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CREB1 (cAMP responsive element binding protein 1)

Identity

Alias (NCBI)CREB
CREB-1
HGNC (Hugo) CREB1
LocusID (NCBI) 1385
Atlas_Id 46517
Location 2q33.3  [Link to chromosome band 2q33]
Location_base_pair Starts at 207529962 and ends at 207605988 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CREB1 (2q33.3)::CREB1 (2q33.3)CREB1 (2q33.3)::EWSR1 (22q12.2)CREB1 (2q33.3)::FASTKD2 (2q33.3)
CREB1 (2q33.3)::PARD3B (2q33.3)EWSR1 (22q12.2)::CREB1 (2q33.3)EWSR1 22q12.2::CREB1 2q33.3
CREB1 2q33.3::FASTKD2 2q33.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)CREB1   2345
Cards
Entrez_Gene (NCBI)CREB1    cAMP responsive element binding protein 1
AliasesCREB; CREB-1
GeneCards (Weizmann)CREB1
Ensembl hg19 (Hinxton)ENSG00000118260 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000118260 [Gene_View]  ENSG00000118260 [Sequence]  chr2:207529962-207605988 [Contig_View]  CREB1 [Vega]
ICGC DataPortalENSG00000118260
TCGA cBioPortalCREB1
AceView (NCBI)CREB1
Genatlas (Paris)CREB1
SOURCE (Princeton)CREB1
Genetics Home Reference (NIH)CREB1
Genomic and cartography
GoldenPath hg38 (UCSC)CREB1  -     chr2:207529962-207605988 +  2q33.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)CREB1  -     2q33.3   [Description]    (hg19-Feb_2009)
GoldenPathCREB1 - 2q33.3 [CytoView hg19]  CREB1 - 2q33.3 [CytoView hg38]
ImmunoBaseENSG00000118260
Genome Data Viewer NCBICREB1 [Mapview hg19]  
OMIM123810   612160   
Gene and transcription
Genbank (Entrez)AK091534 AK095116 AK123952 AK126342 AK298740
RefSeq transcript (Entrez)NM_001320793 NM_001371426 NM_001371427 NM_001371428 NM_004379 NM_134442
Consensus coding sequences : CCDS (NCBI)CREB1
Gene ExpressionCREB1 [ NCBI-GEO ]   CREB1 [ EBI - ARRAY_EXPRESS ]   CREB1 [ SEEK ]   CREB1 [ MEM ]
Gene Expression Viewer (FireBrowse)CREB1 [ Firebrowse - Broad ]
GenevisibleExpression of CREB1 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)1385
GTEX Portal (Tissue expression)CREB1
Human Protein AtlasENSG00000118260-CREB1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP16220   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP16220  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP16220
PhosPhoSitePlusP16220
Domaine pattern : Prosite (Expaxy)BZIP (PS50217)    BZIP_BASIC (PS00036)    KID (PS50953)   
Domains : Interpro (EBI)bZIP    Coactivator_CBP_pKID    CREB1    Leuzip_CREB   
Domain families : Pfam (Sanger)bZIP_1 (PF00170)    pKID (PF02173)   
Domain families : Pfam (NCBI)pfam00170    pfam02173   
Domain families : Smart (EMBL)BRLZ (SM00338)  
Conserved Domain (NCBI)CREB1
PDB (RSDB)2LXT    5ZK1    5ZKO   
PDB Europe2LXT    5ZK1    5ZKO   
PDB (PDBSum)2LXT    5ZK1    5ZKO   
PDB (IMB)2LXT    5ZK1    5ZKO   
Structural Biology KnowledgeBase2LXT    5ZK1    5ZKO   
SCOP (Structural Classification of Proteins)2LXT    5ZK1    5ZKO   
CATH (Classification of proteins structures)2LXT    5ZK1    5ZKO   
SuperfamilyP16220
AlphaFold pdb e-kbP16220   
Human Protein Atlas [tissue]ENSG00000118260-CREB1 [tissue]
HPRD00442
Protein Interaction databases
DIP (DOE-UCLA)P16220
IntAct (EBI)P16220
BioGRIDCREB1
STRING (EMBL)CREB1
ZODIACCREB1
Ontologies - Pathways
QuickGOP16220
Ontology : AmiGOchromatin  euchromatin  RNA polymerase II cis-regulatory region sequence-specific DNA binding  RNA polymerase II cis-regulatory region sequence-specific DNA binding  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription activator activity, RNA polymerase II-specific  DNA-binding transcription activator activity, RNA polymerase II-specific  DNA-binding transcription factor activity  protein binding  nucleus  nucleoplasm  nucleoplasm  transcription regulator complex  regulation of transcription by RNA polymerase II  protein phosphorylation  signal transduction  axonogenesis  lactation  memory  circadian rhythm  regulation of cell size  response to xenobiotic stimulus  response to organic substance  negative regulation of transcription by competitive promoter binding  enzyme binding  pituitary gland development  secretory granule organization  response to glucagon  cAMP response element binding  cAMP response element binding  cellular response to hepatocyte growth factor stimulus  positive regulation of multicellular organism growth  identical protein binding  positive regulation of fat cell differentiation  positive regulation of osteoclast differentiation  positive regulation of transcription, DNA-templated  positive regulation of transcription by RNA polymerase II  positive regulation of transcription by RNA polymerase II  positive regulation of transcription by RNA polymerase II  positive regulation of hormone secretion  positive regulation of lipid biosynthetic process  protein stabilization  positive regulation of cardiac muscle tissue development  lung saccule development  type I pneumocyte differentiation  RNA polymerase II-specific DNA-binding transcription factor binding  cellular response to zinc ion  cellular response to retinoic acid  RNA polymerase II transcription regulator complex  ATF4-CREB1 transcription factor complex  ATF4-CREB1 transcription factor complex  cellular response to leukemia inhibitory factor  sequence-specific double-stranded DNA binding  
