| Nomenclature |
|---|
| HGNC (Hugo) | CREB3L4 18854 |
| Cards |
|---|
| Entrez_Gene (NCBI) | CREB3L4 148327 cAMP responsive element binding protein 3 like 4 |
| Aliases | AIBZIP; ATCE1; CREB3; CREB4; |
| JAL; hJAL |
| GeneCards (Weizmann) | CREB3L4 |
| Ensembl hg19 (Hinxton) | ENSG00000143578 [Gene_View] |
| Ensembl hg38 (Hinxton) | ENSG00000143578 [Gene_View] ENSG00000143578 [Sequence] chr1:153967839-153974364 [Contig_View] CREB3L4 [Vega] |
| ICGC DataPortal | ENSG00000143578 |
| TCGA cBioPortal | CREB3L4 |
| AceView (NCBI) | CREB3L4 |
| Genatlas (Paris) | CREB3L4 |
| WikiGenes | 148327 |
| SOURCE (Princeton) | CREB3L4 |
| Genetics Home Reference (NIH) | CREB3L4 |
| Genomic and cartography |
|---|
| GoldenPath hg38 (UCSC) | CREB3L4 - chr1:153967839-153974364 + 1q21.3 [Description] (hg38-Dec_2013) |
| GoldenPath hg19 (UCSC) | CREB3L4 - 1q21.3 [Description] (hg19-Feb_2009) |
| Ensembl | CREB3L4 - 1q21.3 [CytoView hg19] CREB3L4 - 1q21.3 [CytoView hg38] |
| Mapping of homologs : NCBI | CREB3L4 [Mapview hg19] CREB3L4 [Mapview hg38] |
| OMIM | 607138 |
| Gene and transcription |
|---|
| Genbank (Entrez) | AA652478 AB052778 AF394167 AF468007 AK297703 |
| RefSeq transcript (Entrez) | NM_001255978 NM_001255979 NM_001255980 NM_001255981 NM_130898 |
| RefSeq genomic (Entrez) | |
| Consensus coding sequences : CCDS (NCBI) | CREB3L4 |
| Cluster EST : Unigene | Hs.745148 [ NCBI ] |
| CGAP (NCI) | Hs.745148 |
| Alternative Splicing Gallery | ENSG00000143578 |
| Gene Expression | CREB3L4 [ NCBI-GEO ] CREB3L4 [ EBI - ARRAY_EXPRESS ]
CREB3L4 [ SEEK ] CREB3L4 [ MEM ] |
| Gene Expression Viewer (FireBrowse) | CREB3L4 [ Firebrowse - Broad ] |
| SOURCE (Princeton) | Expression in : [Datasets] [Normal Tissue Atlas] [carcinoma Classsification] [NCI60] |
| Genevestigator | Expression in : [tissues] [cell-lines] [cancer] [perturbations] |
| BioGPS (Tissue expression) | 148327 |
| GTEX Portal (Tissue expression) | CREB3L4 |
| Human Protein Atlas | ENSG00000143578-CREB3L4 [pathology] [cell] [tissue] |
| Protein : pattern, domain, 3D structure |
|---|
| UniProt/SwissProt | Q8TEY5 [function] [subcellular_location] [family_and_domains] [pathology_and_biotech] [ptm_processing] [expression] [interaction] |
| NextProt | Q8TEY5 [Sequence] [Exons] [Medical] [Publications] |
| With graphics : InterPro | Q8TEY5 |
| Splice isoforms : SwissVar | Q8TEY5 |
| PhosPhoSitePlus | Q8TEY5 |
| Domaine pattern : Prosite (Expaxy) | BZIP (PS50217) |
| Domains : Interpro (EBI) | bZIP CREB4 |
| Domain families : Pfam (Sanger) | bZIP_1 (PF00170) |
| Domain families : Pfam (NCBI) | pfam00170 |
| Domain families : Smart (EMBL) | BRLZ (SM00338) |
| Conserved Domain (NCBI) | CREB3L4 |
| DMDM Disease mutations | 148327 |
| Blocks (Seattle) | CREB3L4 |
| Superfamily | Q8TEY5 |
| Human Protein Atlas [tissue] | ENSG00000143578-CREB3L4 [tissue] |
| Peptide Atlas | Q8TEY5 |
| HPRD | 06323 |
| IPI | IPI00152889 IPI00514670 IPI00644441 IPI00645041 IPI00647386 |
| Protein Interaction databases |
|---|
| DIP (DOE-UCLA) | Q8TEY5 |
| IntAct (EBI) | Q8TEY5 |
| FunCoup | ENSG00000143578 |
| BioGRID | CREB3L4 |
| STRING (EMBL) | CREB3L4 |
| ZODIAC | CREB3L4 |
| Ontologies - Pathways |
|---|
| QuickGO | Q8TEY5 |
| Ontology : AmiGO | Golgi membrane DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription activator activity, RNA polymerase II-specific nucleoplasm mitochondrion endoplasmic reticulum endoplasmic reticulum membrane Golgi apparatus spermatogenesis integral component of membrane endoplasmic reticulum unfolded protein response nuclear membrane cAMP response element binding positive regulation of transcription by RNA polymerase II |
