD
Probes
Litterature
PubMed55 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXCPD
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Fri Jan 1 18:11:09 CET 2021
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