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CREM (cAMP responsive element modulator)

Identity

Alias_symbol (synonym)hCREM-2
Other aliasCREM-2
ICER
HGNC (Hugo) CREM
LocusID (NCBI) 1390
Atlas_Id 51595
Location 10p11.21  [Link to chromosome band 10p11]
Location_base_pair Starts at 35127457 and ends at 35212958 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ANXA2 (15q22.2) / CREM (10p11.21)CCNY (10p11.21) / CREM (10p11.21)CREM (10p11.21) / SEC61G (7p11.2)
EWSR1 (22q12.2) / CREM (10p11.21)PTMA (2q37.1) / CREM (10p11.21)VRK2 (2p16.1) / CREM (10p11.21)
CCNY 10p11.21 / CREM 10p11.21

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 4 ]
  t(10;10)(p11;p11) CCNY/CREM
t(10;22)(p11;q12) EWSR1/CREM
t(10;22)(p11;q12) EWSR1/CREM
t(10;22)(p11;q12) EWSR1/CREM


External links

Nomenclature
HGNC (Hugo)CREM   2352
Cards
Entrez_Gene (NCBI)CREM  1390  cAMP responsive element modulator
AliasesCREM-2; ICER; hCREM-2
GeneCards (Weizmann)CREM
Ensembl hg19 (Hinxton)ENSG00000095794 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000095794 [Gene_View]  ENSG00000095794 [Sequence]  chr10:35127457-35212958 [Contig_View]  CREM [Vega]
ICGC DataPortalENSG00000095794
TCGA cBioPortalCREM
AceView (NCBI)CREM
Genatlas (Paris)CREM
WikiGenes1390
SOURCE (Princeton)CREM
Genetics Home Reference (NIH)CREM
Genomic and cartography
GoldenPath hg38 (UCSC)CREM  -     chr10:35127457-35212958 +  10p11.21   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)CREM  -     10p11.21   [Description]    (hg19-Feb_2009)
EnsemblCREM - 10p11.21 [CytoView hg19]  CREM - 10p11.21 [CytoView hg38]
Mapping of homologs : NCBICREM [Mapview hg19]  CREM [Mapview hg38]
OMIM123812   
Gene and transcription
Genbank (Entrez)AA453346 AB209533 AF069065 AF417233 AF417234
RefSeq transcript (Entrez)NM_001267562 NM_001267563 NM_001267564 NM_001267565 NM_001267566 NM_001267567 NM_001267568 NM_001267569 NM_001267570 NM_001352445 NM_001352446 NM_001352465 NM_001352466 NM_001352467 NM_001881 NM_181571 NM_182717 NM_182718 NM_182719 NM_182720 NM_182721 NM_182722 NM_182723 NM_182724 NM_182725 NM_182769 NM_182770 NM_182771 NM_182772 NM_182850 NM_182853 NM_183011 NM_183012 NM_183013 NM_183060
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)CREM
Cluster EST : UnigeneHs.200250 [ NCBI ]
CGAP (NCI)Hs.200250
Alternative Splicing GalleryENSG00000095794
Gene ExpressionCREM [ NCBI-GEO ]   CREM [ EBI - ARRAY_EXPRESS ]   CREM [ SEEK ]   CREM [ MEM ]
Gene Expression Viewer (FireBrowse)CREM [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)1390
GTEX Portal (Tissue expression)CREM
Human Protein AtlasENSG00000095794-CREM [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ03060   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ03060  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ03060
Splice isoforms : SwissVarQ03060
PhosPhoSitePlusQ03060
Domaine pattern : Prosite (Expaxy)BZIP (PS50217)    BZIP_BASIC (PS00036)    KID (PS50953)   
Domains : Interpro (EBI)bZIP    Coactivator_CBP_pKID    Leuzip_CREB   
Domain families : Pfam (Sanger)bZIP_1 (PF00170)    pKID (PF02173)   
Domain families : Pfam (NCBI)pfam00170    pfam02173   
Domain families : Smart (EMBL)BRLZ (SM00338)  
Conserved Domain (NCBI)CREM
DMDM Disease mutations1390
Blocks (Seattle)CREM
SuperfamilyQ03060
Human Protein Atlas [tissue]ENSG00000095794-CREM [tissue]
Peptide AtlasQ03060
HPRD00444
IPI###############################################################################################################################################################################################################################################################   
Protein Interaction databases
DIP (DOE-UCLA)Q03060
IntAct (EBI)Q03060
FunCoupENSG00000095794
BioGRIDCREM
STRING (EMBL)CREM
ZODIACCREM
Ontologies - Pathways