| Ontology : EGO-EBI | Golgi membrane DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription activator activity, RNA polymerase II-specific nucleoplasm mitochondrion endoplasmic reticulum endoplasmic reticulum membrane Golgi apparatus spermatogenesis integral component of membrane endoplasmic reticulum unfolded protein response nuclear membrane cAMP response element binding positive regulation of transcription by RNA polymerase II |
| Pathways : KEGG | PI3K-Akt signaling pathway Adrenergic signaling in cardiomyocytes TNF signaling pathway Cholinergic synapse Dopaminergic synapse Insulin secretion Estrogen signaling pathway Melanogenesis Thyroid hormone synthesis Vasopressin-regulated water reabsorption Huntington's disease Cocaine addiction Amphetamine addiction Alcoholism Hepatitis B Viral carcinogenesis Prostate cancer |
| NDEx Network | CREB3L4 |
| Atlas of Cancer Signalling Network | CREB3L4 |
| Wikipedia pathways | CREB3L4 |
| Orthology - Evolution |
|---|
| OrthoDB | 148327 |
| GeneTree (enSembl) | ENSG00000143578 |
| Phylogenetic Trees/Animal Genes : TreeFam | CREB3L4 |
| HOVERGEN | Q8TEY5 |
| HOGENOM | Q8TEY5 |
| Homologs : HomoloGene | CREB3L4 |
| Homology/Alignments : Family Browser (UCSC) | CREB3L4 |
| Gene fusions - Rearrangements |
|---|
| Fusion : Mitelman | CRTC2/CREB3L4 [1q21.3/1q21.3] [t(1;1)(q21;q21)] |
| Fusion : Mitelman | HIVEP3/CREB3L4 [1p34.2/1q21.3] [t(1;1)(p34;q21)] |
| Fusion : Mitelman | KDM4A/CREB3L4 [1p34.1/1q21.3] [t(1;1)(p34;q21)] |
| Fusion Portal | HIVEP3 1p34.2 CREB3L4 1q21.3 BRCA |
| Fusion Portal | KDM4A 1p34.1 CREB3L4 1q21.3 BRCA |
| Fusion : Quiver | CREB3L4 |
| Polymorphisms : SNP and Copy number variants |
|---|
| NCBI Variation Viewer | CREB3L4 [hg38] |
| dbSNP Single Nucleotide Polymorphism (NCBI) | CREB3L4 |
| dbVar | CREB3L4 |
| ClinVar | CREB3L4 |
| 1000_Genomes | CREB3L4 |
| Exome Variant Server | CREB3L4 |
| ExAC (Exome Aggregation Consortium) | ENSG00000143578 |
| GNOMAD Browser | ENSG00000143578 |
| Varsome Browser | CREB3L4 |
| Genetic variants : HAPMAP | 148327 |
| Genomic Variants (DGV) | CREB3L4 [DGVbeta] |
| DECIPHER | CREB3L4 [patients] [syndromes] [variants] [genes] |
| CONAN: Copy Number Analysis | CREB3L4 |
| Mutations |
|---|
| ICGC Data Portal | CREB3L4 |
| TCGA Data Portal | CREB3L4 |
| Broad Tumor Portal | CREB3L4 |
| OASIS Portal | CREB3L4 [ Somatic mutations - Copy number] |
| Somatic Mutations in Cancer : COSMIC | CREB3L4 [overview] [genome browser] [tissue] [distribution] |
| Mutations and Diseases : HGMD | CREB3L4 |
| LOVD (Leiden Open Variation Database) | Whole genome datasets |
| LOVD (Leiden Open Variation Database) | LOVD - Leiden Open Variation Database |
| LOVD (Leiden Open Variation Database) | LOVD 3.0 shared installation |
| BioMuta | search CREB3L4 |
| DgiDB (Drug Gene Interaction Database) | CREB3L4 |
| DoCM (Curated mutations) | CREB3L4 (select the gene name) |
| CIViC (Clinical Interpretations of Variants in Cancer) | CREB3L4 (select a term) |
| intoGen | CREB3L4 |
| Cancer3D | CREB3L4(select the gene name) |
| Impact of mutations | [PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser] |
| Diseases |
|---|
| OMIM | 607138 |
| Orphanet | |
| DisGeNET | CREB3L4 |
| Medgen | CREB3L4 |
| Genetic Testing Registry | CREB3L4
|
| NextProt | Q8TEY5 [Medical] |
| TSGene | 148327 |
| GENETests | CREB3L4 |
| Target Validation | CREB3L4 |
| Huge Navigator |
CREB3L4 [HugePedia] |
| snp3D : Map Gene to Disease | 148327 |
| BioCentury BCIQ | CREB3L4 |
| ClinGen | CREB3L4 |
| Clinical trials, drugs, therapy |
|---|
| Chemical/Protein Interactions : CTD | 148327 |
| Chemical/Pharm GKB Gene | PA134922919 |
| Clinical trial | CREB3L4 |
| Miscellaneous |
|---|
| canSAR (ICR) | CREB3L4 (select the gene name) |
| Probes |
|---|
| Litterature |
|---|
| PubMed | 17 Pubmed reference(s) in Entrez |
| GeneRIFs | Gene References Into Functions (Entrez) |
| CoreMine | CREB3L4 |
| EVEX | CREB3L4 |
| GoPubMed | CREB3L4 |
| iHOP | CREB3L4 |
