CTBP1 (C-terminal binding protein 1)

2003-02-01  

Identity

HGNC
LOCATION
4p16.3
LOCUSID
ALIAS
BARS,HADDTS
FUSION GENES

Other Information

Locus ID:

NCBI: 1487
MIM: 602618
HGNC: 2494
Ensembl: ENSG00000159692

Variants:

dbSNP: 1487
ClinVar: 1487
TCGA: ENSG00000159692
COSMIC: CTBP1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000159692ENST00000290921Q13363
ENSG00000159692ENST00000290921X5D8Y5
ENSG00000159692ENST00000382952Q13363
ENSG00000159692ENST00000503594H0Y8U5
ENSG00000159692ENST00000504092H0Y8W7
ENSG00000159692ENST00000504784H0Y913
ENSG00000159692ENST00000506180D6RAX2
ENSG00000159692ENST00000510568E7EUB3
ENSG00000159692ENST00000510739H0Y9M9
ENSG00000159692ENST00000513420E9PGB1
ENSG00000159692ENST00000514210E7EPF8
ENSG00000159692ENST00000515399E7ESU7
ENSG00000159692ENST00000629223A0A0D9SGE6

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90

Pathways

PathwaySourceExternal ID
Wnt signaling pathwayKEGGko04310
Notch signaling pathwayKEGGko04330
Chronic myeloid leukemiaKEGGko05220
Wnt signaling pathwayKEGGhsa04310
Notch signaling pathwayKEGGhsa04330
Pathways in cancerKEGGhsa05200
Chronic myeloid leukemiaKEGGhsa05220
DiseaseREACTOMER-HSA-1643685
Diseases of signal transductionREACTOMER-HSA-5663202
Signaling by WNT in cancerREACTOMER-HSA-4791275
TCF7L2 mutants don't bind CTBPREACTOMER-HSA-5339700
Signal TransductionREACTOMER-HSA-162582
Signaling by WntREACTOMER-HSA-195721
Degradation of beta-catenin by the destruction complexREACTOMER-HSA-195253
Repression of WNT target genesREACTOMER-HSA-4641265
TCF dependent signaling in response to WNTREACTOMER-HSA-201681
Deactivation of the beta-catenin transactivating complexREACTOMER-HSA-3769402

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
127007652003Coordinated histone modifications mediated by a CtBP co-repressor complex.295
118645952002CtBP, an unconventional transcriptional corepressor in development and oncogenesis.188
194505122009A two-step model for colon adenoma initiation and progression caused by APC loss.127
124192292002Transcription corepressor CtBP is an NAD(+)-regulated dehydrogenase.101
183237762008Subversion of CtBP1-controlled macropinocytosis by human adenovirus serotype 3.86
183544942008The closure of Pak1-dependent macropinosomes requires the phosphorylation of CtBP1/BARS.82
167406592006Redox sensor CtBP mediates hypoxia-induced tumor cell migration.74
162878522005RBP-Jkappa/SHARP recruits CtIP/CtBP corepressors to silence Notch target genes.69
128297902003MLL repression domain interacts with histone deacetylases, the polycomb group proteins HPC2 and BMI-1, and the corepressor C-terminal-binding protein.62
168049022006The expression levels of the transcriptional regulators p300 and CtBP modulate the correlations between SNAIL, ZEB1, E-cadherin and vitamin D receptor in human colon carcinomas.55

Citation

Dessen P

CTBP1 (C-terminal binding protein 1)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/40185/ctbp1