Atlas of Genetics and Cytogenetics in Oncology and Haematology


Home   Genes   Leukemias   Solid Tumours   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

CR1 (complement component 3b/4b receptor 1 (Knops blood group))

Identity

Alias_namescomplement component (3b/4b) receptor 1, including Knops blood group system
complement component (3b/4b) receptor 1 (Knops blood group)
complement component 3b/4b receptor 1 (Knops blood group)
Alias_symbol (synonym)CD35
KN
Other aliasC3BR
C4BR
HGNC (Hugo) CR1
LocusID (NCBI) 1378
Atlas_Id 46094
Location 1q32.2  [Link to chromosome band 1q32]
Location_base_pair Starts at 207669473 and ends at 207815110 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
CR1 (1q32.2) / CLEC2D (12p13.31)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)CR1   2334
LRG (Locus Reference Genomic)LRG_814
Cards
Entrez_Gene (NCBI)CR1  1378  complement component 3b/4b receptor 1 (Knops blood group)
AliasesC3BR; C4BR; CD35; KN
GeneCards (Weizmann)CR1
Ensembl hg19 (Hinxton)ENSG00000203710 [Gene_View]  chr1:207669473-207815110 [Contig_View]  CR1 [Vega]
Ensembl hg38 (Hinxton)ENSG00000203710 [Gene_View]  chr1:207669473-207815110 [Contig_View]  CR1 [Vega]
ICGC DataPortalENSG00000203710
TCGA cBioPortalCR1
AceView (NCBI)CR1
Genatlas (Paris)CR1
WikiGenes1378
SOURCE (Princeton)CR1
Genetics Home Reference (NIH)CR1
Genomic and cartography
GoldenPath hg19 (UCSC)CR1  -     chr1:207669473-207815110 +  1q32.2   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)CR1  -     1q32.2   [Description]    (hg38-Dec_2013)
EnsemblCR1 - 1q32.2 [CytoView hg19]  CR1 - 1q32.2 [CytoView hg38]
Mapping of homologs : NCBICR1 [Mapview hg19]  CR1 [Mapview hg38]
OMIM120620   607486   611162   
Gene and transcription
Genbank (Entrez)AK298486 AK309342 BC032550 BF900429 BX113709
RefSeq transcript (Entrez)NM_000573 NM_000651
RefSeq genomic (Entrez)NC_000001 NC_018912 NG_007481 NT_004487 NW_004929294
Consensus coding sequences : CCDS (NCBI)CR1
Cluster EST : UnigeneHs.334019 [ NCBI ]
CGAP (NCI)Hs.334019
Alternative Splicing GalleryENSG00000203710
Gene ExpressionCR1 [ NCBI-GEO ]   CR1 [ EBI - ARRAY_EXPRESS ]   CR1 [ SEEK ]   CR1 [ MEM ]
Gene Expression Viewer (FireBrowse)CR1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)1378
GTEX Portal (Tissue expression)CR1
Protein : pattern, domain, 3D structure
UniProt/SwissProtP17927   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP17927  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP17927
Splice isoforms : SwissVarP17927
PhosPhoSitePlusP17927
Domaine pattern : Prosite (Expaxy)SUSHI (PS50923)   
Domains : Interpro (EBI)Sushi_SCR_CCP_dom   
Domain families : Pfam (Sanger)Sushi (PF00084)   
Domain families : Pfam (NCBI)pfam00084   
Domain families : Smart (EMBL)CCP (SM00032)  
Conserved Domain (NCBI)CR1
DMDM Disease mutations1378
Blocks (Seattle)CR1
PDB (SRS)1GKG    1GKN    1GOP    1PPQ    2MCY    2MCZ    2Q7Z   
PDB (PDBSum)1GKG    1GKN    1GOP    1PPQ    2MCY    2MCZ    2Q7Z   
PDB (IMB)1GKG    1GKN    1GOP    1PPQ    2MCY    2MCZ    2Q7Z   
PDB (RSDB)1GKG    1GKN    1GOP    1PPQ    2MCY    2MCZ    2Q7Z   
Structural Biology KnowledgeBase1GKG    1GKN    1GOP    1PPQ    2MCY    2MCZ    2Q7Z   
SCOP (Structural Classification of Proteins)1GKG    1GKN    1GOP    1PPQ    2MCY    2MCZ    2Q7Z   
CATH (Classification of proteins structures)1GKG    1GKN    1GOP    1PPQ    2MCY    2MCZ    2Q7Z   
SuperfamilyP17927
Human Protein AtlasENSG00000203710
Peptide AtlasP17927
HPRD00398
IPIIPI00940136   IPI00039288   IPI00640083   IPI01012690   IPI01013926   IPI00642262   IPI01014731   IPI00981872   
Protein Interaction databases
DIP (DOE-UCLA)P17927
IntAct (EBI)P17927
FunCoupENSG00000203710
BioGRIDCR1
STRING (EMBL)CR1
