Atlas of Genetics and Cytogenetics in Oncology and Haematology


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CRBN (cereblon)

Identity

Alias (NCBI)MRT2
MRT2A
HGNC (Hugo) CRBN
HGNC Alias symbMRT2
HGNC Previous nameMRT2A
HGNC Previous namemental retardation, non-syndromic, autosomal recessive, 2A
LocusID (NCBI) 51185
Atlas_Id 55691
Location 3p26.2  [Link to chromosome band 3p26]
Location_base_pair Starts at 3149633 and ends at 3179717 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CRBN (3p26.2) / GRM7 (3p26.1)CRBN (3p26.2) / SFMBT1 (3p21.1)WDR33 (2q14.3) / CRBN (3p26.2)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  CRBN/GRM7 (3p26)


External links

Nomenclature
HGNC (Hugo)CRBN   30185
Cards
Entrez_Gene (NCBI)CRBN  51185  cereblon
AliasesMRT2; MRT2A
GeneCards (Weizmann)CRBN
Ensembl hg19 (Hinxton)ENSG00000113851 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000113851 [Gene_View]  ENSG00000113851 [Sequence]  chr3:3149633-3179717 [Contig_View]  CRBN [Vega]
ICGC DataPortalENSG00000113851
TCGA cBioPortalCRBN
AceView (NCBI)CRBN
Genatlas (Paris)CRBN
WikiGenes51185
SOURCE (Princeton)CRBN
Genetics Home Reference (NIH)CRBN
Genomic and cartography
GoldenPath hg38 (UCSC)CRBN  -     chr3:3149633-3179717 -  3p26.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)CRBN  -     3p26.2   [Description]    (hg19-Feb_2009)
GoldenPathCRBN - 3p26.2 [CytoView hg19]  CRBN - 3p26.2 [CytoView hg38]
ImmunoBaseENSG00000113851
genome Data Viewer NCBICRBN [Mapview hg19]  
OMIM607417   609262   
Gene and transcription
Genbank (Entrez)AA991754 AF117230 AK027507 AK058191 AK123077
RefSeq transcript (Entrez)NM_001173482 NM_016302
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)CRBN
Alternative Splicing GalleryENSG00000113851
Gene ExpressionCRBN [ NCBI-GEO ]   CRBN [ EBI - ARRAY_EXPRESS ]   CRBN [ SEEK ]   CRBN [ MEM ]
Gene Expression Viewer (FireBrowse)CRBN [ Firebrowse - Broad ]
GenevisibleExpression of CRBN in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)51185
GTEX Portal (Tissue expression)CRBN
Human Protein AtlasENSG00000113851-CRBN [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ96SW2   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ96SW2  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ96SW2
Splice isoforms : SwissVarQ96SW2
PhosPhoSitePlusQ96SW2
Domaine pattern : Prosite (Expaxy)CULT (PS51788)    LON_N (PS51787)   
Domains : Interpro (EBI)CULT    Lon_substr-bd    PUA-like_sf    Yippee/Mis18/Cereblon   
Domain families : Pfam (Sanger)LON_substr_bdg (PF02190)    Yippee-Mis18 (PF03226)   
Domain families : Pfam (NCBI)pfam02190    pfam03226   
Domain families : Smart (EMBL)LON (SM00464)  
Conserved Domain (NCBI)CRBN
DMDM Disease mutations51185
Blocks (Seattle)CRBN
PDB (RSDB)4M91    4TZ4    5FQD    5HXB    5V3O    6BN7    6BN8    6BN9    6BNB    6BOY    6H0F    6H0G   
PDB Europe4M91    4TZ4    5FQD    5HXB    5V3O    6BN7    6BN8    6BN9    6BNB    6BOY    6H0F    6H0G   
PDB (PDBSum)4M91    4TZ4    5FQD    5HXB    5V3O    6BN7    6BN8    6BN9    6BNB    6BOY    6H0F    6H0G   
PDB (IMB)4M91    4TZ4    5FQD    5HXB    5V3O    6BN7    6BN8    6BN9    6BNB    6BOY    6H0F    6H0G   
Structural Biology KnowledgeBase4M91    4TZ4    5FQD    5HXB    5V3O    6BN7    6BN8    6BN9    6BNB    6BOY    6H0F    6H0G   
SCOP (Structural Classification of Proteins)4M91    4TZ4    5FQD    5HXB    5V3O    6BN7    6BN8    6BN9    6BNB    6BOY    6H0F    6H0G   
