CPLX2 (complexin 2)

2018-11-01  

Identity

HGNC
CPLX2
LOCATION
5q35.2
LOCUSID
10814
ALIAS
921-L,CPX-2,CPX2,Hfb1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 10814
MIM: 605033
HGNC: 2310
Ensembl: ENSG00000145920

Variants:

dbSNP: 10814
ClinVar: 10814
TCGA: ENSG00000145920
COSMIC: CPLX2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000145920ENST00000359546Q6PUV4
ENSG00000145920ENST00000393745Q6PUV4
ENSG00000145920ENST00000502265D6RBA5
ENSG00000145920ENST00000509837D6RGY3
ENSG00000145920ENST00000512824D6RI05
ENSG00000145920ENST00000514150D6R960
ENSG00000145920ENST00000515025D6RDN3
ENSG00000145920ENST00000515094Q6PUV4

Expression (GTEx)

0
100
200
300
400
500
600
700
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Synaptic vesicle cycleKEGGko04721
Synaptic vesicle cycleKEGGhsa04721

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
156532592005Decreased expression of vesicular glutamate transporter 1 and complexin II mRNAs in schizophrenia: further evidence for a synaptic pathology affecting glutamate neurons.60
208199812010Modification of cognitive performance in schizophrenia by complexin 2 gene polymorphisms.33
120825662002Altered immunoreactivity of complexin protein in prefrontal cortex in severe mental illness.23
161314042005Association study of polymorphisms in synaptic vesicle-associated genes, SYN2 and CPLX2, with schizophrenia.18
201983152010Association of genetic variants with hemorrhagic stroke in Japanese individuals.11
128078772003Expression of mutant huntingtin blocks exocytosis in PC12 cells by depletion of complexin II.10
278662312017Presynaptic proteins complexin-I and complexin-II differentially influence cognitive function in early and late stages of Alzheimer's disease.9
182403222008Regulation of complexin 1 and complexin 2 in the developing human prefrontal cortex.5
252976952015Complexin2 modulates working memory-related neural activity in patients with schizophrenia.4

Citation

Dessen P

CPLX2 (complexin 2)

Atlas Genet Cytogenet Oncol Haematol. 2018-11-01

Online version: http://atlasgeneticsoncology.org/gene/57731/cplx2