Atlas of Genetics and Cytogenetics in Oncology and Haematology


Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

CPSF3 (cleavage and polyadenylation specific factor 3)

Identity

Alias (NCBI)CPSF-73
CPSF73
HGNC (Hugo) CPSF3
HGNC Alias symbCPSF-73
CPSF73
YSH1
HGNC Previous namecleavage and polyadenylation specific factor 3, 73kD subunit
 cleavage and polyadenylation specific factor 3, 73kDa
LocusID (NCBI) 51692
Atlas_Id 50692
Location 2p25.1  [Link to chromosome band 2p25]
Location_base_pair Starts at 9423654 and ends at 9473101 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CPSF3 (2p25.1) / CPSF3 (2p25.1)HPCAL1 (2p25.1) / CPSF3 (2p25.1)ITGB1BP1 (2p25.1) / CPSF3 (2p25.1)
HPCAL1 2p25.1 / CPSF3 2p25.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)CPSF3   2326
Cards
Entrez_Gene (NCBI)CPSF3    cleavage and polyadenylation specific factor 3
AliasesCPSF-73; CPSF73
GeneCards (Weizmann)CPSF3
Ensembl hg19 (Hinxton)ENSG00000119203 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000119203 [Gene_View]  ENSG00000119203 [Sequence]  chr2:9423654-9473101 [Contig_View]  CPSF3 [Vega]
ICGC DataPortalENSG00000119203
TCGA cBioPortalCPSF3
AceView (NCBI)CPSF3
Genatlas (Paris)CPSF3
SOURCE (Princeton)CPSF3
Genetics Home Reference (NIH)CPSF3
Genomic and cartography
GoldenPath hg38 (UCSC)CPSF3  -     chr2:9423654-9473101 +  2p25.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)CPSF3  -     2p25.1   [Description]    (hg19-Feb_2009)
GoldenPathCPSF3 - 2p25.1 [CytoView hg19]  CPSF3 - 2p25.1 [CytoView hg38]
ImmunoBaseENSG00000119203
Genome Data Viewer NCBICPSF3 [Mapview hg19]  
OMIM606029   
Gene and transcription
Genbank (Entrez)AA635764 AF017269 AF171877 AK025440 AK223487
RefSeq transcript (Entrez)NM_001321833 NM_001321834 NM_001321835 NM_001321836 NM_016207
Consensus coding sequences : CCDS (NCBI)CPSF3
Gene ExpressionCPSF3 [ NCBI-GEO ]   CPSF3 [ EBI - ARRAY_EXPRESS ]   CPSF3 [ SEEK ]   CPSF3 [ MEM ]
Gene Expression Viewer (FireBrowse)CPSF3 [ Firebrowse - Broad ]
GenevisibleExpression of CPSF3 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)51692
GTEX Portal (Tissue expression)CPSF3
Human Protein AtlasENSG00000119203-CPSF3 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9UKF6   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9UKF6  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9UKF6
PhosPhoSitePlusQ9UKF6
Domains : Interpro (EBI)Beta_Casp    CPSF73-100_C    Metallo-B-lactamas    RibonucZ/Hydroxyglut_hydro    RMMBL   
Domain families : Pfam (Sanger)Beta-Casp (PF10996)    CPSF73-100_C (PF11718)    Lactamase_B (PF00753)    RMMBL (PF07521)   
Domain families : Pfam (NCBI)pfam10996    pfam11718    pfam00753    pfam07521   
Domain families : Smart (EMBL)Beta-Casp (SM01027)  CPSF73-100_C (SM01098)  Lactamase_B (SM00849)  
Conserved Domain (NCBI)CPSF3
PDB (RSDB)2I7T    2I7V    6M8Q    6V4X   
PDB Europe2I7T    2I7V    6M8Q    6V4X   
PDB (PDBSum)2I7T    2I7V    6M8Q    6V4X   
PDB (IMB)2I7T    2I7V    6M8Q    6V4X   
Structural Biology KnowledgeBase2I7T    2I7V    6M8Q    6V4X   
SCOP (Structural Classification of Proteins)2I7T    2I7V    6M8Q    6V4X   
CATH (Classification of proteins structures)2I7T    2I7V    6M8Q    6V4X   
SuperfamilyQ9UKF6
AlphaFold pdb e-kbQ9UKF6   
Human Protein Atlas [tissue]ENSG00000119203-CPSF3 [tissue]
HPRD05825
Protein Interaction databases
DIP (DOE-UCLA)Q9UKF6
IntAct (EBI)Q9UKF6
BioGRIDCPSF3
