CRTAC1 (cartilage acidic protein 1)

2017-10-01  

Identity

HGNC
CRTAC1
LOCATION
10q24.2
LOCUSID
55118
ALIAS
ASPIC,ASPIC1,CEP-68,CEP68,LOTUS
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 55118
MIM: 606276
HGNC: 14882
Ensembl: ENSG00000095713

Variants:

dbSNP: 55118
ClinVar: 55118
TCGA: ENSG00000095713
COSMIC: CRTAC1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000095713ENST00000309155A0A0C4DFP6
ENSG00000095713ENST00000370591Q9NQ79
ENSG00000095713ENST00000370597Q9NQ79
ENSG00000095713ENST00000413387Q5T4F6
ENSG00000095713ENST00000436034H0Y6C6

Expression (GTEx)

0
10
20
30
40
50
60
70
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
163854512006A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease.69
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
170744752007Chondrocyte secreted CRTAC1: a glycosylated extracellular matrix molecule of human articular cartilage.11
176022272007Detection of bone and cartilage-related proteins in plasma of patients with a bone fracture using liquid chromatography-mass spectrometry.7
278553972016Inhibition of Cartilage Acidic Protein 1 Reduces Ultraviolet B Irradiation Induced-Apoptosis through P38 Mitogen-Activated Protein Kinase and Jun Amino-Terminal Kinase Pathways.3
278622992017Cartilage acidic protein 1, a new member of the beta-propeller protein family with amyloid propensity.1
294543542018Cerebrospinal fluid level of Nogo receptor 1 antagonist lateral olfactory tract usher substance (LOTUS) correlates inversely with the extent of neuroinflammation.1
274156162016Sex-Specific Protection of Osteoarthritis by Deleting Cartilage Acid Protein 1.0
319994752020NF-κB/Cartilage Acidic Protein 1 Promotes Ultraviolet B Irradiation-Induced Apoptosis of Human Lens Epithelial Cells.0

Citation

Dessen P

CRTAC1 (cartilage acidic protein 1)

Atlas Genet Cytogenet Oncol Haematol. 2017-10-01

Online version: http://atlasgeneticsoncology.org/gene/57186/crtac1