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CRLF2 (cytokine receptor like factor 2)

Identity

Alias_symbol (synonym)CRL2
TSLPR
Other aliasCRLF2Y
HGNC (Hugo) CRLF2
LocusID (NCBI) 64109
Atlas_Id 51262
Location Xp22.33  [Link to chromosome band Xp22]
Location_base_pair Starts at 1190496 and ends at 1212723 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CHRFAM7A (15q13.2) / CRLF2 (Xp22.33)CRLF2 (Xp22.33) / IGH (14q32.33)CRLF2 (Xp22.33) / P2RY8 (Xp22.33)
CRLF2 (Xp22.33) / U2AF1 (21q22.3)CSF2RA (Xp22.33) / CRLF2 (Xp22.33)GOLGA8A (15q14) / CRLF2 (Xp22.33)
IGH (14q32.33) / CRLF2 (Xp22.33)P2RY8 (Xp22.33) / CRLF2 (Xp22.33)WDR27 (6q27) / CRLF2 (Xp22.33)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Leukemias implicated (Data extracted from papers in the Atlas) [ 6 ]
  del(9p) in Acute Lymphoblastic Leukemia
del(X)(p22p22) P2RY8/CRLF2::del(Y)(p11p11) P2RY8/CRLF2
Acute lymphoblastic leukemia in Down syndrome
Myeloid proliferations in Down syndrome
+X solely in ALL
t(X;14)(p22;q32) or t(Y;14)(p11;q32) IGH/CRLF2