Ontology : EGO-EBIchromatin  euchromatin  RNA polymerase II cis-regulatory region sequence-specific DNA binding  RNA polymerase II cis-regulatory region sequence-specific DNA binding  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription activator activity, RNA polymerase II-specific  DNA-binding transcription activator activity, RNA polymerase II-specific  DNA-binding transcription factor activity  protein binding  nucleus  nucleoplasm  nucleoplasm  transcription regulator complex  regulation of transcription by RNA polymerase II  protein phosphorylation  signal transduction  axonogenesis  lactation  memory  circadian rhythm  regulation of cell size  response to xenobiotic stimulus  response to organic substance  negative regulation of transcription by competitive promoter binding  enzyme binding  pituitary gland development  secretory granule organization  response to glucagon  cAMP response element binding  cAMP response element binding  cellular response to hepatocyte growth factor stimulus  positive regulation of multicellular organism growth  identical protein binding  positive regulation of fat cell differentiation  positive regulation of osteoclast differentiation  positive regulation of transcription, DNA-templated  positive regulation of transcription by RNA polymerase II  positive regulation of transcription by RNA polymerase II  positive regulation of transcription by RNA polymerase II  positive regulation of hormone secretion  positive regulation of lipid biosynthetic process  protein stabilization  positive regulation of cardiac muscle tissue development  lung saccule development  type I pneumocyte differentiation  RNA polymerase II-specific DNA-binding transcription factor binding  cellular response to zinc ion  cellular response to retinoic acid  RNA polymerase II transcription regulator complex  ATF4-CREB1 transcription factor complex  ATF4-CREB1 transcription factor complex  cellular response to leukemia inhibitory factor  sequence-specific double-stranded DNA binding  
Pathways : BIOCARTABIOCARTA_MELANOCYTEPATHWAY    BIOCARTA_HBXPATHWAY    BIOCARTA_CACAMPATHWAY    BIOCARTA_HCMVPATHWAY    BIOCARTA_HIFPATHWAY    BIOCARTA_MAPKPATHWAY    BIOCARTA_ARENRF2PATHWAY    BIOCARTA_P38MAPKPATHWAY    BIOCARTA_DREAMPATHWAY    BIOCARTA_ERK5PATHWAY    BIOCARTA_GPCRPATHWAY    BIOCARTA_CREBPATHWAY    BIOCARTA_CARM1PATHWAY   
Pathways : KEGGKEGG_ANTIGEN_PROCESSING_AND_PRESENTATION    KEGG_MELANOGENESIS    KEGG_VASOPRESSIN_REGULATED_WATER_REABSORPTION    KEGG_HUNTINGTONS_DISEASE    KEGG_PROSTATE_CANCER   
NDEx NetworkCREB1
Atlas of Cancer Signalling NetworkCREB1
Wikipedia pathwaysCREB1
Orthology - Evolution
OrthoDB1385
GeneTree (enSembl)ENSG00000118260
Phylogenetic Trees/Animal Genes : TreeFamCREB1
Homologs : HomoloGeneCREB1
Homology/Alignments : Family Browser (UCSC)CREB1
Gene fusions - Rearrangements
Fusion : MitelmanCREB1::FASTKD2 [2q33.3/2q33.3]  
Fusion : MitelmanCREB1::PARD3B [2q33.3/2q33.3]  
Fusion : MitelmanEWSR1::CREB1 [22q12.2/2q33.3]  
Fusion : QuiverCREB1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCREB1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CREB1
dbVarCREB1
ClinVarCREB1
MonarchCREB1
1000_GenomesCREB1 
Exome Variant ServerCREB1
GNOMAD BrowserENSG00000118260
Varsome BrowserCREB1
ACMGCREB1 variants
VarityP16220
Genomic Variants (DGV)CREB1 [DGVbeta]
DECIPHERCREB1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisCREB1 
Mutations
ICGC Data PortalCREB1 
TCGA Data PortalCREB1 
Broad Tumor PortalCREB1
OASIS PortalCREB1 [ Somatic mutations - Copy number]
Cancer Gene: CensusCREB1 
Somatic Mutations in Cancer : COSMICCREB1  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DCREB1
Mutations and Diseases : HGMDCREB1
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaCREB1
DgiDB (Drug Gene Interaction Database)CREB1
DoCM (Curated mutations)CREB1
CIViC (Clinical Interpretations of Variants in Cancer)CREB1
Cancer3DCREB1
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM123810    612160   
Orphanet12894   
DisGeNETCREB1
MedgenCREB1
Genetic Testing Registry CREB1
NextProtP16220 [Medical]
GENETestsCREB1
Target ValidationCREB1
Huge Navigator CREB1 [HugePedia]
ClinGenCREB1
Clinical trials, drugs, therapy
MyCancerGenomeCREB1
Protein Interactions : CTDCREB1
Pharm GKB GenePA26864
PharosP16220
Clinical trialCREB1
Miscellaneous
canSAR (ICR)CREB1
HarmonizomeCREB1
ARCHS4CREB1
DataMed IndexCREB1
Probes
Litterature
PubMed499 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXCREB1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Jan 20 12:28:55 CET 2022

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