Atlas of Genetics and Cytogenetics in Oncology and Haematology


Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

CSK (CSK, non-receptor tyrosine kinase)

Identity

Other alias-
HGNC (Hugo) CSK
LocusID (NCBI) 1445
Atlas_Id 40166
Location 15q24.1  [Link to chromosome band 15q24]
Location_base_pair Starts at 74782084 and ends at 74803198 bp from pter ( according to hg38-Dec_2013)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  dic(9;12)(p13;p13) PAX5/ETV6


External links

Nomenclature
HGNC (Hugo)CSK   2444
Cards
Entrez_Gene (NCBI)CSK  1445  CSK, non-receptor tyrosine kinase
Aliases
GeneCards (Weizmann)CSK
Ensembl hg19 (Hinxton)ENSG00000103653 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000103653 [Gene_View]  chr15:74782084-74803198 [Contig_View]  CSK [Vega]
ICGC DataPortalENSG00000103653
TCGA cBioPortalCSK
AceView (NCBI)CSK
Genatlas (Paris)CSK
WikiGenes1445
SOURCE (Princeton)CSK
Genetics Home Reference (NIH)CSK
Genomic and cartography
GoldenPath hg38 (UCSC)CSK  -     chr15:74782084-74803198 +  15q24.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)CSK  -     15q24.1   [Description]    (hg19-Feb_2009)
EnsemblCSK - 15q24.1 [CytoView hg19]  CSK - 15q24.1 [CytoView hg38]
Mapping of homologs : NCBICSK [Mapview hg19]  CSK [Mapview hg38]
OMIM124095   
Gene and transcription
Genbank (Entrez)AB451288 AB451420 AK127672 AK223626 AK290531
RefSeq transcript (Entrez)NM_001127190 NM_004383
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)CSK
Cluster EST : UnigeneHs.77793 [ NCBI ]
CGAP (NCI)Hs.77793
Alternative Splicing GalleryENSG00000103653
Gene ExpressionCSK [ NCBI-GEO ]   CSK [ EBI - ARRAY_EXPRESS ]   CSK [ SEEK ]   CSK [ MEM ]
Gene Expression Viewer (FireBrowse)CSK [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)1445
GTEX Portal (Tissue expression)CSK
Protein : pattern, domain, 3D structure
UniProt/SwissProtP41240   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP41240  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP41240
Splice isoforms : SwissVarP41240
PhosPhoSitePlusP41240
Domaine pattern : Prosite (Expaxy)PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_TYR (PS00109)    SH2 (PS50001)    SH3 (PS50002)   
Domains : Interpro (EBI)Kinase-like_dom    Prot_kinase_dom    Protein_kinase_ATP_BS    Ser-Thr/Tyr_kinase_cat_dom    SH2    SH3_domain    Tyr_kinase_AS    Tyr_kinase_cat_dom   
Domain families : Pfam (Sanger)Pkinase_Tyr (PF07714)    SH2 (PF00017)    SH3_1 (PF00018)   
Domain families : Pfam (NCBI)pfam07714    pfam00017    pfam00018   
Domain families : Smart (EMBL)SH2 (SM00252)  SH3 (SM00326)  TyrKc (SM00219)  
Conserved Domain (NCBI)CSK
DMDM Disease mutations1445
Blocks (Seattle)CSK
PDB (SRS)1BYG    1CSK    3D7T    3D7U    3EAC    3EAZ   
PDB (PDBSum)1BYG    1CSK    3D7T    3D7U    3EAC    3EAZ   
PDB (IMB)1BYG    1CSK    3D7T    3D7U    3EAC    3EAZ   
PDB (RSDB)1BYG    1CSK    3D7T    3D7U    3EAC    3EAZ   
Structural Biology KnowledgeBase1BYG    1CSK    3D7T    3D7U    3EAC    3EAZ   
SCOP (Structural Classification of Proteins)1BYG    1CSK    3D7T    3D7U    3EAC    3EAZ   
CATH (Classification of proteins structures)1BYG    1CSK    3D7T    3D7U    3EAC    3EAZ   
SuperfamilyP41240
Human Protein AtlasENSG00000103653
Peptide AtlasP41240
HPRD00496
IPIIPI00013212   IPI00910540   
Protein Interaction databases
DIP (DOE-UCLA)P41240
IntAct (EBI)P41240
FunCoupENSG00000103653
BioGRIDCSK
STRING (EMBL)CSK
ZODIACCSK
Ontologies - Pathways
QuickGOP41240
Ontology : AmiGOregulation of cytokine production  adaptive immune response  protein tyrosine kinase activity  non-membrane spanning protein tyrosine kinase activity  receptor binding  protein binding  ATP binding  cytoplasm  cytosol  plasma membrane  plasma membrane  cell-cell junction  protein phosphorylation  transmembrane receptor protein tyrosine kinase signaling pathway  epidermal growth factor receptor signaling pathway  central nervous system development  brain development  protein C-terminus binding  negative regulation of cell proliferation  negative regulation of low-density lipoprotein particle clearance  kinase activity  protein phosphatase binding  cell differentiation  extrinsic component of cytoplasmic side of plasma membrane  T cell costimulation  negative regulation of interleukin-6 production  negative regulation of kinase activity  protein kinase A