Atlas of Genetics and Cytogenetics in Oncology and Haematology


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CREB3 (cAMP responsive element binding protein 3)

Identity

Alias_namescAMP responsive element binding protein 3 (luman)
Alias_symbol (synonym)LZIP
Luman
sLZIP
Other aliasLUMAN
HGNC (Hugo) CREB3
LocusID (NCBI) 10488
Atlas_Id 51721
Location 9p13.3  [Link to chromosome band 9p13]
Location_base_pair Starts at 35732317 and ends at 35737005 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
CREB3 (9p13.3) / SNRPA (19q13.2)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)CREB3   2347
Cards
Entrez_Gene (NCBI)CREB3  10488  cAMP responsive element binding protein 3
AliasesLUMAN; LZIP; sLZIP
GeneCards (Weizmann)CREB3
Ensembl hg19 (Hinxton)ENSG00000107175 [Gene_View]  chr9:35732317-35737005 [Contig_View]  CREB3 [Vega]
Ensembl hg38 (Hinxton)ENSG00000107175 [Gene_View]  chr9:35732317-35737005 [Contig_View]  CREB3 [Vega]
ICGC DataPortalENSG00000107175
TCGA cBioPortalCREB3
AceView (NCBI)CREB3
Genatlas (Paris)CREB3
WikiGenes10488
SOURCE (Princeton)CREB3
Genetics Home Reference (NIH)CREB3
Genomic and cartography
GoldenPath hg19 (UCSC)CREB3  -     chr9:35732317-35737005 +  9p13.3   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)CREB3  -     9p13.3   [Description]    (hg38-Dec_2013)
EnsemblCREB3 - 9p13.3 [CytoView hg19]  CREB3 - 9p13.3 [CytoView hg38]
Mapping of homologs : NCBICREB3 [Mapview hg19]  CREB3 [Mapview hg38]
OMIM606443   
Gene and transcription
Genbank (Entrez)AF009368 AF029674 AF211848 AK299781 AK313635
RefSeq transcript (Entrez)NM_006368
RefSeq genomic (Entrez)NC_000009 NC_018920 NT_008413 NW_004929342
Consensus coding sequences : CCDS (NCBI)CREB3
Cluster EST : UnigeneHs.522110 [ NCBI ]
CGAP (NCI)Hs.522110
Alternative Splicing GalleryENSG00000107175
Gene ExpressionCREB3 [ NCBI-GEO ]   CREB3 [ EBI - ARRAY_EXPRESS ]   CREB3 [ SEEK ]   CREB3 [ MEM ]
Gene Expression Viewer (FireBrowse)CREB3 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)10488
GTEX Portal (Tissue expression)CREB3
Protein : pattern, domain, 3D structure
UniProt/SwissProtO43889   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO43889  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO43889
Splice isoforms : SwissVarO43889
PhosPhoSitePlusO43889
Domaine pattern : Prosite (Expaxy)BZIP (PS50217)    BZIP_BASIC (PS00036)   
Domains : Interpro (EBI)bZIP    Luman   
Domain families : Pfam (Sanger)bZIP_1 (PF00170)   
Domain families : Pfam (NCBI)pfam00170   
Domain families : Smart (EMBL)BRLZ (SM00338)  
Conserved Domain (NCBI)CREB3
DMDM Disease mutations10488
Blocks (Seattle)CREB3
SuperfamilyO43889
Human Protein AtlasENSG00000107175
Peptide AtlasO43889
IPIIPI00014590   IPI00413475   
Protein Interaction databases
DIP (DOE-UCLA)O43889
IntAct (EBI)O43889
FunCoupENSG00000107175
BioGRIDCREB3
STRING (EMBL)CREB3
ZODIACCREB3
Ontologies - Pathways
QuickGOO43889
Ontology : AmiGOGolgi membrane  RNA polymerase II regulatory region sequence-specific DNA binding  RNA polymerase II core promoter proximal region sequence-specific DNA binding  transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding  transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding  regulation of cell growth  positive regulation of defense response to virus by host  DNA binding  chromatin binding  transcription factor activity, sequence-specific DNA binding  protein binding  nucleus  nucleus  cytoplasm  cytoplasm  endoplasmic reticulum  endoplasmic reticulum  endoplasmic reticulum membrane  endoplasmic reticulum membrane  Golgi apparatus  cytosol  transcription, DNA-templated  transcription from RNA polymerase II promoter  chemotaxis  positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response  cAMP response element binding protein binding  membrane  membrane  integral component of membrane  integral component of membrane  viral process  nuclear body  establishment of viral latency  release from viral latency  release from viral latency  integral component of endoplasmic reticulum membrane  positive regulation of cell migration  CCR1 chemokine receptor binding  response to endoplasmic reticulum stress  response to endoplasmic reticulum stress  cAMP response element binding  regulation of cell proliferation  protein homodimerization activity  cytoplasmic sequestering of transcription factor  neuronal cell body  negative regulation of cell cycle  positive regulation of transcription, DNA-templated  positive regulation of transcription from RNA polymerase II promoter  positive regulation of transcription from RNA polymerase II promoter  protein dimerization activity  induction of positive chemotaxis  induction of positive chemotaxis  induction of positive chemotaxis  positive regulation of calcium ion transport  positive regulation of monocyte chemotaxis  positive regulation of deacetylase activity  negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway  negative regulation of ligand-dependent nuclear receptor transcription coactivator activity  negative regulation of ligand-dependent nuclear receptor transcription coactivator activity  
