Atlas of Genetics and Cytogenetics in Oncology and Haematology

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CRKL (CRK like proto-oncogene, adaptor protein)

Identity

Alias_namesv-crk avian sarcoma virus CT10 oncogene homolog-like
Other alias-
HGNC (Hugo) CRKL
LocusID (NCBI) 1399
Atlas_Id 40150
Location 22q11.21  [Link to chromosome band 22q11]
Location_base_pair Starts at 20917426 and ends at 20953749 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CRKL (22q11.21) / AP3D1 (19p13.3)CRKL (22q11.21) / ARHGEF6 (Xq26.3)CRKL (22q11.21) / MAPK1 (22q11.21)
CRKL (22q11.21) / SNAP29 (22q11.21)CRKL (22q11.21) / SPTBN1 (2p16.2)DGCR8 (22q11.21) / CRKL (22q11.21)
KLHL7 (7p15.3) / CRKL (22q11.21)DGCR8 22q11.21 / CRKL 22q11.21

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  Chronic myelogenous leukaemia (CML)

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 2 ]
  CRKL/MAPK1 (22q11)
DGCR8/CRKL (22q11)

External links

Nomenclature
HGNC (Hugo)CRKL   2363
Cards
Entrez_Gene (NCBI)CRKL  1399  CRK like proto-oncogene, adaptor protein
Aliases
GeneCards (Weizmann)CRKL
Ensembl hg19 (Hinxton)ENSG00000099942 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000099942 [Gene_View]  ENSG00000099942 [Sequence]  chr22:20917426-20953749 [Contig_View]  CRKL [Vega]
ICGC DataPortalENSG00000099942
TCGA cBioPortalCRKL
AceView (NCBI)CRKL
Genatlas (Paris)CRKL
WikiGenes1399
SOURCE (Princeton)CRKL
Genetics Home Reference (NIH)CRKL
Genomic and cartography
GoldenPath hg38 (UCSC)CRKL  -     chr22:20917426-20953749 +  22q11.21   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)CRKL  -     22q11.21   [Description]    (hg19-Feb_2009)
EnsemblCRKL - 22q11.21 [CytoView hg19]  CRKL - 22q11.21 [CytoView hg38]
Mapping of homologs : NCBICRKL [Mapview hg19]  CRKL [Mapview hg38]
OMIM602007   
Gene and transcription
Genbank (Entrez)AA844269 AK000311 AK292909 BC026248 BC033281
RefSeq transcript (Entrez)NM_005207
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)CRKL
Cluster EST : UnigeneHs.5613 [ NCBI ]
CGAP (NCI)Hs.5613
Alternative Splicing GalleryENSG00000099942
Gene ExpressionCRKL [ NCBI-GEO ]   CRKL [ EBI - ARRAY_EXPRESS ]   CRKL [ SEEK ]   CRKL [ MEM ]
Gene Expression Viewer (FireBrowse)CRKL [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)1399
GTEX Portal (Tissue expression)CRKL
Human Protein AtlasENSG00000099942-CRKL [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP46109   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP46109  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP46109
Splice isoforms : SwissVarP46109
PhosPhoSitePlusP46109
Domaine pattern : Prosite (Expaxy)SH2 (PS50001)    SH3 (PS50002)   
Domains : Interpro (EBI)CRK_SH3_C    CRK_SH3_N    SH2    SH2_dom_sf    SH3-like_dom_sf    SH3_domain   
Domain families : Pfam (Sanger)SH2 (PF00017)    SH3_1 (PF00018)    SH3_2 (PF07653)   
Domain families : Pfam (NCBI)pfam00017    pfam00018    pfam07653   
Domain families : Smart (EMBL)SH2 (SM00252)  SH3 (SM00326)  
Conserved Domain (NCBI)CRKL
DMDM Disease mutations1399
Blocks (Seattle)CRKL
PDB (SRS)2BZX    2BZY    2DBK    2EO3    2LQN    2LQW   
PDB (PDBSum)2BZX    2BZY    2DBK    2EO3    2LQN    2LQW   
PDB (IMB)2BZX    2BZY    2DBK    2EO3    2LQN    2LQW   
PDB (RSDB)2BZX    2BZY    2DBK    2EO3    2LQN    2LQW   
Structural Biology KnowledgeBase2BZX    2BZY    2DBK    2EO3    2LQN    2LQW   
SCOP (Structural Classification of Proteins)2BZX    2BZY    2DBK    2EO3    2LQN    2LQW   
CATH (Classification of proteins structures)2BZX    2BZY    2DBK    2EO3    2LQN    2LQW   
SuperfamilyP46109
Human Protein Atlas [tissue]ENSG00000099942-CRKL [tissue]
Peptide AtlasP46109
HPRD03596
IPIIPI00004839   
Protein Interaction databases
DIP (DOE-UCLA)P46109
IntAct (EBI)P46109
FunCoupENSG00000099942
BioGRIDCRKL
STRING (EMBL)CRKL
ZODIACCRKL
Ontologies - Pathways
QuickGOP46109
