CPNE3 (copine 3)

2003-05-01  

Identity

HGNC
CPNE3
LOCATION
8q21.3
LOCUSID
8895
ALIAS
CPN3,PRO1071
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 8895
MIM: 604207
HGNC: 2316
Ensembl: ENSG00000085719

Variants:

dbSNP: 8895
ClinVar: 8895
TCGA: ENSG00000085719
COSMIC: CPNE3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000085719ENST00000517391H0YB26
ENSG00000085719ENST00000517490O75131
ENSG00000085719ENST00000517490A0A024R994
ENSG00000085719ENST00000522240E5RFT7
ENSG00000085719ENST00000523469E5RHZ0
ENSG00000085719ENST00000620393A0A087WUS8
ENSG00000085719ENST00000621245A0A087WXR6
ENSG00000085719ENST00000621526A0A0G2JMP5
ENSG00000085719ENST00000621783A0A087WYQ3

Expression (GTEx)

0
10
20
30
40
50
60
70
80
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
MetabolismREACTOMER-HSA-1430728
Metabolism of lipids and lipoproteinsREACTOMER-HSA-556833
Phospholipid metabolismREACTOMER-HSA-1483257
Glycerophospholipid biosynthesisREACTOMER-HSA-1483206
Neutrophil degranulationREACTOMER-HSA-6798695

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
182640962008Multiple loci identified in a genome-wide association study of prostate cancer.448
182640962008Multiple loci identified in a genome-wide association study of prostate cancer.448
200108702010Copine-III interacts with ErbB2 and promotes tumor cell migration.18
237138112013Quantitative proteomic analysis identifies CPNE3 as a novel metastasis-promoting gene in NSCLC.17
230627522012Transcriptomic analysis of postmortem brain identifies dysregulated splicing events in novel candidate genes for schizophrenia.10
298672022018Epithelial membrane protein 1 promotes tumor metastasis by enhancing cell migration via copine-III and Rac1.7
300781892019Circulating exosomal CPNE3 as a diagnostic and prognostic biomarker for colorectal cancer.7
267190322016Direct binding of Copine3 with Jab1 activates downstream ErbB2 signaling and motility in SKBr3 breast cancer cells.6
286708592017High expression of CPNE3 predicts adverse prognosis in acute myeloid leukemia.4
292971772019Low CPNE3 expression is associated with risk of acute myocardial infarction: A feasible genetic marker of acute myocardial infarction in patients with stable coronary artery disease.2

Citation

Dessen P

CPNE3 (copine 3)

Atlas Genet Cytogenet Oncol Haematol. 2003-05-01

Online version: http://atlasgeneticsoncology.org/gene/40139/cpne3