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CREB1 (cAMP responsive element binding protein 1)

Identity

Other aliasCREB
CREB-1
HGNC (Hugo) CREB1
LocusID (NCBI) 1385
Atlas_Id 46517
Location 2q33.3  [Link to chromosome band 2q33]
Location_base_pair Starts at 208394616 and ends at 208470284 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
CREB1 (2q33.3) / CREB1 (2q33.3)CREB1 (2q33.3) / EWSR1 (22q12.2)CREB1 (2q33.3) / FASTKD2 (2q33.3)
CREB1 (2q33.3) / PARD3B (2q33.3)EWSR1 (22q12.2) / CREB1 (2q33.3)EWSR1 22q12.2 / CREB1 2q33.3
CREB1 2q33.3 / FASTKD2 2q33.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 4 ]
  Soft Tissues: Angiomatoid fibrous histiocytoma
Soft Tissues: Clear cell sarcoma
Soft tissue tumors: an overview
Soft Tissues: Angiomatoid fibrous histiocytoma with t(2;22)(q34;q12) EWSR1/CREB1


External links

Nomenclature
HGNC (Hugo)CREB1   2345
Cards
Entrez_Gene (NCBI)CREB1  1385  cAMP responsive element binding protein 1
AliasesCREB; CREB-1
GeneCards (Weizmann)CREB1
Ensembl hg19 (Hinxton)ENSG00000118260 [Gene_View]  chr2:208394616-208470284 [Contig_View]  CREB1 [Vega]
Ensembl hg38 (Hinxton)ENSG00000118260 [Gene_View]  chr2:208394616-208470284 [Contig_View]  CREB1 [Vega]
ICGC DataPortalENSG00000118260
TCGA cBioPortalCREB1
AceView (NCBI)CREB1
Genatlas (Paris)CREB1
WikiGenes1385
SOURCE (Princeton)CREB1
Genetics Home Reference (NIH)CREB1
Genomic and cartography
GoldenPath hg19 (UCSC)CREB1  -     chr2:208394616-208470284 +  2q33.3   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)CREB1  -     2q33.3   [Description]    (hg38-Dec_2013)
EnsemblCREB1 - 2q33.3 [CytoView hg19]  CREB1 - 2q33.3 [CytoView hg38]
Mapping of homologs : NCBICREB1 [Mapview hg19]  CREB1 [Mapview hg38]
OMIM123810   612160   
Gene and transcription
Genbank (Entrez)AK091534 AK095116 AK123952 AK126342 AK298740
RefSeq transcript (Entrez)NM_001320793 NM_004379 NM_134442
RefSeq genomic (Entrez)NC_000002 NC_018913 NG_023299 NT_005403 NW_004929305
Consensus coding sequences : CCDS (NCBI)CREB1
Cluster EST : UnigeneHs.717136 [ NCBI ]
CGAP (NCI)Hs.717136
Alternative Splicing GalleryENSG00000118260
Gene ExpressionCREB1 [ NCBI-GEO ]   CREB1 [ EBI - ARRAY_EXPRESS ]   CREB1 [ SEEK ]   CREB1 [ MEM ]
Gene Expression Viewer (FireBrowse)CREB1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)1385
GTEX Portal (Tissue expression)CREB1
Protein : pattern, domain, 3D structure
UniProt/SwissProtP16220   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP16220  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP16220
Splice isoforms : SwissVarP16220
PhosPhoSitePlusP16220
Domaine pattern : Prosite (Expaxy)BZIP (PS50217)    BZIP_BASIC (PS00036)    KID (PS50953)   
Domains : Interpro (EBI)bZIP    Coactivator_CBP_pKID    Leuzip_CREB   
Domain families : Pfam (Sanger)bZIP_1 (PF00170)    pKID (PF02173)   
Domain families : Pfam (NCBI)pfam00170    pfam02173   
Domain families : Smart (EMBL)BRLZ (SM00338)  
Conserved Domain (NCBI)CREB1
DMDM Disease mutations1385
Blocks (Seattle)CREB1
PDB (SRS)2LXT   
PDB (PDBSum)2LXT   
PDB (IMB)2LXT   
PDB (RSDB)2LXT   
Structural Biology KnowledgeBase2LXT   
SCOP (Structural Classification of Proteins)2LXT   
CATH (Classification of proteins structures)2LXT   
SuperfamilyP16220
Human Protein AtlasENSG00000118260
Peptide AtlasP16220
HPRD00442
IPIIPI00027713   IPI00218334   IPI00922143   IPI00433048   IPI01011288   IPI00927217   IPI00816761   IPI00816692   IPI00927413   IPI00927840   IPI00926065   IPI00924733   IPI00925815   IPI00926858   
Protein Interaction databases
DIP (DOE-UCLA)P16220
IntAct (EBI)P16220
FunCoupENSG00000118260
BioGRIDCREB1
STRING (EMBL)CREB1
ZODIACCREB1
Ontologies - Pathways
QuickGOP16220