External links

Nomenclature
HGNC (Hugo)CRLF2   14281
Cards
Entrez_Gene (NCBI)CRLF2  64109  cytokine receptor like factor 2
AliasesCRL2; CRLF2Y; TSLPR
GeneCards (Weizmann)CRLF2
Ensembl hg19 (Hinxton)ENSG00000205755 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000205755 [Gene_View]  ENSG00000205755 [Sequence]  chrX:1190496-1212723 [Contig_View]  CRLF2 [Vega]
ICGC DataPortalENSG00000205755
TCGA cBioPortalCRLF2
AceView (NCBI)CRLF2
Genatlas (Paris)CRLF2
WikiGenes64109
SOURCE (Princeton)CRLF2
Genetics Home Reference (NIH)CRLF2
Genomic and cartography
GoldenPath hg38 (UCSC)CRLF2  -     chrX:1190496-1212723 -  Xp22.33   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)CRLF2  -     Xp22.33   [Description]    (hg19-Feb_2009)
EnsemblCRLF2 - Xp22.33 [CytoView hg19]  CRLF2 - Xp22.33 [CytoView hg38]
Mapping of homologs : NCBICRLF2 [Mapview hg19]  CRLF2 [Mapview hg38]
OMIM300357   400023   
Gene and transcription
Genbank (Entrez)AB052639 AF142570 AF338733 AK026800 AK223303
RefSeq transcript (Entrez)NM_001012288 NM_022148
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)CRLF2
Cluster EST : UnigeneHs.287729 [ NCBI ]
CGAP (NCI)Hs.287729
Alternative Splicing GalleryENSG00000205755
Gene ExpressionCRLF2 [ NCBI-GEO ]   CRLF2 [ EBI - ARRAY_EXPRESS ]   CRLF2 [ SEEK ]   CRLF2 [ MEM ]
Gene Expression Viewer (FireBrowse)CRLF2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)64109
GTEX Portal (Tissue expression)CRLF2
Human Protein AtlasENSG00000205755-CRLF2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9HC73   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9HC73  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9HC73
Splice isoforms : SwissVarQ9HC73
PhosPhoSitePlusQ9HC73
Domaine pattern : Prosite (Expaxy)FN3 (PS50853)   
Domains : Interpro (EBI)FN3_dom    Ig-like_fold   
Domain families : Pfam (Sanger)
Domain families : Pfam (NCBI)
Conserved Domain (NCBI)CRLF2
DMDM Disease mutations64109
Blocks (Seattle)CRLF2
SuperfamilyQ9HC73
Human Protein Atlas [tissue]ENSG00000205755-CRLF2 [tissue]
Peptide AtlasQ9HC73
HPRD02288
IPIIPI00030172   IPI00385014   IPI00553195   
Protein Interaction databases
DIP (DOE-UCLA)Q9HC73
IntAct (EBI)Q9HC73
FunCoupENSG00000205755
BioGRIDCRLF2
STRING (EMBL)CRLF2
ZODIACCRLF2
Ontologies - Pathways
QuickGOQ9HC73
Ontology : AmiGOcytokine receptor activity  cytokine receptor activity  extracellular region  plasma membrane  positive regulation of cell proliferation  integral component of membrane  cytokine-mediated signaling pathway  positive regulation of mast cell activation  interleukin-7-mediated signaling pathway  positive regulation of STAT cascade  positive regulation of interleukin-5 secretion  
Ontology : EGO-EBIcytokine receptor activity  cytokine receptor activity  extracellular region  plasma membrane  positive regulation of cell proliferation  integral component of membrane  cytokine-mediated signaling pathway  positive regulation of mast cell activation  interleukin-7-mediated signaling pathway  positive regulation of STAT cascade  positive regulation of interleukin-5 secretion  
Pathways : KEGGCytokine-cytokine receptor interaction    Jak-STAT signaling pathway   
NDEx NetworkCRLF2
Atlas of Cancer Signalling NetworkCRLF2
Wikipedia pathwaysCRLF2
Orthology - Evolution
OrthoDB64109
GeneTree (enSembl)ENSG00000205755
Phylogenetic Trees/Animal Genes : TreeFamCRLF2
HOVERGENQ9HC73
HOGENOMQ9HC73
Homologs : HomoloGeneCRLF2
Homology/Alignments : Family Browser (UCSC)CRLF2
Gene fusions - Rearrangements
Fusion : MitelmanCSF2RA/CRLF2 [Xp22.33/Xp22.33]  [del(X)(p22p22)]  
Fusion : MitelmanIGH/CRLF2 [14q32.33/Xp22.33]  [t(X;14)(p22;q32)]  [t(Y;14)(p11;q32)]  
Fusion : MitelmanP2RY8/CRLF2 [Xp22.33/Xp22.33]  [del(X)(p22p22)]  
Fusion : QuiverCRLF2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCRLF2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CRLF2
dbVarCRLF2
ClinVarCRLF2
1000_GenomesCRLF2 
Exome Variant ServerCRLF2
ExAC (Exome Aggregation Consortium)ENSG00000205755
GNOMAD BrowserENSG00000205755
Genetic variants : HAPMAP64109
Genomic Variants (DGV)CRLF2 [DGVbeta]
DECIPHERCRLF2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisCRLF2 
Mutations
ICGC Data PortalCRLF2 
TCGA Data PortalCRLF2 
Broad Tumor PortalCRLF2
OASIS PortalCRLF2 [ Somatic mutations - Copy number]
Cancer Gene: CensusCRLF2 
Somatic Mutations in Cancer : COSMICCRLF2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDCRLF2
BioMutasearch CRLF2
DgiDB (Drug Gene Interaction Database)CRLF2
DoCM (Curated mutations)CRLF2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CRLF2 (select a term)
intoGenCRLF2
Cancer3DCRLF2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM300357    400023   
Orphanet
DisGeNETCRLF2
MedgenCRLF2
Genetic Testing Registry CRLF2
NextProtQ9HC73 [Medical]
TSGene64109
GENETestsCRLF2
Target ValidationCRLF2
Huge Navigator CRLF2 [HugePedia]
snp3D : Map Gene to Disease64109
BioCentury BCIQCRLF2
ClinGenCRLF2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD64109
Chemical/Pharm GKB GenePA26883
Clinical trialCRLF2
Miscellaneous
canSAR (ICR)CRLF2 (select the gene name)
Probes
Litterature
PubMed57 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineCRLF2
EVEXCRLF2
GoPubMedCRLF2
iHOPCRLF2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Fri Jun 22 16:20:56 CEST 2018
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