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CPSF2 (cleavage and polyadenylation specific factor 2)

Identity

Alias_namescleavage and polyadenylation specific factor 2, 100kD subunit
cleavage and polyadenylation specific factor 2, 100kDa
Alias_symbol (synonym)KIAA1367
Other aliasCPSF100
HGNC (Hugo) CPSF2
LocusID (NCBI) 53981
Atlas_Id 54920
Location 14q32.12  [Link to chromosome band 14q32]
Location_base_pair Starts at 92121954 and ends at 92164199 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
CPSF2 (14q32.12) / SLMAP (3p14.3)FAM92A1 (8q22.1) / CPSF2 (14q32.12)PGM1 (1p31.3) / CPSF2 (14q32.12)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)CPSF2   2325
Cards
Entrez_Gene (NCBI)CPSF2  53981  cleavage and polyadenylation specific factor 2
AliasesCPSF100
GeneCards (Weizmann)CPSF2
Ensembl hg19 (Hinxton)ENSG00000165934 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000165934 [Gene_View]  chr14:92121954-92164199 [Contig_View]  CPSF2 [Vega]
ICGC DataPortalENSG00000165934
TCGA cBioPortalCPSF2
AceView (NCBI)CPSF2
Genatlas (Paris)CPSF2
WikiGenes53981
SOURCE (Princeton)CPSF2
Genetics Home Reference (NIH)CPSF2
Genomic and cartography
GoldenPath hg38 (UCSC)CPSF2  -     chr14:92121954-92164199 +  14q32.12   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)CPSF2  -     14q32.12   [Description]    (hg19-Feb_2009)
EnsemblCPSF2 - 14q32.12 [CytoView hg19]  CPSF2 - 14q32.12 [CytoView hg38]
Mapping of homologs : NCBICPSF2 [Mapview hg19]  CPSF2 [Mapview hg38]
OMIM606028   
Gene and transcription
Genbank (Entrez)AB037788 AK001627 AK001912 AK023583 AL442079
RefSeq transcript (Entrez)NM_001322270 NM_001322271 NM_001322272 NM_017437
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)CPSF2
Cluster EST : UnigeneHs.736541 [ NCBI ]
CGAP (NCI)Hs.736541
Alternative Splicing GalleryENSG00000165934
Gene ExpressionCPSF2 [ NCBI-GEO ]   CPSF2 [ EBI - ARRAY_EXPRESS ]   CPSF2 [ SEEK ]   CPSF2 [ MEM ]
Gene Expression Viewer (FireBrowse)CPSF2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)53981
GTEX Portal (Tissue expression)CPSF2
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9P2I0   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9P2I0  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9P2I0
Splice isoforms : SwissVarQ9P2I0
PhosPhoSitePlusQ9P2I0
Domains : Interpro (EBI)Beta_Casp    CPSF2    Cpsf2_C    Metallo-B-lactamas    RMMBL   
Domain families : Pfam (Sanger)Beta-Casp (PF10996)    CPSF100_C (PF13299)    Lactamase_B_6 (PF16661)    RMMBL (PF07521)   
Domain families : Pfam (NCBI)pfam10996    pfam13299    pfam16661    pfam07521   
Domain families : Smart (EMBL)Beta-Casp (SM01027)  Lactamase_B (SM00849)  
Conserved Domain (NCBI)CPSF2
DMDM Disease mutations53981
Blocks (Seattle)CPSF2
SuperfamilyQ9P2I0
Human Protein AtlasENSG00000165934
Peptide AtlasQ9P2I0
HPRD05824
IPIIPI00419531   IPI00902580   IPI01025975   IPI01025748   
Protein Interaction databases
DIP (DOE-UCLA)Q9P2I0
IntAct (EBI)Q9P2I0
FunCoupENSG00000165934
BioGRIDCPSF2
STRING (EMBL)CPSF2
ZODIACCPSF2
Ontologies - Pathways
QuickGOQ9P2I0
Ontology : AmiGOmRNA splicing, via spliceosome  RNA binding  protein binding  nucleoplasm  mRNA cleavage and polyadenylation specificity factor complex  termination of RNA polymerase II transcription  mRNA polyadenylation  mRNA cleavage  mRNA 3'-end processing by stem-loop binding and cleavage  mRNA export from nucleus  membrane  mRNA 3'-end processing  
Ontology : EGO-EBImRNA splicing, via spliceosome  RNA binding  protein binding  nucleoplasm  mRNA cleavage and polyadenylation specificity factor complex  termination of RNA polymerase II transcription  mRNA polyadenylation  mRNA cleavage  mRNA 3'-end processing by stem-loop binding and cleavage  mRNA export from nucleus  membrane  mRNA 3'-end processing  
Pathways : BIOCARTAPolyadenylation of mRNA [Genes]   
Pathways : KEGGmRNA surveillance pathway   
NDEx NetworkCPSF2
Atlas of Cancer Signalling NetworkCPSF2
Wikipedia pathwaysCPSF2
Orthology - Evolution
OrthoDB53981
GeneTree (enSembl)ENSG00000165934
Phylogenetic Trees/Animal Genes : TreeFamCPSF2
HOVERGENQ9P2I0
HOGENOMQ9P2I0
Homologs : HomoloGeneCPSF2
Homology/Alignments : Family Browser (UCSC)CPSF2
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCPSF2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CPSF2
dbVarCPSF2
ClinVarCPSF2
1000_GenomesCPSF2 
Exome Variant ServerCPSF2
ExAC (Exome Aggregation Consortium)CPSF2 (select the gene name)
Genetic variants : HAPMAP53981
Genomic Variants (DGV)CPSF2 [DGVbeta]
DECIPHERCPSF2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisCPSF2 
Mutations
ICGC Data PortalCPSF2 
TCGA Data PortalCPSF2 
Broad Tumor PortalCPSF2
OASIS PortalCPSF2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCPSF2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDCPSF2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch CPSF2
DgiDB (Drug Gene Interaction Database)CPSF2
DoCM (Curated mutations)CPSF2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CPSF2 (select a term)
intoGenCPSF2
Cancer3DCPSF2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM606028   
Orphanet
MedgenCPSF2
Genetic Testing Registry CPSF2
NextProtQ9P2I0 [Medical]
TSGene53981
GENETestsCPSF2
Target ValidationCPSF2
Huge Navigator CPSF2 [HugePedia]
snp3D : Map Gene to Disease53981
BioCentury BCIQCPSF2
ClinGenCPSF2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD53981
Chemical/Pharm GKB GenePA26842
Clinical trialCPSF2
Miscellaneous
canSAR (ICR)CPSF2 (select the gene name)
Probes
Litterature
PubMed56 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineCPSF2
EVEXCPSF2
GoPubMedCPSF2
iHOPCPSF2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed Jun 7 12:29:26 CEST 2017

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