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CRYL1 (crystallin lambda 1)

Identity

Alias (NCBI)GDH
HEL30
gul3DH
lambda-CRY
HGNC (Hugo) CRYL1
HGNC Alias symbGDH
lambda-CRY
MGC149525
MGC149526
HGNC Alias namecrystallin, lamda 1
 L-gulonate 3-dehydrogenase
 lambda-crystallin homolog
HGNC Previous namecrystallin, lambda 1
LocusID (NCBI) 51084
Atlas_Id 54240
Location 13q12.11  [Link to chromosome band 13q12]
Location_base_pair Starts at 20403669 and ends at 20525857 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ATP8A2 (13q12.13) / CRYL1 (13q12.11)CRYL1 (13q12.11) / ATPAF1 (1p33)CRYL1 (13q12.11) / ATRNL1 (10q25.3)
CRYL1 (13q12.11) / NDRG2 (14q11.2)CRYL1 (13q12.11) / RBFOX1 (16p13.3)CRYL1 (13q12.11) / SPACA7 (13q34)
CRYL1 (13q12.11) / TCF25 (16q24.3)NCAM2 (21q21.1) / CRYL1 (13q12.11)PSPC1 (13q12.11) / CRYL1 (13q12.11)
USP31 (16p12.2) / CRYL1 (13q12.11)ATP8A2 13q12.13 / CRYL1 13q12.11CRYL1 13q12.11 / SPACA7 13q34
NCAM2 21q21.1 / CRYL1 13q12.11PSPC1 13q12.11 / CRYL1 13q12.11

