Atlas of Genetics and Cytogenetics in Oncology and Haematology


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CRX (cone-rod homeobox)

Identity

Alias_namesCORD2
Alias_symbol (synonym)CRD
LCA7
OTX3
Other alias
HGNC (Hugo) CRX
LocusID (NCBI) 1406
Atlas_Id 51475
Location 19q13.33  [Link to chromosome band 19q13]
Location_base_pair Starts at 47821840 and ends at 47843329 bp from pter ( according to hg38-Dec_2013)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)CRX   2383
Cards
Entrez_Gene (NCBI)CRX  1406  cone-rod homeobox
AliasesCORD2; CRD; LCA7; OTX3
GeneCards (Weizmann)CRX
Ensembl hg19 (Hinxton)ENSG00000105392 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000105392 [Gene_View]  chr19:47821840-47843329 [Contig_View]  CRX [Vega]
ICGC DataPortalENSG00000105392
TCGA cBioPortalCRX
AceView (NCBI)CRX
Genatlas (Paris)CRX
WikiGenes1406
SOURCE (Princeton)CRX
Genetics Home Reference (NIH)CRX
Genomic and cartography
GoldenPath hg38 (UCSC)CRX  -     chr19:47821840-47843329 +  19q13.33   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)CRX  -     19q13.33   [Description]    (hg19-Feb_2009)
EnsemblCRX - 19q13.33 [CytoView hg19]  CRX - 19q13.33 [CytoView hg38]
Mapping of homologs : NCBICRX [Mapview hg19]  CRX [Mapview hg38]
OMIM120970   268000   602225   613829   
Gene and transcription
Genbank (Entrez)AF335593 AF335594 AF335595 AF442496 AL711350
RefSeq transcript (Entrez)NM_000554
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)CRX
Cluster EST : UnigeneHs.639114 [ NCBI ]
CGAP (NCI)Hs.639114
Alternative Splicing GalleryENSG00000105392
Gene ExpressionCRX [ NCBI-GEO ]   CRX [ EBI - ARRAY_EXPRESS ]   CRX [ SEEK ]   CRX [ MEM ]
Gene Expression Viewer (FireBrowse)CRX [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)1406
GTEX Portal (Tissue expression)CRX
Protein : pattern, domain, 3D structure
UniProt/SwissProtO43186   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO43186  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO43186
Splice isoforms : SwissVarO43186
PhosPhoSitePlusO43186
Domaine pattern : Prosite (Expaxy)HOMEOBOX_1 (PS00027)    HOMEOBOX_2 (PS50071)   
Domains : Interpro (EBI)CRX    Homeobox-like    Homeobox_CS    Homeobox_dom    Otx_TF_C   
Domain families : Pfam (Sanger)Homeobox (PF00046)    TF_Otx (PF03529)   
Domain families : Pfam (NCBI)pfam00046    pfam03529   
Domain families : Smart (EMBL)HOX (SM00389)  
Conserved Domain (NCBI)CRX
DMDM Disease mutations1406
Blocks (Seattle)CRX
SuperfamilyO43186
Human Protein AtlasENSG00000105392
Peptide AtlasO43186
HPRD03748
IPIIPI00011226   IPI00954900   IPI00977106   
Protein Interaction databases
DIP (DOE-UCLA)O43186
IntAct (EBI)O43186
FunCoupENSG00000105392
BioGRIDCRX
STRING (EMBL)CRX
ZODIACCRX
Ontologies - Pathways
QuickGOO43186
Ontology : AmiGORNA polymerase II core promoter proximal region sequence-specific DNA binding  transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding  transcription factor activity, sequence-specific DNA binding  protein binding  nucleus  regulation of transcription, DNA-templated  transcription from RNA polymerase II promoter  visual perception  circadian rhythm  animal organ morphogenesis  nuclear hormone receptor binding  leucine zipper domain binding  positive regulation of transcription from RNA polymerase II promoter  positive regulation of photoreceptor cell differentiation  response to stimulus  
Ontology : EGO-EBIRNA polymerase II core promoter proximal region sequence-specific DNA binding  transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding  transcription factor activity, sequence-specific DNA binding  protein binding  nucleus  regulation of transcription, DNA-templated  transcription from RNA polymerase II promoter  visual perception  circadian rhythm  animal organ morphogenesis  nuclear hormone receptor binding  leucine zipper domain binding  positive regulation of transcription from RNA polymerase II promoter  positive regulation of photoreceptor cell differentiation  response to stimulus  
NDEx NetworkCRX
Atlas of Cancer Signalling NetworkCRX
Wikipedia pathwaysCRX
Orthology - Evolution
OrthoDB1406
GeneTree (enSembl)ENSG00000105392
Phylogenetic Trees/Animal Genes : TreeFamCRX
HOVERGENO43186
HOGENOMO43186
Homologs : HomoloGeneCRX
Homology/Alignments : Family Browser (UCSC)CRX
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCRX [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CRX
dbVarCRX
ClinVarCRX
1000_GenomesCRX 
Exome Variant ServerCRX
ExAC (Exome Aggregation Consortium)CRX (select the gene name)
Genetic variants : HAPMAP1406
Genomic Variants (DGV)CRX [DGVbeta]
DECIPHERCRX [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisCRX 
Mutations
ICGC Data PortalCRX 
TCGA Data PortalCRX 
Broad Tumor PortalCRX
OASIS PortalCRX [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCRX  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDCRX
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)Eye diseases - LOVD
LOVD (Leiden Open Variation Database)MSeqDR-LSDB Mitochondrial Disease Locus Specific Database
BioMutasearch CRX
DgiDB (Drug Gene Interaction Database)CRX
DoCM (Curated mutations)CRX (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CRX (select a term)
intoGenCRX
Cancer3DCRX(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM120970    268000    602225    613829   
Orphanet659    1843    3243   
MedgenCRX
Genetic Testing Registry CRX
NextProtO43186 [Medical]
TSGene1406
GENETestsCRX
Target ValidationCRX
Huge Navigator CRX [HugePedia]
snp3D : Map Gene to Disease1406
BioCentury BCIQCRX
ClinGenCRX
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD1406
Chemical/Pharm GKB GenePA26903
Clinical trialCRX
Miscellaneous
canSAR (ICR)CRX (select the gene name)
Probes
Litterature
PubMed62 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineCRX
EVEXCRX
GoPubMedCRX
iHOPCRX
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed Jun 7 12:29:39 CEST 2017

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