Atlas of Genetics and Cytogenetics in Oncology and Haematology


Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

CRLS1 (cardiolipin synthase 1)

Identity

Alias_namesC20orf155
chromosome 20 open reading frame 155
Alias_symbol (synonym)dJ967N21.6
CLS1
GCD10
Other aliasCLS
HGNC (Hugo) CRLS1
LocusID (NCBI) 54675
Atlas_Id 54238
Location 20p12.3  [Link to chromosome band 20p12]
Location_base_pair Starts at 6007252 and ends at 6040051 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
ABCA11P (4p16.3) / CRLS1 (20p12.3)CRLS1 (20p12.3) / KCNK17 (6p21.2)CRLS1 (20p12.3) / NFX1 (9p13.3)
CRLS1 (20p12.3) / PSMF1 (20p13)CRLS1 (20p12.3) / SEL1L2 (20p12.1)CRLS1 (20p12.3) / TEX9 (15q21.3)
CRLS1 (20p12.3) / TRAPPC6A (19q13.32)CRLS1 20p12.3 / NFX1 9p13.3CRLS1 20p12.3 / SEL1L2 20p12.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  Lung: Translocations in Small Cell Carcinoma


External links

Nomenclature
HGNC (Hugo)CRLS1   16148
Cards
Entrez_Gene (NCBI)CRLS1  54675  cardiolipin synthase 1
AliasesC20orf155; CLS; CLS1; GCD10; 
dJ967N21.6
GeneCards (Weizmann)CRLS1
Ensembl hg19 (Hinxton)ENSG00000088766 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000088766 [Gene_View]  chr20:6007252-6040051 [Contig_View]  CRLS1 [Vega]
ICGC DataPortalENSG00000088766
TCGA cBioPortalCRLS1
AceView (NCBI)CRLS1
Genatlas (Paris)CRLS1
WikiGenes54675
SOURCE (Princeton)CRLS1
Genetics Home Reference (NIH)CRLS1
Genomic and cartography
GoldenPath hg38 (UCSC)CRLS1  -     chr20:6007252-6040051 +  20p12.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)CRLS1  -     20p12.3   [Description]    (hg19-Feb_2009)
EnsemblCRLS1 - 20p12.3 [CytoView hg19]  CRLS1 - 20p12.3 [CytoView hg38]
Mapping of homologs : NCBICRLS1 [Mapview hg19]  CRLS1 [Mapview hg38]
OMIM608188   
Gene and transcription
Genbank (Entrez)AF241784 AK310368 AL832419 BC069010 BI553536
RefSeq transcript (Entrez)NM_001127458 NM_001323561 NM_001323562 NM_001323563 NM_001323564 NM_019095
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)CRLS1
Cluster EST : UnigeneHs.743956 [ NCBI ]
CGAP (NCI)Hs.743956
Alternative Splicing GalleryENSG00000088766
Gene ExpressionCRLS1 [ NCBI-GEO ]   CRLS1 [ EBI - ARRAY_EXPRESS ]   CRLS1 [ SEEK ]   CRLS1 [ MEM ]
Gene Expression Viewer (FireBrowse)CRLS1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)54675
GTEX Portal (Tissue expression)CRLS1
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9UJA2   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9UJA2  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9UJA2
Splice isoforms : SwissVarQ9UJA2
PhosPhoSitePlusQ9UJA2
Domains : Interpro (EBI)CDP-OH_P_trans   
Domain families : Pfam (Sanger)CDP-OH_P_transf (PF01066)   
Domain families : Pfam (NCBI)pfam01066   
Conserved Domain (NCBI)CRLS1
DMDM Disease mutations54675
Blocks (Seattle)CRLS1
SuperfamilyQ9UJA2
Human Protein AtlasENSG00000088766
Peptide AtlasQ9UJA2
HPRD12187
IPIIPI00005167   IPI00895872   IPI00844540   
Protein Interaction databases
DIP (DOE-UCLA)Q9UJA2
IntAct (EBI)Q9UJA2
FunCoupENSG00000088766
BioGRIDCRLS1
STRING (EMBL)CRLS1
ZODIACCRLS1
Ontologies - Pathways
QuickGOQ9UJA2
