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CSNK2A1 (casein kinase 2 alpha 1)

Identity

Alias_namescasein kinase 2
Other aliasCK2A1
CKII
CSNK2A3
HGNC (Hugo) CSNK2A1
LocusID (NCBI) 1457
Atlas_Id 43221
Location 20p13  [Link to chromosome band 20p13]
Location_base_pair Starts at 463338 and ends at 524482 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
CNBP (3q21.3) / CSNK2A1 (20p13)CSNK2A1 (20p13) / CSNK2A1 (20p13)SH3GLB1 (1p22.3) / CSNK2A1 (20p13)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)CSNK2A1   2457
Cards
Entrez_Gene (NCBI)CSNK2A1  1457  casein kinase 2 alpha 1
AliasesCK2A1; CKII; CSNK2A3
GeneCards (Weizmann)CSNK2A1
Ensembl hg19 (Hinxton)ENSG00000101266 [Gene_View]  chr20:463338-524482 [Contig_View]  CSNK2A1 [Vega]
Ensembl hg38 (Hinxton)ENSG00000101266 [Gene_View]  chr20:463338-524482 [Contig_View]  CSNK2A1 [Vega]
ICGC DataPortalENSG00000101266
TCGA cBioPortalCSNK2A1
AceView (NCBI)CSNK2A1
Genatlas (Paris)CSNK2A1
WikiGenes1457
SOURCE (Princeton)CSNK2A1
Genetics Home Reference (NIH)CSNK2A1
Genomic and cartography
GoldenPath hg19 (UCSC)CSNK2A1  -     chr20:463338-524482 -  20p13   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)CSNK2A1  -     20p13   [Description]    (hg38-Dec_2013)
EnsemblCSNK2A1 - 20p13 [CytoView hg19]  CSNK2A1 - 20p13 [CytoView hg38]
Mapping of homologs : NCBICSNK2A1 [Mapview hg19]  CSNK2A1 [Mapview hg38]
OMIM115440   
Gene and transcription
Genbank (Entrez)AB451279 AB451411 AK302583 AK312535 AU130091
RefSeq transcript (Entrez)NM_001895 NM_177559 NM_177560
RefSeq genomic (Entrez)NC_000020 NC_018931 NG_011970 NT_011387 NW_004929416
Consensus coding sequences : CCDS (NCBI)CSNK2A1
Cluster EST : UnigeneHs.644056 [ NCBI ]
CGAP (NCI)Hs.644056
Alternative Splicing GalleryENSG00000101266
Gene ExpressionCSNK2A1 [ NCBI-GEO ]   CSNK2A1 [ EBI - ARRAY_EXPRESS ]   CSNK2A1 [ SEEK ]   CSNK2A1 [ MEM ]
Gene Expression Viewer (FireBrowse)CSNK2A1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)1457
GTEX Portal (Tissue expression)CSNK2A1
Protein : pattern, domain, 3D structure
UniProt/SwissProtP68400   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP68400  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP68400
Splice isoforms : SwissVarP68400
PhosPhoSitePlusP68400
Domaine pattern : Prosite (Expaxy)PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_ST (PS00108)   
Domains : Interpro (EBI)Kinase-like_dom    Prot_kinase_dom    Protein_kinase_ATP_BS    Ser/Thr_dual-sp_kinase    Ser/Thr_kinase_AS   
Domain families : Pfam (Sanger)Pkinase (PF00069)   
Domain families : Pfam (NCBI)pfam00069   
Domain families : Smart (EMBL)S_TKc (SM00220)  
Conserved Domain (NCBI)CSNK2A1
DMDM Disease mutations1457
Blocks (Seattle)CSNK2A1
PDB (SRS)1JWH    1NA7    1PJK    2PVR    2ZJW    3AMY    3AT2    3AT3    3AT4    3AXW    3BQC    3C13    3FWQ    3H30    3JUH    3MB6    3MB7    3NGA    3NSZ    3OWJ    3OWK    3OWL    3PE1    3PE2    3PE4    3Q04    3Q9W    3Q9X    3Q9Y    3Q9Z    3QA0    3R0T    3RPS    3TAX    3U4U    3U87    3U9C    3W8L    3WAR    3WIK    3WIL    3WOW    4DGL    4FBX    4GRB    4GUB    4GYW    4GYY    4GZ3    4IB5    4KWP    4MD7    4MD8    4MD9    4NH1    4RLL    4UB7    4UBA    5CQU    5CQW   
PDB (PDBSum)1JWH    1NA7    1PJK    2PVR    2ZJW    3AMY    3AT2    3AT3    3AT4    3AXW    3BQC    3C13    3FWQ    3H30    3JUH    3MB6    3MB7    3NGA    3NSZ    3OWJ    3OWK    3OWL    3PE1    3PE2    3PE4    3Q04    3Q9W    3Q9X    3Q9Y    3Q9Z    3QA0    3R0T    3RPS    3TAX    3U4U    3U87    3U9C    3W8L    3WAR    3WIK    3WIL    3WOW    4DGL    4FBX    4GRB    4GUB    4GYW    4GYY    4GZ3    4IB5    4KWP    4MD7    4MD8    4MD9    4NH1    4RLL    4UB7    4UBA    5CQU    5CQW   
