Atlas of Genetics and Cytogenetics in Oncology and Haematology


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CRBN (cereblon)

Identity

Alias_namesMRT2A
mental retardation
Alias_symbol (synonym)MRT2
Other alias
HGNC (Hugo) CRBN
LocusID (NCBI) 51185
Atlas_Id 55691
Location 3p26.2  [Link to chromosome band 3p26]
Location_base_pair Starts at 3149633 and ends at 3179717 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CRBN (3p26.2) / GRM7 (3p26.1)CRBN (3p26.2) / SFMBT1 (3p21.1)WDR33 (2q14.3) / CRBN (3p26.2)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)CRBN   30185
Cards
Entrez_Gene (NCBI)CRBN  51185  cereblon
AliasesMRT2; MRT2A
GeneCards (Weizmann)CRBN
Ensembl hg19 (Hinxton)ENSG00000113851 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000113851 [Gene_View]  chr3:3149633-3179717 [Contig_View]  CRBN [Vega]
ICGC DataPortalENSG00000113851
TCGA cBioPortalCRBN
AceView (NCBI)CRBN
Genatlas (Paris)CRBN
WikiGenes51185
SOURCE (Princeton)CRBN
Genetics Home Reference (NIH)CRBN
Genomic and cartography
GoldenPath hg38 (UCSC)CRBN  -     chr3:3149633-3179717 -  3p26.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)CRBN  -     3p26.2   [Description]    (hg19-Feb_2009)
EnsemblCRBN - 3p26.2 [CytoView hg19]  CRBN - 3p26.2 [CytoView hg38]
Mapping of homologs : NCBICRBN [Mapview hg19]  CRBN [Mapview hg38]
OMIM607417   609262   
Gene and transcription
Genbank (Entrez)AA991754 AF117230 AK027507 AK058191 AK123077
RefSeq transcript (Entrez)NM_001173482 NM_016302
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)CRBN
Cluster EST : UnigeneHs.18925 [ NCBI ]
CGAP (NCI)Hs.18925
Alternative Splicing GalleryENSG00000113851
Gene ExpressionCRBN [ NCBI-GEO ]   CRBN [ EBI - ARRAY_EXPRESS ]   CRBN [ SEEK ]   CRBN [ MEM ]
Gene Expression Viewer (FireBrowse)CRBN [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)51185
GTEX Portal (Tissue expression)CRBN
Human Protein AtlasENSG00000113851-CRBN [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ96SW2   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ96SW2  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ96SW2
Splice isoforms : SwissVarQ96SW2
PhosPhoSitePlusQ96SW2
Domaine pattern : Prosite (Expaxy)CULT (PS51788)    LON_N (PS51787)   
Domains : Interpro (EBI)LON_substr-bd_dom    PUA-like_domain    Yippee/Mis18/Cereblon   
Domain families : Pfam (Sanger)LON_substr_bdg (PF02190)    Yippee-Mis18 (PF03226)   
Domain families : Pfam (NCBI)pfam02190    pfam03226   
Domain families : Smart (EMBL)LON (SM00464)  
Conserved Domain (NCBI)CRBN
DMDM Disease mutations51185
Blocks (Seattle)CRBN
PDB (SRS)4M91    4TZ4    5FQD    5HXB   
PDB (PDBSum)4M91    4TZ4    5FQD    5HXB   
PDB (IMB)4M91    4TZ4    5FQD    5HXB   
PDB (RSDB)4M91    4TZ4    5FQD    5HXB   
Structural Biology KnowledgeBase4M91    4TZ4    5FQD    5HXB   
SCOP (Structural Classification of Proteins)4M91    4TZ4    5FQD    5HXB   
CATH (Classification of proteins structures)4M91    4TZ4    5FQD    5HXB   
SuperfamilyQ96SW2
Human Protein Atlas [tissue]ENSG00000113851-CRBN [tissue]
Peptide AtlasQ96SW2
HPRD16750
IPIIPI00045917   IPI00641620   IPI00925344   IPI00926883   
Protein Interaction databases
DIP (DOE-UCLA)Q96SW2
IntAct (EBI)Q96SW2
FunCoupENSG00000113851
BioGRIDCRBN
STRING (EMBL)CRBN
ZODIACCRBN
Ontologies - Pathways
QuickGOQ96SW2
Ontology : AmiGOprotein binding  nucleus  nucleolus  cytoplasm  membrane  protein ubiquitination  protein ubiquitination  Cul4A-RING E3 ubiquitin ligase complex  negative regulation of protein homooligomerization  negative regulation of ion transmembrane transport  proteasome-mediated ubiquitin-dependent protein catabolic process  metal ion binding  positive regulation of protein homodimerization activity  
Ontology : EGO-EBIprotein binding  nucleus  nucleolus  cytoplasm  membrane  protein ubiquitination  protein ubiquitination  Cul4A-RING E3 ubiquitin ligase complex  negative regulation of protein homooligomerization  negative regulation of ion transmembrane transport  proteasome-mediated ubiquitin-dependent protein catabolic process  metal ion binding  positive regulation of protein homodimerization activity  
NDEx NetworkCRBN
Atlas of Cancer Signalling NetworkCRBN
Wikipedia pathwaysCRBN
Orthology - Evolution
OrthoDB51185
GeneTree (enSembl)ENSG00000113851
Phylogenetic Trees/Animal Genes : TreeFamCRBN
HOVERGENQ96SW2
HOGENOMQ96SW2
Homologs : HomoloGeneCRBN
Homology/Alignments : Family Browser (UCSC)CRBN
Gene fusions - Rearrangements
Tumor Fusion PortalCRBN
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCRBN [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CRBN
dbVarCRBN
ClinVarCRBN
1000_GenomesCRBN 
Exome Variant ServerCRBN
ExAC (Exome Aggregation Consortium)ENSG00000113851
GNOMAD BrowserENSG00000113851
Genetic variants : HAPMAP51185
Genomic Variants (DGV)CRBN [DGVbeta]
DECIPHERCRBN [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisCRBN 
Mutations
ICGC Data PortalCRBN 
TCGA Data PortalCRBN 
Broad Tumor PortalCRBN
OASIS PortalCRBN [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCRBN  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDCRBN
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch CRBN
DgiDB (Drug Gene Interaction Database)CRBN
DoCM (Curated mutations)CRBN (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CRBN (select a term)
intoGenCRBN
Cancer3DCRBN(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM607417    609262   
Orphanet1114    11804   
DisGeNETCRBN
MedgenCRBN
Genetic Testing Registry CRBN
NextProtQ96SW2 [Medical]
TSGene51185
GENETestsCRBN
Target ValidationCRBN
Huge Navigator CRBN [HugePedia]
snp3D : Map Gene to Disease51185
BioCentury BCIQCRBN
ClinGenCRBN
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD51185
Chemical/Pharm GKB GenePA134926851
Clinical trialCRBN
Miscellaneous
canSAR (ICR)CRBN (select the gene name)
Probes
Litterature
PubMed58 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineCRBN
EVEXCRBN
GoPubMedCRBN
iHOPCRBN
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Nov 21 14:08:55 CET 2017

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