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CRISP1 (cysteine rich secretory protein 1)

Identity

Alias_namesAEGL1
acidic epididymal glycoprotein-like 1
Alias_symbol (synonym)CRISP-1
ARP
HUMARP
HSCRISP1D
HSCRISP1G
Other aliasHEL-S-57
HGNC (Hugo) CRISP1
LocusID (NCBI) 167
Atlas_Id 56257
Location 6p12.3  [Link to chromosome band 6p12]
Location_base_pair Starts at 49834266 and ends at 49866505 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
TAF8 (6p21.1) / CRISP1 (6p12.3)TTC39A (1p32.3) / CRISP1 (6p12.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 2 ]
  t(1;6)(p32;p12) TTC39A/CRISP1
t(6;6)(p12;p21) TAF8/CRISP1


External links

Nomenclature
HGNC (Hugo)CRISP1   304
Cards
Entrez_Gene (NCBI)CRISP1  167  cysteine rich secretory protein 1
AliasesAEGL1; ARP; CRISP-1; HEL-S-57; 
HSCRISP1D; HSCRISP1G; HUMARP
GeneCards (Weizmann)CRISP1
Ensembl hg19 (Hinxton)ENSG00000124812 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000124812 [Gene_View]  ENSG00000124812 [Sequence]  chr6:49834266-49866505 [Contig_View]  CRISP1 [Vega]
ICGC DataPortalENSG00000124812
TCGA cBioPortalCRISP1
AceView (NCBI)CRISP1
Genatlas (Paris)CRISP1
WikiGenes167
SOURCE (Princeton)CRISP1
Genetics Home Reference (NIH)CRISP1
Genomic and cartography
GoldenPath hg38 (UCSC)CRISP1  -     chr6:49834266-49866505 -  6p12.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)CRISP1  -     6p12.3   [Description]    (hg19-Feb_2009)
EnsemblCRISP1 - 6p12.3 [CytoView hg19]  CRISP1 - 6p12.3 [CytoView hg38]
Mapping of homologs : NCBICRISP1 [Mapview hg19]  CRISP1 [Mapview hg38]
OMIM601193   
Gene and transcription
Genbank (Entrez)AB451334 AB451479 AK292497 BC028577 BC131707
RefSeq transcript (Entrez)NM_001131 NM_001205220 NM_170609
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)CRISP1
Cluster EST : UnigeneHs.109620 [ NCBI ]
CGAP (NCI)Hs.109620
Alternative Splicing GalleryENSG00000124812
Gene ExpressionCRISP1 [ NCBI-GEO ]   CRISP1 [ EBI - ARRAY_EXPRESS ]   CRISP1 [ SEEK ]   CRISP1 [ MEM ]
Gene Expression Viewer (FireBrowse)CRISP1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)167
GTEX Portal (Tissue expression)CRISP1
Human Protein AtlasENSG00000124812-CRISP1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP54107   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP54107  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP54107
Splice isoforms : SwissVarP54107
PhosPhoSitePlusP54107
Domaine pattern : Prosite (Expaxy)CRISP_1 (PS01009)    CRISP_2 (PS01010)    SHKT (PS51670)   
Domains : Interpro (EBI)Allrgn_V5/Tpx1    Allrgn_V5/Tpx1_CS    CAP_domain    CAP_sf    Cysteine_rich_secretory    SCP_CRISP    ShKT_dom    V5_allergen   
Domain families : Pfam (Sanger)CAP (PF00188)    Crisp (PF08562)   
Domain families : Pfam (NCBI)pfam00188    pfam08562   
Domain families : Smart (EMBL)SCP (SM00198)  
Conserved Domain (NCBI)CRISP1
DMDM Disease mutations167
Blocks (Seattle)CRISP1
SuperfamilyP54107
Human Protein Atlas [tissue]ENSG00000124812-CRISP1 [tissue]
Peptide AtlasP54107
HPRD03118
IPIIPI00004797   IPI00172647   
Protein Interaction databases
DIP (DOE-UCLA)P54107
IntAct (EBI)P54107
FunCoupENSG00000124812
BioGRIDCRISP1
STRING (EMBL)CRISP1
ZODIACCRISP1
Ontologies - Pathways
QuickGOP54107
Ontology : AmiGOcalcium channel regulator activity  extracellular space  nucleus  binding of sperm to zona pellucida  fusion of sperm to egg plasma membrane involved in single fertilization  regulation of acrosome reaction  
Ontology : EGO-EBIcalcium channel regulator activity  extracellular space  nucleus  binding of sperm to zona pellucida  fusion of sperm to egg plasma membrane involved in single fertilization  regulation of acrosome reaction  
NDEx NetworkCRISP1
Atlas of Cancer Signalling NetworkCRISP1
Wikipedia pathwaysCRISP1
Orthology - Evolution
OrthoDB167
GeneTree (enSembl)ENSG00000124812
Phylogenetic Trees/Animal Genes : TreeFamCRISP1
HOVERGENP54107
HOGENOMP54107
Homologs : HomoloGeneCRISP1
Homology/Alignments : Family Browser (UCSC)CRISP1
Gene fusions - Rearrangements
Fusion : QuiverCRISP1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCRISP1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CRISP1
dbVarCRISP1
ClinVarCRISP1
1000_GenomesCRISP1 
Exome Variant ServerCRISP1
ExAC (Exome Aggregation Consortium)ENSG00000124812
GNOMAD BrowserENSG00000124812
Varsome BrowserCRISP1
Genetic variants : HAPMAP167
Genomic Variants (DGV)CRISP1 [DGVbeta]
DECIPHERCRISP1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisCRISP1 
Mutations
ICGC Data PortalCRISP1 
TCGA Data PortalCRISP1 
Broad Tumor PortalCRISP1
OASIS PortalCRISP1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCRISP1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDCRISP1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch CRISP1
DgiDB (Drug Gene Interaction Database)CRISP1
DoCM (Curated mutations)CRISP1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CRISP1 (select a term)
intoGenCRISP1
Cancer3DCRISP1(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM601193   
Orphanet
DisGeNETCRISP1
MedgenCRISP1
Genetic Testing Registry CRISP1
NextProtP54107 [Medical]
TSGene167
GENETestsCRISP1
Target ValidationCRISP1
Huge Navigator CRISP1 [HugePedia]
snp3D : Map Gene to Disease167
BioCentury BCIQCRISP1
ClinGenCRISP1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD167
Chemical/Pharm GKB GenePA24605
Clinical trialCRISP1
Miscellaneous
canSAR (ICR)CRISP1 (select the gene name)
Probes
Litterature
PubMed14 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineCRISP1
EVEXCRISP1
GoPubMedCRISP1
iHOPCRISP1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Nov 6 11:00:14 CET 2018

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