PDB (IMB)1JWH    1NA7    1PJK    2PVR    2ZJW    3AMY    3AT2    3AT3    3AT4    3AXW    3BQC    3C13    3FWQ    3H30    3JUH    3MB6    3MB7    3NGA    3NSZ    3OWJ    3OWK    3OWL    3PE1    3PE2    3PE4    3Q04    3Q9W    3Q9X    3Q9Y    3Q9Z    3QA0    3R0T    3RPS    3TAX    3U4U    3U87    3U9C    3W8L    3WAR    3WIK    3WIL    3WOW    4DGL    4FBX    4GRB    4GUB    4GYW    4GYY    4GZ3    4IB5    4KWP    4MD7    4MD8    4MD9    4NH1    4RLL    4UB7    4UBA    5CQU    5CQW   
PDB (RSDB)1JWH    1NA7    1PJK    2PVR    2ZJW    3AMY    3AT2    3AT3    3AT4    3AXW    3BQC    3C13    3FWQ    3H30    3JUH    3MB6    3MB7    3NGA    3NSZ    3OWJ    3OWK    3OWL    3PE1    3PE2    3PE4    3Q04    3Q9W    3Q9X    3Q9Y    3Q9Z    3QA0    3R0T    3RPS    3TAX    3U4U    3U87    3U9C    3W8L    3WAR    3WIK    3WIL    3WOW    4DGL    4FBX    4GRB    4GUB    4GYW    4GYY    4GZ3    4IB5    4KWP    4MD7    4MD8    4MD9    4NH1    4RLL    4UB7    4UBA    5CQU    5CQW   
Structural Biology KnowledgeBase1JWH    1NA7    1PJK    2PVR    2ZJW    3AMY    3AT2    3AT3    3AT4    3AXW    3BQC    3C13    3FWQ    3H30    3JUH    3MB6    3MB7    3NGA    3NSZ    3OWJ    3OWK    3OWL    3PE1    3PE2    3PE4    3Q04    3Q9W    3Q9X    3Q9Y    3Q9Z    3QA0    3R0T    3RPS    3TAX    3U4U    3U87    3U9C    3W8L    3WAR    3WIK    3WIL    3WOW    4DGL    4FBX    4GRB    4GUB    4GYW    4GYY    4GZ3    4IB5    4KWP    4MD7    4MD8    4MD9    4NH1    4RLL    4UB7    4UBA    5CQU    5CQW   
SCOP (Structural Classification of Proteins)1JWH    1NA7    1PJK    2PVR    2ZJW    3AMY    3AT2    3AT3    3AT4    3AXW    3BQC    3C13    3FWQ    3H30    3JUH    3MB6    3MB7    3NGA    3NSZ    3OWJ    3OWK    3OWL    3PE1    3PE2    3PE4    3Q04    3Q9W    3Q9X    3Q9Y    3Q9Z    3QA0    3R0T    3RPS    3TAX    3U4U    3U87    3U9C    3W8L    3WAR    3WIK    3WIL    3WOW    4DGL    4FBX    4GRB    4GUB    4GYW    4GYY    4GZ3    4IB5    4KWP    4MD7    4MD8    4MD9    4NH1    4RLL    4UB7    4UBA    5CQU    5CQW   
CATH (Classification of proteins structures)1JWH    1NA7    1PJK    2PVR    2ZJW    3AMY    3AT2    3AT3    3AT4    3AXW    3BQC    3C13    3FWQ    3H30    3JUH    3MB6    3MB7    3NGA    3NSZ    3OWJ    3OWK    3OWL    3PE1    3PE2    3PE4    3Q04    3Q9W    3Q9X    3Q9Y    3Q9Z    3QA0    3R0T    3RPS    3TAX    3U4U    3U87    3U9C    3W8L    3WAR    3WIK    3WIL    3WOW    4DGL    4FBX    4GRB    4GUB    4GYW    4GYY    4GZ3    4IB5    4KWP    4MD7    4MD8    4MD9    4NH1    4RLL    4UB7    4UBA    5CQU    5CQW   
SuperfamilyP68400
Human Protein AtlasENSG00000101266
Peptide AtlasP68400
HPRD00277
IPIIPI00744507   IPI00741317   IPI00016613   IPI00472911   
Protein Interaction databases
DIP (DOE-UCLA)P68400
IntAct (EBI)P68400
FunCoupENSG00000101266
BioGRIDCSNK2A1
STRING (EMBL)CSNK2A1
ZODIACCSNK2A1
Ontologies - Pathways
QuickGOP68400
Ontology : AmiGOprotein serine/threonine kinase activity  protein serine/threonine kinase activity  protein serine/threonine kinase activity  protein binding  ATP binding  nucleus  nucleoplasm  cytosol  plasma membrane  transcription, DNA-templated  regulation of transcription, DNA-templated  protein folding  protein phosphorylation  signal transduction  beta-catenin binding  positive regulation of cell proliferation  Wnt signaling pathway  Sin3 complex  NuRD complex  protein phosphatase regulator activity  positive regulation of Wnt signaling pathway  positive regulation of cell growth  PcG protein complex  negative regulation of cysteine-type endopeptidase activity involved in apoptotic process  positive regulation of protein catabolic process  protein autophosphorylation  protein N-terminus binding  rhythmic process  regulation of catalytic activity  Hsp90 protein binding  chaperone-mediated protein folding  mitotic spindle checkpoint  regulation of signal transduction by p53 class mediator  
