Atlas of Genetics and Cytogenetics in Oncology and Haematology


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CRHR2 (corticotropin releasing hormone receptor 2)

Identity

Alias_symbol (synonym)CRF2
CRF-RB
HM-CRF
Other aliasCRFR2
HGNC (Hugo) CRHR2
LocusID (NCBI) 1395
Atlas_Id 50691
Location 7p14.3  [Link to chromosome band 7p14]
Location_base_pair Starts at 30651943 and ends at 30682525 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
LSAMP (3q13.31) / CRHR2 (7p14.3)PDIA4 (7q36.1) / CRHR2 (7p14.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)CRHR2   2358
Cards
Entrez_Gene (NCBI)CRHR2  1395  corticotropin releasing hormone receptor 2
AliasesCRF-RB; CRF2; CRFR2; HM-CRF
GeneCards (Weizmann)CRHR2
Ensembl hg19 (Hinxton)ENSG00000106113 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000106113 [Gene_View]  ENSG00000106113 [Sequence]  chr7:30651943-30682525 [Contig_View]  CRHR2 [Vega]
ICGC DataPortalENSG00000106113
TCGA cBioPortalCRHR2
AceView (NCBI)CRHR2
Genatlas (Paris)CRHR2
WikiGenes1395
SOURCE (Princeton)CRHR2
Genetics Home Reference (NIH)CRHR2
Genomic and cartography
GoldenPath hg38 (UCSC)CRHR2  -     chr7:30651943-30682525 -  7p14.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)CRHR2  -     7p14.3   [Description]    (hg19-Feb_2009)
EnsemblCRHR2 - 7p14.3 [CytoView hg19]  CRHR2 - 7p14.3 [CytoView hg38]
Mapping of homologs : NCBICRHR2 [Mapview hg19]  CRHR2 [Mapview hg38]
OMIM602034   
Gene and transcription
Genbank (Entrez)AF011406 AF019381 AF361106 AF361107 AF361108
RefSeq transcript (Entrez)NM_001202475 NM_001202481 NM_001202482 NM_001202483 NM_001883
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)CRHR2
Cluster EST : UnigeneHs.729970 [ NCBI ]
CGAP (NCI)Hs.729970
Alternative Splicing GalleryENSG00000106113
Gene ExpressionCRHR2 [ NCBI-GEO ]   CRHR2 [ EBI - ARRAY_EXPRESS ]   CRHR2 [ SEEK ]   CRHR2 [ MEM ]
Gene Expression Viewer (FireBrowse)CRHR2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)1395
GTEX Portal (Tissue expression)CRHR2
Human Protein AtlasENSG00000106113-CRHR2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ13324   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ13324  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ13324
Splice isoforms : SwissVarQ13324
PhosPhoSitePlusQ13324
Domaine pattern : Prosite (Expaxy)G_PROTEIN_RECEP_F2_1 (PS00649)    G_PROTEIN_RECEP_F2_2 (PS00650)    G_PROTEIN_RECEP_F2_3 (PS50227)    G_PROTEIN_RECEP_F2_4 (PS50261)   
Domains : Interpro (EBI)GPCR_2-like    GPCR_2_CRF2_rcpt    GPCR_2_CRF_rcpt    GPCR_2_extracell_dom_sf    GPCR_2_extracellular_dom    GPCR_2_secretin-like    GPCR_2_secretin-like_CS   
Domain families : Pfam (Sanger)7tm_2 (PF00002)    HRM (PF02793)   
Domain families : Pfam (NCBI)pfam00002    pfam02793   
Domain families : Smart (EMBL)HormR (SM00008)  
Conserved Domain (NCBI)CRHR2
DMDM Disease mutations1395
Blocks (Seattle)CRHR2
PDB (SRS)3N93    3N95    3N96   
PDB (PDBSum)3N93    3N95    3N96   
PDB (IMB)3N93    3N95    3N96   
PDB (RSDB)3N93    3N95    3N96   
Structural Biology KnowledgeBase3N93    3N95    3N96   
SCOP (Structural Classification of Proteins)3N93    3N95    3N96   
CATH (Classification of proteins structures)3N93    3N95    3N96   
SuperfamilyQ13324
Human Protein Atlas [tissue]ENSG00000106113-CRHR2 [tissue]
Peptide AtlasQ13324
HPRD03614
