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CRH (corticotropin releasing hormone)

Identity

Alias_symbol (synonym)CRF
CRH1
Other alias
HGNC (Hugo) CRH
LocusID (NCBI) 1392
Atlas_Id 46467
Location 8q13.1  [Link to chromosome band 8q13]
Location_base_pair Starts at 67088612 and ends at 67090880 bp from pter ( according to hg19-Feb_2009)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)CRH   2355
Cards
Entrez_Gene (NCBI)CRH  1392  corticotropin releasing hormone
AliasesCRF; CRH1
GeneCards (Weizmann)CRH
Ensembl hg19 (Hinxton)ENSG00000147571 [Gene_View]  chr8:67088612-67090880 [Contig_View]  CRH [Vega]
Ensembl hg38 (Hinxton)ENSG00000147571 [Gene_View]  chr8:67088612-67090880 [Contig_View]  CRH [Vega]
ICGC DataPortalENSG00000147571
TCGA cBioPortalCRH
AceView (NCBI)CRH
Genatlas (Paris)CRH
WikiGenes1392
SOURCE (Princeton)CRH
Genetics Home Reference (NIH)CRH
Genomic and cartography
GoldenPath hg19 (UCSC)CRH  -     chr8:67088612-67090880 -  8q13.1   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)CRH  -     8q13.1   [Description]    (hg38-Dec_2013)
EnsemblCRH - 8q13.1 [CytoView hg19]  CRH - 8q13.1 [CytoView hg38]
Mapping of homologs : NCBICRH [Mapview hg19]  CRH [Mapview hg38]
OMIM122560   
Gene and transcription
Genbank (Entrez)AK075431 BC002599 BC011031 BT007453 CB992265
RefSeq transcript (Entrez)NM_000756
RefSeq genomic (Entrez)NC_000008 NC_018919 NG_016127 NT_008183 NW_004929339
Consensus coding sequences : CCDS (NCBI)CRH
Cluster EST : UnigeneHs.75294 [ NCBI ]
CGAP (NCI)Hs.75294
Alternative Splicing GalleryENSG00000147571
Gene ExpressionCRH [ NCBI-GEO ]   CRH [ EBI - ARRAY_EXPRESS ]   CRH [ SEEK ]   CRH [ MEM ]
Gene Expression Viewer (FireBrowse)CRH [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)1392
GTEX Portal (Tissue expression)CRH
Protein : pattern, domain, 3D structure
UniProt/SwissProtP06850   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP06850  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP06850
Splice isoforms : SwissVarP06850
PhosPhoSitePlusP06850
Domaine pattern : Prosite (Expaxy)CRF (PS00511)   
Domains : Interpro (EBI)Corticotropin-releasing_fac_CS    CRF    Urocortin_CRF   
Domain families : Pfam (Sanger)CRF (PF00473)   
Domain families : Pfam (NCBI)pfam00473   
Domain families : Smart (EMBL)CRF (SM00039)  
Conserved Domain (NCBI)CRH
DMDM Disease mutations1392
Blocks (Seattle)CRH
PDB (SRS)1GOE    3EHT    3EHU   
PDB (PDBSum)1GOE    3EHT    3EHU   
PDB (IMB)1GOE    3EHT    3EHU   
PDB (RSDB)1GOE    3EHT    3EHU   
Structural Biology KnowledgeBase1GOE    3EHT    3EHU   
SCOP (Structural Classification of Proteins)1GOE    3EHT    3EHU   
CATH (Classification of proteins structures)1GOE    3EHT    3EHU   
SuperfamilyP06850
Human Protein AtlasENSG00000147571
Peptide AtlasP06850
HPRD07172
IPIIPI00027839   
Protein Interaction databases
DIP (DOE-UCLA)P06850
IntAct (EBI)P06850
FunCoupENSG00000147571
BioGRIDCRH
STRING (EMBL)CRH
ZODIACCRH
Ontologies - Pathways
QuickGOP06850
Ontology : AmiGOpositive regulation of protein phosphorylation  synaptic transmission, dopaminergic  receptor binding  hormone activity  neuropeptide hormone activity  protein binding  extracellular region  extracellular space  cytoplasm  glucocorticoid biosynthetic process  inflammatory response  signal transduction  synaptic transmission  female pregnancy  parturition  learning or memory  positive regulation of cell proliferation  associative learning  hormone-mediated apoptotic signaling pathway  positive regulation of gene expression  negative regulation of gene expression  negative regulation of norepinephrine secretion  positive regulation of circadian sleep/wake cycle, wakefulness  positive regulation of cell death  regulation of serotonin secretion  diterpenoid metabolic process  hypothalamus development  lung development  adrenal gland development  positive regulation of cAMP biosynthetic process  negative regulation of epinephrine secretion  negative regulation of luteinizing hormone secretion  locomotory exploration behavior  positive regulation of insulin secretion involved in cellular response to glucose stimulus  response to immobilization stress  negative regulation of circadian sleep/wake cycle, REM sleep  response to drug  varicosity  perikaryon  response to estrogen  response to ethanol  response to ether  negative regulation of blood pressure  response to pain  ion homeostasis  response to corticosterone  corticotropin-releasing hormone receptor 1 binding  corticotropin-releasing hormone receptor 2 binding  positive regulation of corticotropin secretion  positive regulation of cortisol secretion  long-term synaptic potentiation  positive regulation of digestive system process  negative regulation of cell death  negative regulation of glucagon secretion  cellular response to cocaine  cellular response to dexamethasone stimulus  positive regulation of calcium ion import  regulation of N-methyl-D-aspartate selective glutamate receptor activity  positive regulation of corticosterone secretion  positive regulation of behavioral fear response  