Ontology : AmiGOactivation of MAPKK activity  blood vessel development  phosphotyrosine residue binding  negative regulation of protein phosphorylation  positive regulation of protein phosphorylation  RNA binding  SH3/SH2 adaptor activity  protein binding  nucleoplasm  endosome  cytosol  cytosol  JNK cascade  Ras protein signal transduction  heart development  positive regulation of cell proliferation  animal organ morphogenesis  anterior/posterior pattern specification  negative regulation of gene expression  cytokine-mediated signaling pathway  intracellular signal transduction  identical protein binding  cadherin binding  thymus development  parathyroid gland development  positive regulation of ERK1 and ERK2 cascade  cellular response to transforming growth factor beta stimulus  positive regulation of substrate adhesion-dependent cell spreading  positive regulation of glial cell migration  
Ontology : EGO-EBIactivation of MAPKK activity  blood vessel development  phosphotyrosine residue binding  negative regulation of protein phosphorylation  positive regulation of protein phosphorylation  RNA binding  SH3/SH2 adaptor activity  protein binding  nucleoplasm  endosome  cytosol  cytosol  JNK cascade  Ras protein signal transduction  heart development  positive regulation of cell proliferation  animal organ morphogenesis  anterior/posterior pattern specification  negative regulation of gene expression  cytokine-mediated signaling pathway  intracellular signal transduction  identical protein binding  cadherin binding  thymus development  parathyroid gland development  positive regulation of ERK1 and ERK2 cascade  cellular response to transforming growth factor beta stimulus  positive regulation of substrate adhesion-dependent cell spreading  positive regulation of glial cell migration  
Pathways : KEGG   
NDEx NetworkCRKL
Atlas of Cancer Signalling NetworkCRKL
Wikipedia pathwaysCRKL
Orthology - Evolution
OrthoDB1399
GeneTree (enSembl)ENSG00000099942
Phylogenetic Trees/Animal Genes : TreeFamCRKL
HOVERGENP46109
HOGENOMP46109
Homologs : HomoloGeneCRKL
Homology/Alignments : Family Browser (UCSC)CRKL
Gene fusions - Rearrangements
Fusion : MitelmanCRKL/MAPK1 [22q11.21/22q11.21]  
Fusion : MitelmanDGCR8/CRKL [22q11.21/22q11.21]  [t(22;22)(q11;q11)]  
Fusion PortalDGCR8 22q11.21 CRKL 22q11.21 LUSC
Fusion : QuiverCRKL
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCRKL [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CRKL
dbVarCRKL
ClinVarCRKL
1000_GenomesCRKL 
Exome Variant ServerCRKL
ExAC (Exome Aggregation Consortium)ENSG00000099942
GNOMAD BrowserENSG00000099942
Varsome BrowserCRKL
Genetic variants : HAPMAP1399
Genomic Variants (DGV)CRKL [DGVbeta]
DECIPHERCRKL [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisCRKL 
Mutations
ICGC Data PortalCRKL 
TCGA Data PortalCRKL 
Broad Tumor PortalCRKL
OASIS PortalCRKL [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCRKL  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDCRKL
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch CRKL
DgiDB (Drug Gene Interaction Database)CRKL
DoCM (Curated mutations)CRKL (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CRKL (select a term)
intoGenCRKL
Cancer3DCRKL(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM602007   
Orphanet19875   
DisGeNETCRKL
MedgenCRKL
Genetic Testing Registry CRKL
NextProtP46109 [Medical]
TSGene1399
GENETestsCRKL
Target ValidationCRKL
Huge Navigator CRKL [HugePedia]
snp3D : Map Gene to Disease1399
BioCentury BCIQCRKL
ClinGenCRKL (curated)
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD1399
Chemical/Pharm GKB GenePA26881
Clinical trialCRKL
Miscellaneous
canSAR (ICR)CRKL (select the gene name)
Probes
Litterature
PubMed206 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineCRKL
EVEXCRKL
GoPubMedCRKL
iHOPCRKL
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Aug 27 11:17:13 CEST 2018
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