CSNK2A1 (casein kinase 2 alpha 1)

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CSNK2A1 (casein kinase 2 alpha 1)

Identity

Alias_names	casein kinase 2
Other alias	CK2A1
	CKII
	Cka1
	Cka2
	OCNDS
HGNC (Hugo)	CSNK2A1
LocusID (NCBI)	1457
Atlas_Id	43221
Location	20p13 [Link to chromosome band 20p13]
Location_base_pair	Starts at 482694 and ends at 543838 bp from pter ( according to hg38-Dec_2013)

Fusion genes
(updated 2017)

Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

	CNBP (3q21.3) / CSNK2A1 (20p13)	CSNK2A1 (20p13) / CSNK2A1 (20p13)	SH3GLB1 (1p22.3) / CSNK2A1 (20p13)

Note	Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, go to How to contribute

DNA/RNA

External links

	Nomenclature
HGNC (Hugo)	CSNK2A1 2457
	Cards
Entrez_Gene (NCBI)	CSNK2A1 1457 casein kinase 2 alpha 1
Aliases	CK2A1; CKII; Cka1; Cka2;
	OCNDS
GeneCards (Weizmann)	CSNK2A1
Ensembl hg19 (Hinxton)	ENSG00000101266 [Gene_View]
Ensembl hg38 (Hinxton)	ENSG00000101266 [Gene_View] ENSG00000101266 [Sequence] chr20:482694-543838 [Contig_View] CSNK2A1 [Vega]
ICGC DataPortal	ENSG00000101266
TCGA cBioPortal	CSNK2A1
AceView (NCBI)	CSNK2A1
Genatlas (Paris)	CSNK2A1
WikiGenes	1457
SOURCE (Princeton)	CSNK2A1
Genetics Home Reference (NIH)	CSNK2A1
	Genomic and cartography
GoldenPath hg38 (UCSC)	CSNK2A1 - chr20:482694-543838 - 20p13 [Description] (hg38-Dec_2013)
GoldenPath hg19 (UCSC)	CSNK2A1 - 20p13 [Description] (hg19-Feb_2009)
Ensembl	CSNK2A1 - 20p13 [CytoView hg19] CSNK2A1 - 20p13 [CytoView hg38]
Mapping of homologs : NCBI	CSNK2A1 [Mapview hg19] CSNK2A1 [Mapview hg38]
OMIM	115440 617062
	Gene and transcription
Genbank (Entrez)	AB451279 AB451411 AK302583 AK312535 AU130091
RefSeq transcript (Entrez)	NM_001362770 NM_001362771 NM_001895 NM_177559 NM_177560
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)	CSNK2A1
Cluster EST : Unigene	Hs.644056 [ NCBI ]
CGAP (NCI)	Hs.644056
Alternative Splicing Gallery	ENSG00000101266
Gene Expression	CSNK2A1 [ NCBI-GEO ] CSNK2A1 [ EBI - ARRAY_EXPRESS ] CSNK2A1 [ SEEK ] CSNK2A1 [ MEM ]
Gene Expression Viewer (FireBrowse)	CSNK2A1 [ Firebrowse - Broad ]
SOURCE (Princeton)	Expression in : [Datasets] [Normal Tissue Atlas] [carcinoma Classsification] [NCI60]
Genevestigator	Expression in : [tissues] [cell-lines] [cancer] [perturbations]
BioGPS (Tissue expression)	1457
GTEX Portal (Tissue expression)	CSNK2A1
