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CRKL (v-crk sarcoma virus CT10 oncogene homolog (avian)-like)

Identity

Other names-
HGNC (Hugo) CRKL
LocusID (NCBI) 1399
Location 22q11.21
Location_base_pair Starts at 21271714 and ends at 21308037 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)CRKL   2363
Entrez_Gene (NCBI)CRKL  1399  v-crk sarcoma virus CT10 oncogene homolog (avian)-like
Cards
GeneCards (Weizmann)CRKL
Ensembl (Hinxton)ENSG00000099942 [Gene_View]  chr22:21271714-21308037 [Contig_View]  CRKL [Vega]
AceView (NCBI)CRKL
Genatlas (Paris)CRKL
SOURCE (Stanford)NM_005207
Genomic and cartography
GoldenPath (UCSC)CRKL  -  22q11.21   chr22:21271714-21308037 +  22q11.21   [Description]    (hg19-Feb_2009)
EnsemblCRKL - 22q11.21 [CytoView]
Mapping of homologs : NCBICRKL [Mapview]
OMIM602007   
Gene and transcription
Genbank (Entrez)AA844269 AK000311 AK292909 BC026248 BC033281
RefSeq transcript (SRS)NM_005207
RefSeq transcript (Entrez)NM_005207
RefSeq genomic (SRS)AC_000154 NC_000022 NC_018933 NG_016354 NT_011520 NW_001838740 NW_004078112
RefSeq genomic (Entrez)AC_000154 NC_000022 NC_018933 NG_016354 NT_011520 NW_001838740 NW_004078112
Consensus coding sequences : CCDS (NCBI)CRKL
Cluster EST : UnigeneHs.5613 [ SRS ] Hs.5613 [ NCBI ]
CGAP (NCI)Hs.5613
Alternative Splicing : Fast-db (Paris)GSHG0019848
Alternative Splicing GalleryENSG00000099942
Gene ExpressionCRKL [ NCBI-GEO ]   CRKL [ EBI - ARRAY_EXPRESS ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP46109 (SRS) P46109 (Uniprot)
NextProtP46109
With graphics : InterProP46109
Splice isoforms : SwissVarP46109(Swissvar)
Domaine pattern : Prosite (SRS)SH2 (PS50001)    SH3 (PS50002)   
Domaine pattern : Prosite (Expaxy)SH2 (PS50001)    SH3 (PS50002)   
Domains : Interpro (SRS)SH2    SH3_2    SH3_domain   
Domains : Interpro (EBI)SH2    SH3_2    SH3_domain   
Related proteins : CluSTrP46109
Domain families : Pfam (SRS)SH2 (PF00017)    SH3_1 (PF00018)    SH3_2 (PF07653)   
Domain families : Pfam (Sanger)SH2 (PF00017)    SH3_1 (PF00018)    SH3_2 (PF07653)   
Domain families : Pfam (NCBI)pfam00017    pfam00018    pfam07653   
Domain families : Smart (EMBL)SH2 (SM00252)  SH3 (SM00326)  
DMDM1399
Blocks (Seattle)P46109
PDB (SRS)2BZX    2BZY    2DBK    2EO3    2LQN    2LQW   
PDB (PDBSum)2BZX    2BZY    2DBK    2EO3    2LQN    2LQW   
PDB (IMB)2BZX    2BZY    2DBK    2EO3    2LQN    2LQW   
PDB (RSDB)2BZX    2BZY    2DBK    2EO3    2LQN    2LQW   
Human Protein AtlasENSG00000099942
HPRD03596
IPIIPI00004839   
Protein Interaction databases
DIP (DOE-UCLA)P46109
IntAct (EBI)P46109
FunCoupENSG00000099942
REACTOMECRKL
Protein Interaction Database1399
BioGRIDCRKL
InParanoidP46109
Interologous Interaction database P46109
IntegromeDBCRKL
Polymorphism : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)CRKL
SNP (GeneSNP Utah)CRKL
SNP : HGBaseCRKL
Genetic variants : HAPMAPCRKL
Somatic Mutations in Cancer : COSMICCRKL 
CONAN: Copy Number AnalysisCRKL 
Mutations and Diseases : HGMDCRKL
OMIM602007   
GENETests602007   
Disease Genetic AssociationCRKL
Huge Navigator CRKL [HugePedia]  CRKL [HugeCancerGEM]
Genomic VariantsCRKL  CRKL [DGVbeta]
snp3D : Map Gene to Disease1399
General knowledge
Homologs : HomoloGeneCRKL
Homology/Alignments : Family Browser (UCSC)CRKL
Phylogenetic Trees/Animal Genes : TreeFamCRKL
Chemical/Protein Interactions : CTD1399
Chemical/Pharm GKB GenePA26881
Clinical trialCRKL
Cancer Resource (Charite)ENSG00000099942
Ontology : AmiGOblood vessel development  signal transducer activity  SH3/SH2 adaptor activity  protein binding  cytosol  JNK cascade  Ras protein signal transduction  heart development  organ morphogenesis  anterior/posterior pattern specification  intracellular signal transduction  thymus development  parathyroid gland development  
Ontology : EGO-EBIblood vessel development  signal transducer activity  SH3/SH2 adaptor activity  protein binding  cytosol  JNK cascade  Ras protein signal transduction  heart development  organ morphogenesis  anterior/posterior pattern specification  intracellular signal transduction  thymus development  parathyroid gland development  
Pathways : BIOCARTAIntegrin Signaling Pathway [Genes]    Signaling of Hepatocyte Growth Factor Receptor [Genes]    Inhibition of Cellular Proliferation by Gleevec [Genes]    Links between Pyk2 and Map Kinases [Genes]    IL-2 Receptor Beta Chain in T cell Activation [Genes]   
Pathways : KEGGRegulation of actin cytoskeletonFocal adhesionInsulin signaling pathwayMAPK signaling pathway
Other databases
Probes
Litterature
PubMed136 Pubmed reference(s) in Entrez
PubGeneCRKL
iHOPCRKL
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated01-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed May 1 12:41:43 CEST 2013
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