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CRB2 (crumbs 2, cell polarity complex component)

Identity

Alias_namescrumbs homolog 2 (Drosophila)
crumbs family member 2
Alias_symbol (synonym)FLJ38464
FLJ16786
Other aliasFSGS9
VMCKD
HGNC (Hugo) CRB2
LocusID (NCBI) 286204
Atlas_Id 53813
Location 9q33.3  [Link to chromosome band 9q33]
Location_base_pair Starts at 123356167 and ends at 123378755 bp from pter ( according to hg38-Dec_2013)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)CRB2   18688
Cards
Entrez_Gene (NCBI)CRB2  286204  crumbs 2, cell polarity complex component
AliasesFSGS9; VMCKD
GeneCards (Weizmann)CRB2
Ensembl hg19 (Hinxton)ENSG00000148204 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000148204 [Gene_View]  chr9:123356167-123378755 [Contig_View]  CRB2 [Vega]
ICGC DataPortalENSG00000148204
TCGA cBioPortalCRB2
AceView (NCBI)CRB2
Genatlas (Paris)CRB2
WikiGenes286204
SOURCE (Princeton)CRB2
Genetics Home Reference (NIH)CRB2
Genomic and cartography
GoldenPath hg38 (UCSC)CRB2  -     chr9:123356167-123378755 +  9q33.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)CRB2  -     9q33.3   [Description]    (hg19-Feb_2009)
EnsemblCRB2 - 9q33.3 [CytoView hg19]  CRB2 - 9q33.3 [CytoView hg38]
Mapping of homologs : NCBICRB2 [Mapview hg19]  CRB2 [Mapview hg38]
OMIM219730   609720   616220   
Gene and transcription
Genbank (Entrez)AK095783 AK123000 AK124819 AK126775 AY720432
RefSeq transcript (Entrez)NM_173689
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)CRB2
Cluster EST : UnigeneHs.710092 [ NCBI ]
CGAP (NCI)Hs.710092
Alternative Splicing GalleryENSG00000148204
Gene ExpressionCRB2 [ NCBI-GEO ]   CRB2 [ EBI - ARRAY_EXPRESS ]   CRB2 [ SEEK ]   CRB2 [ MEM ]
Gene Expression Viewer (FireBrowse)CRB2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)286204
GTEX Portal (Tissue expression)CRB2
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ5IJ48   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ5IJ48  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ5IJ48
Splice isoforms : SwissVarQ5IJ48
PhosPhoSitePlusQ5IJ48
Domaine pattern : Prosite (Expaxy)ASX_HYDROXYL (PS00010)    EGF_1 (PS00022)    EGF_2 (PS01186)    EGF_3 (PS50026)    EGF_CA (PS01187)    LAM_G_DOMAIN (PS50025)   
Domains : Interpro (EBI)ConA-like_dom    EGF-like_Ca-bd_dom    EGF-like_CS    EGF-like_dom    EGF-type_Asp/Asn_hydroxyl_site    EGF_Ca-bd_CS    Laminin_G   
Domain families : Pfam (Sanger)EGF (PF00008)    hEGF (PF12661)    Laminin_G_2 (PF02210)   
Domain families : Pfam (NCBI)pfam00008    pfam12661    pfam02210   
Domain families : Smart (EMBL)EGF (SM00181)  EGF_CA (SM00179)  LamG (SM00282)  
Conserved Domain (NCBI)CRB2
DMDM Disease mutations286204
Blocks (Seattle)CRB2
PDB (SRS)2WO6   
PDB (PDBSum)2WO6   
PDB (IMB)2WO6   
PDB (RSDB)2WO6   
Structural Biology KnowledgeBase2WO6   
SCOP (Structural Classification of Proteins)2WO6   
CATH (Classification of proteins structures)2WO6   
SuperfamilyQ5IJ48
Human Protein AtlasENSG00000148204
Peptide AtlasQ5IJ48
HPRD13093
IPIIPI00410585   IPI00607881   IPI00607804   IPI00167565   
Protein Interaction databases
DIP (DOE-UCLA)Q5IJ48
IntAct (EBI)Q5IJ48
FunCoupENSG00000148204
BioGRIDCRB2
STRING (EMBL)CRB2
ZODIACCRB2
Ontologies - Pathways
QuickGOQ5IJ48
Ontology : AmiGOmesoderm formation  somitogenesis  calcium ion binding  regulation of gastrulation  positive regulation of epithelial to mesenchymal transition  negative regulation of endopeptidase activity  notochord formation  integral component of membrane  apical plasma membrane  aspartic-type endopeptidase inhibitor activity  enzyme binding  positive regulation of BMP signaling pathway  protein complex  membrane raft  maintenance of epithelial cell apical/basal polarity  ingression involved in gastrulation with mouth forming second  extracellular exosome  cardiovascular system development  
Ontology : EGO-EBImesoderm formation  somitogenesis  calcium ion binding  regulation of gastrulation  positive regulation of epithelial to mesenchymal transition  negative regulation of endopeptidase activity  notochord formation  integral component of membrane  apical plasma membrane  aspartic-type endopeptidase inhibitor activity  enzyme binding  positive regulation of BMP signaling pathway  protein complex  membrane raft  maintenance of epithelial cell apical/basal polarity  ingression involved in gastrulation with mouth forming second  extracellular exosome  cardiovascular system development  
Pathways : KEGGHippo signaling pathway   
NDEx NetworkCRB2
Atlas of Cancer Signalling NetworkCRB2
Wikipedia pathwaysCRB2
Orthology - Evolution
OrthoDB286204
GeneTree (enSembl)ENSG00000148204
Phylogenetic Trees/Animal Genes : TreeFamCRB2
HOVERGENQ5IJ48
HOGENOMQ5IJ48
Homologs : HomoloGeneCRB2
Homology/Alignments : Family Browser (UCSC)CRB2
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCRB2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CRB2
dbVarCRB2
ClinVarCRB2
1000_GenomesCRB2 
Exome Variant ServerCRB2
ExAC (Exome Aggregation Consortium)CRB2 (select the gene name)
Genetic variants : HAPMAP286204
Genomic Variants (DGV)CRB2 [DGVbeta]
DECIPHERCRB2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisCRB2 
Mutations
ICGC Data PortalCRB2 
TCGA Data PortalCRB2 
Broad Tumor PortalCRB2
OASIS PortalCRB2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCRB2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDCRB2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch CRB2
DgiDB (Drug Gene Interaction Database)CRB2
DoCM (Curated mutations)CRB2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CRB2 (select a term)
intoGenCRB2
Cancer3DCRB2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM219730    609720    616220   
Orphanet23471    12191   
MedgenCRB2
Genetic Testing Registry CRB2
NextProtQ5IJ48 [Medical]
TSGene286204
GENETestsCRB2
Target ValidationCRB2
Huge Navigator CRB2 [HugePedia]
snp3D : Map Gene to Disease286204
BioCentury BCIQCRB2
ClinGenCRB2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD286204
Chemical/Pharm GKB GenePA134910460
Clinical trialCRB2
Miscellaneous
canSAR (ICR)CRB2 (select the gene name)
Probes
Litterature
PubMed17 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineCRB2
EVEXCRB2
GoPubMedCRB2
iHOPCRB2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed Jun 7 12:29:30 CEST 2017

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