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CREB3L3 (cAMP responsive element binding protein 3 like 3)

Identity

Alias_symbol (synonym)CREB-H
Other aliasCREBH
HYST1481
HGNC (Hugo) CREB3L3
LocusID (NCBI) 84699
Atlas_Id 53956
Location 19p13.3  [Link to chromosome band 19p13]
Location_base_pair Starts at 4153601 and ends at 4173054 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
SHC2 (19p13.3) / CREB3L3 (19p13.3)SHC2 19p13.3 / CREB3L3 19p13.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)CREB3L3   18855
Cards
Entrez_Gene (NCBI)CREB3L3  84699  cAMP responsive element binding protein 3 like 3
AliasesCREB-H; CREBH; HYST1481
GeneCards (Weizmann)CREB3L3
Ensembl hg19 (Hinxton)ENSG00000060566 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000060566 [Gene_View]  chr19:4153601-4173054 [Contig_View]  CREB3L3 [Vega]
ICGC DataPortalENSG00000060566
TCGA cBioPortalCREB3L3
AceView (NCBI)CREB3L3
Genatlas (Paris)CREB3L3
WikiGenes84699
SOURCE (Princeton)CREB3L3
Genetics Home Reference (NIH)CREB3L3
Genomic and cartography
GoldenPath hg38 (UCSC)CREB3L3  -     chr19:4153601-4173054 +  19p13.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)CREB3L3  -     19p13.3   [Description]    (hg19-Feb_2009)
EnsemblCREB3L3 - 19p13.3 [CytoView hg19]  CREB3L3 - 19p13.3 [CytoView hg38]
Mapping of homologs : NCBICREB3L3 [Mapview hg19]  CREB3L3 [Mapview hg38]
OMIM611998   
Gene and transcription
Genbank (Entrez)AB050902 AB073612 AK172839 AK313099 BC101504
RefSeq transcript (Entrez)NM_001271995 NM_001271996 NM_001271997 NM_032607
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)CREB3L3
Cluster EST : UnigeneHs.247744 [ NCBI ]
CGAP (NCI)Hs.247744
Alternative Splicing GalleryENSG00000060566
Gene ExpressionCREB3L3 [ NCBI-GEO ]   CREB3L3 [ EBI - ARRAY_EXPRESS ]   CREB3L3 [ SEEK ]   CREB3L3 [ MEM ]
Gene Expression Viewer (FireBrowse)CREB3L3 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)84699
GTEX Portal (Tissue expression)CREB3L3
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ68CJ9   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ68CJ9  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ68CJ9
Splice isoforms : SwissVarQ68CJ9
PhosPhoSitePlusQ68CJ9
Domaine pattern : Prosite (Expaxy)BZIP (PS50217)    BZIP_BASIC (PS00036)   
Domains : Interpro (EBI)bZIP    CREBH   
Domain families : Pfam (Sanger)bZIP_1 (PF00170)   
Domain families : Pfam (NCBI)pfam00170   
Domain families : Smart (EMBL)BRLZ (SM00338)  
Conserved Domain (NCBI)CREB3L3
DMDM Disease mutations84699
Blocks (Seattle)CREB3L3
SuperfamilyQ68CJ9
Human Protein AtlasENSG00000060566
Peptide AtlasQ68CJ9
HPRD16752
IPIIPI00045957   IPI00847524   IPI00441894   IPI00000632   
Protein Interaction databases
DIP (DOE-UCLA)Q68CJ9
IntAct (EBI)Q68CJ9
FunCoupENSG00000060566
BioGRIDCREB3L3
STRING (EMBL)CREB3L3
ZODIACCREB3L3
Ontologies - Pathways
QuickGOQ68CJ9
Ontology : AmiGOtranscription regulatory region sequence-specific DNA binding  RNA polymerase II regulatory region sequence-specific DNA binding  transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding  transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding  positive regulation of acute inflammatory response  protein binding  nucleus  nucleoplasm  endoplasmic reticulum  endoplasmic reticulum membrane  cytosol  transcription from RNA polymerase II promoter  membrane  integral component of membrane  endoplasmic reticulum unfolded protein response  cAMP response element binding  lipoprotein metabolic process  protein homodimerization activity  positive regulation of transcription from RNA polymerase II promoter  protein heterodimerization activity  positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress  
Ontology : EGO-EBItranscription regulatory region sequence-specific DNA binding  RNA polymerase II regulatory region sequence-specific DNA binding  transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding  transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding  positive regulation of acute inflammatory response  protein binding  nucleus  nucleoplasm  endoplasmic reticulum  endoplasmic reticulum membrane  cytosol  transcription from RNA polymerase II promoter  membrane  integral component of membrane  endoplasmic reticulum unfolded protein response  cAMP response element binding  lipoprotein metabolic process  protein homodimerization activity  positive regulation of transcription from RNA polymerase II promoter  protein heterodimerization activity  positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress  
Pathways : KEGG   
NDEx NetworkCREB3L3
Atlas of Cancer Signalling NetworkCREB3L3
Wikipedia pathwaysCREB3L3
Orthology - Evolution
OrthoDB84699
GeneTree (enSembl)ENSG00000060566
Phylogenetic Trees/Animal Genes : TreeFamCREB3L3
HOVERGENQ68CJ9
HOGENOMQ68CJ9
Homologs : HomoloGeneCREB3L3
Homology/Alignments : Family Browser (UCSC)CREB3L3
Gene fusions - Rearrangements
Fusion : MitelmanSHC2/CREB3L3 [19p13.3/19p13.3]  [t(19;19)(p13;p13)]  
Fusion: TCGASHC2 19p13.3 CREB3L3 19p13.3 LUAD
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCREB3L3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CREB3L3
dbVarCREB3L3
ClinVarCREB3L3
1000_GenomesCREB3L3 
Exome Variant ServerCREB3L3
ExAC (Exome Aggregation Consortium)CREB3L3 (select the gene name)
Genetic variants : HAPMAP84699
Genomic Variants (DGV)CREB3L3 [DGVbeta]
DECIPHERCREB3L3 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisCREB3L3 
Mutations
ICGC Data PortalCREB3L3 
TCGA Data PortalCREB3L3 
Broad Tumor PortalCREB3L3
OASIS PortalCREB3L3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCREB3L3  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDCREB3L3
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch CREB3L3
DgiDB (Drug Gene Interaction Database)CREB3L3
DoCM (Curated mutations)CREB3L3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CREB3L3 (select a term)
intoGenCREB3L3
Cancer3DCREB3L3(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM611998   
Orphanet10944   
MedgenCREB3L3
Genetic Testing Registry CREB3L3
NextProtQ68CJ9 [Medical]
TSGene84699
GENETestsCREB3L3
Target ValidationCREB3L3
Huge Navigator CREB3L3 [HugePedia]
snp3D : Map Gene to Disease84699
BioCentury BCIQCREB3L3
ClinGenCREB3L3
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD84699
Chemical/Pharm GKB GenePA134882161
Clinical trialCREB3L3
Miscellaneous
canSAR (ICR)CREB3L3 (select the gene name)
Probes
Litterature
PubMed22 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineCREB3L3
EVEXCREB3L3
GoPubMedCREB3L3
iHOPCREB3L3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed Jun 7 12:29:33 CEST 2017

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