Ontology : AmiGORNA polymerase II core promoter proximal region sequence-specific DNA binding  RNA polymerase II distal enhancer sequence-specific DNA binding  transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding  RNA polymerase II activating transcription factor binding  transcriptional activator activity, RNA polymerase II transcription factor binding  response to hypoxia  transcription factor activity, sequence-specific DNA binding  transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding  transcription cofactor activity  protein binding  nucleus  nucleoplasm  nucleoplasm  nuclear euchromatin  mitochondrial matrix  transcription from RNA polymerase II promoter  protein phosphorylation  signal transduction  transforming growth factor beta receptor signaling pathway  axon guidance  aging  lactation  memory  circadian rhythm  regulation of cell size  visual learning  response to organic substance  negative regulation of transcription by competitive promoter binding  response to activity  viral process  enzyme binding  pituitary gland development  axon  Hsp70 protein binding  positive regulation of transforming growth factor beta3 production  secretory granule organization  response to glucagon  chemotaxis to arachidonic acid  histone acetyltransferase binding  response to nicotine  cAMP response element binding  cellular response to hepatocyte growth factor stimulus  cellular response to platelet-derived growth factor stimulus  response to antidepressant  positive regulation of multicellular organism growth  regulation of circadian rhythm  identical protein binding  positive regulation of apoptotic process  positive regulation of fat cell differentiation  positive regulation of osteoclast differentiation  positive regulation of transcription, DNA-templated  positive regulation of RNA polymerase II transcriptional preinitiation complex assembly  positive regulation of transcription from RNA polymerase II promoter  positive regulation of hormone secretion  positive regulation of lipid biosynthetic process  regulation of fibroblast proliferation  protein stabilization  regulation of glial cell proliferation  lung saccule development  Type I pneumocyte differentiation  cellular response to zinc ion  cellular response to fatty acid  positive regulation of long-term synaptic potentiation  negative regulation of neuron death  response to L-glutamate  cellular response to nerve growth factor stimulus  cellular response to insulin-like growth factor stimulus  ATF4-CREB1 transcription factor complex  arrestin family protein binding  
Ontology : EGO-EBIRNA polymerase II core promoter proximal region sequence-specific DNA binding  RNA polymerase II distal enhancer sequence-specific DNA binding  transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding  RNA polymerase II activating transcription factor binding  transcriptional activator activity, RNA polymerase II transcription factor binding  response to hypoxia  transcription factor activity, sequence-specific DNA binding  transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding  transcription cofactor activity  protein binding  nucleus  nucleoplasm  nucleoplasm  nuclear euchromatin  mitochondrial matrix  transcription from RNA polymerase II promoter  protein phosphorylation  signal transduction  transforming growth factor beta receptor signaling pathway  axon guidance  aging  lactation  memory  circadian rhythm  regulation of cell size  visual learning  response to organic substance  negative regulation of transcription by competitive promoter binding  response to activity  viral process  enzyme binding  pituitary gland development  axon  Hsp70 protein binding  positive regulation of transforming growth factor beta3 production  secretory granule organization  response to glucagon  chemotaxis to arachidonic acid  histone acetyltransferase binding  response to nicotine  cAMP response element binding  cellular response to hepatocyte growth factor stimulus  cellular response to platelet-derived growth factor stimulus  response to antidepressant  positive regulation of multicellular organism growth  regulation of circadian rhythm  identical protein binding  positive regulation of apoptotic process  positive regulation of fat cell differentiation  positive regulation of osteoclast differentiation  positive regulation of transcription, DNA-templated  positive regulation of RNA polymerase II transcriptional preinitiation complex assembly  positive regulation of transcription from RNA polymerase II promoter  positive regulation of hormone secretion  positive regulation of lipid biosynthetic process  regulation of fibroblast proliferation  protein stabilization  regulation of glial cell proliferation  lung saccule development  Type I pneumocyte differentiation  cellular response to zinc ion  cellular response to fatty acid  positive regulation of long-term synaptic potentiation  negative regulation of neuron death  response to L-glutamate  cellular response to nerve growth factor stimulus  cellular response to insulin-like growth factor stimulus  ATF4-CREB1 transcription factor complex  arrestin family protein binding  
