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CREBL2 (cAMP responsive element binding protein like 2)

Identity

Alias_namescAMP responsive element binding protein-like 2
Other alias-
HGNC (Hugo) CREBL2
LocusID (NCBI) 1389
Atlas_Id 40145
Location 12p13.1  [Link to chromosome band 12p13]
Location_base_pair Starts at 12611833 and ends at 12645108 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
APOLD1 (12p13.1) / CREBL2 (12p13.2)CREBL2 (12p13.2) / CPNE1 (20q11.22)CREBL2 (12p13.2) / CREBL2 (12p13.2)
CREBL2 (12p13.2) / FAM234B (12p13.1)HEBP1 (12p13.1) / CREBL2 (12p13.2)PLBD1 (12p13.1) / CREBL2 (12p13.2)
HEBP1 12p13.1 / CREBL2 12p13.2PLBD1 12p13.1 / CREBL2 12p13.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)CREBL2   2350
Cards
Entrez_Gene (NCBI)CREBL2  1389  cAMP responsive element binding protein like 2
Aliases
GeneCards (Weizmann)CREBL2
Ensembl hg19 (Hinxton)ENSG00000111269 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000111269 [Gene_View]  chr12:12611833-12645108 [Contig_View]  CREBL2 [Vega]
ICGC DataPortalENSG00000111269
TCGA cBioPortalCREBL2
AceView (NCBI)CREBL2
Genatlas (Paris)CREBL2
WikiGenes1389
SOURCE (Princeton)CREBL2
Genetics Home Reference (NIH)CREBL2
Genomic and cartography
GoldenPath hg38 (UCSC)CREBL2  -     chr12:12611833-12645108 +  12p13.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)CREBL2  -     12p13.1   [Description]    (hg19-Feb_2009)
EnsemblCREBL2 - 12p13.1 [CytoView hg19]  CREBL2 - 12p13.1 [CytoView hg38]
Mapping of homologs : NCBICREBL2 [Mapview hg19]  CREBL2 [Mapview hg38]
OMIM603476   
Gene and transcription
Genbank (Entrez)AB451461 AF039081 AI375846 AK002189 AK307202
RefSeq transcript (Entrez)NM_001310
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)CREBL2
Cluster EST : UnigeneHs.591156 [ NCBI ]
CGAP (NCI)Hs.591156
Alternative Splicing GalleryENSG00000111269
Gene ExpressionCREBL2 [ NCBI-GEO ]   CREBL2 [ EBI - ARRAY_EXPRESS ]   CREBL2 [ SEEK ]   CREBL2 [ MEM ]
Gene Expression Viewer (FireBrowse)CREBL2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)1389
GTEX Portal (Tissue expression)CREBL2
Protein : pattern, domain, 3D structure
UniProt/SwissProtO60519   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO60519  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO60519
Splice isoforms : SwissVarO60519
PhosPhoSitePlusO60519
Domains : Interpro (EBI)bZIP   
Domain families : Pfam (Sanger)bZIP_2 (PF07716)   
Domain families : Pfam (NCBI)pfam07716   
Conserved Domain (NCBI)CREBL2
DMDM Disease mutations1389
Blocks (Seattle)CREBL2
SuperfamilyO60519
Human Protein AtlasENSG00000111269
Peptide AtlasO60519
HPRD07541
IPIIPI00015183   IPI00719521   
Protein Interaction databases
DIP (DOE-UCLA)O60519
IntAct (EBI)O60519
FunCoupENSG00000111269
BioGRIDCREBL2
STRING (EMBL)CREBL2
ZODIACCREBL2
Ontologies - Pathways
QuickGOO60519
Ontology : AmiGOtranscription factor activity, sequence-specific DNA binding  nucleus  transcription, DNA-templated  cell cycle  signal transduction  cell differentiation  positive regulation of peptidyl-serine phosphorylation  sequence-specific DNA binding  positive regulation of fat cell differentiation  positive regulation of transcription, DNA-templated  positive regulation of glucose import  positive regulation of lipid biosynthetic process  protein stabilization  
Ontology : EGO-EBItranscription factor activity, sequence-specific DNA binding  nucleus  transcription, DNA-templated  cell cycle  signal transduction  cell differentiation  positive regulation of peptidyl-serine phosphorylation  sequence-specific DNA binding  positive regulation of fat cell differentiation  positive regulation of transcription, DNA-templated  positive regulation of glucose import  positive regulation of lipid biosynthetic process  protein stabilization  
NDEx NetworkCREBL2
Atlas of Cancer Signalling NetworkCREBL2
Wikipedia pathwaysCREBL2
Orthology - Evolution
OrthoDB1389
GeneTree (enSembl)ENSG00000111269
Phylogenetic Trees/Animal Genes : TreeFamCREBL2
HOVERGENO60519
HOGENOMO60519
Homologs : HomoloGeneCREBL2
Homology/Alignments : Family Browser (UCSC)CREBL2
Gene fusions - Rearrangements
Fusion : MitelmanHEBP1/CREBL2 [12p13.1/12p13.2]  [t(12;12)(p13;p13)]  
Fusion : MitelmanPLBD1/CREBL2 [12p13.1/12p13.2]  [t(12;12)(p13;p13)]  
Fusion: TCGAHEBP1 12p13.1 CREBL2 12p13.2 LUAD
Fusion: TCGAPLBD1 12p13.1 CREBL2 12p13.2 BLCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCREBL2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CREBL2
dbVarCREBL2
ClinVarCREBL2
1000_GenomesCREBL2 
Exome Variant ServerCREBL2
ExAC (Exome Aggregation Consortium)CREBL2 (select the gene name)
Genetic variants : HAPMAP1389
Genomic Variants (DGV)CREBL2 [DGVbeta]
DECIPHERCREBL2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisCREBL2 
Mutations
ICGC Data PortalCREBL2 
TCGA Data PortalCREBL2 
Broad Tumor PortalCREBL2
OASIS PortalCREBL2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCREBL2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDCREBL2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch CREBL2
DgiDB (Drug Gene Interaction Database)CREBL2
DoCM (Curated mutations)CREBL2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CREBL2 (select a term)
intoGenCREBL2
Cancer3DCREBL2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM603476   
Orphanet
MedgenCREBL2
Genetic Testing Registry CREBL2
NextProtO60519 [Medical]
TSGene1389
GENETestsCREBL2
Target ValidationCREBL2
Huge Navigator CREBL2 [HugePedia]
snp3D : Map Gene to Disease1389
BioCentury BCIQCREBL2
ClinGenCREBL2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD1389
Chemical/Pharm GKB GenePA26868
Clinical trialCREBL2
Miscellaneous
canSAR (ICR)CREBL2 (select the gene name)
Probes
Litterature
PubMed10 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineCREBL2
EVEXCREBL2
GoPubMedCREBL2
iHOPCREBL2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed Jun 7 12:29:34 CEST 2017

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