Ontology : EGO-EBIprotein serine/threonine kinase activity  protein serine/threonine kinase activity  protein serine/threonine kinase activity  protein binding  ATP binding  nucleus  nucleoplasm  cytosol  plasma membrane  transcription, DNA-templated  regulation of transcription, DNA-templated  protein folding  protein phosphorylation  signal transduction  beta-catenin binding  positive regulation of cell proliferation  Wnt signaling pathway  Sin3 complex  NuRD complex  protein phosphatase regulator activity  positive regulation of Wnt signaling pathway  positive regulation of cell growth  PcG protein complex  negative regulation of cysteine-type endopeptidase activity involved in apoptotic process  positive regulation of protein catabolic process  protein autophosphorylation  protein N-terminus binding  rhythmic process  regulation of catalytic activity  Hsp90 protein binding  chaperone-mediated protein folding  mitotic spindle checkpoint  regulation of signal transduction by p53 class mediator  
Pathways : BIOCARTAIL 2 signaling pathway [Genes]    IL 6 signaling pathway [Genes]    IGF-1 Signaling Pathway [Genes]    EGF Signaling Pathway [Genes]    Nerve growth factor pathway (NGF) [Genes]    TPO Signaling Pathway [Genes]    WNT Signaling Pathway [Genes]    Lissencephaly gene (LIS1) in neuronal migration and development [Genes]    Insulin Signaling Pathway [Genes]    EPO Signaling Pathway [Genes]    PDGF Signaling Pathway [Genes]   
Pathways : KEGGRibosome biogenesis in eukaryotes    NF-kappa B signaling pathway    Wnt signaling pathway    Adherens junction    Tight junction    Measles    Herpes simplex infection    Epstein-Barr virus infection   
NDEx NetworkCSNK2A1
Atlas of Cancer Signalling NetworkCSNK2A1
Wikipedia pathwaysCSNK2A1
Orthology - Evolution
OrthoDB1457
GeneTree (enSembl)ENSG00000101266
Phylogenetic Trees/Animal Genes : TreeFamCSNK2A1
HOVERGENP68400
HOGENOMP68400
Homologs : HomoloGeneCSNK2A1
Homology/Alignments : Family Browser (UCSC)CSNK2A1
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCSNK2A1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CSNK2A1
dbVarCSNK2A1
ClinVarCSNK2A1
1000_GenomesCSNK2A1 
Exome Variant ServerCSNK2A1
ExAC (Exome Aggregation Consortium)CSNK2A1 (select the gene name)
Genetic variants : HAPMAP1457
Genomic Variants (DGV)CSNK2A1 [DGVbeta]
DECIPHER (Syndromes)20:463338-524482  ENSG00000101266
CONAN: Copy Number AnalysisCSNK2A1 
Mutations
ICGC Data PortalCSNK2A1 
TCGA Data PortalCSNK2A1 
Broad Tumor PortalCSNK2A1
OASIS PortalCSNK2A1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCSNK2A1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDCSNK2A1
intOGen PortalCSNK2A1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)The Globin Gene Server
BioMutasearch CSNK2A1
DgiDB (Drug Gene Interaction Database)CSNK2A1
DoCM (Curated mutations)CSNK2A1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CSNK2A1 (select a term)
intoGenCSNK2A1
Cancer3DCSNK2A1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM115440   
Orphanet
MedgenCSNK2A1
Genetic Testing Registry CSNK2A1
NextProtP68400 [Medical]
TSGene1457
GENETestsCSNK2A1
Huge Navigator CSNK2A1 [HugePedia]
snp3D : Map Gene to Disease1457
BioCentury BCIQCSNK2A1
ClinGenCSNK2A1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD1457
Chemical/Pharm GKB GenePA26957
Clinical trialCSNK2A1
Miscellaneous
canSAR (ICR)CSNK2A1 (select the gene name)
Probes
Litterature
PubMed499 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineCSNK2A1
EVEXCSNK2A1
GoPubMedCSNK2A1
iHOPCSNK2A1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Mar 30 14:57:46 CEST 2017

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