Pathways : BIOCARTATranscription Regulation by Methyltransferase of CARM1 [Genes]    Hypoxia-Inducible Factor in the Cardiovascular System [Genes]    Melanocyte Development and Pigmentation [Genes]    Transcription factor CREB and its extracellular signals [Genes]    Ca++/ Calmodulin-dependent Protein Kinase Activation [Genes]    Inhibition of Huntington's disease neurodegeneration by histone deacetylase inhibitors [Genes]    Repression of Pain Sensation by the Transcriptional Regulator DREAM [Genes]    Calcium Signaling by HBx of Hepatitis B virus [Genes]    Human Cytomegalovirus and Map Kinase Pathways [Genes]    MAPKinase Signaling Pathway [Genes]    Role of Erk5 in Neuronal Survival [Genes]    Signaling Pathway from G-Protein Families [Genes]    p38 MAPK Signaling Pathway [Genes]    Oxidative Stress Induced Gene Expression Via Nrf2 [Genes]   
Pathways : KEGGPI3K-Akt signaling pathway    Adrenergic signaling in cardiomyocytes    Osteoclast differentiation    Antigen processing and presentation    TNF signaling pathway    Circadian rhythm    Circadian entrainment    Cholinergic synapse    Dopaminergic synapse    Insulin secretion    Estrogen signaling pathway    Melanogenesis    Thyroid hormone synthesis    Vasopressin-regulated water reabsorption    Huntington's disease    Cocaine addiction    Amphetamine addiction    Alcoholism    Tuberculosis    Hepatitis B    HTLV-I infection    Viral carcinogenesis    Prostate cancer   
NDEx NetworkCREB1
Atlas of Cancer Signalling NetworkCREB1
Wikipedia pathwaysCREB1
Orthology - Evolution
OrthoDB1385
GeneTree (enSembl)ENSG00000118260
Phylogenetic Trees/Animal Genes : TreeFamCREB1
HOVERGENP16220
HOGENOMP16220
Homologs : HomoloGeneCREB1
Homology/Alignments : Family Browser (UCSC)CREB1
Gene fusions - Rearrangements
Fusion : MitelmanCREB1/FASTKD2 [2q33.3/2q33.3]  
Fusion : MitelmanCREB1/PARD3B [2q33.3/2q33.3]  [t(2;2)(q33;q33)]  
Fusion : MitelmanEWSR1/CREB1 [22q12.2/2q33.3]  [t(2;22)(q33;q12)]  
Fusion: TCGACREB1 2q33.3 FASTKD2 2q33.3 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCREB1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CREB1
dbVarCREB1
ClinVarCREB1
1000_GenomesCREB1 
Exome Variant ServerCREB1
ExAC (Exome Aggregation Consortium)CREB1 (select the gene name)
Genetic variants : HAPMAP1385
Genomic Variants (DGV)CREB1 [DGVbeta]
DECIPHER (Syndromes)2:208394616-208470284  ENSG00000118260
CONAN: Copy Number AnalysisCREB1 
Mutations
ICGC Data PortalCREB1 
TCGA Data PortalCREB1 
Broad Tumor PortalCREB1
OASIS PortalCREB1 [ Somatic mutations - Copy number]
Cancer Gene: CensusCREB1 
Somatic Mutations in Cancer : COSMICCREB1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDCREB1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)Mendelian genes
BioMutasearch CREB1
DgiDB (Drug Gene Interaction Database)CREB1
DoCM (Curated mutations)CREB1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CREB1 (select a term)
intoGenCREB1
Cancer3DCREB1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM123810    612160   
Orphanet12894   
MedgenCREB1
Genetic Testing Registry CREB1
NextProtP16220 [Medical]
TSGene1385
GENETestsCREB1
Huge Navigator CREB1 [HugePedia]
snp3D : Map Gene to Disease1385
BioCentury BCIQCREB1
ClinGenCREB1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD1385
Chemical/Pharm GKB GenePA26864
Clinical trialCREB1
Miscellaneous
canSAR (ICR)CREB1 (select the gene name)
Probes
Litterature
PubMed499 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineCREB1
EVEXCREB1
GoPubMedCREB1
iHOPCREB1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Thu Mar 30 14:57:34 CEST 2017

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