Human Protein Atlas	ENSG00000101266-CSNK2A1 [pathology] [cell] [tissue]
	Protein : pattern, domain, 3D structure
UniProt/SwissProt	P68400 [function] [subcellular_location] [family_and_domains] [pathology_and_biotech] [ptm_processing] [expression] [interaction]
NextProt	P68400 [Sequence] [Exons] [Medical] [Publications]
With graphics : InterPro	P68400
Splice isoforms : SwissVar	P68400
PhosPhoSitePlus	P68400
Domaine pattern : Prosite (Expaxy)	PROTEIN_KINASE_ATP (PS00107) PROTEIN_KINASE_DOM (PS50011) PROTEIN_KINASE_ST (PS00108)
Domains : Interpro (EBI)	Kinase-like_dom_sf Prot_kinase_dom Protein_kinase_ATP_BS Ser/Thr_kinase_AS
Domain families : Pfam (Sanger)	Pkinase (PF00069)
Domain families : Pfam (NCBI)	pfam00069
Domain families : Smart (EMBL)	S_TKc (SM00220)
Conserved Domain (NCBI)	CSNK2A1
DMDM Disease mutations	1457
Blocks (Seattle)	CSNK2A1
PDB (SRS)	1JWH 1NA7 1PJK 2PVR 2ZJW 3AMY 3AT2 3AT3 3AT4 3AXW 3BQC 3C13 3FWQ 3H30 3JUH 3MB6 3MB7 3NGA 3NSZ 3OWJ 3OWK 3OWL 3PE1 3PE2 3PE4 3Q04 3Q9W 3Q9X 3Q9Y 3Q9Z 3QA0 3R0T 3RPS 3TAX 3U4U 3U87 3U9C 3W8L 3WAR 3WIK 3WIL 3WOW 4DGL 4FBX 4GRB 4GUB 4GYW 4GYY 4GZ3 4IB5 4KWP 4MD7 4MD8 4MD9 4NH1 4RLL 4UB7 4UBA 5B0X 5CLP 5CQU 5CQW 5CS6 5CSH 5CSP 5CSV 5CT0 5CTP 5CU0 5CU2 5CU3 5CU4 5CU6 5CVF 5CVG 5CVH 5CX9 5H8B 5H8E 5H8G 5HGV 5KU8 5KWH 5M44 5M4C 5M4F 5M4I 5MMF 5MMR 5MO5 5MO6 5MO7 5MO8 5MOD 5MOE 5MOH 5MOT 5MOV 5MOW 5MP8 5MPJ 5N1V 5N9K 5N9L 5N9N 5NQC 5OMY 5ONI 5OQU 5ORH 5ORJ 5ORK 5OS7 5OS8 5OSL 5OSZ 5OT5 5OT6 5OTD 5OTH 5OTI 5OTL 5OTO 5OTQ 5OTR 5OTY 5OTZ 5OUE 5OUL 5OUM 5OUU 5OYF 5T1H 5VIE 5VIF 6EHK 6EHU 6EII
PDB (PDBSum)	1JWH 1NA7 1PJK 2PVR 2ZJW 3AMY 3AT2 3AT3 3AT4 3AXW 3BQC 3C13 3FWQ 3H30 3JUH 3MB6 3MB7 3NGA 3NSZ 3OWJ 3OWK 3OWL 3PE1 3PE2 3PE4 3Q04 3Q9W 3Q9X 3Q9Y 3Q9Z 3QA0 3R0T 3RPS 3TAX 3U4U 3U87 3U9C 3W8L 3WAR 3WIK 3WIL 3WOW 4DGL 4FBX 4GRB 4GUB 4GYW 4GYY 4GZ3 4IB5 4KWP 4MD7 4MD8 4MD9 4NH1 4RLL 4UB7 4UBA 5B0X 5CLP 5CQU 5CQW 5CS6 5CSH 5CSP 5CSV 5CT0 5CTP 5CU0 5CU2 5CU3 5CU4 5CU6 5CVF 5CVG 5CVH 5CX9 5H8B 5H8E 5H8G 5HGV 5KU8 5KWH 5M44 5M4C 5M4F 5M4I 5MMF 5MMR 5MO5 5MO6 5MO7 5MO8 5MOD 5MOE 5MOH 5MOT 5MOV 5MOW 5MP8 5MPJ 5N1V 5N9K 5N9L 5N9N 5NQC 5OMY 5ONI 5OQU 5ORH 5ORJ 5ORK 5OS7 5OS8 5OSL 5OSZ 5OT5 5OT6 5OTD 5OTH 5OTI 5OTL 5OTO 5OTQ 5OTR 5OTY 5OTZ 5OUE 5OUL 5OUM 5OUU 5OYF 5T1H 5VIE 5VIF 6EHK 6EHU 6EII
