CSPG4 (chondroitin sulfate proteoglycan 4)

2003-02-01  

Identity

HGNC
LOCATION
15q24.2
LOCUSID
ALIAS
CSPG4A,HMW-MAA,MCSP,MCSPG,MEL-CSPG,MSK16,NG2
FUSION GENES

Other Information

Locus ID:

NCBI: 1464
MIM: 601172
HGNC: 2466
Ensembl: ENSG00000173546

Variants:

dbSNP: 1464
ClinVar: 1464
TCGA: ENSG00000173546
COSMIC: CSPG4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000173546ENST00000308508Q6UVK1

Expression (GTEx)

0
50
100
150
200
250

Pathways

PathwaySourceExternal ID
DiseaseREACTOMER-HSA-1643685
Diseases of glycosylationREACTOMER-HSA-3781865
Diseases associated with glycosaminoglycan metabolismREACTOMER-HSA-3560782
Defective B4GALT7 causes EDS, progeroid typeREACTOMER-HSA-3560783
Defective B3GAT3 causes JDSSDHDREACTOMER-HSA-3560801
Defective CHSY1 causes TPBSREACTOMER-HSA-3595177
Defective CHST3 causes SEDCJDREACTOMER-HSA-3595172
Defective CHST14 causes EDS, musculocontractural typeREACTOMER-HSA-3595174
MetabolismREACTOMER-HSA-1430728
Metabolism of carbohydratesREACTOMER-HSA-71387
Glycosaminoglycan metabolismREACTOMER-HSA-1630316
Heparan sulfate/heparin (HS-GAG) metabolismREACTOMER-HSA-1638091
A tetrasaccharide linker sequence is required for GAG synthesisREACTOMER-HSA-1971475
Chondroitin sulfate/dermatan sulfate metabolismREACTOMER-HSA-1793185
Chondroitin sulfate biosynthesisREACTOMER-HSA-2022870
Dermatan sulfate biosynthesisREACTOMER-HSA-2022923
CS/DS degradationREACTOMER-HSA-2024101
Defective B3GALT6 causes EDSP2 and SEMDJL1REACTOMER-HSA-4420332

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
210928572010NG2+ CNS glial progenitors remain committed to the oligodendrocyte lineage in postnatal life and following neurodegeneration.262
211235842010NG2 glia generate new oligodendrocytes but few astrocytes in a murine experimental autoimmune encephalomyelitis model of demyelinating disease.91
239950702013Act1 mediates IL-17-induced EAE pathogenesis selectively in NG2+ glial cells.68
192047262009Transcriptomic and genetic studies identify IL-33 as a candidate gene for Alzheimer's disease.63
184698522008The progenitor cell marker NG2/MPG promotes chemoresistance by activation of integrin-dependent PI3K/Akt signaling.62
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
175919202007Differential phosphorylation of NG2 proteoglycan by ERK and PKCalpha helps balance cell proliferation and migration.51
216582542011Chondroitin sulfates play a major role in breast cancer metastasis: a role for CSPG4 and CHST11 gene expression in forming surface P-selectin ligands in aggressive breast cancer cells.49
220041312011CSPG4, a potential therapeutic target, facilitates malignant progression of melanoma.49
152107342004Melanoma chondroitin sulfate proteoglycan enhances FAK and ERK activation by distinct mechanisms.48

Citation

Dessen P

CSPG4 (chondroitin sulfate proteoglycan 4)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/40174/cspg4