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)CRYL1   18246
Cards
Entrez_Gene (NCBI)CRYL1    crystallin lambda 1
AliasesGDH; HEL30; gul3DH; lambda-CRY
GeneCards (Weizmann)CRYL1
Ensembl hg19 (Hinxton)ENSG00000165475 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000165475 [Gene_View]  ENSG00000165475 [Sequence]  chr13:20403669-20525857 [Contig_View]  CRYL1 [Vega]
ICGC DataPortalENSG00000165475
TCGA cBioPortalCRYL1
AceView (NCBI)CRYL1
Genatlas (Paris)CRYL1
SOURCE (Princeton)CRYL1
Genetics Home Reference (NIH)CRYL1
Genomic and cartography
GoldenPath hg38 (UCSC)CRYL1  -     chr13:20403669-20525857 -  13q12.11   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)CRYL1  -     13q12.11   [Description]    (hg19-Feb_2009)
GoldenPathCRYL1 - 13q12.11 [CytoView hg19]  CRYL1 - 13q12.11 [CytoView hg38]
ImmunoBaseENSG00000165475
Genome Data Viewer NCBICRYL1 [Mapview hg19]  
OMIM609877   
Gene and transcription
Genbank (Entrez)AF077049 AF087898 AF160216 AK024041 AK301605
RefSeq transcript (Entrez)NM_001363647 NM_015974
Consensus coding sequences : CCDS (NCBI)CRYL1
Gene ExpressionCRYL1 [ NCBI-GEO ]   CRYL1 [ EBI - ARRAY_EXPRESS ]   CRYL1 [ SEEK ]   CRYL1 [ MEM ]
Gene Expression Viewer (FireBrowse)CRYL1 [ Firebrowse - Broad ]
GenevisibleExpression of CRYL1 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)51084
GTEX Portal (Tissue expression)CRYL1
Human Protein AtlasENSG00000165475-CRYL1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9Y2S2   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9Y2S2  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9Y2S2
Catalytic activity : Enzyme1.1.1.45 [ Enzyme-Expasy ]   1.1.1.451.1.1.45 [ IntEnz-EBI ]   1.1.1.45 [ BRENDA ]   1.1.1.45 [ KEGG ]   [ MEROPS ]
PhosPhoSitePlusQ9Y2S2
Domaine pattern : Prosite (Expaxy)3HCDH (PS00067)   
Domains : Interpro (EBI)3-OHacyl-CoA_DH    3-OHacyl-CoA_DH_CS    3-OHacyl-CoA_DH_NAD-bd    3HC_DH_C    6-PGluconate_DH-like_C_sf    6PGD_dom2    NAD(P)-bd_dom_sf   
Domain families : Pfam (Sanger)3HCDH (PF00725)    3HCDH_N (PF02737)   
Domain families : Pfam (NCBI)pfam00725    pfam02737   
Conserved Domain (NCBI)CRYL1
PDB (RSDB)3F3S   
PDB Europe3F3S   
PDB (PDBSum)3F3S   
PDB (IMB)3F3S   
Structural Biology KnowledgeBase3F3S   
SCOP (Structural Classification of Proteins)3F3S   
CATH (Classification of proteins structures)3F3S   
SuperfamilyQ9Y2S2
AlphaFold pdb e-kbQ9Y2S2   
Human Protein Atlas [tissue]ENSG00000165475-CRYL1 [tissue]
HPRD16762
Protein Interaction databases
DIP (DOE-UCLA)Q9Y2S2
IntAct (EBI)Q9Y2S2
BioGRIDCRYL1
STRING (EMBL)CRYL1
ZODIACCRYL1
Ontologies - Pathways
QuickGOQ9Y2S2
Ontology : AmiGOcytosol  cytosol  fatty acid metabolic process  oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor  glucuronate catabolic process to xylulose 5-phosphate  protein homodimerization activity  L-gulonate 3-dehydrogenase activity  L-gulonate 3-dehydrogenase activity  extracellular exosome  NAD+ binding  
Ontology : EGO-EBIcytosol  cytosol  fatty acid metabolic process  oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor  glucuronate catabolic process to xylulose 5-phosphate  protein homodimerization activity  L-gulonate 3-dehydrogenase activity  L-gulonate 3-dehydrogenase activity  extracellular exosome  NAD+ binding  
Pathways : KEGGPentose and glucuronate interconversions   
NDEx NetworkCRYL1
Atlas of Cancer Signalling NetworkCRYL1
Wikipedia pathwaysCRYL1
Orthology - Evolution
OrthoDB51084
GeneTree (enSembl)ENSG00000165475
Phylogenetic Trees/Animal Genes : TreeFamCRYL1
Homologs : HomoloGeneCRYL1
Homology/Alignments : Family Browser (UCSC)CRYL1
Gene fusions - Rearrangements
Fusion : MitelmanATP8A2/CRYL1 [13q12.13/13q12.11]  
Fusion : MitelmanCRYL1/SPACA7 [13q12.11/13q34]  
Fusion : MitelmanNCAM2/CRYL1 [21q21.1/13q12.11]  
Fusion : MitelmanPSPC1/CRYL1 [13q12.11/13q12.11]  
Fusion : MitelmanUSP31/CRYL1 [16p12.2/13q12.11]  
Fusion : QuiverCRYL1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCRYL1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CRYL1
dbVarCRYL1
ClinVarCRYL1
MonarchCRYL1
1000_GenomesCRYL1 
Exome Variant ServerCRYL1
GNOMAD BrowserENSG00000165475
Varsome BrowserCRYL1
ACMGCRYL1 variants
VarityQ9Y2S2
Genomic Variants (DGV)CRYL1 [DGVbeta]
DECIPHERCRYL1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisCRYL1 
Mutations
ICGC Data PortalCRYL1 
TCGA Data PortalCRYL1 
Broad Tumor PortalCRYL1
OASIS PortalCRYL1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCRYL1  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DCRYL1
Mutations and Diseases : HGMDCRYL1
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaCRYL1
DgiDB (Drug Gene Interaction Database)CRYL1
DoCM (Curated mutations)CRYL1
CIViC (Clinical Interpretations of Variants in Cancer)CRYL1
Cancer3DCRYL1
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM609877   
Orphanet
DisGeNETCRYL1
MedgenCRYL1
Genetic Testing Registry CRYL1
NextProtQ9Y2S2 [Medical]
GENETestsCRYL1
Target ValidationCRYL1
Huge Navigator CRYL1 [HugePedia]
ClinGenCRYL1
Clinical trials, drugs, therapy
MyCancerGenomeCRYL1
Protein Interactions : CTDCRYL1
Pharm GKB GenePA26923
PharosQ9Y2S2
Clinical trialCRYL1
Miscellaneous
canSAR (ICR)CRYL1
HarmonizomeCRYL1
DataMed IndexCRYL1
Probes
Litterature
PubMed17 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXCRYL1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Mon Oct 4 15:05:18 CEST 2021

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