PDB (IMB)	1JWH 1NA7 1PJK 2PVR 2ZJW 3AMY 3AT2 3AT3 3AT4 3AXW 3BQC 3C13 3FWQ 3H30 3JUH 3MB6 3MB7 3NGA 3NSZ 3OWJ 3OWK 3OWL 3PE1 3PE2 3PE4 3Q04 3Q9W 3Q9X 3Q9Y 3Q9Z 3QA0 3R0T 3RPS 3TAX 3U4U 3U87 3U9C 3W8L 3WAR 3WIK 3WIL 3WOW 4DGL 4FBX 4GRB 4GUB 4GYW 4GYY 4GZ3 4IB5 4KWP 4MD7 4MD8 4MD9 4NH1 4RLL 4UB7 4UBA 5B0X 5CLP 5CQU 5CQW 5CS6 5CSH 5CSP 5CSV 5CT0 5CTP 5CU0 5CU2 5CU3 5CU4 5CU6 5CVF 5CVG 5CVH 5CX9 5H8B 5H8E 5H8G 5HGV 5KU8 5KWH 5M44 5M4C 5M4F 5M4I 5MMF 5MMR 5MO5 5MO6 5MO7 5MO8 5MOD 5MOE 5MOH 5MOT 5MOV 5MOW 5MP8 5MPJ 5N1V 5N9K 5N9L 5N9N 5NQC 5OMY 5ONI 5OQU 5ORH 5ORJ 5ORK 5OS7 5OS8 5OSL 5OSZ 5OT5 5OT6 5OTD 5OTH 5OTI 5OTL 5OTO 5OTQ 5OTR 5OTY 5OTZ 5OUE 5OUL 5OUM 5OUU 5OYF 5T1H 5VIE 5VIF 6EHK 6EHU 6EII
PDB (RSDB)	1JWH 1NA7 1PJK 2PVR 2ZJW 3AMY 3AT2 3AT3 3AT4 3AXW 3BQC 3C13 3FWQ 3H30 3JUH 3MB6 3MB7 3NGA 3NSZ 3OWJ 3OWK 3OWL 3PE1 3PE2 3PE4 3Q04 3Q9W 3Q9X 3Q9Y 3Q9Z 3QA0 3R0T 3RPS 3TAX 3U4U 3U87 3U9C 3W8L 3WAR 3WIK 3WIL 3WOW 4DGL 4FBX 4GRB 4GUB 4GYW 4GYY 4GZ3 4IB5 4KWP 4MD7 4MD8 4MD9 4NH1 4RLL 4UB7 4UBA 5B0X 5CLP 5CQU 5CQW 5CS6 5CSH 5CSP 5CSV 5CT0 5CTP 5CU0 5CU2 5CU3 5CU4 5CU6 5CVF 5CVG 5CVH 5CX9 5H8B 5H8E 5H8G 5HGV 5KU8 5KWH 5M44 5M4C 5M4F 5M4I 5MMF 5MMR 5MO5 5MO6 5MO7 5MO8 5MOD 5MOE 5MOH 5MOT 5MOV 5MOW 5MP8 5MPJ 5N1V 5N9K 5N9L 5N9N 5NQC 5OMY 5ONI 5OQU 5ORH 5ORJ 5ORK 5OS7 5OS8 5OSL 5OSZ 5OT5 5OT6 5OTD 5OTH 5OTI 5OTL 5OTO 5OTQ 5OTR 5OTY 5OTZ 5OUE 5OUL 5OUM 5OUU 5OYF 5T1H 5VIE 5VIF 6EHK 6EHU 6EII
Structural Biology KnowledgeBase	1JWH 1NA7 1PJK 2PVR 2ZJW 3AMY 3AT2 3AT3 3AT4 3AXW 3BQC 3C13 3FWQ 3H30 3JUH 3MB6 3MB7 3NGA 3NSZ 3OWJ 3OWK 3OWL 3PE1 3PE2 3PE4 3Q04 3Q9W 3Q9X 3Q9Y 3Q9Z 3QA0 3R0T 3RPS 3TAX 3U4U 3U87 3U9C 3W8L 3WAR 3WIK 3WIL 3WOW 4DGL 4FBX 4GRB 4GUB 4GYW 4GYY 4GZ3 4IB5 4KWP 4MD7 4MD8 4MD9 4NH1 4RLL 4UB7 4UBA 5B0X 5CLP 5CQU 5CQW 5CS6 5CSH 5CSP 5CSV 5CT0 5CTP 5CU0 5CU2 5CU3 5CU4 5CU6 5CVF 5CVG 5CVH 5CX9 5H8B 5H8E 5H8G 5HGV 5KU8 5KWH 5M44 5M4C 5M4F 5M4I 5MMF 5MMR 5MO5 5MO6 5MO7 5MO8 5MOD 5MOE 5MOH 5MOT 5MOV 5MOW 5MP8 5MPJ 5N1V 5N9K 5N9L 5N9N 5NQC 5OMY 5ONI 5OQU 5ORH 5ORJ 5ORK 5OS7 5OS8 5OSL 5OSZ 5OT5 5OT6 5OTD 5OTH 5OTI 5OTL 5OTO 5OTQ 5OTR 5OTY 5OTZ 5OUE 5OUL 5OUM 5OUU 5OYF 5T1H 5VIE 5VIF 6EHK 6EHU 6EII