IPIIPI00297620   IPI00219074   IPI00181589   IPI00984791   IPI00984235   IPI00917350   IPI00916894   
Protein Interaction databases
DIP (DOE-UCLA)Q13324
IntAct (EBI)Q13324
FunCoupENSG00000106113
BioGRIDCRHR2
STRING (EMBL)CRHR2
ZODIACCRHR2
Ontologies - Pathways
QuickGOQ13324
Ontology : AmiGOprotein binding  plasma membrane  integral component of plasma membrane  cell surface receptor signaling pathway  G protein-coupled receptor signaling pathway  adenylate cyclase-modulating G protein-coupled receptor signaling pathway  hormone-mediated signaling pathway  corticotrophin-releasing factor receptor activity  peptide hormone binding  axon  dendrite  corticotropin-releasing hormone receptor activity  axon terminus  long-term synaptic potentiation  cellular response to corticotropin-releasing hormone stimulus  
Ontology : EGO-EBIprotein binding  plasma membrane  integral component of plasma membrane  cell surface receptor signaling pathway  G protein-coupled receptor signaling pathway  adenylate cyclase-modulating G protein-coupled receptor signaling pathway  hormone-mediated signaling pathway  corticotrophin-releasing factor receptor activity  peptide hormone binding  axon  dendrite  corticotropin-releasing hormone receptor activity  axon terminus  long-term synaptic potentiation  cellular response to corticotropin-releasing hormone stimulus  
Pathways : KEGGNeuroactive ligand-receptor interaction   
NDEx NetworkCRHR2
Atlas of Cancer Signalling NetworkCRHR2
Wikipedia pathwaysCRHR2
Orthology - Evolution
OrthoDB1395
GeneTree (enSembl)ENSG00000106113
Phylogenetic Trees/Animal Genes : TreeFamCRHR2
HOVERGENQ13324
HOGENOMQ13324
Homologs : HomoloGeneCRHR2
Homology/Alignments : Family Browser (UCSC)CRHR2
Gene fusions - Rearrangements
Fusion : QuiverCRHR2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCRHR2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CRHR2
dbVarCRHR2
ClinVarCRHR2
1000_GenomesCRHR2 
Exome Variant ServerCRHR2
ExAC (Exome Aggregation Consortium)ENSG00000106113
GNOMAD BrowserENSG00000106113
Varsome BrowserCRHR2
Genetic variants : HAPMAP1395
Genomic Variants (DGV)CRHR2 [DGVbeta]
DECIPHERCRHR2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisCRHR2 
Mutations
ICGC Data PortalCRHR2 
TCGA Data PortalCRHR2 
Broad Tumor PortalCRHR2
OASIS PortalCRHR2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCRHR2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDCRHR2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch CRHR2
DgiDB (Drug Gene Interaction Database)CRHR2
DoCM (Curated mutations)CRHR2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CRHR2 (select a term)
intoGenCRHR2
Cancer3DCRHR2(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM602034   
Orphanet
DisGeNETCRHR2
MedgenCRHR2
Genetic Testing Registry CRHR2
NextProtQ13324 [Medical]
TSGene1395
GENETestsCRHR2
Target ValidationCRHR2
Huge Navigator CRHR2 [HugePedia]
snp3D : Map Gene to Disease1395
BioCentury BCIQCRHR2
ClinGenCRHR2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD1395
Chemical/Pharm GKB GenePA26875
Clinical trialCRHR2
Miscellaneous
canSAR (ICR)CRHR2 (select the gene name)
Probes
Litterature
PubMed101 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineCRHR2
EVEXCRHR2
GoPubMedCRHR2
iHOPCRHR2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Nov 6 11:00:13 CET 2018

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