CATH (Classification of proteins structures)4M91    4TZ4    5FQD    5HXB    5V3O    6BN7    6BN8    6BN9    6BNB    6BOY    6H0F    6H0G   
SuperfamilyQ96SW2
Human Protein Atlas [tissue]ENSG00000113851-CRBN [tissue]
Peptide AtlasQ96SW2
HPRD16750
IPIIPI00045917   IPI00641620   IPI00925344   IPI00926883   
Protein Interaction databases
DIP (DOE-UCLA)Q96SW2
IntAct (EBI)Q96SW2
FunCoupENSG00000113851
BioGRIDCRBN
STRING (EMBL)CRBN
ZODIACCRBN
Ontologies - Pathways
QuickGOQ96SW2
Ontology : AmiGOprotein binding  nucleus  cytoplasm  membrane  protein ubiquitination  protein ubiquitination  protein ubiquitination  negative regulation of protein complex assembly  positive regulation of protein complex assembly  Cul4A-RING E3 ubiquitin ligase complex  Cul4A-RING E3 ubiquitin ligase complex  negative regulation of ion transmembrane transport  proteasome-mediated ubiquitin-dependent protein catabolic process  ion channel binding  metal ion binding  perinuclear region of cytoplasm  
Ontology : EGO-EBIprotein binding  nucleus  cytoplasm  membrane  protein ubiquitination  protein ubiquitination  protein ubiquitination  negative regulation of protein complex assembly  positive regulation of protein complex assembly  Cul4A-RING E3 ubiquitin ligase complex  Cul4A-RING E3 ubiquitin ligase complex  negative regulation of ion transmembrane transport  proteasome-mediated ubiquitin-dependent protein catabolic process  ion channel binding  metal ion binding  perinuclear region of cytoplasm  
NDEx NetworkCRBN
Atlas of Cancer Signalling NetworkCRBN
Wikipedia pathwaysCRBN
Orthology - Evolution
OrthoDB51185
GeneTree (enSembl)ENSG00000113851
Phylogenetic Trees/Animal Genes : TreeFamCRBN
HOGENOMQ96SW2
Homologs : HomoloGeneCRBN
Homology/Alignments : Family Browser (UCSC)CRBN
Gene fusions - Rearrangements
Fusion : QuiverCRBN
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCRBN [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CRBN
dbVarCRBN
ClinVarCRBN
1000_GenomesCRBN 
Exome Variant ServerCRBN
GNOMAD BrowserENSG00000113851
Varsome BrowserCRBN
Genetic variants : HAPMAP51185
Genomic Variants (DGV)CRBN [DGVbeta]
DECIPHERCRBN [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisCRBN 
Mutations
ICGC Data PortalCRBN 
TCGA Data PortalCRBN 
Broad Tumor PortalCRBN
OASIS PortalCRBN [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCRBN  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DCRBN
Mutations and Diseases : HGMDCRBN
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch CRBN
DgiDB (Drug Gene Interaction Database)CRBN
DoCM (Curated mutations)CRBN (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CRBN (select a term)
intoGenCRBN
Cancer3DCRBN(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM607417    609262   
Orphanet1114    11804   
DisGeNETCRBN
MedgenCRBN
Genetic Testing Registry CRBN
NextProtQ96SW2 [Medical]
TSGene51185
GENETestsCRBN
Target ValidationCRBN
Huge Navigator CRBN [HugePedia]
snp3D : Map Gene to Disease51185
BioCentury BCIQCRBN
ClinGenCRBN
Clinical trials, drugs, therapy
Protein Interactions : CTD51185
Pharm GKB GenePA134926851
Clinical trialCRBN
Miscellaneous
canSAR (ICR)CRBN (select the gene name)
HarmonizomeCRBN
DataMed IndexCRBN
Probes
Litterature
PubMed98 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineCRBN
EVEXCRBN
GoPubMedCRBN
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Thu Jul 16 15:09:00 CEST 2020

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