CRISP3 (cysteine rich secretory protein 3)

2007-02-01  

Identity

HGNC
CRISP3
LOCATION
6p12.3
LOCUSID
10321
ALIAS
Aeg2,CRISP-3,CRS3,SGP28,dJ442L6.3
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 10321
MIM: 618062
HGNC: 16904
Ensembl: ENSG00000096006

Variants:

dbSNP: 10321
ClinVar: 10321
TCGA: ENSG00000096006
COSMIC: CRISP3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000096006ENST00000263045P54108
ENSG00000096006ENST00000354620I3L0A1
ENSG00000096006ENST00000371159J3KPA1
ENSG00000096006ENST00000433368P54108

Expression (GTEx)

0
500
1000
1500
2000
2500
3000
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
Neutrophil degranulationREACTOMER-HSA-6798695

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
176345402007Association of cysteine-rich secretory protein 3 and beta-microseminoprotein with outcome after radical prostatectomy.29
202374962010New genetic associations detected in a host response study to hepatitis B vaccine.27
122235132002Identification of human cysteine-rich secretory protein 3 (CRISP-3) as a matrix protein in a subset of peroxidase-negative granules of neutrophils and in the granules of eosinophils.21
154614602004Cysteine-rich secretory protein 3 is a ligand of alpha1B-glycoprotein in human plasma.21
124337212002Cysteine-rich secretory protein-3: a potential biomarker for prostate cancer.18
159509342005beta-Microseminoprotein binds CRISP-3 in human seminal plasma.18
206255112010Gene transcription changes in asthmatic chronic rhinosinusitis with nasal polyps and comparison to those in atopic dermatitis.17
218145742011Cysteine-rich secretory protein-3 (CRISP3) is strongly up-regulated in prostate carcinomas with the TMPRSS2-ERG fusion gene.17
176653932007Low salivary dehydroepiandrosterone and androgen-regulated cysteine-rich secretory protein 3 levels in Sjögren's syndrome.16
163885012006Immunohistochemical detection of cysteine-rich secretory protein 3 in tissue and in serum from men with cancer or benign enlargement of the prostate gland.15

Citation

Dessen P

CRISP3 (cysteine rich secretory protein 3)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46180/crisp3