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CROCC (ciliary rootlet coiled-coil, rootletin)

Identity

Alias (NCBI)ROLT
TAX1BP2
HGNC (Hugo) CROCC
HGNC Alias symbrootletin
ROLT
HGNC Alias namerootletin, ciliary rootlet protein
LocusID (NCBI) 9696
Atlas_Id 56628
Location 1p36.13  [Link to chromosome band 1p36]
Location_base_pair Starts at 16921931 and ends at 16972960 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CROCC (1p36.13) / FAM60A (12p11.21)CROCC (1p36.13) / PSG3 (19q13.2)TMSB4X (Xp22.2) / CROCC (1p36.13)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)CROCC   21299
Cards
Entrez_Gene (NCBI)CROCC    ciliary rootlet coiled-coil, rootletin
AliasesROLT; TAX1BP2
GeneCards (Weizmann)CROCC
Ensembl hg19 (Hinxton)ENSG00000058453 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000058453 [Gene_View]  ENSG00000058453 [Sequence]  chr1:16921931-16972960 [Contig_View]  CROCC [Vega]
ICGC DataPortalENSG00000058453
TCGA cBioPortalCROCC
AceView (NCBI)CROCC
Genatlas (Paris)CROCC
SOURCE (Princeton)CROCC
Genetics Home Reference (NIH)CROCC
Genomic and cartography
GoldenPath hg38 (UCSC)CROCC  -     chr1:16921931-16972960 +  1p36.13   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)CROCC  -     1p36.13   [Description]    (hg19-Feb_2009)
GoldenPathCROCC - 1p36.13 [CytoView hg19]  CROCC - 1p36.13 [CytoView hg38]
ImmunoBaseENSG00000058453
Genome Data Viewer NCBICROCC [Mapview hg19]  
OMIM615776   
Gene and transcription
Genbank (Entrez)AB007914 AF527734 AK026910 BC126911 BC126912
RefSeq transcript (Entrez)NM_014675
Consensus coding sequences : CCDS (NCBI)CROCC
Gene ExpressionCROCC [ NCBI-GEO ]   CROCC [ EBI - ARRAY_EXPRESS ]   CROCC [ SEEK ]   CROCC [ MEM ]
Gene Expression Viewer (FireBrowse)CROCC [ Firebrowse - Broad ]
GenevisibleExpression of CROCC in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)9696
GTEX Portal (Tissue expression)CROCC
Human Protein AtlasENSG00000058453-CROCC [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ5TZA2   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ5TZA2  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ5TZA2
PhosPhoSitePlusQ5TZA2
Domains : Interpro (EBI)Rootletin   
Domain families : Pfam (Sanger)
Domain families : Pfam (NCBI)
Conserved Domain (NCBI)CROCC
PDB (RSDB)6L5H    6L5J   
PDB Europe6L5H    6L5J   
PDB (PDBSum)6L5H    6L5J   
PDB (IMB)6L5H    6L5J   
Structural Biology KnowledgeBase6L5H    6L5J   
SCOP (Structural Classification of Proteins)6L5H    6L5J   
CATH (Classification of proteins structures)6L5H    6L5J   
SuperfamilyQ5TZA2
AlphaFold pdb e-kbQ5TZA2   
Human Protein Atlas [tissue]ENSG00000058453-CROCC [tissue]
HPRD16758
Protein Interaction databases
DIP (DOE-UCLA)Q5TZA2
IntAct (EBI)Q5TZA2
BioGRIDCROCC
STRING (EMBL)CROCC
ZODIACCROCC
Ontologies - Pathways
QuickGOQ5TZA2
Ontology : AmiGOphotoreceptor inner segment  actin binding  structural molecule activity  structural constituent of cytoskeleton  protein binding  centrosome  centriole  centriole  cytosol  plasma membrane  centrosome cycle  protein localization  centriole-centriole cohesion  epithelial structure maintenance  actin cytoskeleton  kinesin binding  ciliary basal body organization  protein localization to organelle  ciliary rootlet  photoreceptor cell maintenance  positive regulation of cilium assembly  establishment of organelle localization  extracellular exosome  9+2 motile cilium  subapical part of cell  positive regulation of protein localization to cilium  
Ontology : EGO-EBIphotoreceptor inner segment  actin binding  structural molecule activity  structural constituent of cytoskeleton  protein binding  centrosome  centriole  centriole  cytosol  plasma membrane  centrosome cycle  protein localization  centriole-centriole cohesion  epithelial structure maintenance  actin cytoskeleton  kinesin binding  ciliary basal body organization  protein localization to organelle  ciliary rootlet  photoreceptor cell maintenance  positive regulation of cilium assembly  establishment of organelle localization  extracellular exosome  9+2 motile cilium  subapical part of cell  positive regulation of protein localization to cilium  
NDEx NetworkCROCC
Atlas of Cancer Signalling NetworkCROCC
Wikipedia pathwaysCROCC
Orthology - Evolution
OrthoDB9696
GeneTree (enSembl)ENSG00000058453
Phylogenetic Trees/Animal Genes : TreeFamCROCC
Homologs : HomoloGeneCROCC
Homology/Alignments : Family Browser (UCSC)CROCC
Gene fusions - Rearrangements
Fusion : QuiverCROCC
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCROCC [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CROCC
dbVarCROCC
ClinVarCROCC
MonarchCROCC
1000_GenomesCROCC 
Exome Variant ServerCROCC
GNOMAD BrowserENSG00000058453
Varsome BrowserCROCC
ACMGCROCC variants
VarityQ5TZA2
Genomic Variants (DGV)CROCC [DGVbeta]
DECIPHERCROCC [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisCROCC 
Mutations
ICGC Data PortalCROCC 
TCGA Data PortalCROCC 
Broad Tumor PortalCROCC
OASIS PortalCROCC [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCROCC  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DCROCC
Mutations and Diseases : HGMDCROCC
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaCROCC
DgiDB (Drug Gene Interaction Database)CROCC
DoCM (Curated mutations)CROCC
CIViC (Clinical Interpretations of Variants in Cancer)CROCC
Cancer3DCROCC
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM615776   
Orphanet
DisGeNETCROCC
MedgenCROCC
Genetic Testing Registry CROCC
NextProtQ5TZA2 [Medical]
GENETestsCROCC
Target ValidationCROCC
Huge Navigator CROCC [HugePedia]
ClinGenCROCC
Clinical trials, drugs, therapy
MyCancerGenomeCROCC
Protein Interactions : CTDCROCC
Pharm GKB GenePA134911945
PharosQ5TZA2
Clinical trialCROCC
Miscellaneous
canSAR (ICR)CROCC
HarmonizomeCROCC
DataMed IndexCROCC
Probes
Litterature
PubMed41 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXCROCC
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:05:16 CEST 2021

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