Atlas of Genetics and Cytogenetics in Oncology and Haematology

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CRKL (CRK like proto-oncogene, adaptor protein)

Identity

Alias (NCBI)-
HGNC (Hugo) CRKL
HGNC Previous namev-crk avian sarcoma virus CT10 oncogene homolog-like
LocusID (NCBI) 1399
Atlas_Id 40150
Location 22q11.21  [Link to chromosome band 22q11]
Location_base_pair Starts at 20917407 and ends at 20953747 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CRKL (22q11.21) / AP3D1 (19p13.3)CRKL (22q11.21) / ARHGEF6 (Xq26.3)CRKL (22q11.21) / MAPK1 (22q11.21)
CRKL (22q11.21) / SNAP29 (22q11.21)CRKL (22q11.21) / SPTBN1 (2p16.2)DGCR8 (22q11.21) / CRKL (22q11.21)
KLHL7 (7p15.3) / CRKL (22q11.21)DGCR8 22q11.21 / CRKL 22q11.21

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  Chronic myelogenous leukaemia (CML)

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 2 ]
  CRKL/MAPK1 (22q11)
DGCR8/CRKL (22q11)

External links

Nomenclature
HGNC (Hugo)CRKL   2363
Cards
Entrez_Gene (NCBI)CRKL    CRK like proto-oncogene, adaptor protein
Aliases
GeneCards (Weizmann)CRKL
Ensembl hg19 (Hinxton)ENSG00000099942 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000099942 [Gene_View]  ENSG00000099942 [Sequence]  chr22:20917407-20953747 [Contig_View]  CRKL [Vega]
ICGC DataPortalENSG00000099942
TCGA cBioPortalCRKL
AceView (NCBI)CRKL
Genatlas (Paris)CRKL
SOURCE (Princeton)CRKL
Genetics Home Reference (NIH)CRKL
Genomic and cartography
GoldenPath hg38 (UCSC)CRKL  -     chr22:20917407-20953747 +  22q11.21   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)CRKL  -     22q11.21   [Description]    (hg19-Feb_2009)
GoldenPathCRKL - 22q11.21 [CytoView hg19]  CRKL - 22q11.21 [CytoView hg38]
ImmunoBaseENSG00000099942
genome Data Viewer NCBICRKL [Mapview hg19]  
OMIM602007   
Gene and transcription
Genbank (Entrez)AA844269 AK000311 AK292909 BC026248 BC033281
RefSeq transcript (Entrez)NM_005207
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)CRKL
Alternative Splicing GalleryENSG00000099942
Gene ExpressionCRKL [ NCBI-GEO ]   CRKL [ EBI - ARRAY_EXPRESS ]   CRKL [ SEEK ]   CRKL [ MEM ]
Gene Expression Viewer (FireBrowse)CRKL [ Firebrowse - Broad ]
GenevisibleExpression of CRKL in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)1399
GTEX Portal (Tissue expression)CRKL
Human Protein AtlasENSG00000099942-CRKL [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP46109   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP46109  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP46109
Splice isoforms : SwissVarP46109
PhosPhoSitePlusP46109
Domaine pattern : Prosite (Expaxy)SH2 (PS50001)    SH3 (PS50002)   
Domains : Interpro (EBI)CRK_SH3_C    CRK_SH3_N    SH2    SH2_dom_sf    SH3-like_dom_sf    SH3_domain   
Domain families : Pfam (Sanger)SH2 (PF00017)    SH3_1 (PF00018)    SH3_2 (PF07653)   
Domain families : Pfam (NCBI)pfam00017    pfam00018    pfam07653   
Domain families : Smart (EMBL)SH2 (SM00252)  SH3 (SM00326)  
Conserved Domain (NCBI)CRKL
Blocks (Seattle)CRKL
PDB (RSDB)2BZX    2BZY    2DBK    2EO3    2LQN    2LQW   
PDB Europe2BZX    2BZY    2DBK    2EO3    2LQN    2LQW   
PDB (PDBSum)2BZX    2BZY    2DBK    2EO3    2LQN    2LQW   
PDB (IMB)2BZX    2BZY    2DBK    2EO3    2LQN    2LQW   
Structural Biology KnowledgeBase2BZX    2BZY    2DBK    2EO3    2LQN    2LQW   
SCOP (Structural Classification of Proteins)2BZX    2BZY    2DBK    2EO3    2LQN    2LQW   
CATH (Classification of proteins structures)2BZX    2BZY    2DBK    2EO3    2LQN    2LQW   
SuperfamilyP46109
Human Protein Atlas [tissue]ENSG00000099942-CRKL [tissue]
Peptide AtlasP46109
HPRD03596
IPIIPI00004839   
Protein Interaction databases
DIP (DOE-UCLA)P46109
IntAct (EBI)P46109
BioGRIDCRKL
STRING (EMBL)CRKL
ZODIACCRKL
Ontologies - Pathways
QuickGOP46109
Ontology : AmiGOactivation of MAPKK activity  activation of MAPK activity  regulation of cell growth  blood vessel development  urogenital system development  neuron migration  B cell apoptotic process  phosphotyrosine residue binding  negative regulation of protein phosphorylation  positive regulation of protein phosphorylation  outflow tract morphogenesis  RNA binding  protein binding  nucleoplasm  cytosol  cytosol  lipid metabolic process  JNK cascade  Ras protein signal transduction  spermatogenesis  single fertilization  synapse assembly  positive regulation of cell proliferation  fibroblast growth factor receptor signaling pathway  male gonad development  anterior/posterior pattern specification  negative regulation of gene expression  dendrite development  cytokine-mediated signaling pathway  hippocampus development  cerebral cortex development  establishment of cell polarity  neuromuscular junction  protein-containing complex  regulation of cell adhesion mediated by integrin  intracellular signal transduction  helper T cell diapedesis  reelin-mediated signaling pathway  identical protein binding  cadherin binding  positive regulation of Ras protein signal transduction  retinoic acid receptor signaling pathway  thymus development  regulation of dendrite development  T cell receptor signaling pathway  parathyroid gland development  cell chemotaxis  pharynx development  positive regulation of ERK1 and ERK2 cascade  cellular response to transforming growth factor beta stimulus  endothelin receptor signaling pathway  activation of GTPase activity  acetylcholine receptor signaling pathway  cerebellar neuron development  cellular response to interleukin-7  extrinsic component of postsynaptic membrane  positive regulation of substrate adhesion-dependent cell spreading  positive regulation of glial cell migration  regulation of skeletal muscle acetylcholine-gated channel clustering  cranial skeletal system development  regulation of T cell migration  
