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CPSF3 (cleavage and polyadenylation specific factor 3)

Identity

Alias_namescleavage and polyadenylation specific factor 3, 73kD subunit
cleavage and polyadenylation specific factor 3, 73kDa
Alias_symbol (synonym)CPSF-73
CPSF73
YSH1
Other alias
HGNC (Hugo) CPSF3
LocusID (NCBI) 51692
Atlas_Id 50692
Location 2p25.1  [Link to chromosome band 2p25]
Location_base_pair Starts at 9423537 and ends at 9473110 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
CPSF3 (2p25.1) / CPSF3 (2p25.1)HPCAL1 (2p25.1) / CPSF3 (2p25.1)ITGB1BP1 (2p25.1) / CPSF3 (2p25.1)
HPCAL1 2p25.1 / CPSF3 2p25.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)CPSF3   2326
Cards
Entrez_Gene (NCBI)CPSF3  51692  cleavage and polyadenylation specific factor 3
AliasesCPSF-73; CPSF73
GeneCards (Weizmann)CPSF3
Ensembl hg19 (Hinxton)ENSG00000119203 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000119203 [Gene_View]  chr2:9423537-9473110 [Contig_View]  CPSF3 [Vega]
ICGC DataPortalENSG00000119203
TCGA cBioPortalCPSF3
AceView (NCBI)CPSF3
Genatlas (Paris)CPSF3
WikiGenes51692
SOURCE (Princeton)CPSF3
Genetics Home Reference (NIH)CPSF3
Genomic and cartography
GoldenPath hg38 (UCSC)CPSF3  -     chr2:9423537-9473110 +  2p25.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)CPSF3  -     2p25.1   [Description]    (hg19-Feb_2009)
EnsemblCPSF3 - 2p25.1 [CytoView hg19]  CPSF3 - 2p25.1 [CytoView hg38]
Mapping of homologs : NCBICPSF3 [Mapview hg19]  CPSF3 [Mapview hg38]
OMIM606029   
Gene and transcription
Genbank (Entrez)AA635764 AF017269 AF171877 AK025440 AK223487
RefSeq transcript (Entrez)NM_001321833 NM_001321834 NM_001321835 NM_001321836 NM_016207
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)CPSF3
Cluster EST : UnigeneHs.515972 [ NCBI ]
CGAP (NCI)Hs.515972
Alternative Splicing GalleryENSG00000119203
Gene ExpressionCPSF3 [ NCBI-GEO ]   CPSF3 [ EBI - ARRAY_EXPRESS ]   CPSF3 [ SEEK ]   CPSF3 [ MEM ]
Gene Expression Viewer (FireBrowse)CPSF3 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)51692
GTEX Portal (Tissue expression)CPSF3
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9UKF6   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9UKF6  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9UKF6
Splice isoforms : SwissVarQ9UKF6
PhosPhoSitePlusQ9UKF6
Domains : Interpro (EBI)Beta_Casp    CPSF73-100_C    Metallo-B-lactamas    RMMBL   
Domain families : Pfam (Sanger)Beta-Casp (PF10996)    CPSF73-100_C (PF11718)    Lactamase_B (PF00753)    RMMBL (PF07521)   
Domain families : Pfam (NCBI)pfam10996    pfam11718    pfam00753    pfam07521   
Domain families : Smart (EMBL)Beta-Casp (SM01027)  CPSF73-100_C (SM01098)  Lactamase_B (SM00849)  
Conserved Domain (NCBI)CPSF3
DMDM Disease mutations51692
Blocks (Seattle)CPSF3
PDB (SRS)2I7T    2I7V   
PDB (PDBSum)2I7T    2I7V   
PDB (IMB)2I7T    2I7V   
PDB (RSDB)2I7T    2I7V   
Structural Biology KnowledgeBase2I7T    2I7V   
SCOP (Structural Classification of Proteins)2I7T    2I7V   
CATH (Classification of proteins structures)2I7T    2I7V   
SuperfamilyQ9UKF6
Human Protein AtlasENSG00000119203
Peptide AtlasQ9UKF6
HPRD05825
IPIIPI00007818   IPI00807384   IPI00946752   
Protein Interaction databases
DIP (DOE-UCLA)Q9UKF6