Ontology : EGO-EBIpositive regulation of protein phosphorylation  synaptic transmission, dopaminergic  receptor binding  hormone activity  neuropeptide hormone activity  protein binding  extracellular region  extracellular space  cytoplasm  glucocorticoid biosynthetic process  inflammatory response  signal transduction  synaptic transmission  female pregnancy  parturition  learning or memory  positive regulation of cell proliferation  associative learning  hormone-mediated apoptotic signaling pathway  positive regulation of gene expression  negative regulation of gene expression  negative regulation of norepinephrine secretion  positive regulation of circadian sleep/wake cycle, wakefulness  positive regulation of cell death  regulation of serotonin secretion  diterpenoid metabolic process  hypothalamus development  lung development  adrenal gland development  positive regulation of cAMP biosynthetic process  negative regulation of epinephrine secretion  negative regulation of luteinizing hormone secretion  locomotory exploration behavior  positive regulation of insulin secretion involved in cellular response to glucose stimulus  response to immobilization stress  negative regulation of circadian sleep/wake cycle, REM sleep  response to drug  varicosity  perikaryon  response to estrogen  response to ethanol  response to ether  negative regulation of blood pressure  response to pain  ion homeostasis  response to corticosterone  corticotropin-releasing hormone receptor 1 binding  corticotropin-releasing hormone receptor 2 binding  positive regulation of corticotropin secretion  positive regulation of cortisol secretion  long-term synaptic potentiation  positive regulation of digestive system process  negative regulation of cell death  negative regulation of glucagon secretion  cellular response to cocaine  cellular response to dexamethasone stimulus  positive regulation of calcium ion import  regulation of N-methyl-D-aspartate selective glutamate receptor activity  positive regulation of corticosterone secretion  positive regulation of behavioral fear response  
Pathways : KEGGLong-term depression    Alcoholism   
NDEx NetworkCRH
Atlas of Cancer Signalling NetworkCRH
Wikipedia pathwaysCRH
Orthology - Evolution
OrthoDB1392
GeneTree (enSembl)ENSG00000147571
Phylogenetic Trees/Animal Genes : TreeFamCRH
HOVERGENP06850
HOGENOMP06850
Homologs : HomoloGeneCRH
Homology/Alignments : Family Browser (UCSC)CRH
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCRH [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CRH
dbVarCRH
ClinVarCRH
1000_GenomesCRH 
Exome Variant ServerCRH
ExAC (Exome Aggregation Consortium)CRH (select the gene name)
Genetic variants : HAPMAP1392
Genomic Variants (DGV)CRH [DGVbeta]
DECIPHER (Syndromes)8:67088612-67090880  ENSG00000147571
CONAN: Copy Number AnalysisCRH 
Mutations
ICGC Data PortalCRH 
TCGA Data PortalCRH 
Broad Tumor PortalCRH
OASIS PortalCRH [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCRH  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDCRH
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch CRH
DgiDB (Drug Gene Interaction Database)CRH
DoCM (Curated mutations)CRH (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CRH (select a term)
intoGenCRH
Cancer3DCRH(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM122560   
Orphanet13801   
MedgenCRH
Genetic Testing Registry CRH
NextProtP06850 [Medical]
TSGene1392
GENETestsCRH
Huge Navigator CRH [HugePedia]
snp3D : Map Gene to Disease1392
BioCentury BCIQCRH
ClinGenCRH
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD1392
Chemical/Pharm GKB GenePA119
Clinical trialCRH
Miscellaneous
canSAR (ICR)CRH (select the gene name)
Probes
Litterature
PubMed178 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineCRH
EVEXCRH
GoPubMedCRH
iHOPCRH
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Mar 14 13:01:43 CET 2017

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