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CTBP1 (C-terminal binding protein 1)

Identity

Alias_symbol (synonym)BARS
Other alias
HGNC (Hugo) CTBP1
LocusID (NCBI) 1487
Atlas_Id 40185
Location 4p16.3  [Link to chromosome band 4p16]
Location_base_pair Starts at 1211440 and ends at 1249120 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
ASAH1 (8p22) / CTBP1 (4p16.3)CTBP1 (4p16.3) / ATF6 (1q23.3)CTBP1 (4p16.3) / CTBP1 (4p16.3)
FZD3 (8p21.1) / CTBP1 (4p16.3)MAEA (4p16.3) / CTBP1 (4p16.3)RNF212 (4p16.3) / CTBP1 (4p16.3)
MAEA 4p16.3 / CTBP1 4p16.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Leukemias implicated (Data extracted from papers in the Atlas) [ 4 ]
  inv(3)(p24q26) ?/MECOM
inv(3)(q21q26) RPN1/MECOM
t(3;7)(q26;q21) CDK6/MECOM
t(3;21)(q26;q11) NRIP1/MECOM


External links

Nomenclature
HGNC (Hugo)CTBP1   2494
Cards
Entrez_Gene (NCBI)CTBP1  1487  C-terminal binding protein 1
AliasesBARS
GeneCards (Weizmann)CTBP1
Ensembl hg19 (Hinxton)ENSG00000159692 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000159692 [Gene_View]  chr4:1211440-1249120 [Contig_View]  CTBP1 [Vega]
ICGC DataPortalENSG00000159692
TCGA cBioPortalCTBP1
AceView (NCBI)CTBP1
Genatlas (Paris)CTBP1
WikiGenes1487
SOURCE (Princeton)CTBP1
Genetics Home Reference (NIH)CTBP1
Genomic and cartography
GoldenPath hg38 (UCSC)CTBP1  -     chr4:1211440-1249120 -  4p16.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)CTBP1  -     4p16.3   [Description]    (hg19-Feb_2009)
EnsemblCTBP1 - 4p16.3 [CytoView hg19]  CTBP1 - 4p16.3 [CytoView hg38]
Mapping of homologs : NCBICTBP1 [Mapview hg19]  CTBP1 [Mapview hg38]
OMIM194190   602618   
Gene and transcription
Genbank (Entrez)AF091555 AL137653 BC011655 BC053320 BC064333
RefSeq transcript (Entrez)NM_001012614 NM_001328
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)CTBP1
Cluster EST : UnigeneHs.208597 [ NCBI ]
CGAP (NCI)Hs.208597
Alternative Splicing GalleryENSG00000159692
Gene ExpressionCTBP1 [ NCBI-GEO ]   CTBP1 [ EBI - ARRAY_EXPRESS ]   CTBP1 [ SEEK ]   CTBP1 [ MEM ]
Gene Expression Viewer (FireBrowse)CTBP1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)1487
GTEX Portal (Tissue expression)CTBP1
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ13363   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ13363  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ13363
Splice isoforms : SwissVarQ13363
PhosPhoSitePlusQ13363
Domaine pattern : Prosite (Expaxy)D_2_HYDROXYACID_DH_1 (PS00065)    D_2_HYDROXYACID_DH_3 (PS00671)   
Domains : Interpro (EBI)D-isomer_2_OHA_DH_cat_dom    D-isomer_DH_CS    D-isomer_DH_CS1    D-isomer_DH_NAD-bd    NAD(P)-bd_dom   
Domain families : Pfam (Sanger)2-Hacid_dh (PF00389)    2-Hacid_dh_C (PF02826)   
Domain families : Pfam (NCBI)pfam00389    pfam02826   
Conserved Domain (NCBI)CTBP1
DMDM Disease mutations1487
Blocks (Seattle)CTBP1
PDB (SRS)1MX3    4LCE    4U6Q    4U6S   
PDB (PDBSum)1MX3    4LCE    4U6Q    4U6S   
PDB (IMB)1MX3    4LCE    4U6Q    4U6S   
PDB (RSDB)1MX3    4LCE    4U6Q    4U6S   
Structural Biology KnowledgeBase1MX3    4LCE    4U6Q    4U6S   
SCOP (Structural Classification of Proteins)1MX3    4LCE    4U6Q    4U6S   
CATH (Classification of proteins structures)1MX3    4LCE    4U6Q    4U6S   
SuperfamilyQ13363
Human Protein AtlasENSG00000159692
Peptide AtlasQ13363
HPRD04015
IPIIPI00012835   IPI00450767   IPI00966719   IPI00554626   IPI00968298   IPI00964612   IPI00964890   IPI00964078   IPI00965152   IPI00965652   IPI00965405   IPI00964334   
Protein Interaction databases
DIP (DOE-UCLA)Q13363
IntAct (EBI)Q13363
FunCoupENSG00000159692
BioGRIDCTBP1
STRING (EMBL)CTBP1
ZODIACCTBP1
Ontologies - Pathways
QuickGOQ13363