QuickGOQ03060
Ontology : AmiGOnegative regulation of transcription by RNA polymerase II  RNA polymerase II regulatory region sequence-specific DNA binding  transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding  DNA binding  protein binding  nucleus  transcription factor complex  cytoplasm  glucose metabolic process  transcription, DNA-templated  regulation of transcription, DNA-templated  regulation of transcription, DNA-templated  fatty acid metabolic process  glycosphingolipid metabolic process  signal transduction  multicellular organism development  spermatogenesis  cAMP response element binding protein binding  cell differentiation  regulation of circadian rhythm  positive regulation of transcription by RNA polymerase II  retinoic acid receptor signaling pathway  rhythmic process  
Ontology : EGO-EBInegative regulation of transcription by RNA polymerase II  RNA polymerase II regulatory region sequence-specific DNA binding  transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding  DNA binding  protein binding  nucleus  transcription factor complex  cytoplasm  glucose metabolic process  transcription, DNA-templated  regulation of transcription, DNA-templated  regulation of transcription, DNA-templated  fatty acid metabolic process  glycosphingolipid metabolic process  signal transduction  multicellular organism development  spermatogenesis  cAMP response element binding protein binding  cell differentiation  regulation of circadian rhythm  positive regulation of transcription by RNA polymerase II  retinoic acid receptor signaling pathway  rhythmic process  
Pathways : BIOCARTARepression of Pain Sensation by the Transcriptional Regulator DREAM [Genes]    Regulation of Spermatogenesis by CREM [Genes]   
NDEx NetworkCREM
Atlas of Cancer Signalling NetworkCREM
Wikipedia pathwaysCREM
Orthology - Evolution
OrthoDB1390
GeneTree (enSembl)ENSG00000095794
Phylogenetic Trees/Animal Genes : TreeFamCREM
HOVERGENQ03060
HOGENOMQ03060
Homologs : HomoloGeneCREM
Homology/Alignments : Family Browser (UCSC)CREM
Gene fusions - Rearrangements
Fusion : MitelmanCCNY/CREM [10p11.21/10p11.21]  [t(10;10)(p11;p11)]  
Fusion PortalCCNY 10p11.21 CREM 10p11.21 LUSC
Fusion : QuiverCREM
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCREM [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CREM
dbVarCREM
ClinVarCREM
1000_GenomesCREM 
Exome Variant ServerCREM
ExAC (Exome Aggregation Consortium)ENSG00000095794
GNOMAD BrowserENSG00000095794
Genetic variants : HAPMAP1390
Genomic Variants (DGV)CREM [DGVbeta]
DECIPHERCREM [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisCREM 
Mutations
ICGC Data PortalCREM 
TCGA Data PortalCREM 
Broad Tumor PortalCREM
OASIS PortalCREM [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCREM  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDCREM
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch CREM
DgiDB (Drug Gene Interaction Database)CREM
DoCM (Curated mutations)CREM (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CREM (select a term)
intoGenCREM
Cancer3DCREM(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM123812   
Orphanet
DisGeNETCREM
MedgenCREM
Genetic Testing Registry CREM
NextProtQ03060 [Medical]
TSGene1390
GENETestsCREM
Target ValidationCREM
Huge Navigator CREM [HugePedia]
snp3D : Map Gene to Disease1390
BioCentury BCIQCREM
ClinGenCREM
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD1390
Chemical/Pharm GKB GenePA26871
Clinical trialCREM
Miscellaneous
canSAR (ICR)CREM (select the gene name)
Probes
Litterature
PubMed119 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineCREM
EVEXCREM
GoPubMedCREM
iHOPCREM
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Fri Jun 22 16:20:53 CEST 2018

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