CPSF6 (cleavage and polyadenylation specific factor 6)

2012-11-01  

Identity

HGNC
LOCATION
12q15
LOCUSID
ALIAS
CFIM,CFIM68,CFIM72,HPBRII-4,HPBRII-7
FUSION GENES

Other Information

Locus ID:

NCBI: 11052
MIM: 604979
HGNC: 13871
Ensembl: ENSG00000111605

Variants:

dbSNP: 11052
ClinVar: 11052
TCGA: ENSG00000111605
COSMIC: CPSF6

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000111605ENST00000266679Q16630
ENSG00000111605ENST00000435070Q16630
ENSG00000111605ENST00000456847F8WJN3
ENSG00000111605ENST00000550075F8W084
ENSG00000111605ENST00000551516F8VNP8
ENSG00000111605ENST00000650046A0A3B3ISW1

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90

Pathways

PathwaySourceExternal ID
mRNA surveillance pathwayKEGGko03015
mRNA surveillance pathwayKEGGhsa03015
DiseaseREACTOMER-HSA-1643685
Diseases of signal transductionREACTOMER-HSA-5663202
Signaling by FGFR in diseaseREACTOMER-HSA-1226099
Signaling by FGFR1 in diseaseREACTOMER-HSA-5655302
FGFR1 mutant receptor activationREACTOMER-HSA-1839124
Signaling by cytosolic FGFR1 fusion mutantsREACTOMER-HSA-1839117

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
202276652010Flexible use of nuclear import pathways by HIV-1.224
228137492012Genome-wide analysis of pre-mRNA 3' end processing reveals a decisive role of human cleavage factor I in the regulation of 3' UTR length.155
159372202005Analysis of a noncanonical poly(A) site reveals a tripartite mechanism for vertebrate poly(A) site recognition.107
229569062012CPSF6 defines a conserved capsid interface that modulates HIV-1 replication.103
170241862006An interaction between U2AF 65 and CF I(m) links the splicing and 3' end processing machineries.95
253567222014Host cofactors and pharmacologic ligands share an essential interface in HIV-1 capsid that is lost upon disassembly.85
146906002003A mechanism for the regulation of pre-mRNA 3' processing by human cleavage factor Im.80
146906002003A mechanism for the regulation of pre-mRNA 3' processing by human cleavage factor Im.80
268584522016A critical role for alternative polyadenylation factor CPSF6 in targeting HIV-1 integration to transcriptionally active chromatin.77
255188612014Structural basis of HIV-1 capsid recognition by PF74 and CPSF6.76

Citation

Dessen P

CPSF6 (cleavage and polyadenylation specific factor 6)

Atlas Genet Cytogenet Oncol Haematol. 2012-11-01

Online version: http://atlasgeneticsoncology.org/gene/52984/cpsf6