STRING (EMBL)CPSF3
ZODIACCPSF3
Ontologies - Pathways
QuickGOQ9UKF6
Ontology : AmiGOmRNA splicing, via spliceosome  RNA binding  RNA binding  endoribonuclease activity  endoribonuclease activity  protein binding  nucleoplasm  mRNA cleavage and polyadenylation specificity factor complex  mRNA cleavage and polyadenylation specificity factor complex  termination of RNA polymerase II transcription  mRNA polyadenylation  mRNA cleavage  mRNA 3'-end processing by stem-loop binding and cleavage  mRNA 3'-end processing by stem-loop binding and cleavage  mRNA export from nucleus  5'-3' exonuclease activity  5'-3' exonuclease activity  mRNA 3'-end processing  metal ion binding  RNA phosphodiester bond hydrolysis, endonucleolytic  
Ontology : EGO-EBImRNA splicing, via spliceosome  RNA binding  RNA binding  endoribonuclease activity  endoribonuclease activity  protein binding  nucleoplasm  mRNA cleavage and polyadenylation specificity factor complex  mRNA cleavage and polyadenylation specificity factor complex  termination of RNA polymerase II transcription  mRNA polyadenylation  mRNA cleavage  mRNA 3'-end processing by stem-loop binding and cleavage  mRNA 3'-end processing by stem-loop binding and cleavage  mRNA export from nucleus  5'-3' exonuclease activity  5'-3' exonuclease activity  mRNA 3'-end processing  metal ion binding  RNA phosphodiester bond hydrolysis, endonucleolytic  
Pathways : BIOCARTAPolyadenylation of mRNA [Genes]   
Pathways : KEGGmRNA surveillance pathway   
NDEx NetworkCPSF3
Atlas of Cancer Signalling NetworkCPSF3
Wikipedia pathwaysCPSF3
Orthology - Evolution
OrthoDB51692
GeneTree (enSembl)ENSG00000119203
Phylogenetic Trees/Animal Genes : TreeFamCPSF3
Homologs : HomoloGeneCPSF3
Homology/Alignments : Family Browser (UCSC)CPSF3
Gene fusions - Rearrangements
Fusion : MitelmanHPCAL1/CPSF3 [2p25.1/2p25.1]  
Fusion : QuiverCPSF3
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCPSF3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CPSF3
dbVarCPSF3
ClinVarCPSF3
MonarchCPSF3
1000_GenomesCPSF3 
Exome Variant ServerCPSF3
GNOMAD BrowserENSG00000119203
Varsome BrowserCPSF3
ACMGCPSF3 variants
VarityQ9UKF6
Genomic Variants (DGV)CPSF3 [DGVbeta]
DECIPHERCPSF3 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisCPSF3 
Mutations
ICGC Data PortalCPSF3 
TCGA Data PortalCPSF3 
Broad Tumor PortalCPSF3
OASIS PortalCPSF3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCPSF3  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DCPSF3
Mutations and Diseases : HGMDCPSF3
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaCPSF3
DgiDB (Drug Gene Interaction Database)CPSF3
DoCM (Curated mutations)CPSF3
CIViC (Clinical Interpretations of Variants in Cancer)CPSF3
Cancer3DCPSF3
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM606029   
Orphanet
DisGeNETCPSF3
MedgenCPSF3
Genetic Testing Registry CPSF3
NextProtQ9UKF6 [Medical]
GENETestsCPSF3
Target ValidationCPSF3
Huge Navigator CPSF3 [HugePedia]
ClinGenCPSF3
Clinical trials, drugs, therapy
MyCancerGenomeCPSF3
Protein Interactions : CTDCPSF3
Pharm GKB GenePA26843
PharosQ9UKF6
Clinical trialCPSF3
Miscellaneous
canSAR (ICR)CPSF3
HarmonizomeCPSF3
DataMed IndexCPSF3
Probes
Litterature
PubMed85 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXCPSF3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Oct 4 15:05:04 CEST 2021

Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.