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CRKL (v-crk avian sarcoma virus CT10 oncogene homolog-like)

Identity

Other names-
HGNC (Hugo) CRKL
LocusID (NCBI) 1399
Location 22q11.21
Location_base_pair Starts at 21271714 and ends at 21308037 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Leukemias implicated (Data extracted from papers in the Atlas)

Leukemias 11q23ChildAMLID1615

External links

Nomenclature
HGNC (Hugo)CRKL   2363
Cards
Entrez_Gene (NCBI)CRKL  1399  v-crk avian sarcoma virus CT10 oncogene homolog-like
GeneCards (Weizmann)CRKL
Ensembl hg19 (Hinxton)ENSG00000099942 [Gene_View]  chr22:21271714-21308037 [Contig_View]  CRKL [Vega]
Ensembl hg38 (Hinxton)ENSG00000099942 [Gene_View]  chr22:21271714-21308037 [Contig_View]  CRKL [Vega]
ICGC DataPortalENSG00000099942
cBioPortalCRKL
AceView (NCBI)CRKL
Genatlas (Paris)CRKL
WikiGenes1399
SOURCE (Princeton)CRKL
Genomic and cartography
GoldenPath hg19 (UCSC)CRKL  -     chr22:21271714-21308037 +  22q11.21   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)CRKL  -     22q11.21   [Description]    (hg38-Dec_2013)
EnsemblCRKL - 22q11.21 [CytoView hg19]  CRKL - 22q11.21 [CytoView hg38]
Mapping of homologs : NCBICRKL [Mapview hg19]  CRKL [Mapview hg38]
OMIM602007   
Gene and transcription
Genbank (Entrez)AA844269 AK000311 AK292909 BC026248 BC033281
RefSeq transcript (Entrez)NM_005207
RefSeq genomic (Entrez)AC_000154 NC_000022 NC_018933 NG_016354 NT_011520 NW_001838740 NW_004929430
Consensus coding sequences : CCDS (NCBI)CRKL
Cluster EST : UnigeneHs.5613 [ NCBI ]
CGAP (NCI)Hs.5613
Alternative Splicing : Fast-db (Paris)GSHG0019848
Alternative Splicing GalleryENSG00000099942
Gene ExpressionCRKL [ NCBI-GEO ]     CRKL [ SEEK ]   CRKL [ MEM ]
SOURCE (Princeton)Expression in : [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP46109 (Uniprot)
NextProtP46109  [Medical]
With graphics : InterProP46109
Splice isoforms : SwissVarP46109 (Swissvar)
Domaine pattern : Prosite (Expaxy)SH2 (PS50001)    SH3 (PS50002)   
Domains : Interpro (EBI)SH2    SH3_2    SH3_domain   
Related proteins : CluSTrP46109
Domain families : Pfam (Sanger)SH2 (PF00017)    SH3_1 (PF00018)    SH3_2 (PF07653)   
Domain families : Pfam (NCBI)pfam00017    pfam00018    pfam07653   
Domain families : Smart (EMBL)SH2 (SM00252)  SH3 (SM00326)  
DMDM Disease mutations1399
Blocks (Seattle)P46109
PDB (SRS)2BZX    2BZY    2DBK    2EO3    2LQN    2LQW   
PDB (PDBSum)2BZX    2BZY    2DBK    2EO3    2LQN    2LQW   
PDB (IMB)2BZX    2BZY    2DBK    2EO3    2LQN    2LQW   
PDB (RSDB)2BZX    2BZY    2DBK    2EO3    2LQN    2LQW   
Human Protein AtlasENSG00000099942
Peptide AtlasP46109
HPRD03596
IPIIPI00004839   
Protein Interaction databases
DIP (DOE-UCLA)P46109
IntAct (EBI)P46109
FunCoupENSG00000099942
BioGRIDCRKL
IntegromeDBCRKL
STRING (EMBL)CRKL
Ontologies - Pathways
QuickGOP46109
Ontology : AmiGOactivation of MAPKK activity  blood vessel development  signal transducer activity  SH3/SH2 adaptor activity  protein binding  endosome  cytosol  JNK cascade  Ras protein signal transduction  heart development  organ morphogenesis  anterior/posterior pattern specification  positive regulation of signal transduction  intracellular signal transduction  poly(A) RNA binding  neurotrophin TRK receptor signaling pathway  thymus development  parathyroid gland development  extracellular vesicular exosome  
Ontology : EGO-EBIactivation of MAPKK activity  blood vessel development  signal transducer activity  SH3/SH2 adaptor activity  protein binding  endosome  cytosol  JNK cascade  Ras protein signal transduction  heart development  organ morphogenesis  anterior/posterior pattern specification  positive regulation of signal transduction  intracellular signal transduction  poly(A) RNA binding  neurotrophin TRK receptor signaling pathway  thymus development  parathyroid gland development  extracellular vesicular exosome  
Pathways : BIOCARTAIntegrin Signaling Pathway [Genes]    Signaling of Hepatocyte Growth Factor Receptor [Genes]    Inhibition of Cellular Proliferation by Gleevec [Genes]    Links between Pyk2 and Map Kinases [Genes]    IL-2 Receptor Beta Chain in T cell Activation [Genes]   
Pathways : KEGGMAPK signaling pathway    ErbB signaling pathway    Rap1 signaling pathway    Chemokine signaling pathway    Focal adhesion    Fc gamma R-mediated phagocytosis    Neurotrophin signaling pathway    Regulation of actin cytoskeleton    Insulin signaling pathway    Bacterial invasion of epithelial cells    Shigellosis    Pathways in cancer    MicroRNAs in cancer    Renal cell carcinoma    Chronic myeloid leukemia   
Protein Interaction DatabaseCRKL
DoCM (Curated mutations)CRKL
Wikipedia pathwaysCRKL
Gene fusion - rearrangements
Polymorphisms : SNP, variants
NCBI Variation ViewerCRKL [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CRKL
dbVarCRKL
ClinVarCRKL
1000_GenomesCRKL 
Exome Variant ServerCRKL
SNP (GeneSNP Utah)CRKL
SNP : HGBaseCRKL
Genetic variants : HAPMAPCRKL
Genomic VariantsCRKL  CRKL [DGVbeta]
Mutations
ICGC Data PortalENSG00000099942 
Somatic Mutations in Cancer : COSMICCRKL 
CONAN: Copy Number AnalysisCRKL 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)22:21271714-21308037
Mutations and Diseases : HGMDCRKL
OMIM602007   
MedgenCRKL
NextProtP46109 [Medical]
GENETestsCRKL
Disease Genetic AssociationCRKL
Huge Navigator CRKL [HugePedia]  CRKL [HugeCancerGEM]
snp3D : Map Gene to Disease1399
DGIdb (Drug Gene Interaction db)CRKL
General knowledge
Homologs : HomoloGeneCRKL
Homology/Alignments : Family Browser (UCSC)CRKL
Phylogenetic Trees/Animal Genes : TreeFamCRKL
Chemical/Protein Interactions : CTD1399
Chemical/Pharm GKB GenePA26881
Clinical trialCRKL
Cancer Resource (Charite)ENSG00000099942
Other databases
Probes
Litterature
PubMed157 Pubmed reference(s) in Entrez
CoreMineCRKL
GoPubMedCRKL
iHOPCRKL
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated12-2014Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Sat Dec 20 20:59:24 CET 2014
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