Ontology : AmiGOnegative regulation of transcription from RNA polymerase II promoter  RNA polymerase II transcription corepressor activity  transcription factor activity, sequence-specific DNA binding  protein binding  nucleus  nucleus  nucleoplasm  nucleoplasm  transcription factor complex  cytoplasm  transcription, DNA-templated  protein phosphorylation  protein C-terminus binding  transcription factor binding  negative regulation of cell proliferation  oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor  transcriptional repressor complex  transcriptional repressor complex  viral genome replication  protein domain specific binding  protein domain specific binding  positive regulation of histone deacetylation  negative regulation of histone acetylation  negative regulation of transcription, DNA-templated  white fat cell differentiation  NAD binding  regulation of cell cycle  oxidation-reduction process  repressing transcription factor binding  negative regulation of histone H4 acetylation  negative regulation of transcription from RNA polymerase II promoter by histone modification  
Ontology : EGO-EBInegative regulation of transcription from RNA polymerase II promoter  RNA polymerase II transcription corepressor activity  transcription factor activity, sequence-specific DNA binding  protein binding  nucleus  nucleus  nucleoplasm  nucleoplasm  transcription factor complex  cytoplasm  transcription, DNA-templated  protein phosphorylation  protein C-terminus binding  transcription factor binding  negative regulation of cell proliferation  oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor  transcriptional repressor complex  transcriptional repressor complex  viral genome replication  protein domain specific binding  protein domain specific binding  positive regulation of histone deacetylation  negative regulation of histone acetylation  negative regulation of transcription, DNA-templated  white fat cell differentiation  NAD binding  regulation of cell cycle  oxidation-reduction process  repressing transcription factor binding  negative regulation of histone H4 acetylation  negative regulation of transcription from RNA polymerase II promoter by histone modification  
Pathways : BIOCARTASUMOylation as a mechanism to modulate CtBP-dependent gene responses [Genes]    WNT Signaling Pathway [Genes]   
Pathways : KEGGWnt signaling pathway    Notch signaling pathway    Pathways in cancer    Chronic myeloid leukemia   
NDEx NetworkCTBP1
Atlas of Cancer Signalling NetworkCTBP1
Wikipedia pathwaysCTBP1
Orthology - Evolution
OrthoDB1487
GeneTree (enSembl)ENSG00000159692
Phylogenetic Trees/Animal Genes : TreeFamCTBP1
HOVERGENQ13363
HOGENOMQ13363
Homologs : HomoloGeneCTBP1
Homology/Alignments : Family Browser (UCSC)CTBP1
Gene fusions - Rearrangements
Fusion : MitelmanMAEA/CTBP1 [4p16.3/4p16.3]  [t(4;4)(p16;p16)]  
Fusion: TCGAMAEA 4p16.3 CTBP1 4p16.3 LAML
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCTBP1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CTBP1
dbVarCTBP1
ClinVarCTBP1
1000_GenomesCTBP1 
Exome Variant ServerCTBP1
ExAC (Exome Aggregation Consortium)CTBP1 (select the gene name)
Genetic variants : HAPMAP1487
Genomic Variants (DGV)CTBP1 [DGVbeta]
DECIPHERCTBP1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisCTBP1 
Mutations
ICGC Data PortalCTBP1 
TCGA Data PortalCTBP1 
Broad Tumor PortalCTBP1
OASIS PortalCTBP1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCTBP1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDCTBP1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch CTBP1
DgiDB (Drug Gene Interaction Database)CTBP1
DoCM (Curated mutations)CTBP1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CTBP1 (select a term)
intoGenCTBP1
Cancer3DCTBP1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM194190    602618   
Orphanet
MedgenCTBP1
Genetic Testing Registry CTBP1
NextProtQ13363 [Medical]
TSGene1487
GENETestsCTBP1
Target ValidationCTBP1
Huge Navigator CTBP1 [HugePedia]
snp3D : Map Gene to Disease1487
BioCentury BCIQCTBP1
ClinGenCTBP1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD1487
Chemical/Pharm GKB GenePA26995
Clinical trialCTBP1
Miscellaneous
canSAR (ICR)CTBP1 (select the gene name)
Probes
Litterature
PubMed175 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineCTBP1
EVEXCTBP1
GoPubMedCTBP1
iHOPCTBP1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Sep 25 19:04:11 CEST 2017

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