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CSF2RB (colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage))

Identity

Other namesCD131
CDw131
IL3RB
IL5RB
SMDP5
HGNC (Hugo) CSF2RB
LocusID (NCBI) 1439
Atlas_Id 40163
Location 22q12.3
Location_base_pair Starts at 37309675 and ends at 37336479 bp from pter ( according to hg19-Feb_2009)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)CSF2RB   2436
Cards
Entrez_Gene (NCBI)CSF2RB  1439  colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)
GeneCards (Weizmann)CSF2RB
Ensembl hg19 (Hinxton)ENSG00000100368 [Gene_View]  chr22:37309675-37336479 [Contig_View]  CSF2RB [Vega]
Ensembl hg38 (Hinxton)ENSG00000100368 [Gene_View]  chr22:37309675-37336479 [Contig_View]  CSF2RB [Vega]
ICGC DataPortalENSG00000100368
TCGA cBioPortalCSF2RB
AceView (NCBI)CSF2RB
Genatlas (Paris)CSF2RB
WikiGenes1439
SOURCE (Princeton)CSF2RB
Genomic and cartography
GoldenPath hg19 (UCSC)CSF2RB  -     chr22:37309675-37336479 +  22q12.3   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)CSF2RB  -     22q12.3   [Description]    (hg38-Dec_2013)
EnsemblCSF2RB - 22q12.3 [CytoView hg19]  CSF2RB - 22q12.3 [CytoView hg38]
Mapping of homologs : NCBICSF2RB [Mapview hg19]  CSF2RB [Mapview hg38]
OMIM138981   614370   
Gene and transcription
Genbank (Entrez)AK302993 BC070085 CR456428 CU012989 CU013277
RefSeq transcript (Entrez)NM_000395
RefSeq genomic (Entrez)NC_000022 NC_018933 NG_008040 NT_011520 NW_004929430
Consensus coding sequences : CCDS (NCBI)CSF2RB
Cluster EST : UnigeneHs.592192 [ NCBI ]
CGAP (NCI)Hs.592192
Alternative Splicing : Fast-db (Paris)GSHG0019990
Alternative Splicing GalleryENSG00000100368
Gene ExpressionCSF2RB [ NCBI-GEO ]     CSF2RB [ SEEK ]   CSF2RB [ MEM ]
SOURCE (Princeton)Expression in : [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP32927 (Uniprot)
NextProtP32927  [Medical]
With graphics : InterProP32927
Splice isoforms : SwissVarP32927 (Swissvar)
Domaine pattern : Prosite (Expaxy)FN3 (PS50853)    HEMATOPO_REC_S_F1 (PS01355)   
Domains : Interpro (EBI)FN3_dom    Hempt_rcpt_S_F1_CS    Ig-like_fold    IL-6_rcpt_alpha-bd    IL3_rcpt_beta   
Related proteins : CluSTrP32927
Domain families : Pfam (Sanger)fn3 (PF00041)    IL6Ra-bind (PF09240)   
Domain families : Pfam (NCBI)pfam00041    pfam09240   
Domain families : Smart (EMBL)FN3 (SM00060)  
DMDM Disease mutations1439
Blocks (Seattle)P32927
PDB (SRS)1C8P    1EGJ    1GH7    2GYS    3CXE   
PDB (PDBSum)1C8P    1EGJ    1GH7    2GYS    3CXE   
PDB (IMB)1C8P    1EGJ    1GH7    2GYS    3CXE   
PDB (RSDB)1C8P    1EGJ    1GH7    2GYS    3CXE   
Human Protein AtlasENSG00000100368
Peptide AtlasP32927
HPRD00739
IPIIPI00465234   IPI00879222   IPI00879346   IPI01012760   
Protein Interaction databases
DIP (DOE-UCLA)P32927
IntAct (EBI)P32927
FunCoupENSG00000100368
BioGRIDCSF2RB
IntegromeDBCSF2RB
STRING (EMBL)CSF2RB
Ontologies - Pathways
QuickGOP32927
Ontology : AmiGOreceptor activity  interleukin-3 receptor activity  interleukin-5 receptor activity  protein binding  plasma membrane  integral component of plasma membrane  signal transduction  respiratory gaseous exchange  granulocyte macrophage colony-stimulating factor receptor complex  response to lipopolysaccharide  cellular response to interleukin-3  interleukin-5-mediated signaling pathway  interleukin-3-mediated signaling pathway  
Ontology : EGO-EBIreceptor activity  interleukin-3 receptor activity  interleukin-5 receptor activity  protein binding  plasma membrane  integral component of plasma membrane  signal transduction  respiratory gaseous exchange  granulocyte macrophage colony-stimulating factor receptor complex  response to lipopolysaccharide  cellular response to interleukin-3  interleukin-5-mediated signaling pathway  interleukin-3-mediated signaling pathway  
Pathways : BIOCARTAIL 3 signaling pathway [Genes]    Regulation of BAD phosphorylation [Genes]   
Pathways : KEGGCytokine-cytokine receptor interaction    Apoptosis    Jak-STAT signaling pathway   
Protein Interaction DatabaseCSF2RB
DoCM (Curated mutations)CSF2RB
Wikipedia pathwaysCSF2RB
Gene fusion - Rearrangements
Gene fusion: TCGA
Polymorphisms : SNP, variants
NCBI Variation ViewerCSF2RB [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CSF2RB
dbVarCSF2RB
ClinVarCSF2RB
1000_GenomesCSF2RB 
Exome Variant ServerCSF2RB
SNP (GeneSNP Utah)CSF2RB
SNP : HGBaseCSF2RB
Genetic variants : HAPMAPCSF2RB
Genomic Variants (DGV)CSF2RB [DGVbeta]
Mutations
ICGC Data PortalCSF2RB 
TCGA Data PortalCSF2RB 
Tumor PortalCSF2RB
Somatic Mutations in Cancer : COSMICCSF2RB 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)22:37309675-37336479
CONAN: Copy Number AnalysisCSF2RB 
Mutations and Diseases : HGMDCSF2RB
OMIM138981    614370   
MedgenCSF2RB
NextProtP32927 [Medical]
GENETestsCSF2RB
Disease Genetic AssociationCSF2RB
Huge Navigator CSF2RB [HugePedia]  CSF2RB [HugeCancerGEM]
snp3D : Map Gene to Disease1439
DGIdb (Drug Gene Interaction db)CSF2RB
General knowledge
Homologs : HomoloGeneCSF2RB
Homology/Alignments : Family Browser (UCSC)CSF2RB
Phylogenetic Trees/Animal Genes : TreeFamCSF2RB
Chemical/Protein Interactions : CTD1439
Chemical/Pharm GKB GenePA26939
Clinical trialCSF2RB
Cancer Resource (Charite)ENSG00000100368
Other databases
Probes
Litterature
PubMed91 Pubmed reference(s) in Entrez
CoreMineCSF2RB
GoPubMedCSF2RB
iHOPCSF2RB
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated02-2015Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Apr 13 14:15:52 CEST 2015

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