Atlas of Genetics and Cytogenetics in Oncology and Haematology

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CRP (C-reactive protein)

Identity

Alias (NCBI)PTX1
HGNC (Hugo) CRP
HGNC Alias symbPTX1
HGNC Alias namepentraxin 1
HGNC Previous nameC-reactive protein, pentraxin-related
LocusID (NCBI) 1401
Atlas_Id 46502
Location 1q23.2  [Link to chromosome band 1q23]
Location_base_pair Starts at 159712289 and ends at 159714589 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CRP (1q23.2) / SEPHS2 (16p11.2)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)CRP   2367
Cards
Entrez_Gene (NCBI)CRP    C-reactive protein
AliasesPTX1
GeneCards (Weizmann)CRP
Ensembl hg19 (Hinxton)ENSG00000132693 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000132693 [Gene_View]  ENSG00000132693 [Sequence]  chr1:159712289-159714589 [Contig_View]  CRP [Vega]
ICGC DataPortalENSG00000132693
TCGA cBioPortalCRP
AceView (NCBI)CRP
Genatlas (Paris)CRP
SOURCE (Princeton)CRP
Genetics Home Reference (NIH)CRP
Genomic and cartography
GoldenPath hg38 (UCSC)CRP  -     chr1:159712289-159714589 -  1q23.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)CRP  -     1q23.2   [Description]    (hg19-Feb_2009)
GoldenPathCRP - 1q23.2 [CytoView hg19]  CRP - 1q23.2 [CytoView hg38]
ImmunoBaseENSG00000132693
genome Data Viewer NCBICRP [Mapview hg19]  
OMIM123260   
Gene and transcription
Genbank (Entrez)AI609949 AK289443 AK313624 BC020766 BC070257
RefSeq transcript (Entrez)NM_000567 NM_001329057 NM_001329058 NM_001382703
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)CRP
Alternative Splicing GalleryENSG00000132693
Gene ExpressionCRP [ NCBI-GEO ]   CRP [ EBI - ARRAY_EXPRESS ]   CRP [ SEEK ]   CRP [ MEM ]
Gene Expression Viewer (FireBrowse)CRP [ Firebrowse - Broad ]
GenevisibleExpression of CRP in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)1401
GTEX Portal (Tissue expression)CRP
Human Protein AtlasENSG00000132693-CRP [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP02741   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP02741  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP02741
Splice isoforms : SwissVarP02741
PhosPhoSitePlusP02741
Domaine pattern : Prosite (Expaxy)PTX_1 (PS00289)    PTX_2 (PS51828)   
Domains : Interpro (EBI)ConA-like_dom_sf    Pentaxin_CS    Pentraxin-related   
Domain families : Pfam (Sanger)Pentaxin (PF00354)   
Domain families : Pfam (NCBI)pfam00354   
Domain families : Smart (EMBL)PTX (SM00159)  
Conserved Domain (NCBI)CRP
Blocks (Seattle)CRP
PDB (RSDB)1B09    1CRV    1GNH    1LJ7    3L2Y    3PVN    3PVO   
PDB Europe1B09    1CRV    1GNH    1LJ7    3L2Y    3PVN    3PVO   
PDB (PDBSum)1B09    1CRV    1GNH    1LJ7    3L2Y    3PVN    3PVO   
PDB (IMB)1B09    1CRV    1GNH    1LJ7    3L2Y    3PVN    3PVO   
Structural Biology KnowledgeBase1B09    1CRV    1GNH    1LJ7    3L2Y    3PVN    3PVO   
SCOP (Structural Classification of Proteins)1B09    1CRV    1GNH    1LJ7    3L2Y    3PVN    3PVO   
CATH (Classification of proteins structures)1B09    1CRV    1GNH    1LJ7    3L2Y    3PVN    3PVO   
SuperfamilyP02741
Human Protein Atlas [tissue]ENSG00000132693-CRP [tissue]
Peptide AtlasP02741
HPRD00422
IPIIPI00022389   IPI00218876   IPI00943038   IPI00642842   
Protein Interaction databases
DIP (DOE-UCLA)P02741
IntAct (EBI)P02741
BioGRIDCRP
STRING (EMBL)CRP
ZODIACCRP
Ontologies - Pathways
QuickGOP02741
Ontology : AmiGOcomplement component C1q binding  complement component C1q binding  calcium ion binding  protein binding  extracellular region  extracellular space  extracellular space  acute-phase response  inflammatory response  complement activation, classical pathway  opsonization  positive regulation of gene expression  negative regulation of macrophage derived foam cell differentiation  negative regulation of lipid storage  low-density lipoprotein particle binding  low-density lipoprotein particle binding  positive regulation of superoxide anion generation  negative regulation of mononuclear cell proliferation  choline binding  identical protein binding  negative regulation by host of viral process  innate immune response  virion binding  low-density lipoprotein particle receptor binding  defense response to Gram-positive bacterium  negative regulation of blood vessel diameter  negative regulation of blood vessel diameter  regulation of interleukin-8 secretion  
Ontology : EGO-EBIcomplement component C1q binding  complement component C1q binding  calcium ion binding  protein binding  extracellular region  extracellular space  extracellular space  acute-phase response  inflammatory response  complement activation, classical pathway  opsonization  positive regulation of gene expression  negative regulation of macrophage derived foam cell differentiation  negative regulation of lipid storage  low-density lipoprotein particle binding  low-density lipoprotein particle binding  positive regulation of superoxide anion generation  negative regulation of mononuclear cell proliferation  choline binding  identical protein binding  negative regulation by host of viral process  innate immune response  virion binding  low-density lipoprotein particle receptor binding  defense response to Gram-positive bacterium  negative regulation of blood vessel diameter  negative regulation of blood vessel diameter  regulation of interleukin-8 secretion  
NDEx NetworkCRP
Atlas of Cancer Signalling NetworkCRP
Wikipedia pathwaysCRP
Orthology - Evolution
OrthoDB1401
GeneTree (enSembl)ENSG00000132693
Phylogenetic Trees/Animal Genes : TreeFamCRP
HOGENOMP02741
Homologs : HomoloGeneCRP
Homology/Alignments : Family Browser (UCSC)CRP
Gene fusions - Rearrangements
Fusion : QuiverCRP
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCRP [hg38]
dbVarCRP
ClinVarCRP
MonarchCRP
1000_GenomesCRP 
Exome Variant ServerCRP
GNOMAD BrowserENSG00000132693
Varsome BrowserCRP
Genomic Variants (DGV)CRP [DGVbeta]
DECIPHERCRP [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisCRP 
Mutations
ICGC Data PortalCRP 
TCGA Data PortalCRP 
Broad Tumor PortalCRP
OASIS PortalCRP [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCRP  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DCRP
Mutations and Diseases : HGMDCRP
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch CRP
DgiDB (Drug Gene Interaction Database)CRP
DoCM (Curated mutations)CRP (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CRP (select a term)
intoGenCRP
Cancer3DCRP(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM123260   
Orphanet
DisGeNETCRP
MedgenCRP
Genetic Testing Registry CRP
NextProtP02741 [Medical]
GENETestsCRP
Target ValidationCRP
Huge Navigator CRP [HugePedia]
ClinGenCRP
Clinical trials, drugs, therapy
MyCancerGenomeCRP
Protein Interactions : CTD
Pharm GKB GenePA120
PharosP02741
Clinical trialCRP
Miscellaneous
canSAR (ICR)CRP (select the gene name)
HarmonizomeCRP
DataMed IndexCRP
Probes
Litterature
PubMed499 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXCRP
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Fri Jan 1 18:11:26 CET 2021
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