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CPSF3L (cleavage and polyadenylation specific factor 3-like)

Identity

Alias_symbol (synonym)FLJ20542
RC-68
CPSF73L
INT11
INTS11
Other aliasRC68
HGNC (Hugo) CPSF3L
LocusID (NCBI) 54973
Atlas_Id 40601
Location 1p36.33  [Link to chromosome band 1p36]
Location_base_pair Starts at 1246965 and ends at 1260067 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
ACAP3 (1p36.33) / CPSF3L (1p36.33)CPSF3L (1p36.33) / ADCK3 (1q42.13)CPSF3L (1p36.33) / CPSF3L (1p36.33)
CPSF3L (1p36.33) / CSF1R (5q32)EPHB2 (1p36.12) / CPSF3L (1p36.33)RAVER2 (1p31.3) / CPSF3L (1p36.33)
ACAP3 1p36.33 / CPSF3L 1p36.33

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)CPSF3L   26052
Cards
Entrez_Gene (NCBI)CPSF3L  54973  cleavage and polyadenylation specific factor 3-like
AliasesCPSF73L; INT11; INTS11; RC-68; 
RC68
GeneCards (Weizmann)CPSF3L
Ensembl hg19 (Hinxton)ENSG00000127054 [Gene_View]  chr1:1246965-1260067 [Contig_View]  CPSF3L [Vega]
Ensembl hg38 (Hinxton)ENSG00000127054 [Gene_View]  chr1:1246965-1260067 [Contig_View]  CPSF3L [Vega]
ICGC DataPortalENSG00000127054
TCGA cBioPortalCPSF3L
AceView (NCBI)CPSF3L
Genatlas (Paris)CPSF3L
WikiGenes54973
SOURCE (Princeton)CPSF3L
Genetics Home Reference (NIH)CPSF3L
Genomic and cartography
GoldenPath hg19 (UCSC)CPSF3L  -     chr1:1246965-1260067 -  1p36.33   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)CPSF3L  -     1p36.33   [Description]    (hg38-Dec_2013)
EnsemblCPSF3L - 1p36.33 [CytoView hg19]  CPSF3L - 1p36.33 [CytoView hg38]
Mapping of homologs : NCBICPSF3L [Mapview hg19]  CPSF3L [Mapview hg38]
OMIM611354   
Gene and transcription
Genbank (Entrez)AA687684 AK000549 AK021939 AK022675 AK023356
RefSeq transcript (Entrez)NM_001256456 NM_001256460 NM_001256462 NM_001256463 NM_017871 NM_032179
RefSeq genomic (Entrez)NC_000001 NC_018912 NT_032977 NW_004929288
Consensus coding sequences : CCDS (NCBI)CPSF3L
Cluster EST : UnigeneHs.6449 [ NCBI ]
CGAP (NCI)Hs.6449
Alternative Splicing GalleryENSG00000127054
Gene ExpressionCPSF3L [ NCBI-GEO ]   CPSF3L [ EBI - ARRAY_EXPRESS ]   CPSF3L [ SEEK ]   CPSF3L [ MEM ]
Gene Expression Viewer (FireBrowse)CPSF3L [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)54973
GTEX Portal (Tissue expression)CPSF3L
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ5TA45   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ5TA45  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ5TA45
Splice isoforms : SwissVarQ5TA45
Catalytic activity : Enzyme3.1.27.- [ Enzyme-Expasy ]   3.1.27.-3.1.27.- [ IntEnz-EBI ]   3.1.27.- [ BRENDA ]   3.1.27.- [ KEGG ]   
PhosPhoSitePlusQ5TA45
Domains : Interpro (EBI)Beta_Casp    Metallo-B-lactamas    RMMBL   
Domain families : Pfam (Sanger)Beta-Casp (PF10996)    Lactamase_B_6 (PF16661)    RMMBL (PF07521)   
Domain families : Pfam (NCBI)pfam10996    pfam16661    pfam07521   
Domain families : Smart (EMBL)Beta-Casp (SM01027)  Lactamase_B (SM00849)  
Conserved Domain (NCBI)CPSF3L
DMDM Disease mutations54973
Blocks (Seattle)CPSF3L
SuperfamilyQ5TA45
