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CRIM1 (cysteine rich transmembrane BMP regulator 1)

Identity

Alias_namesS52
cysteine-rich motor neuron 1
cysteine rich transmembrane BMP regulator 1 (chordin-like)
Other aliasCRIM-1
HGNC (Hugo) CRIM1
LocusID (NCBI) 51232
Atlas_Id 40148
Location 2p22.2  [Link to chromosome band 2p22]
Location_base_pair Starts at 36356227 and ends at 36551135 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
CRIM1 (2p22.3) / ANKRD12 (18p11.22)CRIM1 (2p22.3) / EEF1B2 (2q33.3)CRIM1 (2p22.3) / FEZ2 (2p22.2)
CRIM1 (2p22.3) / IQCA1 (2q37.2)CRIM1 (2p22.3) / RAPGEF5 (7p15.3)CRIM1 (2p22.3) / RNF170 (8p11.21)
CRIM1 (2p22.3) / SYNRG (17q12)CRIM1 (2p22.3) / TACR1 (2p12)IFITM1 (11p15.5) / CRIM1 (2p22.3)
MGRN1 (16p13.3) / CRIM1 (2p22.3)PPIG (2q31.1) / CRIM1 (2p22.3)TTTY14 (Yq11.222) / CRIM1 (2p22.3)
CRIM1 2p22.3 / EEF1B2 2q33.3CRIM1 2p22.3 / TACR1 2p12PPIG 2q31.1 / CRIM1 2p22.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)CRIM1   2359
Cards
Entrez_Gene (NCBI)CRIM1  51232  cysteine rich transmembrane BMP regulator 1
AliasesCRIM-1; S52
GeneCards (Weizmann)CRIM1
Ensembl hg19 (Hinxton)ENSG00000150938 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000150938 [Gene_View]  chr2:36356227-36551135 [Contig_View]  CRIM1 [Vega]
ICGC DataPortalENSG00000150938
TCGA cBioPortalCRIM1
AceView (NCBI)CRIM1
Genatlas (Paris)CRIM1
WikiGenes51232
SOURCE (Princeton)CRIM1
Genetics Home Reference (NIH)CRIM1
Genomic and cartography
GoldenPath hg38 (UCSC)CRIM1  -     chr2:36356227-36551135 +  2p22.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)CRIM1  -     2p22.2   [Description]    (hg19-Feb_2009)
EnsemblCRIM1 - 2p22.2 [CytoView hg19]  CRIM1 - 2p22.2 [CytoView hg38]
Mapping of homologs : NCBICRIM1 [Mapview hg19]  CRIM1 [Mapview hg38]
OMIM606189   
Gene and transcription
Genbank (Entrez)AB209139 AF167706 AK026159 AK300817 AY358371
RefSeq transcript (Entrez)NM_016441
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)CRIM1
Cluster EST : UnigeneHs.699247 [ NCBI ]
CGAP (NCI)Hs.699247
Alternative Splicing GalleryENSG00000150938
Gene ExpressionCRIM1 [ NCBI-GEO ]   CRIM1 [ EBI - ARRAY_EXPRESS ]   CRIM1 [ SEEK ]   CRIM1 [ MEM ]
Gene Expression Viewer (FireBrowse)CRIM1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)51232
GTEX Portal (Tissue expression)CRIM1
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9NZV1   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9NZV1  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9NZV1
Splice isoforms : SwissVarQ9NZV1
PhosPhoSitePlusQ9NZV1
Domaine pattern : Prosite (Expaxy)ANTISTASIN (PS51252)    IGFBP_N_2 (PS51323)    VWFC_1 (PS01208)    VWFC_2 (PS50184)   
Domains : Interpro (EBI)Antistasin-like    Growth_fac_rcpt_    Hirudin/antistatin    IGFBP-like    VWF_dom   
Domain families : Pfam (Sanger)Antistasin (PF02822)    IGFBP (PF00219)    VWC (PF00093)   
Domain families : Pfam (NCBI)pfam02822    pfam00219    pfam00093   
Domain families : Smart (EMBL)IB (SM00121)  VWC (SM00214)  VWC_out (SM00215)  
Conserved Domain (NCBI)CRIM1
DMDM Disease mutations51232
Blocks (Seattle)CRIM1
SuperfamilyQ9NZV1
Human Protein AtlasENSG00000150938
Peptide AtlasQ9NZV1
HPRD08392
