Atlas of Genetics and Cytogenetics in Oncology and Haematology

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Taking over the Atlas
Dear Colleagues,
The Atlas, once more, is in great danger, and I will have to proceed to a collective economic lay-off of all the team involved in the Atlas before the begining of April 2015 (a foundation having suddenly withdrawn its commitment to support the Atlas). I ask you herein if any Scientific Society (a Society of Cytogenetics, of Clinical Genetics, of Hematology, or a Cancer Society, or any other...), any University and/or Hospital, any Charity, or any database would be interested in taking over the Atlas, in whole or in part. If taking charge of the whole lot is too big, a consortium of various actors could be the solution (I am myself trying to find partners). Could you please spread the information, contact the relevant authorities, and find partners.
Survival of the Atlas will be critically dependant upon your ability to find solutions (and urgently!).
Kind regards.
Jean-Loup Huret
Donations are also welcome
If each casual visitor gives 3 Euros or Dollars, the Atlas is saved in a week !
If each professional gives 100 Euros or Dollars once a year (now), the Atlas is saved in 2 weeks !
Don't let the Atlas imminent demise
Note: we send fiscal receipts for donations equal or above 50 Euros or Dollars

Donate (in Euros)

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CRB1 (crumbs family member 1, photoreceptor morphogenesis associated)


Other namesLCA8
HGNC (Hugo) CRB1
LocusID (NCBI) 23418
Location 1q31.3
Location_base_pair Starts at 197237334 and ends at 197447585 bp from pter ( according to hg19-Feb_2009)

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

External links

HGNC (Hugo)CRB1   2343
Entrez_Gene (NCBI)CRB1  23418  crumbs family member 1, photoreceptor morphogenesis associated
GeneCards (Weizmann)CRB1
Ensembl hg19 (Hinxton)ENSG00000134376 [Gene_View]  chr1:197237334-197447585 [Contig_View]  CRB1 [Vega]
Ensembl hg38 (Hinxton)ENSG00000134376 [Gene_View]  chr1:197237334-197447585 [Contig_View]  CRB1 [Vega]
ICGC DataPortalENSG00000134376
AceView (NCBI)CRB1
Genatlas (Paris)CRB1
SOURCE (Princeton)CRB1
Genomic and cartography
GoldenPath hg19 (UCSC)CRB1  -     chr1:197237334-197447585 +  1q31.3   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)CRB1  -     1q31.3   [Description]    (hg38-Dec_2013)
EnsemblCRB1 - 1q31.3 [CytoView hg19]  CRB1 - 1q31.3 [CytoView hg38]
Mapping of homologs : NCBICRB1 [Mapview hg19]  CRB1 [Mapview hg38]
OMIM172870   600105   604210   613835   
Gene and transcription
Genbank (Entrez)AB208923 AF154671 AJ748821 AK289733 AK299367
RefSeq transcript (Entrez)NM_001193640 NM_001257965 NM_001257966 NM_012076 NM_201253
RefSeq genomic (Entrez)NC_000001 NC_018912 NG_008483 NT_004487 NW_004929293
Consensus coding sequences : CCDS (NCBI)CRB1
Cluster EST : UnigeneHs.126135 [ NCBI ]
CGAP (NCI)Hs.126135
Alternative Splicing : Fast-db (Paris)GSHG0001305
Alternative Splicing GalleryENSG00000134376
Gene ExpressionCRB1 [ NCBI-GEO ]     CRB1 [ SEEK ]   CRB1 [ MEM ]
SOURCE (Princeton)Expression in : [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP82279 (Uniprot)
NextProtP82279  [Medical]
With graphics : InterProP82279
Splice isoforms : SwissVarP82279 (Swissvar)
Domaine pattern : Prosite (Expaxy)ASX_HYDROXYL (PS00010)    EGF_1 (PS00022)    EGF_2 (PS01186)    EGF_3 (PS50026)    EGF_CA (PS01187)    LAM_G_DOMAIN (PS50025)   
Domains : Interpro (EBI)ConA-like_dom    EG-like_dom    EGF-like_Ca-bd_dom    EGF-like_CS    EGF-type_Asp/Asn_hydroxyl_site    EGF_Ca-bd_CS    Growth_fac_rcpt_N_dom    Laminin_G   
Related proteins : CluSTrP82279
Domain families : Pfam (Sanger)EGF (PF00008)    hEGF (PF12661)    Laminin_G_2 (PF02210)   
Domain families : Pfam (NCBI)pfam00008    pfam12661    pfam02210   
Domain families : Smart (EMBL)EGF (SM00181)  EGF_CA (SM00179)  LamG (SM00282)  
DMDM Disease mutations23418
Blocks (Seattle)P82279
Human Protein AtlasENSG00000134376
Peptide AtlasP82279
IPIIPI00397504   IPI00015785   IPI00607552   IPI00607891   IPI00922394   IPI00883900   IPI00942642   IPI01009270   IPI01025325   IPI00556358   
Protein Interaction databases
IntAct (EBI)P82279
Ontologies - Pathways
Ontology : AmiGOcalcium ion binding  protein binding  extracellular region  microvillus  plasma membrane organization  establishment or maintenance of cell polarity  cell-cell signaling  integral component of membrane  apical plasma membrane  eye photoreceptor cell development  
Ontology : EGO-EBIcalcium ion binding  protein binding  extracellular region  microvillus  plasma membrane organization  establishment or maintenance of cell polarity  cell-cell signaling  integral component of membrane  apical plasma membrane  eye photoreceptor cell development  
Pathways : KEGGHippo signaling pathway   
Protein Interaction DatabaseCRB1
DoCM (Curated mutations)CRB1
Wikipedia pathwaysCRB1
Gene fusion - rearrangements
Polymorphisms : SNP, variants
NCBI Variation ViewerCRB1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CRB1
Exome Variant ServerCRB1
SNP (GeneSNP Utah)CRB1
Genetic variants : HAPMAPCRB1
Genomic Variants (DGV)CRB1 [DGVbeta]
ICGC Data PortalENSG00000134376 
Somatic Mutations in Cancer : COSMICCRB1 
CONAN: Copy Number AnalysisCRB1 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)Eye diseases - LOVD
LOVD (Leiden Open Variation Database)MSeqDR-LSDB Mitochondrial Disease Locus Specific Database
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
DECIPHER (Syndromes)1:197237334-197447585
Mutations and Diseases : HGMDCRB1
OMIM172870    600105    604210    613835   
NextProtP82279 [Medical]
Disease Genetic AssociationCRB1
Huge Navigator CRB1 [HugePedia]  CRB1 [HugeCancerGEM]
snp3D : Map Gene to Disease23418
DGIdb (Drug Gene Interaction db)CRB1
General knowledge
Homologs : HomoloGeneCRB1
Homology/Alignments : Family Browser (UCSC)CRB1
Phylogenetic Trees/Animal Genes : TreeFamCRB1
Chemical/Protein Interactions : CTD23418
Chemical/Pharm GKB GenePA26863
Clinical trialCRB1
Cancer Resource (Charite)ENSG00000134376
Other databases
PubMed63 Pubmed reference(s) in Entrez
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI


Written09-2002Dessen P, Le Minor S
Updated02-2015Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Sat Mar 28 15:06:47 CET 2015

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