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CPSF1 (cleavage and polyadenylation specific factor 1)

Identity

Alias_namescleavage and polyadenylation specific factor 1, 160kD subunit
cleavage and polyadenylation specific factor 1, 160kDa
Other aliasCPSF160
HSU37012
P/cl.18
HGNC (Hugo) CPSF1
LocusID (NCBI) 29894
Atlas_Id 62063
Location 8q24.3  [Link to chromosome band 8q24]
Location_base_pair Starts at 144393231 and ends at 144409349 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
CPSF1 (8q24.3) / CPSF1 (8q24.3)CPSF1 (8q24.3) / KRT6A (12q13.13)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)CPSF1   2324
Cards
Entrez_Gene (NCBI)CPSF1  29894  cleavage and polyadenylation specific factor 1
AliasesCPSF160; HSU37012; P/cl.18
GeneCards (Weizmann)CPSF1
Ensembl hg19 (Hinxton)ENSG00000071894 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000071894 [Gene_View]  chr8:144393231-144409349 [Contig_View]  CPSF1 [Vega]
ICGC DataPortalENSG00000071894
TCGA cBioPortalCPSF1
AceView (NCBI)CPSF1
Genatlas (Paris)CPSF1
WikiGenes29894
SOURCE (Princeton)CPSF1
Genetics Home Reference (NIH)CPSF1
Genomic and cartography
GoldenPath hg38 (UCSC)CPSF1  -     chr8:144393231-144409349 -  8q24.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)CPSF1  -     8q24.3   [Description]    (hg19-Feb_2009)
EnsemblCPSF1 - 8q24.3 [CytoView hg19]  CPSF1 - 8q24.3 [CytoView hg38]
Mapping of homologs : NCBICPSF1 [Mapview hg19]  CPSF1 [Mapview hg38]
OMIM606027   
Gene and transcription
Genbank (Entrez)AB046744 AK293601 BC009954 BC017232 BC028197
RefSeq transcript (Entrez)NM_013291
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)CPSF1
Cluster EST : UnigeneHs.493202 [ NCBI ]
CGAP (NCI)Hs.493202
Alternative Splicing GalleryENSG00000071894
Gene ExpressionCPSF1 [ NCBI-GEO ]   CPSF1 [ EBI - ARRAY_EXPRESS ]   CPSF1 [ SEEK ]   CPSF1 [ MEM ]
Gene Expression Viewer (FireBrowse)CPSF1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)29894
GTEX Portal (Tissue expression)CPSF1
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ10570   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ10570  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ10570
Splice isoforms : SwissVarQ10570
PhosPhoSitePlusQ10570
Domains : Interpro (EBI)Cleavage/polyA-sp_fac_asu_C   
Domain families : Pfam (Sanger)CPSF_A (PF03178)   
Domain families : Pfam (NCBI)pfam03178   
Conserved Domain (NCBI)CPSF1
DMDM Disease mutations29894
Blocks (Seattle)CPSF1
SuperfamilyQ10570
Human Protein AtlasENSG00000071894
Peptide AtlasQ10570
HPRD05823
IPIIPI00026219   IPI00985205   
Protein Interaction databases
DIP (DOE-UCLA)Q10570
IntAct (EBI)Q10570
FunCoupENSG00000071894
BioGRIDCPSF1
STRING (EMBL)CPSF1
ZODIACCPSF1
Ontologies - Pathways
QuickGOQ10570
Ontology : AmiGOmRNA splicing, via spliceosome  protein binding  nucleoplasm  nucleoplasm  mRNA cleavage and polyadenylation specificity factor complex  termination of RNA polymerase II transcription  mRNA polyadenylation  mRNA cleavage  tRNA splicing, via endonucleolytic cleavage and ligation  mRNA export from nucleus  enzyme binding  mRNA 3'-end processing  mRNA 3'-UTR AU-rich region binding  pre-mRNA cleavage required for polyadenylation  
Ontology : EGO-EBImRNA splicing, via spliceosome  protein binding  nucleoplasm  nucleoplasm  mRNA cleavage and polyadenylation specificity factor complex  termination of RNA polymerase II transcription  mRNA polyadenylation  mRNA cleavage  tRNA splicing, via endonucleolytic cleavage and ligation  mRNA export from nucleus  enzyme binding  mRNA 3'-end processing  mRNA 3'-UTR AU-rich region binding  pre-mRNA cleavage required for polyadenylation  
Pathways : BIOCARTAPolyadenylation of mRNA [Genes]   
Pathways : KEGGmRNA surveillance pathway   
NDEx NetworkCPSF1
Atlas of Cancer Signalling NetworkCPSF1
Wikipedia pathwaysCPSF1
Orthology - Evolution
OrthoDB29894
GeneTree (enSembl)ENSG00000071894
Phylogenetic Trees/Animal Genes : TreeFamCPSF1
HOVERGENQ10570
HOGENOMQ10570
Homologs : HomoloGeneCPSF1
Homology/Alignments : Family Browser (UCSC)CPSF1
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCPSF1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CPSF1
dbVarCPSF1
ClinVarCPSF1
1000_GenomesCPSF1 
Exome Variant ServerCPSF1
ExAC (Exome Aggregation Consortium)CPSF1 (select the gene name)
Genetic variants : HAPMAP29894
Genomic Variants (DGV)CPSF1 [DGVbeta]
DECIPHERCPSF1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisCPSF1 
Mutations
ICGC Data PortalCPSF1 
TCGA Data PortalCPSF1 
Broad Tumor PortalCPSF1
OASIS PortalCPSF1 [ Somatic mutations - Copy number]
Mutations and Diseases : HGMDCPSF1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch CPSF1
DgiDB (Drug Gene Interaction Database)CPSF1
DoCM (Curated mutations)CPSF1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CPSF1 (select a term)
intoGenCPSF1
Cancer3DCPSF1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM606027   
Orphanet
MedgenCPSF1
Genetic Testing Registry CPSF1
NextProtQ10570 [Medical]
TSGene29894
GENETestsCPSF1
Target ValidationCPSF1
Huge Navigator CPSF1 [HugePedia]
snp3D : Map Gene to Disease29894
BioCentury BCIQCPSF1
ClinGenCPSF1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD29894
Chemical/Pharm GKB GenePA26841
Clinical trialCPSF1
Miscellaneous
canSAR (ICR)CPSF1 (select the gene name)
Probes
Litterature
PubMed48 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineCPSF1
EVEXCPSF1
GoPubMedCPSF1
iHOPCPSF1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 18 13:05:19 CEST 2017

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