SCOP (Structural Classification of Proteins)	1JWH 1NA7 1PJK 2PVR 2ZJW 3AMY 3AT2 3AT3 3AT4 3AXW 3BQC 3C13 3FWQ 3H30 3JUH 3MB6 3MB7 3NGA 3NSZ 3OWJ 3OWK 3OWL 3PE1 3PE2 3PE4 3Q04 3Q9W 3Q9X 3Q9Y 3Q9Z 3QA0 3R0T 3RPS 3TAX 3U4U 3U87 3U9C 3W8L 3WAR 3WIK 3WIL 3WOW 4DGL 4FBX 4GRB 4GUB 4GYW 4GYY 4GZ3 4IB5 4KWP 4MD7 4MD8 4MD9 4NH1 4RLL 4UB7 4UBA 5B0X 5CLP 5CQU 5CQW 5CS6 5CSH 5CSP 5CSV 5CT0 5CTP 5CU0 5CU2 5CU3 5CU4 5CU6 5CVF 5CVG 5CVH 5CX9 5H8B 5H8E 5H8G 5HGV 5KU8 5KWH 5M44 5M4C 5M4F 5M4I 5MMF 5MMR 5MO5 5MO6 5MO7 5MO8 5MOD 5MOE 5MOH 5MOT 5MOV 5MOW 5MP8 5MPJ 5N1V 5N9K 5N9L 5N9N 5NQC 5OMY 5ONI 5OQU 5ORH 5ORJ 5ORK 5OS7 5OS8 5OSL 5OSZ 5OT5 5OT6 5OTD 5OTH 5OTI 5OTL 5OTO 5OTQ 5OTR 5OTY 5OTZ 5OUE 5OUL 5OUM 5OUU 5OYF 5T1H 5VIE 5VIF 6EHK 6EHU 6EII
CATH (Classification of proteins structures)	1JWH 1NA7 1PJK 2PVR 2ZJW 3AMY 3AT2 3AT3 3AT4 3AXW 3BQC 3C13 3FWQ 3H30 3JUH 3MB6 3MB7 3NGA 3NSZ 3OWJ 3OWK 3OWL 3PE1 3PE2 3PE4 3Q04 3Q9W 3Q9X 3Q9Y 3Q9Z 3QA0 3R0T 3RPS 3TAX 3U4U 3U87 3U9C 3W8L 3WAR 3WIK 3WIL 3WOW 4DGL 4FBX 4GRB 4GUB 4GYW 4GYY 4GZ3 4IB5 4KWP 4MD7 4MD8 4MD9 4NH1 4RLL 4UB7 4UBA 5B0X 5CLP 5CQU 5CQW 5CS6 5CSH 5CSP 5CSV 5CT0 5CTP 5CU0 5CU2 5CU3 5CU4 5CU6 5CVF 5CVG 5CVH 5CX9 5H8B 5H8E 5H8G 5HGV 5KU8 5KWH 5M44 5M4C 5M4F 5M4I 5MMF 5MMR 5MO5 5MO6 5MO7 5MO8 5MOD 5MOE 5MOH 5MOT 5MOV 5MOW 5MP8 5MPJ 5N1V 5N9K 5N9L 5N9N 5NQC 5OMY 5ONI 5OQU 5ORH 5ORJ 5ORK 5OS7 5OS8 5OSL 5OSZ 5OT5 5OT6 5OTD 5OTH 5OTI 5OTL 5OTO 5OTQ 5OTR 5OTY 5OTZ 5OUE 5OUL 5OUM 5OUU 5OYF 5T1H 5VIE 5VIF 6EHK 6EHU 6EII
Superfamily	P68400
Human Protein Atlas [tissue]	ENSG00000101266-CSNK2A1 [tissue]
Peptide Atlas	P68400
HPRD	00277
IPI	IPI00744507 IPI00741317 IPI00016613 IPI00472911
	Protein Interaction databases
DIP (DOE-UCLA)	P68400
IntAct (EBI)	P68400
FunCoup	ENSG00000101266
BioGRID	CSNK2A1
STRING (EMBL)	CSNK2A1
ZODIAC	CSNK2A1
	Ontologies - Pathways
QuickGO	P68400
Ontology : AmiGO	protein serine/threonine kinase activity protein serine/threonine kinase activity protein serine/threonine kinase activity protein serine/threonine kinase activity protein binding ATP binding nucleus nucleus nucleoplasm nucleoplasm cytosol plasma membrane protein kinase CK2 complex transcription, DNA-templated regulation of transcription, DNA-templated protein phosphorylation apoptotic process cell cycle signal transduction positive regulation of cell proliferation Wnt signaling pathway kinase activity Sin3 complex NuRD complex peptidyl-serine phosphorylation peptidyl-threonine phosphorylation positive regulation of Wnt signaling pathway positive regulation of cell growth PcG protein complex identical protein binding negative regulation of cysteine-type