Human Protein AtlasENSG00000127054
Peptide AtlasQ5TA45
HPRD13377
IPIIPI00063404   IPI00306882   IPI00514973   IPI01011963   IPI00976242   IPI00514001   IPI00386782   IPI00513900   IPI00513774   IPI00514808   IPI00985429   IPI00983607   IPI00983072   IPI00982142   IPI00984775   IPI00983750   IPI00985405   IPI00979575   IPI00981641   IPI00977321   IPI00976734   IPI00982774   IPI00975582   
Protein Interaction databases
DIP (DOE-UCLA)Q5TA45
IntAct (EBI)Q5TA45
FunCoupENSG00000127054
BioGRIDCPSF3L
STRING (EMBL)CPSF3L
ZODIACCPSF3L
Ontologies - Pathways
QuickGOQ5TA45
Ontology : AmiGOprotein binding  nucleoplasm  cytoplasm  snRNA processing  hydrolase activity  integrator complex  snRNA transcription from RNA polymerase II promoter  blood microparticle  
Ontology : EGO-EBIprotein binding  nucleoplasm  cytoplasm  snRNA processing  hydrolase activity  integrator complex  snRNA transcription from RNA polymerase II promoter  blood microparticle  
NDEx NetworkCPSF3L
Atlas of Cancer Signalling NetworkCPSF3L
Wikipedia pathwaysCPSF3L
Orthology - Evolution
OrthoDB54973
GeneTree (enSembl)ENSG00000127054
Phylogenetic Trees/Animal Genes : TreeFamCPSF3L
HOVERGENQ5TA45
HOGENOMQ5TA45
Homologs : HomoloGeneCPSF3L
Homology/Alignments : Family Browser (UCSC)CPSF3L
Gene fusions - Rearrangements
Fusion : MitelmanACAP3/CPSF3L [1p36.33/1p36.33]  [t(1;1)(p36;p36)]  
Fusion : MitelmanEPHB2/CPSF3L [1p36.12/1p36.33]  [t(1;1)(p36;p36)]  
Fusion: TCGAACAP3 1p36.33 CPSF3L 1p36.33 LUSC OV
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCPSF3L [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CPSF3L
dbVarCPSF3L
ClinVarCPSF3L
1000_GenomesCPSF3L 
Exome Variant ServerCPSF3L
ExAC (Exome Aggregation Consortium)CPSF3L (select the gene name)
Genetic variants : HAPMAP54973
Genomic Variants (DGV)CPSF3L [DGVbeta]
DECIPHER (Syndromes)1:1246965-1260067  ENSG00000127054
CONAN: Copy Number AnalysisCPSF3L 
Mutations
ICGC Data PortalCPSF3L 
TCGA Data PortalCPSF3L 
Broad Tumor PortalCPSF3L
OASIS PortalCPSF3L [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCPSF3L  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDCPSF3L
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch CPSF3L
DgiDB (Drug Gene Interaction Database)CPSF3L
DoCM (Curated mutations)CPSF3L (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CPSF3L (select a term)
intoGenCPSF3L
Cancer3DCPSF3L(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM611354   
Orphanet
MedgenCPSF3L
Genetic Testing Registry CPSF3L
NextProtQ5TA45 [Medical]
TSGene54973
GENETestsCPSF3L
Huge Navigator CPSF3L [HugePedia]
snp3D : Map Gene to Disease54973
BioCentury BCIQCPSF3L
ClinGenCPSF3L
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD54973
Chemical/Pharm GKB GenePA142672080
Clinical trialCPSF3L
Miscellaneous
canSAR (ICR)CPSF3L (select the gene name)
Probes
Litterature
PubMed24 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineCPSF3L
EVEXCPSF3L
GoPubMedCPSF3L
iHOPCPSF3L
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Mar 14 13:01:35 CET 2017

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