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CS (citrate synthase)

Identity

Other alias-
HGNC (Hugo) CS
LocusID (NCBI) 1431
Atlas_Id 43924
Location 12q13.3  [Link to chromosome band 12q13]
Location_base_pair Starts at 56271699 and ends at 56300391 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
CAPN1 (11q13.1) / CS (12q13.3)CNPY2 (12q13.3) / CS (12q13.3)CS (12q13.3) / MUCL1 (12q13.2)
CS (12q13.3) / PRIM1 (12q13.3)CS (12q13.3) / SUPT16H (14q11.2)MRPL30 (2q11.2) / CS (12q13.3)
RNF41 (12q13.2) / CS (12q13.3)CS 12q13.3 / MUCL1 12q13.2CS 12q13.3 / PRIM1 12q13.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)CS   2422
Cards
Entrez_Gene (NCBI)CS  1431  citrate synthase
Aliases
GeneCards (Weizmann)CS
Ensembl hg19 (Hinxton)ENSG00000062485 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000062485 [Gene_View]  chr12:56271699-56300391 [Contig_View]  CS [Vega]
ICGC DataPortalENSG00000062485
TCGA cBioPortalCS
AceView (NCBI)CS
Genatlas (Paris)CS
WikiGenes1431
SOURCE (Princeton)CS
Genetics Home Reference (NIH)CS
Genomic and cartography
GoldenPath hg38 (UCSC)CS  -     chr12:56271699-56300391 -  12q13.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)CS  -     12q13.3   [Description]    (hg19-Feb_2009)
EnsemblCS - 12q13.3 [CytoView hg19]  CS - 12q13.3 [CytoView hg38]
Mapping of homologs : NCBICS [Mapview hg19]  CS [Mapview hg38]
OMIM118950   
Gene and transcription
Genbank (Entrez)AF047042 AF053631 AF147410 AK074956 AK095856
RefSeq transcript (Entrez)NM_004077 NM_198324
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)CS
Cluster EST : UnigeneHs.743252 [ NCBI ]
CGAP (NCI)Hs.743252
Alternative Splicing GalleryENSG00000062485
Gene ExpressionCS [ NCBI-GEO ]   CS [ EBI - ARRAY_EXPRESS ]   CS [ SEEK ]   CS [ MEM ]
Gene Expression Viewer (FireBrowse)CS [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)1431
GTEX Portal (Tissue expression)CS
Protein : pattern, domain, 3D structure
UniProt/SwissProtO75390   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO75390  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO75390
Splice isoforms : SwissVarO75390
Catalytic activity : Enzyme2.3.3.1 [ Enzyme-Expasy ]   2.3.3.12.3.3.1 [ IntEnz-EBI ]   2.3.3.1 [ BRENDA ]   2.3.3.1 [ KEGG ]   
PhosPhoSitePlusO75390
Domaine pattern : Prosite (Expaxy)CITRATE_SYNTHASE (PS00480)   
Domains : Interpro (EBI)Citrate_synth-like_lrg_a-sub    Citrate_synthase    Citrate_synthase_AS    Citrate_synthase_euk   
Domain families : Pfam (Sanger)Citrate_synt (PF00285)   
Domain families : Pfam (NCBI)pfam00285   
Conserved Domain (NCBI)CS
DMDM Disease mutations1431
Blocks (Seattle)CS
SuperfamilyO75390
Human Protein AtlasENSG00000062485
Peptide AtlasO75390
HPRD00349
IPI###############################################################################################################################################################################################################################################################   
Protein Interaction databases
DIP (DOE-UCLA)O75390
IntAct (EBI)O75390
FunCoupENSG00000062485
BioGRIDCS
STRING (EMBL)CS
ZODIACCS
Ontologies - Pathways
QuickGOO75390
Ontology : AmiGORNA binding  citrate (Si)-synthase activity  citrate (Si)-synthase activity  nucleus  mitochondrion  mitochondrial matrix  mitochondrial matrix  carbohydrate metabolic process  tricarboxylic acid cycle  tricarboxylic acid cycle  extracellular exosome  
Ontology : EGO-EBIRNA binding  citrate (Si)-synthase activity  citrate (Si)-synthase activity  nucleus  mitochondrion  mitochondrial matrix  mitochondrial matrix  carbohydrate metabolic process  tricarboxylic acid cycle  tricarboxylic acid cycle  extracellular exosome  
Pathways : BIOCARTAShuttle for transfer of acetyl groups from mitochondria to the cytosol [Genes]   
Pathways : KEGGCitrate cycle (TCA cycle)    Glyoxylate and dicarboxylate metabolism   
NDEx NetworkCS
Atlas of Cancer Signalling NetworkCS
Wikipedia pathwaysCS
Orthology - Evolution
OrthoDB1431
GeneTree (enSembl)ENSG00000062485
Phylogenetic Trees/Animal Genes : TreeFamCS
HOVERGENO75390
HOGENOMO75390
Homologs : HomoloGeneCS
Homology/Alignments : Family Browser (UCSC)CS
Gene fusions - Rearrangements
Fusion : MitelmanCS/MUCL1 [12q13.3/12q13.2]  
Fusion : MitelmanCS/PRIM1 [12q13.3/12q13.3]  [t(12;12)(q13;q13)]  
Fusion: TCGACS 12q13.3 MUCL1 12q13.2 HNSC
Fusion: TCGACS 12q13.3 PRIM1 12q13.3 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCS [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CS
dbVarCS
ClinVarCS
1000_GenomesCS 
Exome Variant ServerCS
ExAC (Exome Aggregation Consortium)CS (select the gene name)
Genetic variants : HAPMAP1431
Genomic Variants (DGV)CS [DGVbeta]
DECIPHERCS [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisCS 
Mutations
ICGC Data PortalCS 
TCGA Data PortalCS 
Broad Tumor PortalCS
OASIS PortalCS [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCS  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDCS
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)MSeqDR-LSDB Mitochondrial Disease Locus Specific Database
BioMutasearch CS
DgiDB (Drug Gene Interaction Database)CS
DoCM (Curated mutations)CS (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CS (select a term)
intoGenCS
Cancer3DCS(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM118950   
Orphanet
MedgenCS
Genetic Testing Registry CS
NextProtO75390 [Medical]
TSGene1431
GENETestsCS
Huge Navigator CS [HugePedia]
snp3D : Map Gene to Disease1431
BioCentury BCIQCS
ClinGenCS
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD1431
Chemical/Pharm GKB GenePA26928
Clinical trialCS
Miscellaneous
canSAR (ICR)CS (select the gene name)
Probes
Litterature
PubMed48 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineCS
EVEXCS
GoPubMedCS
iHOPCS
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Fri May 19 12:11:54 CEST 2017

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