Ontology : EGO-EBIGolgi membrane  RNA polymerase II regulatory region sequence-specific DNA binding  RNA polymerase II core promoter proximal region sequence-specific DNA binding  transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding  transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding  regulation of cell growth  positive regulation of defense response to virus by host  DNA binding  chromatin binding  transcription factor activity, sequence-specific DNA binding  protein binding  nucleus  nucleus  cytoplasm  cytoplasm  endoplasmic reticulum  endoplasmic reticulum  endoplasmic reticulum membrane  endoplasmic reticulum membrane  Golgi apparatus  cytosol  transcription, DNA-templated  transcription from RNA polymerase II promoter  chemotaxis  positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response  cAMP response element binding protein binding  membrane  membrane  integral component of membrane  integral component of membrane  viral process  nuclear body  establishment of viral latency  release from viral latency  release from viral latency  integral component of endoplasmic reticulum membrane  positive regulation of cell migration  CCR1 chemokine receptor binding  response to endoplasmic reticulum stress  response to endoplasmic reticulum stress  cAMP response element binding  regulation of cell proliferation  protein homodimerization activity  cytoplasmic sequestering of transcription factor  neuronal cell body  negative regulation of cell cycle  positive regulation of transcription, DNA-templated  positive regulation of transcription from RNA polymerase II promoter  positive regulation of transcription from RNA polymerase II promoter  protein dimerization activity  induction of positive chemotaxis  induction of positive chemotaxis  induction of positive chemotaxis  positive regulation of calcium ion transport  positive regulation of monocyte chemotaxis  positive regulation of deacetylase activity  negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway  negative regulation of ligand-dependent nuclear receptor transcription coactivator activity  negative regulation of ligand-dependent nuclear receptor transcription coactivator activity  
Pathways : KEGGPI3K-Akt signaling pathway    Adrenergic signaling in cardiomyocytes    TNF signaling pathway    Cholinergic synapse    Dopaminergic synapse    Insulin secretion    Estrogen signaling pathway    Melanogenesis    Thyroid hormone synthesis    Vasopressin-regulated water reabsorption    Huntington's disease    Cocaine addiction    Amphetamine addiction    Alcoholism    Hepatitis B    Viral carcinogenesis    Prostate cancer   
NDEx NetworkCREB3
Atlas of Cancer Signalling NetworkCREB3
Wikipedia pathwaysCREB3
Orthology - Evolution
OrthoDB10488
GeneTree (enSembl)ENSG00000107175
Phylogenetic Trees/Animal Genes : TreeFamCREB3
HOVERGENO43889
HOGENOMO43889
Homologs : HomoloGeneCREB3
Homology/Alignments : Family Browser (UCSC)CREB3
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCREB3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CREB3
dbVarCREB3
ClinVarCREB3
1000_GenomesCREB3 
Exome Variant ServerCREB3
ExAC (Exome Aggregation Consortium)CREB3 (select the gene name)
Genetic variants : HAPMAP10488
Genomic Variants (DGV)CREB3 [DGVbeta]
DECIPHER (Syndromes)9:35732317-35737005  ENSG00000107175
CONAN: Copy Number AnalysisCREB3 
Mutations
ICGC Data PortalCREB3 
TCGA Data PortalCREB3 
Broad Tumor PortalCREB3
OASIS PortalCREB3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCREB3  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDCREB3
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch CREB3
DgiDB (Drug Gene Interaction Database)CREB3
DoCM (Curated mutations)CREB3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CREB3 (select a term)
intoGenCREB3
Cancer3DCREB3(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM606443   
Orphanet
MedgenCREB3
Genetic Testing Registry CREB3
NextProtO43889 [Medical]
TSGene10488
GENETestsCREB3
Huge Navigator CREB3 [HugePedia]
snp3D : Map Gene to Disease10488
BioCentury BCIQCREB3
ClinGenCREB3
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD10488
Chemical/Pharm GKB GenePA26865
Clinical trialCREB3
Miscellaneous
canSAR (ICR)CREB3 (select the gene name)
Probes
Litterature
PubMed50 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineCREB3
EVEXCREB3
GoPubMedCREB3
iHOPCREB3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Mar 14 13:01:41 CET 2017

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