endopeptidase activity involved in apoptotic process positive regulation of protein catabolic process protein N-terminus binding rhythmic process Hsp90 protein binding chaperone-mediated protein folding regulation of signal transduction by p53 class mediator regulation of chromosome separation negative regulation of ubiquitin-dependent protein catabolic process negative regulation of apoptotic signaling pathway
Ontology : EGO-EBI	protein serine/threonine kinase activity protein serine/threonine kinase activity protein serine/threonine kinase activity protein serine/threonine kinase activity protein binding ATP binding nucleus nucleus nucleoplasm nucleoplasm cytosol plasma membrane protein kinase CK2 complex transcription, DNA-templated regulation of transcription, DNA-templated protein phosphorylation apoptotic process cell cycle signal transduction positive regulation of cell proliferation Wnt signaling pathway kinase activity Sin3 complex NuRD complex peptidyl-serine phosphorylation peptidyl-threonine phosphorylation positive regulation of Wnt signaling pathway positive regulation of cell growth PcG protein complex identical protein binding negative regulation of cysteine-type endopeptidase activity involved in apoptotic process positive regulation of protein catabolic process protein N-terminus binding rhythmic process Hsp90 protein binding chaperone-mediated protein folding regulation of signal transduction by p53 class mediator regulation of chromosome separation negative regulation of ubiquitin-dependent protein catabolic process negative regulation of apoptotic signaling pathway
Pathways : KEGG	Ribosome biogenesis in eukaryotes NF-kappa B signaling pathway Wnt signaling pathway Adherens junction Tight junction Measles Herpes simplex infection Epstein-Barr virus infection
NDEx Network	CSNK2A1
Atlas of Cancer Signalling Network	CSNK2A1
Wikipedia pathways	CSNK2A1
	Orthology - Evolution
OrthoDB	1457
GeneTree (enSembl)	ENSG00000101266
Phylogenetic Trees/Animal Genes : TreeFam	CSNK2A1
HOVERGEN	P68400
HOGENOM	P68400
Homologs : HomoloGene	CSNK2A1
Homology/Alignments : Family Browser (UCSC)	CSNK2A1
	Gene fusions - Rearrangements
Fusion : Quiver	CSNK2A1
	Polymorphisms : SNP and Copy number variants
NCBI Variation Viewer	CSNK2A1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)	CSNK2A1
