Atlas of Genetics and Cytogenetics in Oncology and Haematology


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CSNK2B (casein kinase 2 beta)

Identity

Alias_namescasein kinase 2
Other aliasCK2B
CK2N
CSK2B
Ckb1
Ckb2
G5A
HGNC (Hugo) CSNK2B
LocusID (NCBI) 1460
Atlas_Id 40172
Location 6p21.33  [Link to chromosome band 6p21]
Location_base_pair Starts at 31665880 and ends at 31670070 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CSNK2B (6p21.33) / MICA (6p21.33)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)CSNK2B   2460
Cards
Entrez_Gene (NCBI)CSNK2B  1460  casein kinase 2 beta
AliasesCK2B; CK2N; CSK2B; Ckb1; 
Ckb2; G5A
GeneCards (Weizmann)CSNK2B
Ensembl hg19 (Hinxton)ENSG00000204435 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000204435 [Gene_View]  ENSG00000204435 [Sequence]  chr6:31665880-31670070 [Contig_View]  CSNK2B [Vega]
ICGC DataPortalENSG00000204435
TCGA cBioPortalCSNK2B
AceView (NCBI)CSNK2B
Genatlas (Paris)CSNK2B
WikiGenes1460
SOURCE (Princeton)CSNK2B
Genetics Home Reference (NIH)CSNK2B
Genomic and cartography
GoldenPath hg38 (UCSC)CSNK2B  -     chr6:31665880-31670070 +  6p21.33   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)CSNK2B  -     6p21.33   [Description]    (hg19-Feb_2009)
EnsemblCSNK2B - 6p21.33 [CytoView hg19]  CSNK2B - 6p21.33 [CytoView hg38]
Mapping of homologs : NCBICSNK2B [Mapview hg19]  CSNK2B [Mapview hg38]
OMIM115441   
Gene and transcription
Genbank (Entrez)AK300671 AK308742 AK310551 AK310954 AK311860
RefSeq transcript (Entrez)NM_001282385 NM_001320
RefSeq genomic (Entrez)NC_000006 NC_018917 NT_113891 NT_167245 NT_167246 NT_167247 NT_167248 NT_167249
Consensus coding sequences : CCDS (NCBI)CSNK2B
Cluster EST : UnigeneHs.73527 [ NCBI ]
CGAP (NCI)Hs.73527
Alternative Splicing GalleryENSG00000204435
Gene ExpressionCSNK2B [ NCBI-GEO ]   CSNK2B [ EBI - ARRAY_EXPRESS ]   CSNK2B [ SEEK ]   CSNK2B [ MEM ]
Gene Expression Viewer (FireBrowse)CSNK2B [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)1460
GTEX Portal (Tissue expression)CSNK2B
Human Protein AtlasENSG00000204435-CSNK2B [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP67870   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP67870  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP67870
Splice isoforms : SwissVarP67870
PhosPhoSitePlusP67870
Domaine pattern : Prosite (Expaxy)CK2_BETA (PS01101)   
Domains : Interpro (EBI)Casein_kin_II_reg-sub_a-hlx    Casein_kin_II_reg-sub_b-sht    Casein_kinase_II_reg-sub   
Domain families : Pfam (Sanger)CK_II_beta (PF01214)   
Domain families : Pfam (NCBI)pfam01214   
Domain families : Smart (EMBL)CK_II_beta (SM01085)  
Conserved Domain (NCBI)CSNK2B
DMDM Disease mutations1460
Blocks (Seattle)CSNK2B
PDB (SRS)1DS5    1JWH    1QF8    3EED    4DGL    4MD7    4MD8    4MD9    4NH1   
PDB (PDBSum)1DS5    1JWH    1QF8    3EED    4DGL    4MD7    4MD8    4MD9    4NH1   
PDB (IMB)1DS5    1JWH    1QF8    3EED    4DGL    4MD7    4MD8    4MD9    4NH1   
PDB (RSDB)1DS5    1JWH    1QF8    3EED    4DGL    4MD7    4MD8    4MD9    4NH1   
Structural Biology KnowledgeBase1DS5    1JWH    1QF8    3EED    4DGL    4MD7    4MD8    4MD9    4NH1   
SCOP (Structural Classification of Proteins)1DS5    1JWH    1QF8    3EED    4DGL    4MD7    4MD8    4MD9    4NH1   
CATH (Classification of proteins structures)1DS5    1JWH    1QF8    3EED    4DGL    4MD7    4MD8    4MD9    4NH1   
SuperfamilyP67870
Human Protein Atlas [tissue]ENSG00000204435-CSNK2B [tissue]
Peptide AtlasP67870
HPRD00278
IPIIPI00010865   IPI00908480   IPI00640088   IPI00514910   
Protein Interaction databases
DIP (DOE-UCLA)P67870
IntAct (EBI)P67870
FunCoupENSG00000204435
BioGRIDCSNK2B
STRING (EMBL)CSNK2B
ZODIACCSNK2B
Ontologies - Pathways
QuickGOP67870
