Atlas of Genetics and Cytogenetics in Oncology and Haematology

Home   Genes   Leukemias   Solid Tumours   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   
X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

CRKL (v-crk avian sarcoma virus CT10 oncogene homolog-like)

Identity

Other names-
HGNC (Hugo) CRKL
LocusID (NCBI) 1399
Atlas_Id 40150
Location 22q11.21  [Link to chromosome band 22q11]
Location_base_pair Starts at 21271714 and ends at 21308037 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)		CRKL (22q11.21) / AP3D1 (19p13.3)CRKL (22q11.21) / ARHGEF6 (Xq26.3)CRKL (22q11.21) / MAPK1 (22q11.21)
CRKL (22q11.21) / SNAP29 (22q11.21)CRKL (22q11.21) / SPTBN1 (2p16.2)DGCR8 (22q11.21) / CRKL (22q11.21)
KLHL7 (7p15.3) / CRKL (22q11.21)DGCR8 22q11.21 / CRKL 22q11.21

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  Chronic myelogenous leukaemia (CML)

External links

Nomenclature
HGNC (Hugo)CRKL   2363
Cards
Entrez_Gene (NCBI)CRKL  1399  v-crk avian sarcoma virus CT10 oncogene homolog-like
Aliases
GeneCards (Weizmann)CRKL
Ensembl hg19 (Hinxton)ENSG00000099942 [Gene_View]  chr22:21271714-21308037 [Contig_View]  CRKL [Vega]
Ensembl hg38 (Hinxton)ENSG00000099942 [Gene_View]  chr22:21271714-21308037 [Contig_View]  CRKL [Vega]
ICGC DataPortalENSG00000099942
TCGA cBioPortalCRKL
AceView (NCBI)CRKL
Genatlas (Paris)CRKL
WikiGenes1399
SOURCE (Princeton)CRKL
Genomic and cartography
GoldenPath hg19 (UCSC)CRKL  -     chr22:21271714-21308037 +  22q11.21   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)CRKL  -     22q11.21   [Description]    (hg38-Dec_2013)
EnsemblCRKL - 22q11.21 [CytoView hg19]  CRKL - 22q11.21 [CytoView hg38]
Mapping of homologs : NCBICRKL [Mapview hg19]  CRKL [Mapview hg38]
OMIM602007   
Gene and transcription
Genbank (Entrez)AA844269 AK000311 AK292909 BC026248 BC033281
RefSeq transcript (Entrez)NM_005207
RefSeq genomic (Entrez)NC_000022 NC_018933 NG_016354 NT_011520 NW_004929430
Consensus coding sequences : CCDS (NCBI)CRKL
Cluster EST : UnigeneHs.5613 [ NCBI ]
CGAP (NCI)Hs.5613
Alternative Splicing GalleryENSG00000099942
Gene ExpressionCRKL [ NCBI-GEO ]   CRKL [ EBI - ARRAY_EXPRESS ]   CRKL [ SEEK ]   CRKL [ MEM ]
Gene Expression Viewer (FireBrowse)CRKL [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)1399
GTEX Portal (Tissue expression)CRKL
Protein : pattern, domain, 3D structure
UniProt/SwissProtP46109 (Uniprot)
NextProtP46109  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP46109
Splice isoforms : SwissVarP46109 (Swissvar)
PhosPhoSitePlusP46109
Domaine pattern : Prosite (Expaxy)SH2 (PS50001)    SH3 (PS50002)   
Domains : Interpro (EBI)SH2    SH3_2    SH3_domain   
Domain families : Pfam (Sanger)SH2 (PF00017)    SH3_1 (PF00018)    SH3_2 (PF07653)   
Domain families : Pfam (NCBI)pfam00017    pfam00018    pfam07653   
Domain families : Smart (EMBL)SH2 (SM00252)  SH3 (SM00326)  
DMDM Disease mutations1399
Blocks (Seattle)CRKL
PDB (SRS)2BZX    2BZY    2DBK    2EO3    2LQN    2LQW   
PDB (PDBSum)2BZX    2BZY    2DBK    2EO3    2LQN    2LQW   
PDB (IMB)2BZX    2BZY    2DBK    2EO3    2LQN    2LQW   
PDB (RSDB)2BZX    2BZY    2DBK    2EO3    2LQN    2LQW   
Structural Biology KnowledgeBase2BZX    2BZY    2DBK    2EO3    2LQN    2LQW   
SCOP (Structural Classification of Proteins)2BZX    2BZY    2DBK    2EO3    2LQN    2LQW   
CATH (Classification of proteins structures)2BZX    2BZY    2DBK    2EO3    2LQN    2LQW   
SuperfamilyP46109
Human Protein AtlasENSG00000099942
Peptide AtlasP46109
HPRD03596
IPIIPI00004839   
Protein Interaction databases
DIP (DOE-UCLA)P46109
IntAct (EBI)P46109
