CST1 (cystatin SN)

2009-09-01  

Identity

HGNC
LOCATION
20p11.21
LOCUSID
ALIAS
-
FUSION GENES

Other Information

Locus ID:

NCBI: 1469
MIM: 123855
HGNC: 2473
Ensembl: ENSG00000170373

Variants:

dbSNP: 1469
ClinVar: 1469
TCGA: ENSG00000170373
COSMIC: CST1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000170373ENST00000304749P01037
ENSG00000170373ENST00000398402P01037

Expression (GTEx)

0
1
2
3
4
5
6
7

Pathways

PathwaySourceExternal ID
Salivary secretionKEGGko04970
Salivary secretionKEGGhsa04970

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
195135492009Identification of Cystatin SN as a novel tumor marker for colorectal cancer.27
194638002009Upregulation of the cysteine protease inhibitor, cystatin SN, contributes to cell proliferation and cathepsin inhibition in gastric cancer.26
285234672017Elevated expression of CST1 promotes breast cancer progression and predicts a poor prognosis.17
255772482015Identification of cystatin SN as a novel biomarker for pancreatic cancer.12
256483682015Expression of Cystatin SN significantly correlates with recurrence, metastasis, and survival duration in surgically resected non-small cell lung cancer patients.9
283835582017Extracellular cystatin SN and cathepsin B prevent cellular senescence by inhibiting abnormal glycogen accumulation.6
298452242018Let‑7d inhibits colorectal cancer cell proliferation through the CST1/p65 pathway.6
300125142019Human cystatin SN is an endogenous protease inhibitor that prevents allergic rhinitis.6
309768122019Mammalian CST averts replication failure by preventing G-quadruplex accumulation.6
296986142018Expression and Functional Analysis of CST1 in Intractable Nasal Polyps.5

Citation

Dessen P

CST1 (cystatin SN)

Atlas Genet Cytogenet Oncol Haematol. 2009-09-01

Online version: http://atlasgeneticsoncology.org/gene/51081/cst1