CRIP2 (cysteine rich protein 2)

2011-08-01  

Identity

HGNC
CRIP2
LOCATION
14q32.33
LOCUSID
1397
ALIAS
CRIP,CRP2,ESP1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 1397
MIM: 601183
HGNC: 2361
Ensembl: ENSG00000182809

Variants:

dbSNP: 1397
ClinVar: 1397
TCGA: ENSG00000182809
COSMIC: CRIP2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000182809ENST00000329146P52943
ENSG00000182809ENST00000483017P52943
ENSG00000182809ENST00000538259H0YFA4
ENSG00000182809ENST00000550577H0YHD8

Expression (GTEx)

0
50
100
150
200
250
300
350
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
125309672003Cysteine-rich LIM-only proteins CRP1 and CRP2 are potent smooth muscle differentiation cofactors.85
215403302011Cysteine-rich intestinal protein 2 (CRIP2) acts as a repressor of NF-kappaB-mediated proangiogenic cytokine transcription to suppress tumorigenesis and angiogenesis.26
296620842018HOXA9 inhibits HIF-1α-mediated glycolysis through interacting with CRIP2 to repress cutaneous squamous cell carcinoma development.18
221540842012The LIM domain protein, CRIP2, promotes apoptosis in esophageal squamous cell carcinoma.9
268831982016CRP2, a new invadopodia actin bundling factor critically promotes breast cancer cell invasion and metastasis.7
204601092010ADAM19 autolysis is activated by LPS and promotes non-classical secretion of cysteine-rich protein 2.2

Citation

Dessen P

CRIP2 (cysteine rich protein 2)

Atlas Genet Cytogenet Oncol Haematol. 2011-08-01

Online version: http://atlasgeneticsoncology.org/gene/52310/crip2