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CRHR1 (corticotropin releasing hormone receptor 1)

Identity

Alias_namesCRHR
Alias_symbol (synonym)CRF-R
CRF1
Other aliasCRF-R-1
CRF-R1
CRFR-1
CRFR1
CRH-R-1
CRH-R1
CRHR1L
HGNC (Hugo) CRHR1
LocusID (NCBI) 1394
Atlas_Id 46116
Location 17q21.31  [Link to chromosome band 17q21]
Location_base_pair Starts at 45784280 and ends at 45835828 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
CRHR1 (17q21.31) / CENPP (9q22.31)CRHR1 (17q21.31) / TTBK1 (6p21.1)CRHR1 17q21.31 / CENPP 9q22.31

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)CRHR1   2357
Cards
Entrez_Gene (NCBI)CRHR1  1394  corticotropin releasing hormone receptor 1
AliasesCRF-R; CRF-R-1; CRF-R1; CRF1; 
CRFR-1; CRFR1; CRH-R-1; CRH-R1; CRHR; CRHR1L
GeneCards (Weizmann)CRHR1
Ensembl hg19 (Hinxton)ENSG00000120088 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000120088 [Gene_View]  chr17:45784280-45835828 [Contig_View]  CRHR1 [Vega]
ICGC DataPortalENSG00000120088
TCGA cBioPortalCRHR1
AceView (NCBI)CRHR1
Genatlas (Paris)CRHR1
WikiGenes1394
SOURCE (Princeton)CRHR1
Genetics Home Reference (NIH)CRHR1
Genomic and cartography
GoldenPath hg38 (UCSC)CRHR1  -     chr17:45784280-45835828 +  17q21.31   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)CRHR1  -     17q21.31   [Description]    (hg19-Feb_2009)
EnsemblCRHR1 - 17q21.31 [CytoView hg19]  CRHR1 - 17q21.31 [CytoView hg38]
Mapping of homologs : NCBICRHR1 [Mapview hg19]  CRHR1 [Mapview hg38]
OMIM122561   
Gene and transcription
Genbank (Entrez)AB451466 AF180301 AF369651 AF369652 AF369653
RefSeq transcript (Entrez)NM_001145146 NM_001145147 NM_001145148 NM_001303018 NM_001303020 NM_004382
RefSeq genomic (Entrez)NC_000017 NC_018928 NG_009902 NT_167251 NT_187663
Consensus coding sequences : CCDS (NCBI)CRHR1
Cluster EST : UnigeneHs.417628 [ NCBI ]
CGAP (NCI)Hs.417628
Alternative Splicing GalleryENSG00000120088
Gene ExpressionCRHR1 [ NCBI-GEO ]   CRHR1 [ EBI - ARRAY_EXPRESS ]   CRHR1 [ SEEK ]   CRHR1 [ MEM ]
Gene Expression Viewer (FireBrowse)CRHR1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)1394
GTEX Portal (Tissue expression)CRHR1
Protein : pattern, domain, 3D structure
UniProt/SwissProtP34998   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP34998  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP34998
Splice isoforms : SwissVarP34998
PhosPhoSitePlusP34998
Domaine pattern : Prosite (Expaxy)G_PROTEIN_RECEP_F2_1 (PS00649)    G_PROTEIN_RECEP_F2_2 (PS00650)    G_PROTEIN_RECEP_F2_3 (PS50227)    G_PROTEIN_RECEP_F2_4 (PS50261)   
Domains : Interpro (EBI)GPCR_2-like    GPCR_2_CRF1_rcpt    GPCR_2_CRF_rcpt    GPCR_2_extracellular_dom    GPCR_2_secretin-like    GPCR_2_secretin-like_CS   
Domain families : Pfam (Sanger)7tm_2 (PF00002)    HRM (PF02793)   
Domain families : Pfam (NCBI)pfam00002    pfam02793   
Domain families : Smart (EMBL)HormR (SM00008)  
Conserved Domain (NCBI)CRHR1
DMDM Disease mutations1394
Blocks (Seattle)CRHR1
PDB (SRS)2L27    3EHS    3EHT    3EHU    4K5Y    4Z9G   
PDB (PDBSum)2L27    3EHS    3EHT    3EHU    4K5Y    4Z9G   
PDB (IMB)2L27    3EHS    3EHT    3EHU    4K5Y    4Z9G   
PDB (RSDB)2L27    3EHS    3EHT    3EHU    4K5Y    4Z9G   
Structural Biology KnowledgeBase2L27    3EHS    3EHT    3EHU    4K5Y    4Z9G   
SCOP (Structural Classification of Proteins)2L27    3EHS    3EHT    3EHU    4K5Y    4Z9G   
CATH (Classification of proteins structures)2L27    3EHS    3EHT    3EHU    4K5Y    4Z9G   
SuperfamilyP34998
Human Protein AtlasENSG00000120088
Peptide AtlasP34998
HPRD08830
IPIIPI00219267   IPI00219268   IPI00219269   IPI00902555   IPI00789829   IPI00179195   IPI00003083   IPI00939423   IPI01009378   