dbVar	CSNK2A1
ClinVar	CSNK2A1
1000_Genomes	CSNK2A1
Exome Variant Server	CSNK2A1
ExAC (Exome Aggregation Consortium)	ENSG00000101266
GNOMAD Browser	ENSG00000101266
Varsome Browser	CSNK2A1
Genetic variants : HAPMAP	1457
Genomic Variants (DGV)	CSNK2A1 [DGVbeta]
DECIPHER	CSNK2A1 [patients] [syndromes] [variants] [genes]
CONAN: Copy Number Analysis	CSNK2A1
	Mutations
ICGC Data Portal	CSNK2A1
TCGA Data Portal	CSNK2A1
Broad Tumor Portal	CSNK2A1
OASIS Portal	CSNK2A1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMIC	CSNK2A1 [overview] [genome browser] [tissue] [distribution]
Mutations and Diseases : HGMD	CSNK2A1
intOGen Portal	CSNK2A1
LOVD (Leiden Open Variation Database)	Whole genome datasets
LOVD (Leiden Open Variation Database)	LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)	LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)	The Globin Gene Server
BioMuta	search CSNK2A1
DgiDB (Drug Gene Interaction Database)	CSNK2A1
DoCM (Curated mutations)	CSNK2A1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)	CSNK2A1 (select a term)
intoGen	CSNK2A1
Cancer3D	CSNK2A1(select the gene name)
Impact of mutations	[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
	Diseases
OMIM	115440 617062
Orphanet
DisGeNET	CSNK2A1
Medgen	CSNK2A1
Genetic Testing Registry	CSNK2A1
NextProt	P68400 [Medical]
TSGene	1457
GENETests	CSNK2A1
Target Validation	CSNK2A1
Huge Navigator	CSNK2A1 [HugePedia]
snp3D : Map Gene to Disease	1457
BioCentury BCIQ	CSNK2A1
ClinGen	CSNK2A1
	Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD	1457
Chemical/Pharm GKB Gene	PA26957
Clinical trial	CSNK2A1
	Miscellaneous
canSAR (ICR)	CSNK2A1 (select the gene name)
	Probes
	Litterature
PubMed	499 Pubmed reference(s) in Entrez
GeneRIFs	Gene References Into Functions (Entrez)
CoreMine	CSNK2A1
EVEX	CSNK2A1
GoPubMed	CSNK2A1
iHOP	CSNK2A1

Genes in title	automatic search in PubMed
REVIEW articles	automatic search in PubMed
Last year publications	automatic search in PubMed

Search in all EBI NCBI

indexed on : Mon Aug 27 11:17:25 CEST 2018

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Atlas of Genetics and Cytogenetics in Oncology and Haematology

CSNK2A1 (casein kinase 2 alpha 1)

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, go to How to contribute

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to How to contribute