CRCP (CGRP receptor component)

2014-08-01  

Identity

HGNC
LOCATION
7q11.21
LOCUSID
ALIAS
C17,CGRP-RCP,CGRPRCP,POLR3I,POLR3J,RCP,RCP9,RPC9
FUSION GENES

Other Information

Locus ID:

NCBI: 27297
MIM: 606121
HGNC: 17888
Ensembl: ENSG00000241258

Variants:

dbSNP: 27297
ClinVar: 27297
TCGA: ENSG00000241258
COSMIC: CRCP

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000241258ENST00000338592O75575
ENSG00000241258ENST00000360415H7BY40
ENSG00000241258ENST00000395326O75575
ENSG00000241258ENST00000395326A0A024RDL0
ENSG00000241258ENST00000398684O75575
ENSG00000241258ENST00000431089O75575

Expression (GTEx)

0
5
10
15
20
25
30
35

Pathways

PathwaySourceExternal ID
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
Cytosolic sensors of pathogen-associated DNAREACTOMER-HSA-1834949
Gene ExpressionREACTOMER-HSA-74160
RNA Polymerase I, RNA Polymerase III, and Mitochondrial TranscriptionREACTOMER-HSA-504046
RNA Polymerase III TranscriptionREACTOMER-HSA-74158
RNA Polymerase III Abortive And Retractive InitiationREACTOMER-HSA-749476
RNA Polymerase III Transcription InitiationREACTOMER-HSA-76046
RNA Polymerase III Transcription Initiation From Type 1 PromoterREACTOMER-HSA-76061
RNA Polymerase III Transcription Initiation From Type 2 PromoterREACTOMER-HSA-76066
RNA Polymerase III Transcription Initiation From Type 3 PromoterREACTOMER-HSA-76071
RNA Polymerase III Chain ElongationREACTOMER-HSA-73780
RNA Polymerase III Transcription TerminationREACTOMER-HSA-73980

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
220744082011Calcitonin gene-related peptide (CGRP) and its receptor components in human and rat spinal trigeminal nucleus and spinal cord at C1-level.38
124829732003An Rpb4/Rpb7-like complex in yeast RNA polymerase III contains the orthologue of mammalian CGRP-RCP.19
271551502016Immunohistochemical localization of the calcitonin gene-related peptide binding site in the primate trigeminovascular system using functional antagonist antibodies.19
275665462016Receptor Activity-modifying Protein-directed G Protein Signaling Specificity for the Calcitonin Gene-related Peptide Family of Receptors.18
186367542008Functional and biophysical analysis of the C-terminus of the CGRP-receptor; a family B GPCR.16
200999002010Refolding and characterization of a soluble ectodomain complex of the calcitonin gene-related peptide receptor.16
199130632010Mapping interaction sites within the N-terminus of the calcitonin gene-related peptide receptor; the role of residues 23-60 of the calcitonin receptor-like receptor.9
119372642002Regulation and function of the CGRP receptor complex in human granulopoiesis.6
190537662008Identification of potent, selective, and metabolically stable peptide antagonists to the calcitonin gene-related peptide (CGRP) receptor.6

Citation

Dessen P

CRCP (CGRP receptor component)

Atlas Genet Cytogenet Oncol Haematol. 2014-08-01

Online version: http://atlasgeneticsoncology.org/gene/54236/crcp