FunCoupENSG00000099942
BioGRIDCRKL
STRING (EMBL)CRKL
ZODIACCRKL
Ontologies - Pathways
QuickGOP46109
Ontology : AmiGOactivation of MAPKK activity  blood vessel development  signal transducer activity  SH3/SH2 adaptor activity  protein binding  endosome  cytosol  JNK cascade  Ras protein signal transduction  heart development  positive regulation of cell proliferation  organ morphogenesis  anterior/posterior pattern specification  intracellular signal transduction  poly(A) RNA binding  thymus development  parathyroid gland development  extracellular exosome  
Ontology : EGO-EBIactivation of MAPKK activity  blood vessel development  signal transducer activity  SH3/SH2 adaptor activity  protein binding  endosome  cytosol  JNK cascade  Ras protein signal transduction  heart development  positive regulation of cell proliferation  organ morphogenesis  anterior/posterior pattern specification  intracellular signal transduction  poly(A) RNA binding  thymus development  parathyroid gland development  extracellular exosome  
Pathways : BIOCARTAIntegrin Signaling Pathway [Genes]    Signaling of Hepatocyte Growth Factor Receptor [Genes]    Inhibition of Cellular Proliferation by Gleevec [Genes]    Links between Pyk2 and Map Kinases [Genes]    IL-2 Receptor Beta Chain in T cell Activation [Genes]   
Pathways : KEGGMAPK signaling pathway    ErbB signaling pathway    Rap1 signaling pathway    Chemokine signaling pathway    Focal adhesion    Fc gamma R-mediated phagocytosis    Neurotrophin signaling pathway    Regulation of actin cytoskeleton    Insulin signaling pathway    Bacterial invasion of epithelial cells    Shigellosis    Pathways in cancer    MicroRNAs in cancer    Renal cell carcinoma    Chronic myeloid leukemia   
NDEx NetworkCRKL
Atlas of Cancer Signalling NetworkCRKL
Wikipedia pathwaysCRKL
Orthology - Evolution
OrthoDB1399
GeneTree (enSembl)ENSG00000099942
Phylogenetic Trees/Animal Genes : TreeFamCRKL
Homologs : HomoloGeneCRKL
Homology/Alignments : Family Browser (UCSC)CRKL
Gene fusions - Rearrangements
Fusion: TCGADGCR8 22q11.21 CRKL 22q11.21 LUSC
Polymorphisms : SNP, variants
NCBI Variation ViewerCRKL [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CRKL
dbVarCRKL
ClinVarCRKL
1000_GenomesCRKL 
Exome Variant ServerCRKL
ExAC (Exome Aggregation Consortium)CRKL (select the gene name)
Genetic variants : HAPMAP1399
Genomic Variants (DGV)CRKL [DGVbeta]
Mutations
ICGC Data PortalCRKL 
TCGA Data PortalCRKL 
Broad Tumor PortalCRKL
OASIS PortalCRKL [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCRKL 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch CRKL
DgiDB (Drug Gene Interaction Database)CRKL
DoCM (Curated mutations)CRKL (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CRKL (select a term)
intoGenCRKL
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)22:21271714-21308037  ENSG00000099942
CONAN: Copy Number AnalysisCRKL 
Mutations and Diseases : HGMDCRKL
OMIM602007   
MedgenCRKL
Genetic Testing Registry CRKL
NextProtP46109 [Medical]
TSGene1399
GENETestsCRKL
Huge Navigator CRKL [HugePedia]
snp3D : Map Gene to Disease1399
BioCentury BCIQCRKL
ClinGenCRKL
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD1399
Chemical/Pharm GKB GenePA26881
Clinical trialCRKL
Miscellaneous
canSAR (ICR)CRKL (select the gene name)
Probes
Litterature
PubMed187 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineCRKL
EVEXCRKL
GoPubMedCRKL
iHOPCRKL
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Sep 19 18:44:06 CEST 2016
Home   Genes   Leukemias   Solid Tumours   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.