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CRADD (CASP2 and RIPK1 domain containing adaptor with death domain)

Identity

Alias_symbol (synonym)RAIDD
Other aliasMRT34
HGNC (Hugo) CRADD
LocusID (NCBI) 8738
Atlas_Id 40144
Location 12q22  [Link to chromosome band 12q22]
Location_base_pair Starts at 93677371 and ends at 93850755 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CRADD (12q22) / S100A8 (1q21.3)EEA1 (12q22) / CRADD (12q22)ERBB3 (12q13.2) / CRADD (12q22)
EEA1 12q22 / CRADD 12q22

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 2 ]
  t(12;12)(q13;q22) ERBB3/CRADD
t(12;22)(q22;q13) ACO2/CRADD


External links

Nomenclature
HGNC (Hugo)CRADD   2340
Cards
Entrez_Gene (NCBI)CRADD  8738  CASP2 and RIPK1 domain containing adaptor with death domain
AliasesMRT34; RAIDD
GeneCards (Weizmann)CRADD
Ensembl hg19 (Hinxton)ENSG00000169372 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000169372 [Gene_View]  ENSG00000169372 [Sequence]  chr12:93677371-93850755 [Contig_View]  CRADD [Vega]
ICGC DataPortalENSG00000169372
TCGA cBioPortalCRADD
AceView (NCBI)CRADD
Genatlas (Paris)CRADD
WikiGenes8738
SOURCE (Princeton)CRADD
Genetics Home Reference (NIH)CRADD
Genomic and cartography
GoldenPath hg38 (UCSC)CRADD  -     chr12:93677371-93850755 +  12q22   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)CRADD  -     12q22   [Description]    (hg19-Feb_2009)
EnsemblCRADD - 12q22 [CytoView hg19]  CRADD - 12q22 [CytoView hg38]
Mapping of homologs : NCBICRADD [Mapview hg19]  CRADD [Mapview hg38]
OMIM603454   614499   
Gene and transcription
Genbank (Entrez)AA150833 AB451280 AB451412 AI417529 AI791547
RefSeq transcript (Entrez)NM_001320099 NM_001320100 NM_001320101 NM_001330126 NM_003805
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)CRADD
Cluster EST : UnigeneHs.719191 [ NCBI ]
CGAP (NCI)Hs.719191
Alternative Splicing GalleryENSG00000169372
Gene ExpressionCRADD [ NCBI-GEO ]   CRADD [ EBI - ARRAY_EXPRESS ]   CRADD [ SEEK ]   CRADD [ MEM ]
Gene Expression Viewer (FireBrowse)CRADD [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)8738
GTEX Portal (Tissue expression)CRADD
Human Protein AtlasENSG00000169372-CRADD [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP78560   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP78560  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP78560
Splice isoforms : SwissVarP78560
PhosPhoSitePlusP78560
Domaine pattern : Prosite (Expaxy)CARD (PS50209)    DEATH_DOMAIN (PS50017)   
Domains : Interpro (EBI)CARD    CRADD    CRADD_Death    DEATH-like_dom_sf    Death_domain   
Domain families : Pfam (Sanger)CARD (PF00619)    Death (PF00531)   
Domain families : Pfam (NCBI)pfam00619    pfam00531   
Domain families : Smart (EMBL)CARD (SM00114)  DEATH (SM00005)  
Conserved Domain (NCBI)CRADD
DMDM Disease mutations8738
Blocks (Seattle)CRADD
PDB (SRS)2O71    2OF5    3CRD   
PDB (PDBSum)2O71    2OF5    3CRD   
PDB (IMB)2O71    2OF5    3CRD   
PDB (RSDB)2O71    2OF5    3CRD   
Structural Biology KnowledgeBase2O71    2OF5    3CRD   
SCOP (Structural Classification of Proteins)2O71    2OF5    3CRD   
CATH (Classification of proteins structures)2O71    2OF5    3CRD   
SuperfamilyP78560
Human Protein Atlas [tissue]ENSG00000169372-CRADD [tissue]
Peptide AtlasP78560
HPRD04584
IPIIPI00020364   IPI01022606   IPI00908919   IPI01022890   IPI01022402   
Protein Interaction databases
DIP (DOE-UCLA)P78560
IntAct (EBI)P78560
FunCoupENSG00000169372
BioGRIDCRADD
STRING (EMBL)CRADD
ZODIACCRADD
Ontologies - Pathways
QuickGOP78560
Ontology : AmiGOprotease binding  protease binding  protein binding  nucleus  cytoplasm  cytoplasm  cytosol  activation of cysteine-type endopeptidase activity involved in apoptotic process  DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest  DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest  extrinsic apoptotic signaling pathway via death domain receptors  protein binding, bridging  regulation of apoptotic process  positive regulation of apoptotic process  death domain binding  cellular response to mechanical stimulus  cellular response to mechanical stimulus  positive regulation of apoptotic signaling pathway  
Ontology : EGO-EBIprotease binding  protease binding  protein binding  nucleus  cytoplasm  cytoplasm  cytosol  activation of cysteine-type endopeptidase activity involved in apoptotic process  DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest  DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest  extrinsic apoptotic signaling pathway via death domain receptors  protein binding, bridging  regulation of apoptotic process  positive regulation of apoptotic process  death domain binding  cellular response to mechanical stimulus  cellular response to mechanical stimulus  positive regulation of apoptotic signaling pathway  
NDEx NetworkCRADD
Atlas of Cancer Signalling NetworkCRADD
Wikipedia pathwaysCRADD
Orthology - Evolution
OrthoDB8738
GeneTree (enSembl)ENSG00000169372
Phylogenetic Trees/Animal Genes : TreeFamCRADD
HOVERGENP78560
HOGENOMP78560
Homologs : HomoloGeneCRADD
Homology/Alignments : Family Browser (UCSC)CRADD
Gene fusions - Rearrangements
Fusion : MitelmanERBB3/CRADD [12q13.2/12q22]  [t(12;12)(q13;q22)]  
Fusion PortalEEA1 12q22 CRADD 12q22 BLCA
Fusion : QuiverCRADD
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCRADD [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CRADD
dbVarCRADD
ClinVarCRADD
1000_GenomesCRADD 
Exome Variant ServerCRADD
ExAC (Exome Aggregation Consortium)ENSG00000169372
GNOMAD BrowserENSG00000169372
Varsome BrowserCRADD
Genetic variants : HAPMAP8738
Genomic Variants (DGV)CRADD [DGVbeta]
DECIPHERCRADD [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisCRADD 
Mutations
ICGC Data PortalCRADD 
TCGA Data PortalCRADD 
Broad Tumor PortalCRADD
OASIS PortalCRADD [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCRADD  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDCRADD
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch CRADD
DgiDB (Drug Gene Interaction Database)CRADD
DoCM (Curated mutations)CRADD (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CRADD (select a term)
intoGenCRADD
Cancer3DCRADD(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM603454    614499   
Orphanet11804   
DisGeNETCRADD
MedgenCRADD
Genetic Testing Registry CRADD
NextProtP78560 [Medical]
TSGene8738
GENETestsCRADD
Target ValidationCRADD
Huge Navigator CRADD [HugePedia]
snp3D : Map Gene to Disease8738
BioCentury BCIQCRADD
ClinGenCRADD
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD8738
Chemical/Pharm GKB GenePA26860
Clinical trialCRADD
Miscellaneous
canSAR (ICR)CRADD (select the gene name)
Probes
Litterature
PubMed54 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineCRADD
EVEXCRADD
GoPubMedCRADD
iHOPCRADD
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Nov 6 11:00:04 CET 2018

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