Protein Interaction databases
DIP (DOE-UCLA)P34998
IntAct (EBI)P34998
FunCoupENSG00000120088
BioGRIDCRHR1
STRING (EMBL)CRHR1
ZODIACCRHR1
Ontologies - Pathways
QuickGOP34998
Ontology : AmiGOprotein binding  endosome  plasma membrane  integral component of plasma membrane  immune response  cell surface receptor signaling pathway  activation of adenylate cyclase activity  female pregnancy  parturition  regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway  positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway  corticotrophin-releasing factor receptor activity  integral component of membrane  intrinsic component of plasma membrane  corticotropin secretion  cellular response to corticotropin-releasing hormone stimulus  negative regulation of voltage-gated calcium channel activity  regulation of corticosterone secretion  
Ontology : EGO-EBIprotein binding  endosome  plasma membrane  integral component of plasma membrane  immune response  cell surface receptor signaling pathway  activation of adenylate cyclase activity  female pregnancy  parturition  regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway  positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway  corticotrophin-releasing factor receptor activity  integral component of membrane  intrinsic component of plasma membrane  corticotropin secretion  cellular response to corticotropin-releasing hormone stimulus  negative regulation of voltage-gated calcium channel activity  regulation of corticosterone secretion  
Pathways : KEGGNeuroactive ligand-receptor interaction    Long-term depression   
NDEx NetworkCRHR1
Atlas of Cancer Signalling NetworkCRHR1
Wikipedia pathwaysCRHR1
Orthology - Evolution
OrthoDB1394
GeneTree (enSembl)ENSG00000120088
Phylogenetic Trees/Animal Genes : TreeFamCRHR1
HOVERGENP34998
HOGENOMP34998
Homologs : HomoloGeneCRHR1
Homology/Alignments : Family Browser (UCSC)CRHR1
Gene fusions - Rearrangements
Fusion : MitelmanCRHR1/CENPP [17q21.31/9q22.31]  
Fusion: TCGACRHR1 17q21.31 CENPP 9q22.31 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCRHR1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CRHR1
dbVarCRHR1
ClinVarCRHR1
1000_GenomesCRHR1 
Exome Variant ServerCRHR1
ExAC (Exome Aggregation Consortium)CRHR1 (select the gene name)
Genetic variants : HAPMAP1394
Genomic Variants (DGV)CRHR1 [DGVbeta]
DECIPHERCRHR1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisCRHR1 
Mutations
ICGC Data PortalCRHR1 
TCGA Data PortalCRHR1 
Broad Tumor PortalCRHR1
OASIS PortalCRHR1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCRHR1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDCRHR1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch CRHR1
DgiDB (Drug Gene Interaction Database)CRHR1
DoCM (Curated mutations)CRHR1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CRHR1 (select a term)
intoGenCRHR1
Cancer3DCRHR1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM122561   
Orphanet
MedgenCRHR1
Genetic Testing Registry CRHR1
NextProtP34998 [Medical]
TSGene1394
GENETestsCRHR1
Target ValidationCRHR1
Huge Navigator CRHR1 [HugePedia]
snp3D : Map Gene to Disease1394
BioCentury BCIQCRHR1
ClinGenCRHR1 (curated)
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD1394
Chemical/Pharm GKB GenePA26874
Clinical trialCRHR1
Miscellaneous
canSAR (ICR)CRHR1 (select the gene name)
Probes
Litterature
PubMed230 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineCRHR1
EVEXCRHR1
GoPubMedCRHR1
iHOPCRHR1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed Jun 7 12:29:35 CEST 2017

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