CRHR1 (corticotropin releasing hormone receptor 1)

2007-02-01  

Identity

HGNC
LOCATION
17q21.31
LOCUSID
ALIAS
CRF-R,CRF-R-1,CRF-R1,CRF1,CRFR-1,CRFR1,CRH-R-1,CRH-R1,CRHR,CRHR1L
FUSION GENES

Other Information

Locus ID:

NCBI: 1394
MIM: 122561
HGNC: 2357
Ensembl: ENSG00000120088

Variants:

dbSNP: 1394
ClinVar: 1394
TCGA: ENSG00000120088
COSMIC: CRHR1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000120088ENST00000293493A0A0A0MQZ1
ENSG00000120088ENST00000314537P34998
ENSG00000120088ENST00000339069B3TIK8
ENSG00000120088ENST00000347197J9JIC6
ENSG00000120088ENST00000352855P34998
ENSG00000120088ENST00000398285P34998
ENSG00000120088ENST00000535778H0YFR5
ENSG00000120088ENST00000577353P34998
ENSG00000120088ENST00000580876J3QKP8
ENSG00000120088ENST00000580955J3QQR1
ENSG00000120088ENST00000583888J3KSM0
ENSG00000120088ENST00000619154K9J956

Expression (GTEx)

0
10
20
30
40
50
60

Pathways

PathwaySourceExternal ID
Neuroactive ligand-receptor interactionKEGGko04080
Long-term depressionKEGGko04730
Neuroactive ligand-receptor interactionKEGGhsa04080
Long-term depressionKEGGhsa04730
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR ligand bindingREACTOMER-HSA-500792
Class B/2 (Secretin family receptors)REACTOMER-HSA-373080
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (s) signalling eventsREACTOMER-HSA-418555

Protein levels (Protein atlas)

Not detected
Low
Medium
High

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA10832corticosteroidsChemicalClinicalAnnotation, VariantAnnotationambiguousPKPD15128701, 18539200, 19210659, 22248724, 27523435
PA165290926fluticasone/salmeterolChemicalClinicalAnnotationassociatedPKPD15128701, 18539200, 19210659, 22248724
PA443450AsthmaDiseaseClinicalAnnotation, VariantAnnotationambiguousPKPD15128701, 18539200, 19210659, 22248724, 27523435
PA447196Anxiety DisordersDiseaseClinicalAnnotationassociatedPD17258395
PA447321Depressive Disorder, MajorDiseaseClinicalAnnotation, VariantAnnotationassociatedPD17258395, 17467808, 24422887
PA448681budesonideChemicalClinicalAnnotationassociatedPKPD15128701, 18539200, 19210659, 22248724
PA449673fluoxetineChemicalClinicalAnnotationassociatedPD17258395
PA449686fluticasone propionateChemicalClinicalAnnotationassociatedPKPD15128701, 18539200, 19210659, 22248724
PA451749triamcinoloneChemicalClinicalAnnotationassociatedPKPD15128701, 18539200, 19210659, 22248724
PA452229antidepressantsChemicalClinicalAnnotationassociatedPD24422887

References

Pubmed IDYearTitleCitations
182502572008Influence of child abuse on adult depression: moderation by the corticotropin-releasing hormone receptor gene.234
182502572008Influence of child abuse on adult depression: moderation by the corticotropin-releasing hormone receptor gene.234
169061642006A new chromosome 17q21.31 microdeletion syndrome associated with a common inversion polymorphism.136
197363542009Protective effect of CRHR1 gene variants on the development of adult depression following childhood maltreatment: replication and extension.99
200108882010The CRF system, stress, depression and anxiety-insights from human genetic studies.99
197505522009Risk and resilience: genetic and environmental influences on development of the stress response.97
195961212009Interaction of childhood maltreatment with the corticotropin-releasing hormone receptor gene: effects on hypothalamic-pituitary-adrenal axis reactivity.93
195961212009Interaction of childhood maltreatment with the corticotropin-releasing hormone receptor gene: effects on hypothalamic-pituitary-adrenal axis reactivity.93
198745742009Genetical genomic determinants of alcohol consumption in rats and humans.93
203517142011Poor replication of candidate genes for major depressive disorder using genome-wide association data.92

Citation

Dessen P

CRHR1 (corticotropin releasing hormone receptor 1)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46116/crhr1