ZODIACCR1
Ontologies - Pathways
QuickGOP17927
Ontology : AmiGOvirus receptor activity  complement component C3b binding  complement component C4b binding  complement component C4b receptor activity  complement receptor mediated signaling pathway  complement component C3b receptor activity  plasma membrane  integral component of plasma membrane  complement activation, classical pathway  cell surface  regulation of complement activation  innate immune response  negative regulation of complement activation, alternative pathway  negative regulation of complement activation, classical pathway  viral entry into host cell  extracellular exosome  negative regulation of serine-type endopeptidase activity  positive regulation of serine-type endopeptidase activity  
Ontology : EGO-EBIvirus receptor activity  complement component C3b binding  complement component C4b binding  complement component C4b receptor activity  complement receptor mediated signaling pathway  complement component C3b receptor activity  plasma membrane  integral component of plasma membrane  complement activation, classical pathway  cell surface  regulation of complement activation  innate immune response  negative regulation of complement activation, alternative pathway  negative regulation of complement activation, classical pathway  viral entry into host cell  extracellular exosome  negative regulation of serine-type endopeptidase activity  positive regulation of serine-type endopeptidase activity  
Pathways : BIOCARTAB Lymphocyte Cell Surface Molecules [Genes]   
Pathways : KEGGComplement and coagulation cascades    Hematopoietic cell lineage    Legionellosis    Leishmaniasis    Malaria    Tuberculosis   
NDEx NetworkCR1
Atlas of Cancer Signalling NetworkCR1
Wikipedia pathwaysCR1
Orthology - Evolution
OrthoDB1378
GeneTree (enSembl)ENSG00000203710
Phylogenetic Trees/Animal Genes : TreeFamCR1
HOVERGENP17927
HOGENOMP17927
Homologs : HomoloGeneCR1
Homology/Alignments : Family Browser (UCSC)CR1
Gene fusions - Rearrangements
Fusion Cancer (Beijing)CR1 [1q32.2]  -  CLEC2D [12p13.31]  [FUSC000226]
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCR1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CR1
dbVarCR1
ClinVarCR1
1000_GenomesCR1 
Exome Variant ServerCR1
ExAC (Exome Aggregation Consortium)CR1 (select the gene name)
Genetic variants : HAPMAP1378
Genomic Variants (DGV)CR1 [DGVbeta]
DECIPHER (Syndromes)1:207669473-207815110  ENSG00000203710
CONAN: Copy Number AnalysisCR1 
Mutations
ICGC Data PortalCR1 
TCGA Data PortalCR1 
Broad Tumor PortalCR1
OASIS PortalCR1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCR1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDCR1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)TBsLVD Tuberculosis susceptibility Locus Variation Database
BioMutasearch CR1
DgiDB (Drug Gene Interaction Database)CR1
DoCM (Curated mutations)CR1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CR1 (select a term)
intoGenCR1
Cancer3DCR1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM120620    607486    611162   
Orphanet
MedgenCR1
Genetic Testing Registry CR1
NextProtP17927 [Medical]
TSGene1378
GENETestsCR1
Huge Navigator CR1 [HugePedia]
snp3D : Map Gene to Disease1378
BioCentury BCIQCR1
ClinGenCR1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD1378
Chemical/Pharm GKB GenePA26855
Clinical trialCR1
Miscellaneous
canSAR (ICR)CR1 (select the gene name)
Probes
Litterature
PubMed194 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineCR1
EVEXCR1
GoPubMedCR1
iHOPCR1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Mar 14 13:01:37 CET 2017

Home   Genes   Leukemias   Solid Tumours   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.