Atlas of Genetics and Cytogenetics in Oncology and Haematology


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CRLF1 (cytokine receptor like factor 1)

Identity

Alias_symbol (synonym)CLF-1
CLF
CISS
CISS1
Other aliasNR6
zcytor5
HGNC (Hugo) CRLF1
LocusID (NCBI) 9244
Atlas_Id 56054
Location 19p13.11  [Link to chromosome band 19p13]
Location_base_pair Starts at 18593225 and ends at 18606850 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
ELL (19p13.11) / CRLF1 (19p13.11)LRWD1 (7q22.1) / CRLF1 (19p13.11)TANC1 (2q24.2) / CRLF1 (19p13.11)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)CRLF1   2364
Cards
Entrez_Gene (NCBI)CRLF1  9244  cytokine receptor like factor 1
AliasesCISS; CISS1; CLF; CLF-1; 
NR6; zcytor5
GeneCards (Weizmann)CRLF1
Ensembl hg19 (Hinxton)ENSG00000006016 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000006016 [Gene_View]  chr19:18593225-18606850 [Contig_View]  CRLF1 [Vega]
ICGC DataPortalENSG00000006016
TCGA cBioPortalCRLF1
AceView (NCBI)CRLF1
Genatlas (Paris)CRLF1
WikiGenes9244
SOURCE (Princeton)CRLF1
Genetics Home Reference (NIH)CRLF1
Genomic and cartography
GoldenPath hg38 (UCSC)CRLF1  -     chr19:18593225-18606850 -  19p13.11   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)CRLF1  -     19p13.11   [Description]    (hg19-Feb_2009)
EnsemblCRLF1 - 19p13.11 [CytoView hg19]  CRLF1 - 19p13.11 [CytoView hg38]
Mapping of homologs : NCBICRLF1 [Mapview hg19]  CRLF1 [Mapview hg38]
OMIM272430   604237   
Gene and transcription
Genbank (Entrez)AF059293 AF073515 AF178684 AY358291 BC044634
RefSeq transcript (Entrez)NM_004750
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)CRLF1
Cluster EST : UnigeneHs.114948 [ NCBI ]
CGAP (NCI)Hs.114948
Alternative Splicing GalleryENSG00000006016
Gene ExpressionCRLF1 [ NCBI-GEO ]   CRLF1 [ EBI - ARRAY_EXPRESS ]   CRLF1 [ SEEK ]   CRLF1 [ MEM ]
Gene Expression Viewer (FireBrowse)CRLF1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)9244
GTEX Portal (Tissue expression)CRLF1
Protein : pattern, domain, 3D structure
UniProt/SwissProtO75462   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO75462  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO75462
Splice isoforms : SwissVarO75462
PhosPhoSitePlusO75462
Domaine pattern : Prosite (Expaxy)FN3 (PS50853)   
Domains : Interpro (EBI)FN3_dom    Growth/epo_recpt_lig-bind    Ig-like_dom    Ig-like_fold   
Domain families : Pfam (Sanger)EpoR_lig-bind (PF09067)    fn3 (PF00041)   
Domain families : Pfam (NCBI)pfam09067    pfam00041   
Domain families : Smart (EMBL)FN3 (SM00060)  
Conserved Domain (NCBI)CRLF1
DMDM Disease mutations9244
Blocks (Seattle)CRLF1
SuperfamilyO75462
Human Protein AtlasENSG00000006016
Peptide AtlasO75462
HPRD09177
IPIIPI00289561   
Protein Interaction databases
DIP (DOE-UCLA)O75462
IntAct (EBI)O75462
FunCoupENSG00000006016
BioGRIDCRLF1
STRING (EMBL)CRLF1
ZODIACCRLF1
Ontologies - Pathways
QuickGOO75462
Ontology : AmiGOureteric bud development  receptor activity  cytokine activity  ciliary neurotrophic factor receptor binding  protein binding  extracellular region  extracellular space  positive regulation of cell proliferation  cytokine binding  negative regulation of neuron apoptotic process  protein heterodimerization activity  CRLF-CLCF1 complex  negative regulation of motor neuron apoptotic process  
Ontology : EGO-EBIureteric bud development  receptor activity  cytokine activity  ciliary neurotrophic factor receptor binding  protein binding  extracellular region  extracellular space  positive regulation of cell proliferation  cytokine binding  negative regulation of neuron apoptotic process  protein heterodimerization activity  CRLF-CLCF1 complex  negative regulation of motor neuron apoptotic process  
NDEx NetworkCRLF1
Atlas of Cancer Signalling NetworkCRLF1
Wikipedia pathwaysCRLF1
Orthology - Evolution
OrthoDB9244
GeneTree (enSembl)ENSG00000006016
Phylogenetic Trees/Animal Genes : TreeFamCRLF1
HOVERGENO75462
HOGENOMO75462
Homologs : HomoloGeneCRLF1
Homology/Alignments : Family Browser (UCSC)CRLF1
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCRLF1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CRLF1
dbVarCRLF1
ClinVarCRLF1
1000_GenomesCRLF1 
Exome Variant ServerCRLF1
ExAC (Exome Aggregation Consortium)CRLF1 (select the gene name)
Genetic variants : HAPMAP9244
Genomic Variants (DGV)CRLF1 [DGVbeta]
DECIPHERCRLF1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisCRLF1 
Mutations
ICGC Data PortalCRLF1 
TCGA Data PortalCRLF1 
Broad Tumor PortalCRLF1
OASIS PortalCRLF1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCRLF1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDCRLF1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch CRLF1
DgiDB (Drug Gene Interaction Database)CRLF1
DoCM (Curated mutations)CRLF1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CRLF1 (select a term)
intoGenCRLF1
Cancer3DCRLF1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM272430    604237   
Orphanet17149    1701   
MedgenCRLF1
Genetic Testing Registry CRLF1
NextProtO75462 [Medical]
TSGene9244
GENETestsCRLF1
Target ValidationCRLF1
Huge Navigator CRLF1 [HugePedia]
snp3D : Map Gene to Disease9244
BioCentury BCIQCRLF1
ClinGenCRLF1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD9244
Chemical/Pharm GKB GenePA26882
Clinical trialCRLF1
Miscellaneous
canSAR (ICR)CRLF1 (select the gene name)
Probes
Litterature
PubMed22 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineCRLF1
EVEXCRLF1
GoPubMedCRLF1
iHOPCRLF1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Aug 1 16:58:39 CEST 2017

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