catalytic subunit binding  adherens junction organization  peptidyl-tyrosine autophosphorylation  regulation of cell proliferation  identical protein binding  negative regulation of Golgi to plasma membrane protein transport  positive regulation of MAP kinase activity  innate immune response  membrane raft  negative regulation of bone resorption  metal ion binding  oligodendrocyte differentiation  negative regulation of phagocytosis  T cell receptor signaling pathway  regulation of Fc receptor mediated stimulatory signaling pathway  extracellular exosome  proline-rich region binding  negative regulation of ERK1 and ERK2 cascade  cellular response to peptide hormone stimulus  
Ontology : EGO-EBIregulation of cytokine production  adaptive immune response  protein tyrosine kinase activity  non-membrane spanning protein tyrosine kinase activity  receptor binding  protein binding  ATP binding  cytoplasm  cytosol  plasma membrane  plasma membrane  cell-cell junction  protein phosphorylation  transmembrane receptor protein tyrosine kinase signaling pathway  epidermal growth factor receptor signaling pathway  central nervous system development  brain development  protein C-terminus binding  negative regulation of cell proliferation  negative regulation of low-density lipoprotein particle clearance  kinase activity  protein phosphatase binding  cell differentiation  extrinsic component of cytoplasmic side of plasma membrane  T cell costimulation  negative regulation of interleukin-6 production  negative regulation of kinase activity  protein kinase A catalytic subunit binding  adherens junction organization  peptidyl-tyrosine autophosphorylation  regulation of cell proliferation  identical protein binding  negative regulation of Golgi to plasma membrane protein transport  positive regulation of MAP kinase activity  innate immune response  membrane raft  negative regulation of bone resorption  metal ion binding  oligodendrocyte differentiation  negative regulation of phagocytosis  T cell receptor signaling pathway  regulation of Fc receptor mediated stimulatory signaling pathway  extracellular exosome  proline-rich region binding  negative regulation of ERK1 and ERK2 cascade  cellular response to peptide hormone stimulus  
Pathways : BIOCARTAIntegrin Signaling Pathway [Genes]    Activation of Src by Protein-tyrosine phosphatase alpha [Genes]    Activation of Csk by cAMP-dependent Protein Kinase Inhibits Signaling through the T Cell Receptor [Genes]    Cell to Cell Adhesion Signaling [Genes]   
Pathways : KEGGEpithelial cell signaling in Helicobacter pylori infection   
NDEx NetworkCSK
Atlas of Cancer Signalling NetworkCSK
Wikipedia pathwaysCSK
Orthology - Evolution
OrthoDB1445
GeneTree (enSembl)ENSG00000103653
Phylogenetic Trees/Animal Genes : TreeFamCSK
HOVERGENP41240
HOGENOMP41240
Homologs : HomoloGeneCSK
Homology/Alignments : Family Browser (UCSC)CSK
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCSK [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CSK
dbVarCSK
ClinVarCSK
1000_GenomesCSK 
Exome Variant ServerCSK
ExAC (Exome Aggregation Consortium)CSK (select the gene name)
Genetic variants : HAPMAP1445
Genomic Variants (DGV)CSK [DGVbeta]
DECIPHERCSK [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisCSK 
Mutations
ICGC Data PortalCSK 
TCGA Data PortalCSK 
Broad Tumor PortalCSK
OASIS PortalCSK [ Somatic mutations - Copy number]
Mutations and Diseases : HGMDCSK
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch CSK
DgiDB (Drug Gene Interaction Database)CSK
DoCM (Curated mutations)CSK (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CSK (select a term)
intoGenCSK
Cancer3DCSK(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM124095   
Orphanet
MedgenCSK
Genetic Testing Registry CSK
NextProtP41240 [Medical]
TSGene1445
GENETestsCSK
Target ValidationCSK
Huge Navigator CSK [HugePedia]
snp3D : Map Gene to Disease1445
BioCentury BCIQCSK
ClinGenCSK
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD1445
Chemical/Pharm GKB GenePA26946
Clinical trialCSK
Miscellaneous
canSAR (ICR)CSK (select the gene name)
Probes
Litterature
PubMed221 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineCSK
EVEXCSK
GoPubMedCSK
iHOPCSK
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed Jun 7 12:29:44 CEST 2017

Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.