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CRTC3 (CREB regulated transcription coactivator 3)

Identity

Alias (NCBI)TORC-3
TORC3
HGNC (Hugo) CRTC3
HGNC Alias symbFLJ21868
LocusID (NCBI) 64784
Atlas_Id 50126
Location 15q26.1  [Link to chromosome band 15q26]
Location_base_pair Starts at 90529923 and ends at 90645345 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CCDC91 (12p11.22) / CRTC3 (15q26.1)CRTC3 (15q26.1) / GIGYF2 (2q37.1)CRTC3 (15q26.1) / MAML2 (11q21)
DBI (2q14.2) / CRTC3 (15q26.1)GNB1L (22q11.21) / CRTC3 (15q26.1)IDI1 (10p15.3) / CRTC3 (15q26.1)
MAML2 (11q21) / CRTC3 (15q26.1)TM9SF4 (20q11.21) / CRTC3 (15q26.1)CRTC3 15q26.1 / MAML2 11q21

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)CRTC3   26148
Cards
Entrez_Gene (NCBI)CRTC3    CREB regulated transcription coactivator 3
AliasesTORC-3; TORC3
GeneCards (Weizmann)CRTC3
Ensembl hg19 (Hinxton)ENSG00000140577 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000140577 [Gene_View]  ENSG00000140577 [Sequence]  chr15:90529923-90645345 [Contig_View]  CRTC3 [Vega]
ICGC DataPortalENSG00000140577
TCGA cBioPortalCRTC3
AceView (NCBI)CRTC3
Genatlas (Paris)CRTC3
SOURCE (Princeton)CRTC3
Genetics Home Reference (NIH)CRTC3
Genomic and cartography
GoldenPath hg38 (UCSC)CRTC3  -     chr15:90529923-90645345 +  15q26.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)CRTC3  -     15q26.1   [Description]    (hg19-Feb_2009)
GoldenPathCRTC3 - 15q26.1 [CytoView hg19]  CRTC3 - 15q26.1 [CytoView hg38]
ImmunoBaseENSG00000140577
Genome Data Viewer NCBICRTC3 [Mapview hg19]  
OMIM608986   
Gene and transcription
Genbank (Entrez)AI969212 AK024981 AK025521 AK074170 AK090443
RefSeq transcript (Entrez)NM_001042574 NM_022769
Consensus coding sequences : CCDS (NCBI)CRTC3
Gene ExpressionCRTC3 [ NCBI-GEO ]   CRTC3 [ EBI - ARRAY_EXPRESS ]   CRTC3 [ SEEK ]   CRTC3 [ MEM ]
Gene Expression Viewer (FireBrowse)CRTC3 [ Firebrowse - Broad ]
GenevisibleExpression of CRTC3 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)64784
GTEX Portal (Tissue expression)CRTC3
Human Protein AtlasENSG00000140577-CRTC3 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ6UUV7   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ6UUV7  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ6UUV7
PhosPhoSitePlusQ6UUV7
Domains : Interpro (EBI)TORC    TORC_C    TORC_M    TORC_N   
Domain families : Pfam (Sanger)TORC_C (PF12886)    TORC_M (PF12885)    TORC_N (PF12884)   
Domain families : Pfam (NCBI)pfam12886    pfam12885    pfam12884   
Conserved Domain (NCBI)CRTC3
SuperfamilyQ6UUV7
AlphaFold pdb e-kbQ6UUV7   
Human Protein Atlas [tissue]ENSG00000140577-CRTC3 [tissue]
HPRD13384
Protein Interaction databases
DIP (DOE-UCLA)Q6UUV7
IntAct (EBI)Q6UUV7
BioGRIDCRTC3
STRING (EMBL)CRTC3
ZODIACCRTC3
Ontologies - Pathways
QuickGOQ6UUV7
Ontology : AmiGOprotein binding  nucleus  nucleoplasm  cytoplasm  cytosol  cAMP response element binding protein binding  positive regulation of CREB transcription factor activity  macrophage activation  negative regulation of cAMP-mediated signaling  positive regulation of transcription by RNA polymerase II  negative regulation of lipid catabolic process  protein homotetramerization  energy homeostasis  
Ontology : EGO-EBIprotein binding  nucleus  nucleoplasm  cytoplasm  cytosol  cAMP response element binding protein binding  positive regulation of CREB transcription factor activity  macrophage activation  negative regulation of cAMP-mediated signaling  positive regulation of transcription by RNA polymerase II  negative regulation of lipid catabolic process  protein homotetramerization  energy homeostasis  
Pathways : KEGGHTLV-I infection   
NDEx NetworkCRTC3
Atlas of Cancer Signalling NetworkCRTC3
Wikipedia pathwaysCRTC3
Orthology - Evolution
OrthoDB64784
GeneTree (enSembl)ENSG00000140577
Phylogenetic Trees/Animal Genes : TreeFamCRTC3
Homologs : HomoloGeneCRTC3
Homology/Alignments : Family Browser (UCSC)CRTC3
Gene fusions - Rearrangements
Fusion : MitelmanCRTC3/MAML2 [15q26.1/11q21]  
Fusion : QuiverCRTC3
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCRTC3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CRTC3
dbVarCRTC3
ClinVarCRTC3
MonarchCRTC3
1000_GenomesCRTC3 
Exome Variant ServerCRTC3
GNOMAD BrowserENSG00000140577
Varsome BrowserCRTC3
ACMGCRTC3 variants
VarityQ6UUV7
Genomic Variants (DGV)CRTC3 [DGVbeta]
DECIPHERCRTC3 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisCRTC3 
Mutations
ICGC Data PortalCRTC3 
TCGA Data PortalCRTC3 
Broad Tumor PortalCRTC3
OASIS PortalCRTC3 [ Somatic mutations - Copy number]
Cancer Gene: CensusCRTC3 
Somatic Mutations in Cancer : COSMICCRTC3  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DCRTC3
Mutations and Diseases : HGMDCRTC3
intOGen PortalCRTC3
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaCRTC3
DgiDB (Drug Gene Interaction Database)CRTC3
DoCM (Curated mutations)CRTC3
CIViC (Clinical Interpretations of Variants in Cancer)CRTC3
Cancer3DCRTC3
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM608986   
Orphanet
DisGeNETCRTC3
MedgenCRTC3
Genetic Testing Registry CRTC3
NextProtQ6UUV7 [Medical]
GENETestsCRTC3
Target ValidationCRTC3
Huge Navigator CRTC3 [HugePedia]
ClinGenCRTC3
Clinical trials, drugs, therapy
MyCancerGenomeCRTC3
Protein Interactions : CTDCRTC3
Pharm GKB GenePA142672074
PharosQ6UUV7
Clinical trialCRTC3
Miscellaneous
canSAR (ICR)CRTC3
HarmonizomeCRTC3
DataMed IndexCRTC3
Probes
Litterature
PubMed56 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXCRTC3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:05:17 CEST 2021

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