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CRB3 (crumbs 3, cell polarity complex component)

Identity

Alias_namescrumbs homolog 3 (Drosophila)
crumbs family member 3
Alias_symbol (synonym)MGC17303
Other alias-
HGNC (Hugo) CRB3
LocusID (NCBI) 92359
Atlas_Id 62078
Location 19p13.3  [Link to chromosome band 19p13]
Location_base_pair Starts at 6464238 and ends at 6467219 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
TANC2 (17q23.2) / CRB3 (19p13.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)CRB3   20237
Cards
Entrez_Gene (NCBI)CRB3  92359  crumbs 3, cell polarity complex component
Aliases
GeneCards (Weizmann)CRB3
Ensembl hg19 (Hinxton)ENSG00000130545 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000130545 [Gene_View]  chr19:6464238-6467219 [Contig_View]  CRB3 [Vega]
ICGC DataPortalENSG00000130545
TCGA cBioPortalCRB3
AceView (NCBI)CRB3
Genatlas (Paris)CRB3
WikiGenes92359
SOURCE (Princeton)CRB3
Genetics Home Reference (NIH)CRB3
Genomic and cartography
GoldenPath hg38 (UCSC)CRB3  -     chr19:6464238-6467219 +  19p13.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)CRB3  -     19p13.3   [Description]    (hg19-Feb_2009)
EnsemblCRB3 - 19p13.3 [CytoView hg19]  CRB3 - 19p13.3 [CytoView hg38]
Mapping of homologs : NCBICRB3 [Mapview hg19]  CRB3 [Mapview hg38]
OMIM609737   
Gene and transcription
Genbank (Entrez)AF503290 AK000653 AK292956 AY103469 AY358684
RefSeq transcript (Entrez)NM_139161 NM_174881 NM_174882
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)CRB3
Cluster EST : UnigeneHs.150319 [ NCBI ]
CGAP (NCI)Hs.150319
Alternative Splicing GalleryENSG00000130545
Gene ExpressionCRB3 [ NCBI-GEO ]   CRB3 [ EBI - ARRAY_EXPRESS ]   CRB3 [ SEEK ]   CRB3 [ MEM ]
Gene Expression Viewer (FireBrowse)CRB3 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)92359
GTEX Portal (Tissue expression)CRb3<.A>
Human Protein AtlasENSG00000130545-CRB3 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9BUF7   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9BUF7  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9BUF7
Splice isoforms : SwissVarQ9BUF7
PhosPhoSitePlusQ9BUF7
Domain families : Pfam (Sanger)
Domain families : Pfam (NCBI)
Conserved Domain (NCBI)CRB3
DMDM Disease mutations92359
Blocks (Seattle)CRB3
PDB (SRS)5I7Z   
PDB (PDBSum)5I7Z   
PDB (IMB)5I7Z   
PDB (RSDB)5I7Z   
Structural Biology KnowledgeBase5I7Z   
SCOP (Structural Classification of Proteins)5I7Z   
CATH (Classification of proteins structures)5I7Z   
SuperfamilyQ9BUF7
Human Protein Atlas [tissue]ENSG00000130545-CRB3 [tissue]
Peptide AtlasQ9BUF7
HPRD16749
IPIIPI00166090   IPI00165433   
Protein Interaction databases
DIP (DOE-UCLA)Q9BUF7
IntAct (EBI)Q9BUF7
FunCoupENSG00000130545
BioGRIDCRB3
STRING (EMBL)CRB3
ZODIACCRB3
Ontologies - Pathways
QuickGOQ9BUF7
Ontology : AmiGOprotein binding  plasma membrane  bicellular tight junction  integral component of membrane  apical plasma membrane  SH3 domain binding  protein domain specific binding  cell junction  protein complex  extracellular exosome  bicellular tight junction assembly  protein localization to plasma membrane  
Ontology : EGO-EBIprotein binding  plasma membrane  bicellular tight junction  integral component of membrane  apical plasma membrane  SH3 domain binding  protein domain specific binding  cell junction  protein complex  extracellular exosome  bicellular tight junction assembly  protein localization to plasma membrane  
Pathways : KEGGTight junction   
NDEx NetworkCRB3
Atlas of Cancer Signalling NetworkCRB3
Wikipedia pathwaysCRB3
Orthology - Evolution
OrthoDB92359
GeneTree (enSembl)ENSG00000130545
Phylogenetic Trees/Animal Genes : TreeFamCRB3
HOVERGENQ9BUF7
HOGENOMQ9BUF7
Homologs : HomoloGeneCRB3
Homology/Alignments : Family Browser (UCSC)CRB3
Gene fusions - Rearrangements
Fusion: Tumor Portal CRB3
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCRB3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CRB3
dbVarCRB3
ClinVarCRB3
1000_GenomesCRB3 
Exome Variant ServerCRB3
ExAC (Exome Aggregation Consortium)ENSG00000130545
GNOMAD BrowserENSG00000130545
Genetic variants : HAPMAP92359
Genomic Variants (DGV)CRB3 [DGVbeta]
DECIPHERCRB3 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisCRB3 
Mutations
ICGC Data PortalCRB3 
TCGA Data PortalCRB3 
Broad Tumor PortalCRB3
OASIS PortalCRB3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCRB3  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDCRB3
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch CRB3
DgiDB (Drug Gene Interaction Database)CRB3
DoCM (Curated mutations)CRB3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CRB3 (select a term)
intoGenCRB3
Cancer3DCRB3(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM609737   
Orphanet
MedgenCRB3
Genetic Testing Registry CRB3
NextProtQ9BUF7 [Medical]
TSGene92359
GENETestsCRB3
Target ValidationCRB3
Huge Navigator CRB3 [HugePedia]
snp3D : Map Gene to Disease92359
BioCentury BCIQCRB3
ClinGenCRB3
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD92359
Chemical/Pharm GKB GenePA134862130
Clinical trialCRB3
Miscellaneous
canSAR (ICR)CRB3 (select the gene name)
Probes
Litterature
PubMed19 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineCRB3
EVEXCRB3
GoPubMedCRB3
iHOPCRB3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Nov 9 11:43:21 CET 2017

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