Atlas of Genetics and Cytogenetics in Oncology and Haematology


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CRY2 (cryptochrome circadian regulator 2)

Identity

Alias_namescryptochrome 2 (photolyase-like)
Other aliasHCRY2
PHLL2
HGNC (Hugo) CRY2
LocusID (NCBI) 1408
Atlas_Id 40155
Location 12q23.3  [Link to chromosome band 12q23]
Location_base_pair Starts at 45847406 and ends at 45883248 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CRY2 (11p11.2) / CRY2 (11p11.2)CRY2 (11p11.2) / RTN4 (2p16.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)CRY2   2385
Cards
Entrez_Gene (NCBI)CRY2  1408  cryptochrome circadian regulator 2
AliasesHCRY2; PHLL2
GeneCards (Weizmann)CRY2
Ensembl hg19 (Hinxton)ENSG00000121671 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000121671 [Gene_View]  ENSG00000121671 [Sequence]  chr11:45847406-45883248 [Contig_View]  CRY2 [Vega]
ICGC DataPortalENSG00000121671
TCGA cBioPortalCRY2
AceView (NCBI)CRY2
Genatlas (Paris)CRY2
WikiGenes1408
SOURCE (Princeton)CRY2
Genetics Home Reference (NIH)CRY2
Genomic and cartography
GoldenPath hg38 (UCSC)CRY2  -     chr11:45847406-45883248 +  12q23.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)CRY2  -     12q23.3   [Description]    (hg19-Feb_2009)
EnsemblCRY2 - 12q23.3 [CytoView hg19]  CRY2 - 12q23.3 [CytoView hg38]
Mapping of homologs : NCBICRY2 [Mapview hg19]  CRY2 [Mapview hg38]
OMIM603732   
Gene and transcription
Genbank (Entrez)AB014558 AI375851 AK001194 AK291260 AK294904
RefSeq transcript (Entrez)NM_001127457 NM_021117
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)CRY2
Cluster EST : UnigeneHs.532491 [ NCBI ]
CGAP (NCI)Hs.532491
Alternative Splicing GalleryENSG00000121671
Gene ExpressionCRY2 [ NCBI-GEO ]   CRY2 [ EBI - ARRAY_EXPRESS ]   CRY2 [ SEEK ]   CRY2 [ MEM ]
Gene Expression Viewer (FireBrowse)CRY2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)1408
GTEX Portal (Tissue expression)CRY2
Human Protein AtlasENSG00000121671-CRY2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ49AN0   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ49AN0  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ49AN0
Splice isoforms : SwissVarQ49AN0
PhosPhoSitePlusQ49AN0
Domaine pattern : Prosite (Expaxy)PHR_CRY_ALPHA_BETA (PS51645)   
Domains : Interpro (EBI)Crypto/Photolyase_FAD-like_sf    Crypto/Photolyase_N_sf    Cryptochr/Photolyase_FAD-bd    DNA_photolyase_N    Rossmann-like_a/b/a_fold   
Domain families : Pfam (Sanger)DNA_photolyase (PF00875)    FAD_binding_7 (PF03441)   
Domain families : Pfam (NCBI)pfam00875    pfam03441   
Conserved Domain (NCBI)CRY2
DMDM Disease mutations1408
Blocks (Seattle)CRY2
SuperfamilyQ49AN0
Human Protein Atlas [tissue]ENSG00000121671-CRY2 [tissue]
Peptide AtlasQ49AN0
HPRD07226
IPIIPI00895886   IPI00216898   
Protein Interaction databases
DIP (DOE-UCLA)Q49AN0
IntAct (EBI)Q49AN0
FunCoupENSG00000121671
BioGRIDCRY2
STRING (EMBL)CRY2
ZODIACCRY2
Ontologies - Pathways
QuickGOQ49AN0
Ontology : AmiGOnegative regulation of transcription by RNA polymerase II  photoreactive repair  transcription regulatory region sequence-specific DNA binding  DNA binding  damaged DNA binding  single-stranded DNA binding  deoxyribodipyrimidine photo-lyase activity  DNA (6-4) photolyase activity  protein binding  extracellular region  nucleus  cytosol  transcription, DNA-templated  circadian rhythm  response to light stimulus  blue light signaling pathway  blue light photoreceptor activity  nuclear speck  protein-chromophore linkage  phosphatase binding  negative regulation of phosphoprotein phosphatase activity  circadian regulation of gene expression  glucose homeostasis  regulation of circadian rhythm  negative regulation of circadian rhythm  entrainment of circadian clock by photoperiod  negative regulation of transcription, DNA-templated  negative regulation of transcription, DNA-templated  FAD binding  regulation of sodium-dependent phosphate transport  negative regulation of glucocorticoid receptor signaling pathway  
