Atlas of Genetics and Cytogenetics in Oncology and Haematology


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CRY1 (cryptochrome circadian clock 1)

Identity

Alias_namesPHLL1
cryptochrome 1 (photolyase-like)
Other alias
HGNC (Hugo) CRY1
LocusID (NCBI) 1407
Atlas_Id 40154
Location 12q23.3  [Link to chromosome band 12q23]
Location_base_pair Starts at 107385143 and ends at 107487635 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
ANKS1B (12q23.1) / CRY1 (12q23.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)CRY1   2384
Cards
Entrez_Gene (NCBI)CRY1  1407  cryptochrome circadian clock 1
AliasesPHLL1
GeneCards (Weizmann)CRY1
Ensembl hg19 (Hinxton)ENSG00000008405 [Gene_View]  chr12:107385143-107487635 [Contig_View]  CRY1 [Vega]
Ensembl hg38 (Hinxton)ENSG00000008405 [Gene_View]  chr12:107385143-107487635 [Contig_View]  CRY1 [Vega]
ICGC DataPortalENSG00000008405
TCGA cBioPortalCRY1
AceView (NCBI)CRY1
Genatlas (Paris)CRY1
WikiGenes1407
SOURCE (Princeton)CRY1
Genetics Home Reference (NIH)CRY1
Genomic and cartography
GoldenPath hg19 (UCSC)CRY1  -     chr12:107385143-107487635 -  12q23.3   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)CRY1  -     12q23.3   [Description]    (hg38-Dec_2013)
EnsemblCRY1 - 12q23.3 [CytoView hg19]  CRY1 - 12q23.3 [CytoView hg38]
Mapping of homologs : NCBICRY1 [Mapview hg19]  CRY1 [Mapview hg38]
OMIM601933   
Gene and transcription
Genbank (Entrez)AK098615 AK125915 AK290552 BC017466 BC030519
RefSeq transcript (Entrez)NM_004075
RefSeq genomic (Entrez)NC_000012 NC_018923 NT_029419 NW_004929384
Consensus coding sequences : CCDS (NCBI)CRY1
Cluster EST : UnigeneHs.151573 [ NCBI ]
CGAP (NCI)Hs.151573
Alternative Splicing GalleryENSG00000008405
Gene ExpressionCRY1 [ NCBI-GEO ]   CRY1 [ EBI - ARRAY_EXPRESS ]   CRY1 [ SEEK ]   CRY1 [ MEM ]
Gene Expression Viewer (FireBrowse)CRY1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)1407
GTEX Portal (Tissue expression)CRY1
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ16526   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ16526  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ16526
Splice isoforms : SwissVarQ16526
PhosPhoSitePlusQ16526
Domaine pattern : Prosite (Expaxy)PHR_CRY_ALPHA_BETA (PS51645)   
Domains : Interpro (EBI)Cryptochr/Photolyase_FAD-bd    DNA_photolyase_N    Rossmann-like_a/b/a_fold   
Domain families : Pfam (Sanger)DNA_photolyase (PF00875)    FAD_binding_7 (PF03441)   
Domain families : Pfam (NCBI)pfam00875    pfam03441   
Conserved Domain (NCBI)CRY1
DMDM Disease mutations1407
Blocks (Seattle)CRY1
SuperfamilyQ16526
Human Protein AtlasENSG00000008405
Peptide AtlasQ16526
HPRD09050
IPIIPI00002540   IPI00384579   IPI01021978   
Protein Interaction databases
DIP (DOE-UCLA)Q16526
IntAct (EBI)Q16526
FunCoupENSG00000008405
BioGRIDCRY1
STRING (EMBL)CRY1
ZODIACCRY1
Ontologies - Pathways
QuickGOQ16526
Ontology : AmiGOnegative regulation of transcription from RNA polymerase II promoter  nucleotide binding  transcription factor activity, transcription factor binding  core promoter sequence-specific DNA binding  core promoter binding  DNA binding  double-stranded DNA binding  deoxyribodipyrimidine photo-lyase activity  DNA (6-4) photolyase activity  protein binding  nucleus  mitochondrion  gluconeogenesis  transcription, DNA-templated  DNA damage induced protein phosphorylation  transcription factor binding  blue light signaling pathway  blue light photoreceptor activity  protein-chromophore linkage  protein kinase binding  phosphatase binding  lipid storage  negative regulation of protein ubiquitination  response to insulin  circadian regulation of gene expression  response to glucagon  nuclear hormone receptor binding  glucose homeostasis  regulation of circadian rhythm  negative regulation of circadian rhythm  histone deacetylase binding  ubiquitin binding  entrainment of circadian clock by photoperiod  negative regulation of G-protein coupled receptor protein signaling pathway  negative regulation of transcription, DNA-templated  negative regulation of transcription, DNA-templated  regulation of DNA damage checkpoint  negative regulation of glucocorticoid receptor signaling pathway  negative regulation of glucocorticoid secretion  
