CSK (C-terminal Src kinase)

2003-02-01  

Identity

HGNC
LOCATION
15q24.1
LOCUSID
ALIAS
-

Other Information

Locus ID:

NCBI: 1445
MIM: 124095
HGNC: 2444
Ensembl: ENSG00000103653

Variants:

dbSNP: 1445
ClinVar: 1445
TCGA: ENSG00000103653
COSMIC: CSK

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000103653ENST00000220003P41240
ENSG00000103653ENST00000220003B2R6Q4
ENSG00000103653ENST00000439220P41240
ENSG00000103653ENST00000439220B2R6Q4
ENSG00000103653ENST00000567123H3BU69
ENSG00000103653ENST00000567571P41240
ENSG00000103653ENST00000567571B2R6Q4
ENSG00000103653ENST00000569462H3BUM9
ENSG00000103653ENST00000569915H3BN15

Expression (GTEx)

0
50
100
150
200
250

Pathways

PathwaySourceExternal ID
Epithelial cell signaling in Helicobacter pylori infectionKEGGko05120
Epithelial cell signaling in Helicobacter pylori infectionKEGGhsa05120
DiseaseREACTOMER-HSA-1643685
Diseases of signal transductionREACTOMER-HSA-5663202
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
TCR signalingREACTOMER-HSA-202403
Phosphorylation of CD3 and TCR zeta chainsREACTOMER-HSA-202427
Costimulation by the CD28 familyREACTOMER-HSA-388841
PD-1 signalingREACTOMER-HSA-389948
Innate Immune SystemREACTOMER-HSA-168249
DAP12 interactionsREACTOMER-HSA-2172127
DAP12 signalingREACTOMER-HSA-2424491
RAF/MAP kinase cascadeREACTOMER-HSA-5673001
MAP2K and MAPK activationREACTOMER-HSA-5674135
Fc epsilon receptor (FCERI) signalingREACTOMER-HSA-2454202
FCERI mediated MAPK activationREACTOMER-HSA-2871796
Cytokine Signaling in Immune systemREACTOMER-HSA-1280215
Signaling by InterleukinsREACTOMER-HSA-449147
Interleukin-2 signalingREACTOMER-HSA-451927
Interleukin receptor SHC signalingREACTOMER-HSA-912526
Interleukin-3, 5 and GM-CSF signalingREACTOMER-HSA-512988
HemostasisREACTOMER-HSA-109582
Platelet activation, signaling and aggregationREACTOMER-HSA-76002
Platelet Aggregation (Plug Formation)REACTOMER-HSA-76009
Integrin alphaIIb beta3 signalingREACTOMER-HSA-354192
Signal TransductionREACTOMER-HSA-162582
Signaling by EGFRREACTOMER-HSA-177929
GRB2 events in EGFR signalingREACTOMER-HSA-179812
SHC1 events in EGFR signalingREACTOMER-HSA-180336
GAB1 signalosomeREACTOMER-HSA-180292
Signaling by Insulin receptorREACTOMER-HSA-74752
Insulin receptor signalling cascadeREACTOMER-HSA-74751
IRS-mediated signallingREACTOMER-HSA-112399
SOS-mediated signallingREACTOMER-HSA-112412
Signalling by NGFREACTOMER-HSA-166520
NGF signalling via TRKA from the plasma membraneREACTOMER-HSA-187037
Signalling to ERKsREACTOMER-HSA-187687
Signalling to RASREACTOMER-HSA-167044
Signalling to p38 via RIT and RINREACTOMER-HSA-187706
Prolonged ERK activation eventsREACTOMER-HSA-169893
Frs2-mediated activationREACTOMER-HSA-170968
ARMS-mediated activationREACTOMER-HSA-170984
Signaling by PDGFREACTOMER-HSA-186797
Downstream signal transductionREACTOMER-HSA-186763
Signaling by VEGFREACTOMER-HSA-194138
VEGFA-VEGFR2 PathwayREACTOMER-HSA-4420097
VEGFR2 mediated cell proliferationREACTOMER-HSA-5218921
Signaling by SCF-KITREACTOMER-HSA-1433557
MAPK family signaling cascadesREACTOMER-HSA-5683057
MAPK1/MAPK3 signalingREACTOMER-HSA-5684996
Signaling by GPCRREACTOMER-HSA-372790
Gastrin-CREB signalling pathway via PKC and MAPKREACTOMER-HSA-881907
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)REACTOMER-HSA-2404192
IGF1R signaling cascadeREACTOMER-HSA-2428924
IRS-related events triggered by IGF1RREACTOMER-HSA-2428928
Signaling by LeptinREACTOMER-HSA-2586552
Developmental BiologyREACTOMER-HSA-1266738
Axon guidanceREACTOMER-HSA-422475
NCAM signaling for neurite out-growthREACTOMER-HSA-375165
RET signalingREACTOMER-HSA-8853659
Oncogenic MAPK signalingREACTOMER-HSA-6802957
Signaling by RAS mutantsREACTOMER-HSA-6802949
Signaling by high-kinase activity BRAF mutantsREACTOMER-HSA-6802948
Signaling by moderate kinase activity BRAF mutantsREACTOMER-HSA-6802946
Paradoxical activation of RAF signaling by kinase inactive BRAFREACTOMER-HSA-6802955
Signaling by BRAF and RAF fusionsREACTOMER-HSA-6802952

Protein levels (Protein atlas)

Not detected
Low
Medium
High

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA30086KDRGenePathwayassociated20124951
PA34183RAF1GenePathwayassociated20124951
PA444552HypertensionDiseaseClinicalAnnotationassociatedPD31327267
PA449899hydrochlorothiazideChemicalClinicalAnnotationassociatedPD31327267

References

Pubmed IDYearTitleCitations
168595112006Beta3 integrin and Src facilitate transforming growth factor-beta mediated induction of epithelial-mesenchymal transition in mammary epithelial cells.117
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
183322192008Calpain 2 and PTP1B function in a novel pathway with Src to regulate invadopodia dynamics and breast cancer cell invasion.76
168584072006Toll-like receptor 3 associates with c-Src tyrosine kinase on endosomes to initiate antiviral signaling.71
125478282003Expression of kinase-inactive c-Src delays oxidative stress-induced disassembly and accelerates calcium-mediated reassembly of tight junctions in the Caco-2 cell monolayer.64
204791552010Blood pressure and hypertension are associated with 7 loci in the Japanese population.63
179512612008Identification of human kinases involved in hepatitis C virus replication by small interference RNA library screening.53
195616432009Autonomous regulation of osteosarcoma cell invasiveness by Wnt5a/Ror2 signaling.53
230421172012CSK regulatory polymorphism is associated with systemic lupus erythematosus and influences B-cell signaling and activation.47
165320302006Histone deacetylase 3 localizes to the plasma membrane and is a substrate of Src.46

Citation

Dessen P

CSK (C-terminal Src kinase)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/40166/csk