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CRKL (v-crk avian sarcoma virus CT10 oncogene homolog-like)

Identity

Other names-
HGNC (Hugo) CRKL
LocusID (NCBI) 1399
Location 22q11.21
Location_base_pair Starts at 21271714 and ends at 21308037 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Leukemias implicated (Data extracted from papers in the Atlas)

Leukemias t0817q24q22ID1494

External links

Nomenclature
HGNC (Hugo)CRKL   2363
Cards
Entrez_Gene (NCBI)CRKL  1399  v-crk avian sarcoma virus CT10 oncogene homolog-like
GeneCards (Weizmann)CRKL
Ensembl (Hinxton)ENSG00000099942 [Gene_View]  chr22:21271714-21308037 [Contig_View]  CRKL [Vega]
ICGC DataPortalENSG00000099942
cBioPortalCRKL
AceView (NCBI)CRKL
Genatlas (Paris)CRKL
WikiGenes1399
SOURCE (Princeton)NM_005207
Genomic and cartography
GoldenPath (UCSC)CRKL  -  22q11.21   chr22:21271714-21308037 +  22q11.21   [Description]    (hg19-Feb_2009)
EnsemblCRKL - 22q11.21 [CytoView]
Mapping of homologs : NCBICRKL [Mapview]
OMIM602007   
Gene and transcription
Genbank (Entrez)AA844269 AK000311 AK292909 BC026248 BC033281
RefSeq transcript (Entrez)NM_005207
RefSeq genomic (Entrez)AC_000154 NC_000022 NC_018933 NG_016354 NT_011520 NW_001838740 NW_004929430
Consensus coding sequences : CCDS (NCBI)CRKL
Cluster EST : UnigeneHs.5613 [ NCBI ]
CGAP (NCI)Hs.5613
Alternative Splicing : Fast-db (Paris)GSHG0019848
Alternative Splicing GalleryENSG00000099942
Gene ExpressionCRKL [ NCBI-GEO ]     CRKL [ SEEK ]   CRKL [ MEM ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP46109 (Uniprot)
NextProtP46109  [Medical]
With graphics : InterProP46109
Splice isoforms : SwissVarP46109 (Swissvar)
Domaine pattern : Prosite (Expaxy)SH2 (PS50001)    SH3 (PS50002)   
Domains : Interpro (EBI)SH2 [organisation]   SH3_2 [organisation]   SH3_domain [organisation]  
Related proteins : CluSTrP46109
Domain families : Pfam (Sanger)SH2 (PF00017)    SH3_1 (PF00018)    SH3_2 (PF07653)   
Domain families : Pfam (NCBI)pfam00017    pfam00018    pfam07653   
Domain families : Smart (EMBL)SH2 (SM00252)  SH3 (SM00326)  
DMDM Disease mutations1399
Blocks (Seattle)P46109
PDB (SRS)2BZX    2BZY    2DBK    2EO3    2LQN    2LQW   
PDB (PDBSum)2BZX    2BZY    2DBK    2EO3    2LQN    2LQW   
PDB (IMB)2BZX    2BZY    2DBK    2EO3    2LQN    2LQW   
PDB (RSDB)2BZX    2BZY    2DBK    2EO3    2LQN    2LQW   
Human Protein AtlasENSG00000099942 [gene] [tissue] [antibody] [cell] [cancer]
Peptide AtlasP46109
HPRD03596
IPIIPI00004839   
Protein Interaction databases
DIP (DOE-UCLA)P46109
IntAct (EBI)P46109
FunCoupENSG00000099942
BioGRIDCRKL
InParanoidP46109
Interologous Interaction database P46109
IntegromeDBCRKL
STRING (EMBL)CRKL
Ontologies - Pathways
Ontology : AmiGOactivation of MAPKK activity  blood vessel development  signal transducer activity  SH3/SH2 adaptor activity  protein binding  endosome  cytosol  JNK cascade  Ras protein signal transduction  heart development  organ morphogenesis  anterior/posterior pattern specification  intracellular signal transduction  neurotrophin TRK receptor signaling pathway  thymus development  parathyroid gland development  
Ontology : EGO-EBIactivation of MAPKK activity  blood vessel development  signal transducer activity  SH3/SH2 adaptor activity  protein binding  endosome  cytosol  JNK cascade  Ras protein signal transduction  heart development  organ morphogenesis  anterior/posterior pattern specification  intracellular signal transduction  neurotrophin TRK receptor signaling pathway  thymus development  parathyroid gland development  
Pathways : BIOCARTAIntegrin Signaling Pathway [Genes]    Signaling of Hepatocyte Growth Factor Receptor [Genes]    Inhibition of Cellular Proliferation by Gleevec [Genes]    Links between Pyk2 and Map Kinases [Genes]    IL-2 Receptor Beta Chain in T cell Activation [Genes]   
Pathways : KEGGMAPK signaling pathway    ErbB signaling pathway    Rap1 signaling pathway    Chemokine signaling pathway    Focal adhesion    Fc gamma R-mediated phagocytosis    Neurotrophin signaling pathway    Regulation of actin cytoskeleton    Insulin signaling pathway    Bacterial invasion of epithelial cells    Shigellosis    Pathways in cancer    MicroRNAs in cancer    Renal cell carcinoma    Chronic myeloid leukemia   
Protein Interaction DatabaseCRKL
Wikipedia pathwaysCRKL
Gene fusion - rearrangments
Polymorphisms : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)CRKL
snp3D : Map Gene to Disease1399
SNP (GeneSNP Utah)CRKL
SNP : HGBaseCRKL
Genetic variants : HAPMAPCRKL
Exome VariantCRKL
1000_GenomesCRKL 
ICGC programENSG00000099942 
Somatic Mutations in Cancer : COSMICCRKL 
CONAN: Copy Number AnalysisCRKL 
Mutations and Diseases : HGMDCRKL
Genomic VariantsCRKL  CRKL [DGVbeta]
dbVarCRKL
ClinVarCRKL
Pred. of missensesPolyPhen-2  SIFT(SG)  SIFT(JCVI)  Align-GVGD  MutAssessor  Mutanalyser  
Pred. splicesGeneSplicer  Human Splicing Finder  MaxEntScan  
Diseases
OMIM602007   
MedgenCRKL
GENETestsCRKL
Disease Genetic AssociationCRKL
Huge Navigator CRKL [HugePedia]  CRKL [HugeCancerGEM]
General knowledge
Homologs : HomoloGeneCRKL
Homology/Alignments : Family Browser (UCSC)CRKL
Phylogenetic Trees/Animal Genes : TreeFamCRKL
Chemical/Protein Interactions : CTD1399
Chemical/Pharm GKB GenePA26881
Clinical trialCRKL
Cancer Resource (Charite)ENSG00000099942
Other databases
Probes
Litterature
PubMed146 Pubmed reference(s) in Entrez
CoreMineCRKL
iHOPCRKL
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated12-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Fri Jul 11 16:51:20 CEST 2014

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