Ontology : AmiGO1-acylglycerol-3-phosphate O-acyltransferase activity  mitochondrion  mitochondrial inner membrane  cardiolipin synthase activity  integral component of membrane  cardiolipin biosynthetic process  cardiolipin biosynthetic process  phosphatidylglycerol acyl-chain remodeling  CDP-diacylglycerol-phosphatidylglycerol phosphatidyltransferase activity  2-acylglycerol-3-phosphate O-acyltransferase activity  response to thyroxine  response to phosphatidylethanolamine  
Ontology : EGO-EBI1-acylglycerol-3-phosphate O-acyltransferase activity  mitochondrion  mitochondrial inner membrane  cardiolipin synthase activity  integral component of membrane  cardiolipin biosynthetic process  cardiolipin biosynthetic process  phosphatidylglycerol acyl-chain remodeling  CDP-diacylglycerol-phosphatidylglycerol phosphatidyltransferase activity  2-acylglycerol-3-phosphate O-acyltransferase activity  response to thyroxine  response to phosphatidylethanolamine  
Pathways : KEGGGlycerophospholipid metabolism   
NDEx NetworkCRLS1
Atlas of Cancer Signalling NetworkCRLS1
Wikipedia pathwaysCRLS1
Orthology - Evolution
OrthoDB54675
GeneTree (enSembl)ENSG00000088766
Phylogenetic Trees/Animal Genes : TreeFamCRLS1
HOVERGENQ9UJA2
HOGENOMQ9UJA2
Homologs : HomoloGeneCRLS1
Homology/Alignments : Family Browser (UCSC)CRLS1
Gene fusions - Rearrangements
Fusion : MitelmanCRLS1/KCNK17 [20p12.3/6p21.2]  
Fusion : MitelmanCRLS1/NFX1 [20p12.3/9p13.3]  [t(9;20)(p13;p12)]  
Fusion : MitelmanCRLS1/SEL1L2 [20p12.3/20p12.1]  [t(20;20)(p12;p12)]  
Fusion: TCGACRLS1 20p12.3 NFX1 9p13.3 KIRC
Fusion: TCGACRLS1 20p12.3 SEL1L2 20p12.1 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCRLS1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CRLS1
dbVarCRLS1
ClinVarCRLS1
1000_GenomesCRLS1 
Exome Variant ServerCRLS1
ExAC (Exome Aggregation Consortium)CRLS1 (select the gene name)
Genetic variants : HAPMAP54675
Genomic Variants (DGV)CRLS1 [DGVbeta]
DECIPHERCRLS1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisCRLS1 
Mutations
ICGC Data PortalCRLS1 
TCGA Data PortalCRLS1 
Broad Tumor PortalCRLS1
OASIS PortalCRLS1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCRLS1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDCRLS1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)MSeqDR-LSDB Mitochondrial Disease Locus Specific Database
BioMutasearch CRLS1
DgiDB (Drug Gene Interaction Database)CRLS1
DoCM (Curated mutations)CRLS1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CRLS1 (select a term)
intoGenCRLS1
Cancer3DCRLS1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM608188   
Orphanet
MedgenCRLS1
Genetic Testing Registry CRLS1
NextProtQ9UJA2 [Medical]
TSGene54675
GENETestsCRLS1
Target ValidationCRLS1
Huge Navigator CRLS1 [HugePedia]
snp3D : Map Gene to Disease54675
BioCentury BCIQCRLS1
ClinGenCRLS1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD54675
Chemical/Pharm GKB GenePA25697
Clinical trialCRLS1
Miscellaneous
canSAR (ICR)CRLS1 (select the gene name)
Probes
Litterature
PubMed18 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineCRLS1
EVEXCRLS1
GoPubMedCRLS1
iHOPCRLS1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Aug 1 16:58:39 CEST 2017

Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.