IPIIPI00009294   IPI00893268   IPI00893193   IPI00893071   
Protein Interaction databases
DIP (DOE-UCLA)Q9NZV1
IntAct (EBI)Q9NZV1
FunCoupENSG00000150938
BioGRIDCRIM1
STRING (EMBL)CRIM1
ZODIACCRIM1
Ontologies - Pathways
QuickGOQ9NZV1
Ontology : AmiGOregulation of cell growth  serine-type endopeptidase inhibitor activity  insulin-like growth factor-activated receptor activity  insulin-like growth factor binding  plasma membrane  nervous system development  negative regulation of endopeptidase activity  integral component of membrane  PDZ domain binding  insulin-like growth factor receptor signaling pathway  extracellular exosome  
Ontology : EGO-EBIregulation of cell growth  serine-type endopeptidase inhibitor activity  insulin-like growth factor-activated receptor activity  insulin-like growth factor binding  plasma membrane  nervous system development  negative regulation of endopeptidase activity  integral component of membrane  PDZ domain binding  insulin-like growth factor receptor signaling pathway  extracellular exosome  
NDEx NetworkCRIM1
Atlas of Cancer Signalling NetworkCRIM1
Wikipedia pathwaysCRIM1
Orthology - Evolution
OrthoDB51232
GeneTree (enSembl)ENSG00000150938
Phylogenetic Trees/Animal Genes : TreeFamCRIM1
HOVERGENQ9NZV1
HOGENOMQ9NZV1
Homologs : HomoloGeneCRIM1
Homology/Alignments : Family Browser (UCSC)CRIM1
Gene fusions - Rearrangements
Fusion : MitelmanCRIM1/EEF1B2 [2p22.3/2q33.3]  
Fusion : MitelmanCRIM1/TACR1 [2p22.3/2p12]  [t(2;2)(p12;p22)]  
Fusion : MitelmanPPIG/CRIM1 [2q31.1/2p22.3]  [t(2;2)(p22;q31)]  
Fusion: TCGACRIM1 2p22.3 EEF1B2 2q33.3 KIRC
Fusion: TCGACRIM1 2p22.3 TACR1 2p12 KIRC
Fusion: TCGAPPIG 2q31.1 CRIM1 2p22.3 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCRIM1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CRIM1
dbVarCRIM1
ClinVarCRIM1
1000_GenomesCRIM1 
Exome Variant ServerCRIM1
ExAC (Exome Aggregation Consortium)CRIM1 (select the gene name)
Genetic variants : HAPMAP51232
Genomic Variants (DGV)CRIM1 [DGVbeta]
DECIPHERCRIM1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisCRIM1 
Mutations
ICGC Data PortalCRIM1 
TCGA Data PortalCRIM1 
Broad Tumor PortalCRIM1
OASIS PortalCRIM1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCRIM1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDCRIM1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch CRIM1
DgiDB (Drug Gene Interaction Database)CRIM1
DoCM (Curated mutations)CRIM1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CRIM1 (select a term)
intoGenCRIM1
Cancer3DCRIM1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM606189   
Orphanet
MedgenCRIM1
Genetic Testing Registry CRIM1
NextProtQ9NZV1 [Medical]
TSGene51232
GENETestsCRIM1
Target ValidationCRIM1
Huge Navigator CRIM1 [HugePedia]
snp3D : Map Gene to Disease51232
BioCentury BCIQCRIM1
ClinGenCRIM1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD51232
Chemical/Pharm GKB GenePA26877
Clinical trialCRIM1
Miscellaneous
canSAR (ICR)CRIM1 (select the gene name)
Probes
Litterature
PubMed27 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineCRIM1
EVEXCRIM1
GoPubMedCRIM1
iHOPCRIM1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 25 19:03:47 CEST 2017

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