Ontology : EGO-EBInegative regulation of transcription by RNA polymerase II  photoreactive repair  transcription regulatory region sequence-specific DNA binding  DNA binding  damaged DNA binding  single-stranded DNA binding  deoxyribodipyrimidine photo-lyase activity  DNA (6-4) photolyase activity  protein binding  extracellular region  nucleus  cytosol  transcription, DNA-templated  circadian rhythm  response to light stimulus  blue light signaling pathway  blue light photoreceptor activity  nuclear speck  protein-chromophore linkage  phosphatase binding  negative regulation of phosphoprotein phosphatase activity  circadian regulation of gene expression  glucose homeostasis  regulation of circadian rhythm  negative regulation of circadian rhythm  entrainment of circadian clock by photoperiod  negative regulation of transcription, DNA-templated  negative regulation of transcription, DNA-templated  FAD binding  regulation of sodium-dependent phosphate transport  negative regulation of glucocorticoid receptor signaling pathway  
Pathways : KEGGCircadian rhythm   
NDEx NetworkCRY2
Atlas of Cancer Signalling NetworkCRY2
Wikipedia pathwaysCRY2
Orthology - Evolution
OrthoDB1408
GeneTree (enSembl)ENSG00000121671
Phylogenetic Trees/Animal Genes : TreeFamCRY2
HOVERGENQ49AN0
HOGENOMQ49AN0
Homologs : HomoloGeneCRY2
Homology/Alignments : Family Browser (UCSC)CRY2
Gene fusions - Rearrangements
Fusion : QuiverCRY2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCRY2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CRY2
dbVarCRY2
ClinVarCRY2
1000_GenomesCRY2 
Exome Variant ServerCRY2
ExAC (Exome Aggregation Consortium)ENSG00000121671
GNOMAD BrowserENSG00000121671
Varsome BrowserCRY2
Genetic variants : HAPMAP1408
Genomic Variants (DGV)CRY2 [DGVbeta]
DECIPHERCRY2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisCRY2 
Mutations
ICGC Data PortalCRY2 
TCGA Data PortalCRY2 
Broad Tumor PortalCRY2
OASIS PortalCRY2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCRY2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDCRY2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch CRY2
DgiDB (Drug Gene Interaction Database)CRY2
DoCM (Curated mutations)CRY2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CRY2 (select a term)
intoGenCRY2
Cancer3DCRY2(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM603732   
Orphanet
DisGeNETCRY2
MedgenCRY2
Genetic Testing Registry CRY2
NextProtQ49AN0 [Medical]
TSGene1408
GENETestsCRY2
Target ValidationCRY2
Huge Navigator CRY2 [HugePedia]
snp3D : Map Gene to Disease1408
BioCentury BCIQCRY2
ClinGenCRY2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD1408
Chemical/Pharm GKB GenePA26905
Clinical trialCRY2
Miscellaneous
canSAR (ICR)CRY2 (select the gene name)
Probes
Litterature
PubMed100 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineCRY2
EVEXCRY2
GoPubMedCRY2
iHOPCRY2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Aug 16 10:55:49 CEST 2018

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