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CREB3L4 (cAMP responsive element binding protein 3 like 4)

Identity

Alias_symbol (synonym)AIbZIP
CREB4
CREB3
hJAL
ATCE1
Other aliasAIBZIP
JAL
HGNC (Hugo) CREB3L4
LocusID (NCBI) 148327
Atlas_Id 43950
Location 1q21.3  [Link to chromosome band 1q21]
Location_base_pair Starts at 153967839 and ends at 153974364 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CREB3L4 (1q21.3) / CREB3L4 (1q21.3)CRTC2 (1q21.3) / CREB3L4 (1q21.3)HIVEP3 (1p34.2) / CREB3L4 (1q21.3)
HYPK (15q15.3) / CREB3L4 (1q21.3)KDM4A (1p34.1) / CREB3L4 (1q21.3)HIVEP3 1p34.2 / CREB3L4 1q21.3
KDM4A 1p34.1 / CREB3L4 1q21.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(1;1)(q21;q21) CRTC2/CREB3L4

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 2 ]
  t(1;1)(p34;q21) HIVEP3/CREB3L4
t(1;1)(p34;q21) KDM4A/CREB3L4

External links

Nomenclature
HGNC (Hugo)CREB3L4   18854
Cards
Entrez_Gene (NCBI)CREB3L4  148327  cAMP responsive element binding protein 3 like 4
AliasesAIBZIP; ATCE1; CREB3; CREB4; 
JAL; hJAL
GeneCards (Weizmann)CREB3L4
Ensembl hg19 (Hinxton)ENSG00000143578 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000143578 [Gene_View]  ENSG00000143578 [Sequence]  chr1:153967839-153974364 [Contig_View]  CREB3L4 [Vega]
ICGC DataPortalENSG00000143578
TCGA cBioPortalCREB3L4
AceView (NCBI)CREB3L4
Genatlas (Paris)CREB3L4
WikiGenes148327
SOURCE (Princeton)CREB3L4
Genetics Home Reference (NIH)CREB3L4
Genomic and cartography
GoldenPath hg38 (UCSC)CREB3L4  -     chr1:153967839-153974364 +  1q21.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)CREB3L4  -     1q21.3   [Description]    (hg19-Feb_2009)
EnsemblCREB3L4 - 1q21.3 [CytoView hg19]  CREB3L4 - 1q21.3 [CytoView hg38]
Mapping of homologs : NCBICREB3L4 [Mapview hg19]  CREB3L4 [Mapview hg38]
OMIM607138   
Gene and transcription
Genbank (Entrez)AA652478 AB052778 AF394167 AF468007 AK297703
RefSeq transcript (Entrez)NM_001255978 NM_001255979 NM_001255980 NM_001255981 NM_130898
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)CREB3L4
Cluster EST : UnigeneHs.745148 [ NCBI ]
CGAP (NCI)Hs.745148
Alternative Splicing GalleryENSG00000143578
Gene ExpressionCREB3L4 [ NCBI-GEO ]   CREB3L4 [ EBI - ARRAY_EXPRESS ]   CREB3L4 [ SEEK ]   CREB3L4 [ MEM ]
Gene Expression Viewer (FireBrowse)CREB3L4 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)148327
GTEX Portal (Tissue expression)CREB3L4
Human Protein AtlasENSG00000143578-CREB3L4 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ8TEY5   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ8TEY5  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ8TEY5
Splice isoforms : SwissVarQ8TEY5
PhosPhoSitePlusQ8TEY5
Domaine pattern : Prosite (Expaxy)BZIP (PS50217)   
Domains : Interpro (EBI)bZIP    CREB4   
Domain families : Pfam (Sanger)bZIP_1 (PF00170)   
Domain families : Pfam (NCBI)pfam00170   
Domain families : Smart (EMBL)BRLZ (SM00338)  
Conserved Domain (NCBI)CREB3L4
DMDM Disease mutations148327
Blocks (Seattle)CREB3L4
SuperfamilyQ8TEY5
Human Protein Atlas [tissue]ENSG00000143578-CREB3L4 [tissue]
Peptide AtlasQ8TEY5
HPRD06323
IPIIPI00152889   IPI00514670   IPI00644441   IPI00645041   IPI00647386   
Protein Interaction databases
DIP (DOE-UCLA)Q8TEY5
IntAct (EBI)Q8TEY5
FunCoupENSG00000143578
BioGRIDCREB3L4
STRING (EMBL)CREB3L4
ZODIACCREB3L4
Ontologies - Pathways
QuickGOQ8TEY5
