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CPLX2 (complexin 2)

Identity

Alias_symbol (synonym)CPX-2
DKFZp547D155
Other alias921-L
CPX2
Hfb1
HGNC (Hugo) CPLX2
LocusID (NCBI) 10814
Atlas_Id 62054
Location 5q35.2  [Link to chromosome band 5q35]
Location_base_pair Starts at 175298501 and ends at 175311023 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
CPLX2 (5q35.2) / CPLX2 (5q35.2)CPLX2 (5q35.2) / RAB6B (3q22.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)CPLX2   2310
Cards
Entrez_Gene (NCBI)CPLX2  10814  complexin 2
Aliases921-L; CPX-2; CPX2; Hfb1
GeneCards (Weizmann)CPLX2
Ensembl hg19 (Hinxton)ENSG00000145920 [Gene_View]  chr5:175298501-175311023 [Contig_View]  CPLX2 [Vega]
Ensembl hg38 (Hinxton)ENSG00000145920 [Gene_View]  chr5:175298501-175311023 [Contig_View]  CPLX2 [Vega]
ICGC DataPortalENSG00000145920
TCGA cBioPortalCPLX2
AceView (NCBI)CPLX2
Genatlas (Paris)CPLX2
WikiGenes10814
SOURCE (Princeton)CPLX2
Genetics Home Reference (NIH)CPLX2
Genomic and cartography
GoldenPath hg19 (UCSC)CPLX2  -     chr5:175298501-175311023 +  5q35.2   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)CPLX2  -     5q35.2   [Description]    (hg38-Dec_2013)
EnsemblCPLX2 - 5q35.2 [CytoView hg19]  CPLX2 - 5q35.2 [CytoView hg38]
Mapping of homologs : NCBICPLX2 [Mapview hg19]  CPLX2 [Mapview hg38]
OMIM605033   
Gene and transcription
Genbank (Entrez)AK055043 AK094266 AK124837 AK126590 AK293819
RefSeq transcript (Entrez)NM_001008220 NM_006650
RefSeq genomic (Entrez)NC_000005 NC_018916 NT_023133 NW_004929325
Consensus coding sequences : CCDS (NCBI)CPLX2
Cluster EST : UnigeneHs.193235 [ NCBI ]
CGAP (NCI)Hs.193235
Alternative Splicing GalleryENSG00000145920
Gene ExpressionCPLX2 [ NCBI-GEO ]   CPLX2 [ EBI - ARRAY_EXPRESS ]   CPLX2 [ SEEK ]   CPLX2 [ MEM ]
Gene Expression Viewer (FireBrowse)CPLX2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)10814
GTEX Portal (Tissue expression)CPLX2
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ6PUV4   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ6PUV4  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ6PUV4
Splice isoforms : SwissVarQ6PUV4
PhosPhoSitePlusQ6PUV4
Domains : Interpro (EBI)Synaphin   
Domain families : Pfam (Sanger)Synaphin (PF05835)   
Domain families : Pfam (NCBI)pfam05835   
Conserved Domain (NCBI)CPLX2
DMDM Disease mutations10814
Blocks (Seattle)CPLX2
SuperfamilyQ6PUV4
Human Protein AtlasENSG00000145920
Peptide AtlasQ6PUV4
HPRD09234
IPIIPI00012759   IPI00910057   IPI00967412   IPI00967688   IPI00968222   IPI00964177   IPI00966328   IPI00966791   
Protein Interaction databases
DIP (DOE-UCLA)Q6PUV4
IntAct (EBI)Q6PUV4
FunCoupENSG00000145920
BioGRIDCPLX2
STRING (EMBL)CPLX2
ZODIACCPLX2
Ontologies - Pathways
QuickGOQ6PUV4
Ontology : AmiGOcytosol  vesicle docking involved in exocytosis  nervous system development  synaptic vesicle exocytosis  syntaxin-1 binding  regulation of exocytosis  cell differentiation  dendrite  positive regulation of synaptic plasticity  mast cell granule  neuronal cell body  mast cell degranulation  synapse  calcium-dependent protein binding  synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex  synaptobrevin 2-SNAP-25-syntaxin-3-complexin complex  
Ontology : EGO-EBIcytosol  vesicle docking involved in exocytosis  nervous system development  synaptic vesicle exocytosis  syntaxin-1 binding  regulation of exocytosis  cell differentiation  dendrite  positive regulation of synaptic plasticity  mast cell granule  neuronal cell body  mast cell degranulation  synapse  calcium-dependent protein binding  synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex  synaptobrevin 2-SNAP-25-syntaxin-3-complexin complex  
Pathways : KEGGSynaptic vesicle cycle   
NDEx NetworkCPLX2
Atlas of Cancer Signalling NetworkCPLX2
Wikipedia pathwaysCPLX2
Orthology - Evolution
OrthoDB10814
GeneTree (enSembl)ENSG00000145920
Phylogenetic Trees/Animal Genes : TreeFamCPLX2
HOVERGENQ6PUV4
HOGENOMQ6PUV4
Homologs : HomoloGeneCPLX2
Homology/Alignments : Family Browser (UCSC)CPLX2
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCPLX2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CPLX2
dbVarCPLX2
ClinVarCPLX2
1000_GenomesCPLX2 
Exome Variant ServerCPLX2
ExAC (Exome Aggregation Consortium)CPLX2 (select the gene name)
Genetic variants : HAPMAP10814
Genomic Variants (DGV)CPLX2 [DGVbeta]
DECIPHER (Syndromes)5:175298501-175311023  ENSG00000145920
CONAN: Copy Number AnalysisCPLX2 
Mutations
ICGC Data PortalCPLX2 
TCGA Data PortalCPLX2 
Broad Tumor PortalCPLX2
OASIS PortalCPLX2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCPLX2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDCPLX2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch CPLX2
DgiDB (Drug Gene Interaction Database)CPLX2
DoCM (Curated mutations)CPLX2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CPLX2 (select a term)
intoGenCPLX2
Cancer3DCPLX2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM605033   
Orphanet
MedgenCPLX2
Genetic Testing Registry CPLX2
NextProtQ6PUV4 [Medical]
TSGene10814
GENETestsCPLX2
Huge Navigator CPLX2 [HugePedia]
snp3D : Map Gene to Disease10814
BioCentury BCIQCPLX2
ClinGenCPLX2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD10814
Chemical/Pharm GKB GenePA26827
Clinical trialCPLX2
Miscellaneous
canSAR (ICR)CPLX2 (select the gene name)
Probes
Litterature
PubMed33 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineCPLX2
EVEXCPLX2
GoPubMedCPLX2
iHOPCPLX2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Mar 14 12:00:13 CET 2017

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