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CREM (cAMP responsive element modulator)

Identity

Alias_symbol (synonym)hCREM-2
Other aliasCREM-2
ICER
HGNC (Hugo) CREM
LocusID (NCBI) 1390
Atlas_Id 51595
Location 10p11.21  [Link to chromosome band 10p11]
Location_base_pair Starts at 35126841 and ends at 35212958 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
ANXA2 (15q22.2) / CREM (10p11.21)CCNY (10p11.21) / CREM (10p11.21)CREM (10p11.21) / SEC61G (7p11.2)
EWSR1 (22q12.2) / CREM (10p11.21)PTMA (2q37.1) / CREM (10p11.21)VRK2 (2p16.1) / CREM (10p11.21)
CCNY 10p11.21 / CREM 10p11.21

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)CREM   2352
Cards
Entrez_Gene (NCBI)CREM  1390  cAMP responsive element modulator
AliasesCREM-2; ICER; hCREM-2
GeneCards (Weizmann)CREM
Ensembl hg19 (Hinxton)ENSG00000095794 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000095794 [Gene_View]  chr10:35126841-35212958 [Contig_View]  CREM [Vega]
ICGC DataPortalENSG00000095794
TCGA cBioPortalCREM
AceView (NCBI)CREM
Genatlas (Paris)CREM
WikiGenes1390
SOURCE (Princeton)CREM
Genetics Home Reference (NIH)CREM
Genomic and cartography
GoldenPath hg38 (UCSC)CREM  -     chr10:35126841-35212958 +  10p11.21   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)CREM  -     10p11.21   [Description]    (hg19-Feb_2009)
EnsemblCREM - 10p11.21 [CytoView hg19]  CREM - 10p11.21 [CytoView hg38]
Mapping of homologs : NCBICREM [Mapview hg19]  CREM [Mapview hg38]
OMIM123812   
Gene and transcription
Genbank (Entrez)###############################################################################################################################################################################################################################################################
RefSeq transcript (Entrez)
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)CREM
Cluster EST : UnigeneHs.200250 [ NCBI ]
CGAP (NCI)Hs.200250
Alternative Splicing GalleryENSG00000095794
Gene ExpressionCREM [ NCBI-GEO ]   CREM [ EBI - ARRAY_EXPRESS ]   CREM [ SEEK ]   CREM [ MEM ]
Gene Expression Viewer (FireBrowse)CREM [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)1390
GTEX Portal (Tissue expression)CREM
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ03060   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ03060  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ03060
Splice isoforms : SwissVarQ03060
PhosPhoSitePlusQ03060
Domaine pattern : Prosite (Expaxy)BZIP (PS50217)    BZIP_BASIC (PS00036)    KID (PS50953)   
Domains : Interpro (EBI)bZIP    Coactivator_CBP_pKID    Leuzip_CREB   
Domain families : Pfam (Sanger)bZIP_1 (PF00170)    pKID (PF02173)   
Domain families : Pfam (NCBI)pfam00170    pfam02173   
Domain families : Smart (EMBL)BRLZ (SM00338)  
Conserved Domain (NCBI)CREM
DMDM Disease mutations1390
Blocks (Seattle)CREM
SuperfamilyQ03060
Human Protein AtlasENSG00000095794
Peptide AtlasQ03060
HPRD00444
IPI###############################################################################################################################################################################################################################################################   
Protein Interaction databases
DIP (DOE-UCLA)Q03060
IntAct (EBI)Q03060
FunCoupENSG00000095794
BioGRIDCREM
STRING (EMBL)CREM
ZODIACCREM
Ontologies - Pathways
QuickGOQ03060
Ontology : AmiGOnegative regulation of transcription from RNA polymerase II promoter  RNA polymerase II regulatory region sequence-specific DNA binding  transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding  DNA binding  protein binding  nucleus  transcription factor complex  cytoplasm  glucose metabolic process  transcription, DNA-templated  regulation of transcription, DNA-templated  regulation of transcription, DNA-templated  fatty acid metabolic process  glycosphingolipid metabolic process  signal transduction  multicellular organism development  spermatogenesis  cAMP response element binding protein binding  cell differentiation  regulation of circadian rhythm  positive regulation of transcription from RNA polymerase II promoter  retinoic acid receptor signaling pathway  rhythmic process  
Ontology : EGO-EBInegative regulation of transcription from RNA polymerase II promoter  RNA polymerase II regulatory region sequence-specific DNA binding  transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding  DNA binding  protein binding  nucleus  transcription factor complex  cytoplasm  glucose metabolic process  transcription, DNA-templated  regulation of transcription, DNA-templated  regulation of transcription, DNA-templated  fatty acid metabolic process  glycosphingolipid metabolic process  signal transduction  multicellular organism development  spermatogenesis  cAMP response element binding protein binding  cell differentiation  regulation of circadian rhythm  positive regulation of transcription from RNA polymerase II promoter  retinoic acid receptor signaling pathway  rhythmic process  
Pathways : BIOCARTARepression of Pain Sensation by the Transcriptional Regulator DREAM [Genes]    Regulation of Spermatogenesis by CREM [Genes]   
Pathways : KEGGAdrenergic signaling in cardiomyocytes    HTLV-I infection   
NDEx NetworkCREM
Atlas of Cancer Signalling NetworkCREM
Wikipedia pathwaysCREM
Orthology - Evolution
OrthoDB1390
GeneTree (enSembl)ENSG00000095794
Phylogenetic Trees/Animal Genes : TreeFamCREM
HOVERGENQ03060
HOGENOMQ03060
Homologs : HomoloGeneCREM
Homology/Alignments : Family Browser (UCSC)CREM
Gene fusions - Rearrangements
Fusion : MitelmanCCNY/CREM [10p11.21/10p11.21]  [t(10;10)(p11;p11)]  
Fusion: TCGACCNY 10p11.21 CREM 10p11.21 LUSC
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCREM [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CREM
dbVarCREM
ClinVarCREM
1000_GenomesCREM 
Exome Variant ServerCREM
ExAC (Exome Aggregation Consortium)CREM (select the gene name)
Genetic variants : HAPMAP1390
Genomic Variants (DGV)CREM [DGVbeta]
DECIPHERCREM [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisCREM 
Mutations
ICGC Data PortalCREM 
TCGA Data PortalCREM 
Broad Tumor PortalCREM
OASIS PortalCREM [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCREM  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDCREM
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch CREM
DgiDB (Drug Gene Interaction Database)CREM
DoCM (Curated mutations)CREM (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CREM (select a term)
intoGenCREM
Cancer3DCREM(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM123812   
Orphanet
MedgenCREM
Genetic Testing Registry CREM
NextProtQ03060 [Medical]
TSGene1390
GENETestsCREM
Target ValidationCREM
Huge Navigator CREM [HugePedia]
snp3D : Map Gene to Disease1390
BioCentury BCIQCREM
ClinGenCREM
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD1390
Chemical/Pharm GKB GenePA26871
Clinical trialCREM
Miscellaneous
canSAR (ICR)CREM (select the gene name)
Probes
Litterature
PubMed115 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineCREM
EVEXCREM
GoPubMedCREM
iHOPCREM
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed Jun 7 12:29:35 CEST 2017

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