Ontology : AmiGOGolgi membrane  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription activator activity, RNA polymerase II-specific  nucleoplasm  mitochondrion  endoplasmic reticulum  endoplasmic reticulum membrane  Golgi apparatus  spermatogenesis  integral component of membrane  endoplasmic reticulum unfolded protein response  nuclear membrane  cAMP response element binding  positive regulation of transcription by RNA polymerase II  
Ontology : EGO-EBIGolgi membrane  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription activator activity, RNA polymerase II-specific  nucleoplasm  mitochondrion  endoplasmic reticulum  endoplasmic reticulum membrane  Golgi apparatus  spermatogenesis  integral component of membrane  endoplasmic reticulum unfolded protein response  nuclear membrane  cAMP response element binding  positive regulation of transcription by RNA polymerase II  
Pathways : KEGGPI3K-Akt signaling pathway    Adrenergic signaling in cardiomyocytes    TNF signaling pathway    Cholinergic synapse    Dopaminergic synapse    Insulin secretion    Estrogen signaling pathway    Melanogenesis    Thyroid hormone synthesis    Vasopressin-regulated water reabsorption    Huntington's disease    Cocaine addiction    Amphetamine addiction    Alcoholism    Hepatitis B    Viral carcinogenesis    Prostate cancer   
NDEx NetworkCREB3L4
Atlas of Cancer Signalling NetworkCREB3L4
Wikipedia pathwaysCREB3L4
Orthology - Evolution
OrthoDB148327
GeneTree (enSembl)ENSG00000143578
Phylogenetic Trees/Animal Genes : TreeFamCREB3L4
HOGENOMQ8TEY5
Homologs : HomoloGeneCREB3L4
Homology/Alignments : Family Browser (UCSC)CREB3L4
Gene fusions - Rearrangements
Fusion : MitelmanCRTC2/CREB3L4 [1q21.3/1q21.3]  [t(1;1)(q21;q21)]  
Fusion : MitelmanHIVEP3/CREB3L4 [1p34.2/1q21.3]  [t(1;1)(p34;q21)]  
Fusion : MitelmanKDM4A/CREB3L4 [1p34.1/1q21.3]  [t(1;1)(p34;q21)]  
Fusion PortalHIVEP3 1p34.2 CREB3L4 1q21.3 BRCA
Fusion PortalKDM4A 1p34.1 CREB3L4 1q21.3 BRCA
Fusion : QuiverCREB3L4
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCREB3L4 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CREB3L4
dbVarCREB3L4
ClinVarCREB3L4
1000_GenomesCREB3L4 
Exome Variant ServerCREB3L4
ExAC (Exome Aggregation Consortium)ENSG00000143578
GNOMAD BrowserENSG00000143578
Varsome BrowserCREB3L4
Genetic variants : HAPMAP148327
Genomic Variants (DGV)CREB3L4 [DGVbeta]
DECIPHERCREB3L4 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisCREB3L4 
Mutations
ICGC Data PortalCREB3L4 
TCGA Data PortalCREB3L4 
Broad Tumor PortalCREB3L4
OASIS PortalCREB3L4 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCREB3L4  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDCREB3L4
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch CREB3L4
DgiDB (Drug Gene Interaction Database)CREB3L4
DoCM (Curated mutations)CREB3L4 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CREB3L4 (select a term)
intoGenCREB3L4
Cancer3DCREB3L4(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM607138   
Orphanet
DisGeNETCREB3L4
MedgenCREB3L4
Genetic Testing Registry CREB3L4
NextProtQ8TEY5 [Medical]
TSGene148327
GENETestsCREB3L4
Target ValidationCREB3L4
Huge Navigator CREB3L4 [HugePedia]
snp3D : Map Gene to Disease148327
BioCentury BCIQCREB3L4
ClinGenCREB3L4
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD148327
Chemical/Pharm GKB GenePA134922919
Clinical trialCREB3L4
Miscellaneous
canSAR (ICR)CREB3L4 (select the gene name)
DataMed IndexCREB3L4
Probes
Litterature
PubMed18 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineCREB3L4
EVEXCREB3L4
GoPubMedCREB3L4
iHOPCREB3L4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Feb 14 16:25:06 CET 2019
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