Ontology : EGO-EBInegative regulation of transcription from RNA polymerase II promoter  nucleotide binding  transcription factor activity, transcription factor binding  core promoter sequence-specific DNA binding  core promoter binding  DNA binding  double-stranded DNA binding  deoxyribodipyrimidine photo-lyase activity  DNA (6-4) photolyase activity  protein binding  nucleus  mitochondrion  gluconeogenesis  transcription, DNA-templated  DNA damage induced protein phosphorylation  transcription factor binding  blue light signaling pathway  blue light photoreceptor activity  protein-chromophore linkage  protein kinase binding  phosphatase binding  lipid storage  negative regulation of protein ubiquitination  response to insulin  circadian regulation of gene expression  response to glucagon  nuclear hormone receptor binding  glucose homeostasis  regulation of circadian rhythm  negative regulation of circadian rhythm  histone deacetylase binding  ubiquitin binding  entrainment of circadian clock by photoperiod  negative regulation of G-protein coupled receptor protein signaling pathway  negative regulation of transcription, DNA-templated  negative regulation of transcription, DNA-templated  regulation of DNA damage checkpoint  negative regulation of glucocorticoid receptor signaling pathway  negative regulation of glucocorticoid secretion  
Pathways : BIOCARTACircadian Rhythms [Genes]   
Pathways : KEGGCircadian rhythm   
NDEx NetworkCRY1
Atlas of Cancer Signalling NetworkCRY1
Wikipedia pathwaysCRY1
Orthology - Evolution
OrthoDB1407
GeneTree (enSembl)ENSG00000008405
Phylogenetic Trees/Animal Genes : TreeFamCRY1
HOVERGENQ16526
HOGENOMQ16526
Homologs : HomoloGeneCRY1
Homology/Alignments : Family Browser (UCSC)CRY1
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCRY1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CRY1
dbVarCRY1
ClinVarCRY1
1000_GenomesCRY1 
Exome Variant ServerCRY1
ExAC (Exome Aggregation Consortium)CRY1 (select the gene name)
Genetic variants : HAPMAP1407
Genomic Variants (DGV)CRY1 [DGVbeta]
DECIPHER (Syndromes)12:107385143-107487635  ENSG00000008405
CONAN: Copy Number AnalysisCRY1 
Mutations
ICGC Data PortalCRY1 
TCGA Data PortalCRY1 
Broad Tumor PortalCRY1
OASIS PortalCRY1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCRY1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDCRY1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)MSeqDR-LSDB Mitochondrial Disease Locus Specific Database
BioMutasearch CRY1
DgiDB (Drug Gene Interaction Database)CRY1
DoCM (Curated mutations)CRY1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CRY1 (select a term)
intoGenCRY1
Cancer3DCRY1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM601933   
Orphanet
MedgenCRY1
Genetic Testing Registry CRY1
NextProtQ16526 [Medical]
TSGene1407
GENETestsCRY1
Huge Navigator CRY1 [HugePedia]
snp3D : Map Gene to Disease1407
BioCentury BCIQCRY1
ClinGenCRY1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD1407
Chemical/Pharm GKB GenePA26904
Clinical trialCRY1
Miscellaneous
canSAR (ICR)CRY1 (select the gene name)
Probes
Litterature
PubMed77 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineCRY1
EVEXCRY1
GoPubMedCRY1
iHOPCRY1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Mar 30 14:57:40 CEST 2017

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