IntAct (EBI)Q9UKF6
FunCoupENSG00000119203
BioGRIDCPSF3
STRING (EMBL)CPSF3
ZODIACCPSF3
Ontologies - Pathways
QuickGOQ9UKF6
Ontology : AmiGOmRNA splicing, via spliceosome  RNA binding  endoribonuclease activity  protein binding  nucleoplasm  mRNA cleavage and polyadenylation specificity factor complex  termination of RNA polymerase II transcription  mRNA polyadenylation  mRNA cleavage  mRNA 3'-end processing by stem-loop binding and cleavage  mRNA export from nucleus  5'-3' exonuclease activity  intracellular ribonucleoprotein complex  mRNA 3'-end processing  metal ion binding  RNA phosphodiester bond hydrolysis, endonucleolytic  
Ontology : EGO-EBImRNA splicing, via spliceosome  RNA binding  endoribonuclease activity  protein binding  nucleoplasm  mRNA cleavage and polyadenylation specificity factor complex  termination of RNA polymerase II transcription  mRNA polyadenylation  mRNA cleavage  mRNA 3'-end processing by stem-loop binding and cleavage  mRNA export from nucleus  5'-3' exonuclease activity  intracellular ribonucleoprotein complex  mRNA 3'-end processing  metal ion binding  RNA phosphodiester bond hydrolysis, endonucleolytic  
Pathways : BIOCARTAPolyadenylation of mRNA [Genes]   
Pathways : KEGGmRNA surveillance pathway   
NDEx NetworkCPSF3
Atlas of Cancer Signalling NetworkCPSF3
Wikipedia pathwaysCPSF3
Orthology - Evolution
OrthoDB51692
GeneTree (enSembl)ENSG00000119203
Phylogenetic Trees/Animal Genes : TreeFamCPSF3
HOVERGENQ9UKF6
HOGENOMQ9UKF6
Homologs : HomoloGeneCPSF3
Homology/Alignments : Family Browser (UCSC)CPSF3
Gene fusions - Rearrangements
Fusion : MitelmanHPCAL1/CPSF3 [2p25.1/2p25.1]  [t(2;2)(p25;p25)]  
Fusion: TCGAHPCAL1 2p25.1 CPSF3 2p25.1 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCPSF3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CPSF3
dbVarCPSF3
ClinVarCPSF3
1000_GenomesCPSF3 
Exome Variant ServerCPSF3
ExAC (Exome Aggregation Consortium)CPSF3 (select the gene name)
Genetic variants : HAPMAP51692
Genomic Variants (DGV)CPSF3 [DGVbeta]
DECIPHERCPSF3 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisCPSF3 
Mutations
ICGC Data PortalCPSF3 
TCGA Data PortalCPSF3 
Broad Tumor PortalCPSF3
OASIS PortalCPSF3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCPSF3  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDCPSF3
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch CPSF3
DgiDB (Drug Gene Interaction Database)CPSF3
DoCM (Curated mutations)CPSF3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CPSF3 (select a term)
intoGenCPSF3
Cancer3DCPSF3(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM606029   
Orphanet
MedgenCPSF3
Genetic Testing Registry CPSF3
NextProtQ9UKF6 [Medical]
TSGene51692
GENETestsCPSF3
Target ValidationCPSF3
Huge Navigator CPSF3 [HugePedia]
snp3D : Map Gene to Disease51692
BioCentury BCIQCPSF3
ClinGenCPSF3
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD51692
Chemical/Pharm GKB GenePA26843
Clinical trialCPSF3
Miscellaneous
canSAR (ICR)CPSF3 (select the gene name)
Probes
Litterature
PubMed45 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineCPSF3
EVEXCPSF3
GoPubMedCPSF3
iHOPCPSF3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 25 19:03:36 CEST 2017

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