Ontology : EGO-EBIactivation of MAPKK activity  activation of MAPK activity  regulation of cell growth  blood vessel development  urogenital system development  neuron migration  B cell apoptotic process  phosphotyrosine residue binding  negative regulation of protein phosphorylation  positive regulation of protein phosphorylation  outflow tract morphogenesis  RNA binding  protein binding  nucleoplasm  cytosol  cytosol  lipid metabolic process  JNK cascade  Ras protein signal transduction  spermatogenesis  single fertilization  synapse assembly  positive regulation of cell proliferation  fibroblast growth factor receptor signaling pathway  male gonad development  anterior/posterior pattern specification  negative regulation of gene expression  dendrite development  cytokine-mediated signaling pathway  hippocampus development  cerebral cortex development  establishment of cell polarity  neuromuscular junction  protein-containing complex  regulation of cell adhesion mediated by integrin  intracellular signal transduction  helper T cell diapedesis  reelin-mediated signaling pathway  identical protein binding  cadherin binding  positive regulation of Ras protein signal transduction  retinoic acid receptor signaling pathway  thymus development  regulation of dendrite development  T cell receptor signaling pathway  parathyroid gland development  cell chemotaxis  pharynx development  positive regulation of ERK1 and ERK2 cascade  cellular response to transforming growth factor beta stimulus  endothelin receptor signaling pathway  activation of GTPase activity  acetylcholine receptor signaling pathway  cerebellar neuron development  cellular response to interleukin-7  extrinsic component of postsynaptic membrane  positive regulation of substrate adhesion-dependent cell spreading  positive regulation of glial cell migration  regulation of skeletal muscle acetylcholine-gated channel clustering  cranial skeletal system development  regulation of T cell migration  
Pathways : KEGGMAPK signaling pathway    ErbB signaling pathway    Rap1 signaling pathway    Chemokine signaling pathway    Focal adhesion    Fc gamma R-mediated phagocytosis    Neurotrophin signaling pathway    Regulation of actin cytoskeleton    Insulin signaling pathway    Bacterial invasion of epithelial cells    Shigellosis    Pathways in cancer    MicroRNAs in cancer    Renal cell carcinoma    Chronic myeloid leukemia   
NDEx NetworkCRKL
Atlas of Cancer Signalling NetworkCRKL
Wikipedia pathwaysCRKL
Orthology - Evolution
OrthoDB1399
GeneTree (enSembl)ENSG00000099942
Phylogenetic Trees/Animal Genes : TreeFamCRKL
HOGENOMP46109
Homologs : HomoloGeneCRKL
Homology/Alignments : Family Browser (UCSC)CRKL
Gene fusions - Rearrangements
Fusion : MitelmanCRKL/MAPK1 [22q11.21/22q11.21]  
Fusion : MitelmanDGCR8/CRKL [22q11.21/22q11.21]  
Fusion PortalDGCR8 22q11.21 CRKL 22q11.21 LUSC
Fusion : QuiverCRKL
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCRKL [hg38]
dbVarCRKL
ClinVarCRKL
MonarchCRKL
1000_GenomesCRKL 
Exome Variant ServerCRKL
GNOMAD BrowserENSG00000099942
Varsome BrowserCRKL
Genomic Variants (DGV)CRKL [DGVbeta]
DECIPHERCRKL [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisCRKL 
Mutations
ICGC Data PortalCRKL 
TCGA Data PortalCRKL 
Broad Tumor PortalCRKL
OASIS PortalCRKL [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCRKL  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DCRKL
Mutations and Diseases : HGMDCRKL
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch CRKL
DgiDB (Drug Gene Interaction Database)CRKL
DoCM (Curated mutations)CRKL (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CRKL (select a term)
intoGenCRKL
Cancer3DCRKL(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM602007   
Orphanet19875   
DisGeNETCRKL
MedgenCRKL
Genetic Testing Registry CRKL
NextProtP46109 [Medical]
GENETestsCRKL
Target ValidationCRKL
Huge Navigator CRKL [HugePedia]
ClinGenCRKL (curated)
Clinical trials, drugs, therapy
MyCancerGenomeCRKL
Protein Interactions : CTD
Pharm GKB GenePA26881
PharosP46109
Clinical trialCRKL
Miscellaneous
canSAR (ICR)CRKL (select the gene name)
HarmonizomeCRKL
DataMed IndexCRKL
Probes
Litterature
PubMed232 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXCRKL
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Fri Jan 1 18:11:25 CET 2021
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