Ontology : AmiGOchromatin  chromatin binding  protein serine/threonine kinase activity  protein serine/threonine kinase activity  receptor binding  protein binding  extracellular region  nucleus  nucleus  nucleoplasm  cytoplasm  cytosol  plasma membrane  cilium  protein kinase CK2 complex  protein kinase CK2 complex  protein folding  phosphatidylcholine biosynthetic process  signal transduction  transcription factor binding  negative regulation of cell proliferation  positive regulation of pathway-restricted SMAD protein phosphorylation  Wnt signaling pathway  macroautophagy  nuclear matrix  peptidyl-threonine phosphorylation  protein kinase regulator activity  protein domain specific binding  PcG protein complex  positive regulation of activin receptor signaling pathway  adiponectin-activated signaling pathway  response to testosterone  secretory granule lumen  identical protein binding  ribonucleoprotein complex binding  neutrophil degranulation  negative regulation of blood vessel endothelial cell migration  cellular protein complex assembly  regulation of protein kinase activity  metal ion binding  regulation of DNA binding  endothelial tube morphogenesis  extracellular exosome  liver regeneration  regulation of signal transduction by p53 class mediator  ficolin-1-rich granule lumen  
Ontology : EGO-EBIchromatin  chromatin binding  protein serine/threonine kinase activity  protein serine/threonine kinase activity  receptor binding  protein binding  extracellular region  nucleus  nucleus  nucleoplasm  cytoplasm  cytosol  plasma membrane  cilium  protein kinase CK2 complex  protein kinase CK2 complex  protein folding  phosphatidylcholine biosynthetic process  signal transduction  transcription factor binding  negative regulation of cell proliferation  positive regulation of pathway-restricted SMAD protein phosphorylation  Wnt signaling pathway  macroautophagy  nuclear matrix  peptidyl-threonine phosphorylation  protein kinase regulator activity  protein domain specific binding  PcG protein complex  positive regulation of activin receptor signaling pathway  adiponectin-activated signaling pathway  response to testosterone  secretory granule lumen  identical protein binding  ribonucleoprotein complex binding  neutrophil degranulation  negative regulation of blood vessel endothelial cell migration  cellular protein complex assembly  regulation of protein kinase activity  metal ion binding  regulation of DNA binding  endothelial tube morphogenesis  extracellular exosome  liver regeneration  regulation of signal transduction by p53 class mediator  ficolin-1-rich granule lumen  
Pathways : KEGGWnt signaling pathway    Adherens junction    Tight junction   
NDEx NetworkCSNK2B
Atlas of Cancer Signalling NetworkCSNK2B
Wikipedia pathwaysCSNK2B
Orthology - Evolution
OrthoDB1460
GeneTree (enSembl)ENSG00000204435
Phylogenetic Trees/Animal Genes : TreeFamCSNK2B
HOVERGENP67870
HOGENOMP67870
Homologs : HomoloGeneCSNK2B
Homology/Alignments : Family Browser (UCSC)CSNK2B
Gene fusions - Rearrangements
Fusion : QuiverCSNK2B
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCSNK2B [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CSNK2B
dbVarCSNK2B
ClinVarCSNK2B
1000_GenomesCSNK2B 
Exome Variant ServerCSNK2B
ExAC (Exome Aggregation Consortium)ENSG00000204435
GNOMAD BrowserENSG00000204435
Genetic variants : HAPMAP1460
Genomic Variants (DGV)CSNK2B [DGVbeta]
DECIPHERCSNK2B [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisCSNK2B 
Mutations
ICGC Data PortalCSNK2B 
TCGA Data PortalCSNK2B 
Broad Tumor PortalCSNK2B
OASIS PortalCSNK2B [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCSNK2B  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDCSNK2B
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch CSNK2B
DgiDB (Drug Gene Interaction Database)CSNK2B
DoCM (Curated mutations)CSNK2B (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CSNK2B (select a term)
intoGenCSNK2B
Cancer3DCSNK2B(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM115441   
Orphanet
DisGeNETCSNK2B
MedgenCSNK2B
Genetic Testing Registry CSNK2B
NextProtP67870 [Medical]
TSGene1460
GENETestsCSNK2B
Target ValidationCSNK2B
Huge Navigator CSNK2B [HugePedia]
snp3D : Map Gene to Disease1460
BioCentury BCIQCSNK2B
ClinGenCSNK2B
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD1460
Chemical/Pharm GKB GenePA26960
Clinical trialCSNK2B
Miscellaneous
canSAR (ICR)CSNK2B (select the gene name)
Probes
Litterature
PubMed251 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineCSNK2B
EVEXCSNK2B
GoPubMedCSNK2B
iHOPCSNK2B
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Fri Jun 22 16:21:07 CEST 2018

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