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CPSF4 (cleavage and polyadenylation specific factor 4)

Identity

Alias_namescleavage and polyadenylation specific factor 4, 30kD subunit
cleavage and polyadenylation specific factor 4, 30kDa
Alias_symbol (synonym)NAR
CPSF30
Other aliasNEB-1
NEB1
HGNC (Hugo) CPSF4
LocusID (NCBI) 10898
Atlas_Id 54950
Location 7q22.1  [Link to chromosome band 7q22]
Location_base_pair Starts at 99438940 and ends at 99457377 bp from pter ( according to hg38-Dec_2013)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)CPSF4   2327
Cards
Entrez_Gene (NCBI)CPSF4  10898  cleavage and polyadenylation specific factor 4
AliasesCPSF30; NAR; NEB-1; NEB1
GeneCards (Weizmann)CPSF4
Ensembl hg19 (Hinxton)ENSG00000160917 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000160917 [Gene_View]  chr7:99438940-99457377 [Contig_View]  CPSF4 [Vega]
ICGC DataPortalENSG00000160917
TCGA cBioPortalCPSF4
AceView (NCBI)CPSF4
Genatlas (Paris)CPSF4
WikiGenes10898
SOURCE (Princeton)CPSF4
Genetics Home Reference (NIH)CPSF4
Genomic and cartography
GoldenPath hg38 (UCSC)CPSF4  -     chr7:99438940-99457377 +  7q22.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)CPSF4  -     7q22.1   [Description]    (hg19-Feb_2009)
EnsemblCPSF4 - 7q22.1 [CytoView hg19]  CPSF4 - 7q22.1 [CytoView hg38]
Mapping of homologs : NCBICPSF4 [Mapview hg19]  CPSF4 [Mapview hg38]
OMIM603052   
Gene and transcription
Genbank (Entrez)AA040394 AI076832 AK301745 AW512538 BC003101
RefSeq transcript (Entrez)NM_001081559 NM_001318160 NM_001318161 NM_001318162 NM_006693
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)CPSF4
Cluster EST : UnigeneHs.489287 [ NCBI ]
CGAP (NCI)Hs.489287
Alternative Splicing GalleryENSG00000160917
Gene ExpressionCPSF4 [ NCBI-GEO ]   CPSF4 [ EBI - ARRAY_EXPRESS ]   CPSF4 [ SEEK ]   CPSF4 [ MEM ]
Gene Expression Viewer (FireBrowse)CPSF4 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)10898
GTEX Portal (Tissue expression)CPSF4
Protein : pattern, domain, 3D structure
UniProt/SwissProtO95639   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO95639  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO95639
Splice isoforms : SwissVarO95639
PhosPhoSitePlusO95639
Domaine pattern : Prosite (Expaxy)ZF_C3H1 (PS50103)    ZF_CCHC (PS50158)   
Domains : Interpro (EBI)Znf_CCCH    Znf_CCHC   
Domain families : Pfam (Sanger)zf-CCCH (PF00642)    zf-CCHC (PF00098)   
Domain families : Pfam (NCBI)pfam00642    pfam00098   
Domain families : Smart (EMBL)ZnF_C2HC (SM00343)  ZnF_C3H1 (SM00356)  
Conserved Domain (NCBI)CPSF4
DMDM Disease mutations10898
Blocks (Seattle)CPSF4
PDB (SRS)2D9N    2RHK   
PDB (PDBSum)2D9N    2RHK   
PDB (IMB)2D9N    2RHK   
PDB (RSDB)2D9N    2RHK   
Structural Biology KnowledgeBase2D9N    2RHK   
SCOP (Structural Classification of Proteins)2D9N    2RHK   
CATH (Classification of proteins structures)2D9N    2RHK   
SuperfamilyO95639
Human Protein AtlasENSG00000160917
Peptide AtlasO95639
HPRD04338
IPIIPI00009137   IPI00029707   IPI00375469   IPI00927478   IPI00924476   IPI00925720   IPI00925041   IPI01014332   IPI00925482   
Protein Interaction databases
DIP (DOE-UCLA)O95639
IntAct (EBI)O95639
FunCoupENSG00000160917
BioGRIDCPSF4
STRING (EMBL)CPSF4
ZODIACCPSF4
Ontologies - Pathways
QuickGOO95639
Ontology : AmiGOmRNA splicing, via spliceosome  RNA binding  RNA binding  endoribonuclease activity  protein binding  nucleoplasm  nucleoplasm  mRNA cleavage and polyadenylation specificity factor complex  termination of RNA polymerase II transcription  mRNA polyadenylation  tRNA splicing, via endonucleolytic cleavage and ligation  mRNA export from nucleus  zinc ion binding  mRNA 3'-end processing  intracellular membrane-bounded organelle  modification by virus of host mRNA processing  RNA phosphodiester bond hydrolysis, endonucleolytic  pre-mRNA cleavage required for polyadenylation  
Ontology : EGO-EBImRNA splicing, via spliceosome  RNA binding  RNA binding  endoribonuclease activity  protein binding  nucleoplasm  nucleoplasm  mRNA cleavage and polyadenylation specificity factor complex  termination of RNA polymerase II transcription  mRNA polyadenylation  tRNA splicing, via endonucleolytic cleavage and ligation  mRNA export from nucleus  zinc ion binding  mRNA 3'-end processing  intracellular membrane-bounded organelle  modification by virus of host mRNA processing  RNA phosphodiester bond hydrolysis, endonucleolytic  pre-mRNA cleavage required for polyadenylation  
Pathways : BIOCARTAPolyadenylation of mRNA [Genes]   
Pathways : KEGGmRNA surveillance pathway    Influenza A   
NDEx NetworkCPSF4
Atlas of Cancer Signalling NetworkCPSF4
Wikipedia pathwaysCPSF4
Orthology - Evolution
OrthoDB10898
GeneTree (enSembl)ENSG00000160917
Phylogenetic Trees/Animal Genes : TreeFamCPSF4
HOVERGENO95639
HOGENOMO95639
Homologs : HomoloGeneCPSF4
Homology/Alignments : Family Browser (UCSC)CPSF4
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCPSF4 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CPSF4
dbVarCPSF4
ClinVarCPSF4
1000_GenomesCPSF4 
Exome Variant ServerCPSF4
ExAC (Exome Aggregation Consortium)CPSF4 (select the gene name)
Genetic variants : HAPMAP10898
Genomic Variants (DGV)CPSF4 [DGVbeta]
DECIPHERCPSF4 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisCPSF4 
Mutations
ICGC Data PortalCPSF4 
TCGA Data PortalCPSF4 
Broad Tumor PortalCPSF4
OASIS PortalCPSF4 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCPSF4  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDCPSF4
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch CPSF4
DgiDB (Drug Gene Interaction Database)CPSF4
DoCM (Curated mutations)CPSF4 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CPSF4 (select a term)
intoGenCPSF4
Cancer3DCPSF4(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM603052   
Orphanet
MedgenCPSF4
Genetic Testing Registry CPSF4
NextProtO95639 [Medical]
TSGene10898
GENETestsCPSF4
Target ValidationCPSF4
Huge Navigator CPSF4 [HugePedia]
snp3D : Map Gene to Disease10898
BioCentury BCIQCPSF4
ClinGenCPSF4
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD10898
Chemical/Pharm GKB GenePA26844
Clinical trialCPSF4
Miscellaneous
canSAR (ICR)CPSF4 (select the gene name)
Probes
Litterature
PubMed39 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineCPSF4
EVEXCPSF4
GoPubMedCPSF4
iHOPCPSF4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 25 19:03:37 CEST 2017

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