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CRLF1 (cytokine receptor like factor 1)

Identity

Alias (NCBI)CISS
CISS1
CLF
CLF-1
NR6
zcytor5
HGNC (Hugo) CRLF1
HGNC Alias symbCLF-1
CLF
CISS
CISS1
HGNC Alias namecold-induced sweating syndrome
LocusID (NCBI) 9244
Atlas_Id 56054
Location 19p13.11  [Link to chromosome band 19p13]
Location_base_pair Starts at 18593237 and ends at 18606799 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ELL (19p13.11)::CRLF1 (19p13.11)LRWD1 (7q22.1)::CRLF1 (19p13.11)TANC1 (2q24.2)::CRLF1 (19p13.11)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)CRLF1   2364
Cards
Entrez_Gene (NCBI)CRLF1    cytokine receptor like factor 1
AliasesCISS; CISS1; CLF; CLF-1; 
NR6; zcytor5
GeneCards (Weizmann)CRLF1
Ensembl hg19 (Hinxton)ENSG00000006016 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000006016 [Gene_View]  ENSG00000006016 [Sequence]  chr19:18593237-18606799 [Contig_View]  CRLF1 [Vega]
ICGC DataPortalENSG00000006016
TCGA cBioPortalCRLF1
AceView (NCBI)CRLF1
Genatlas (Paris)CRLF1
SOURCE (Princeton)CRLF1
Genetics Home Reference (NIH)CRLF1
Genomic and cartography
GoldenPath hg38 (UCSC)CRLF1  -     chr19:18593237-18606799 -  19p13.11   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)CRLF1  -     19p13.11   [Description]    (hg19-Feb_2009)
GoldenPathCRLF1 - 19p13.11 [CytoView hg19]  CRLF1 - 19p13.11 [CytoView hg38]
ImmunoBaseENSG00000006016
Genome Data Viewer NCBICRLF1 [Mapview hg19]  
OMIM272430   604237   
Gene and transcription
Genbank (Entrez)AF059293 AF073515 AF178684 AY358291 BC044634
RefSeq transcript (Entrez)NM_004750
Consensus coding sequences : CCDS (NCBI)CRLF1
Gene ExpressionCRLF1 [ NCBI-GEO ]   CRLF1 [ EBI - ARRAY_EXPRESS ]   CRLF1 [ SEEK ]   CRLF1 [ MEM ]
Gene Expression Viewer (FireBrowse)CRLF1 [ Firebrowse - Broad ]
GenevisibleExpression of CRLF1 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)9244
GTEX Portal (Tissue expression)CRLF1
Human Protein AtlasENSG00000006016-CRLF1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO75462   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO75462  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO75462
PhosPhoSitePlusO75462
Domaine pattern : Prosite (Expaxy)FN3 (PS50853)   
Domains : Interpro (EBI)FN3_dom    FN3_sf    Growth/epo_recpt_lig-bind    Ig-like_dom_sf    Ig-like_fold   
Domain families : Pfam (Sanger)EpoR_lig-bind (PF09067)    fn3 (PF00041)   
Domain families : Pfam (NCBI)pfam09067    pfam00041   
Domain families : Smart (EMBL)FN3 (SM00060)  
Conserved Domain (NCBI)CRLF1
SuperfamilyO75462
AlphaFold pdb e-kbO75462   
Human Protein Atlas [tissue]ENSG00000006016-CRLF1 [tissue]
HPRD09177
Protein Interaction databases
DIP (DOE-UCLA)O75462
IntAct (EBI)O75462
BioGRIDCRLF1
STRING (EMBL)CRLF1
ZODIACCRLF1
Ontologies - Pathways
QuickGOO75462
Ontology : AmiGOureteric bud development  cytokine receptor activity  cytokine activity  ciliary neurotrophic factor receptor binding  protein binding  extracellular region  extracellular space  cytosol  positive regulation of cell population proliferation  external side of plasma membrane  cytokine-mediated signaling pathway  cytokine-mediated signaling pathway  cytokine binding  cytokine binding  positive regulation of tyrosine phosphorylation of STAT protein  positive regulation of tyrosine phosphorylation of STAT protein  receptor complex  negative regulation of neuron apoptotic process  interleukin-27-mediated signaling pathway  CRLF-CLCF1 complex  CRLF-CLCF1 complex  negative regulation of motor neuron apoptotic process  
Ontology : EGO-EBIureteric bud development  cytokine receptor activity  cytokine activity  ciliary neurotrophic factor receptor binding  protein binding  extracellular region  extracellular space  cytosol  positive regulation of cell population proliferation  external side of plasma membrane  cytokine-mediated signaling pathway  cytokine-mediated signaling pathway  cytokine binding  cytokine binding  positive regulation of tyrosine phosphorylation of STAT protein  positive regulation of tyrosine phosphorylation of STAT protein  receptor complex  negative regulation of neuron apoptotic process  interleukin-27-mediated signaling pathway  CRLF-CLCF1 complex  CRLF-CLCF1 complex  negative regulation of motor neuron apoptotic process  
NDEx NetworkCRLF1
Atlas of Cancer Signalling NetworkCRLF1
Wikipedia pathwaysCRLF1
Orthology - Evolution
OrthoDB9244
GeneTree (enSembl)ENSG00000006016
Phylogenetic Trees/Animal Genes : TreeFamCRLF1
Homologs : HomoloGeneCRLF1
Homology/Alignments : Family Browser (UCSC)CRLF1
Gene fusions - Rearrangements
Fusion : QuiverCRLF1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCRLF1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CRLF1
dbVarCRLF1
ClinVarCRLF1
MonarchCRLF1
1000_GenomesCRLF1 
Exome Variant ServerCRLF1
GNOMAD BrowserENSG00000006016
Varsome BrowserCRLF1
ACMGCRLF1 variants
VarityO75462
Genomic Variants (DGV)CRLF1 [DGVbeta]
DECIPHERCRLF1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisCRLF1 
Mutations
ICGC Data PortalCRLF1 
TCGA Data PortalCRLF1 
Broad Tumor PortalCRLF1
OASIS PortalCRLF1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCRLF1  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DCRLF1
Mutations and Diseases : HGMDCRLF1
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaCRLF1
DgiDB (Drug Gene Interaction Database)CRLF1
DoCM (Curated mutations)CRLF1
CIViC (Clinical Interpretations of Variants in Cancer)CRLF1
Cancer3DCRLF1
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM272430    604237   
Orphanet17149    1701   
DisGeNETCRLF1
MedgenCRLF1
Genetic Testing Registry CRLF1
NextProtO75462 [Medical]
GENETestsCRLF1
Target ValidationCRLF1
Huge Navigator CRLF1 [HugePedia]
ClinGenCRLF1
Clinical trials, drugs, therapy
MyCancerGenomeCRLF1
Protein Interactions : CTDCRLF1
Pharm GKB GenePA26882
PharosO75462
Clinical trialCRLF1
Miscellaneous
canSAR (ICR)CRLF1
HarmonizomeCRLF1
ARCHS4CRLF1
DataMed IndexCRLF1
Probes
Litterature
PubMed28 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXCRLF1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Jan 17 15:20:22 CET 2022

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